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Aliases for TMEM167A Gene

Aliases for TMEM167A Gene

  • Transmembrane Protein 167A 2 3 4 5
  • Transmembrane Protein 167 2 3 4
  • TMEM167 3 4

External Ids for TMEM167A Gene

Previous HGNC Symbols for TMEM167A Gene

  • TMEM167

Previous GeneCards Identifiers for TMEM167A Gene

  • GC05M082388
  • GC05M077557
  • GC05M082348

Summaries for TMEM167A Gene

GeneCards Summary for TMEM167A Gene

TMEM167A (Transmembrane Protein 167A) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM167A Gene

  • Involved in the early part of the secretory pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM167A Gene

Genomics for TMEM167A Gene

Regulatory Elements for TMEM167A Gene

Enhancers for TMEM167A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM167A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM167A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM167A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM167A Gene

Chromosome:
5
Start:
83,052,846 bp from pter
End:
83,077,863 bp from pter
Size:
25,018 bases
Orientation:
Minus strand

Genomic View for TMEM167A Gene

Genes around TMEM167A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM167A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM167A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM167A Gene

Proteins for TMEM167A Gene

  • Protein details for TMEM167A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBQ9-KISHA_HUMAN
    Recommended name:
    Protein kish-A
    Protein Accession:
    Q8TBQ9
    Secondary Accessions:
    • Q0P692

    Protein attributes for TMEM167A Gene

    Size:
    72 amino acids
    Molecular mass:
    8060 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM167A Gene

Proteomics data for TMEM167A Gene at MOPED

Post-translational modifications for TMEM167A Gene

Other Protein References for TMEM167A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM167A Gene

Domains & Families for TMEM167A Gene

Protein Domains for TMEM167A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM167A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBQ9

UniProtKB/Swiss-Prot:

KISHA_HUMAN :
  • Belongs to the KISH family.
Family:
  • Belongs to the KISH family.
genes like me logo Genes that share domains with TMEM167A: view

No data available for Gene Families for TMEM167A Gene

Function for TMEM167A Gene

Molecular function for TMEM167A Gene

UniProtKB/Swiss-Prot Function:
Involved in the early part of the secretory pathway.

Phenotypes for TMEM167A Gene

MGI mutant phenotypes for TMEM167A:
inferred from 1 alleles
GenomeRNAi human phenotypes for TMEM167A:
genes like me logo Genes that share phenotypes with TMEM167A: view

Animal Models for TMEM167A Gene

MGI Knock Outs for TMEM167A:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM167A

CRISPR Products

miRNA for TMEM167A Gene

miRTarBase miRNAs that target TMEM167A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM167A Gene

Localization for TMEM167A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM167A Gene

Golgi apparatus membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM167A Gene COMPARTMENTS Subcellular localization image for TMEM167A gene
Compartment Confidence
extracellular 3
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for TMEM167A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM167A: view

Pathways & Interactions for TMEM167A Gene

SuperPathways for TMEM167A Gene

No Data Available

Interacting Proteins for TMEM167A Gene

Gene Ontology (GO) - Biological Process for TMEM167A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM167A Gene

Drugs & Compounds for TMEM167A Gene

No Compound Related Data Available

Transcripts for TMEM167A Gene

Unigene Clusters for TMEM167A Gene

Transmembrane protein 167A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM167A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2:
SP3: - - -

Relevant External Links for TMEM167A Gene

GeneLoc Exon Structure for
TMEM167A
ECgene alternative splicing isoforms for
TMEM167A

Expression for TMEM167A Gene

mRNA expression in normal human tissues for TMEM167A Gene

Protein differential expression in normal tissues from HIPED for TMEM167A Gene

This gene is overexpressed in Nasal epithelium (37.2) and Bone (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMEM167A Gene



SOURCE GeneReport for Unigene cluster for TMEM167A Gene Hs.355606

genes like me logo Genes that share expression patterns with TMEM167A: view

Protein tissue co-expression partners for TMEM167A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM167A Gene

Orthologs for TMEM167A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMEM167A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM167A 35
  • 96.3 (n)
  • 100 (a)
TMEM167A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM167A 35
  • 97.22 (n)
  • 98.61 (a)
TMEM167A 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem167 35
  • 93.06 (n)
  • 97.22 (a)
Tmem167 16
Tmem167 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC100609777 35
  • 99.07 (n)
  • 97.22 (a)
-- 36
  • 97 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem167a 35
  • 93.52 (n)
  • 95.83 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM167A 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM167A 35
  • 84.72 (n)
  • 95.83 (a)
TMEM167A 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM167A 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6388 35
tmem167a 35
  • 81.94 (n)
  • 87.5 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15832 35
zebrafish
(Danio rerio)
Actinopterygii tmem167a 35
  • 75.93 (n)
  • 90.28 (a)
wufa97d03 35
tmem167a 36
  • 41 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5180 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002087 35
  • 64.29 (n)
  • 77.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta ksh 35
  • 65.24 (n)
  • 74.29 (a)
ksh 36
  • 72 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KSH1 36
  • 63 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7895 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03465 35
  • 62.05 (n)
  • 70.77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 78 (a)
OneToOne
Species with no ortholog for TMEM167A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM167A Gene

ENSEMBL:
Gene Tree for TMEM167A (if available)
TreeFam:
Gene Tree for TMEM167A (if available)

Paralogs for TMEM167A Gene

(1) SIMAP similar genes for TMEM167A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TMEM167A Gene

genes like me logo Genes that share paralogs with TMEM167A: view

No data available for Paralogs for TMEM167A Gene

Variants for TMEM167A Gene

Sequence variations from dbSNP and Humsavar for TMEM167A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1583 -- 83,052,403(-) AGCAT(A/T)GTCCA downstream-variant-500B
rs7891 -- 83,053,558(-) ACTAC(C/T)CAAGG utr-variant-3-prime
rs27493 -- 83,054,372(-) ATTGG(C/T)TTCAG utr-variant-3-prime
rs1044363 -- 83,053,123(-) TACCA(A/G)CATTG utr-variant-3-prime
rs1044374 -- 83,052,928(-) TGTGA(C/T)TTTAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM167A Gene

Variant ID Type Subtype PubMed ID
nsv882242 CNV Loss 21882294
nsv511108 CNV Complex 20534489

Variation tolerance for TMEM167A Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM167A Gene

HapMap Linkage Disequilibrium report
TMEM167A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM167A Gene

Disorders for TMEM167A Gene

Relevant External Links for TMEM167A

Genetic Association Database (GAD)
TMEM167A
Human Genome Epidemiology (HuGE) Navigator
TMEM167A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM167A

No disorders were found for TMEM167A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM167A Gene

Publications for TMEM167A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Phenylmethanesulfonyl fluoride elicits and intensifies the clinical expression of neuropathic insults. (PMID: 1316117) Moretto A. … Lotti M. (Arch. Toxicol. 1992) 2 3
  3. Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance. (PMID: 25057126) Ramos Y.F. … Meulenbelt I. (J. Med. Genet. 2014) 3
  4. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein J.I. … Sullivan P.F. (Nat Commun 2014) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TMEM167A Gene

Sources for TMEM167A Gene

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