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Aliases for TMEM167A Gene

Aliases for TMEM167A Gene

  • Transmembrane Protein 167A 2 3 4 5
  • Transmembrane Protein 167 2 3 4
  • TMEM167 3 4
  • Protein Kish-A 3

External Ids for TMEM167A Gene

Previous HGNC Symbols for TMEM167A Gene

  • TMEM167

Previous GeneCards Identifiers for TMEM167A Gene

  • GC05M082388
  • GC05M077557
  • GC05M082348

Summaries for TMEM167A Gene

GeneCards Summary for TMEM167A Gene

TMEM167A (Transmembrane Protein 167A) is a Protein Coding gene. An important paralog of this gene is TMEM167B.

UniProtKB/Swiss-Prot for TMEM167A Gene

  • Involved in the early part of the secretory pathway.

Additional gene information for TMEM167A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM167A Gene

Genomics for TMEM167A Gene

GeneHancer (GH) Regulatory Elements for TMEM167A Gene

Promoters and enhancers for TMEM167A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I083076 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.4 429 2.9 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B XRCC4 TMEM167A LOC105379052
GH05I082975 Enhancer 0.9 ENCODE 5.8 +101.4 101352 2.8 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 ATF7 FOS SP3 YY2 ATP6AP1L LOC105379052 TMEM167A ST13P12 GC05M083013
GH05I083470 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.2 -395.9 -395890 6.4 PKNOX1 FOXA2 SIN3A FEZF1 ZNF2 ZNF213 ZNF143 ZNF263 SP3 REST VCAN TMEM167A VCAN-AS1
GH05I083368 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 2.2 -290.9 -290949 1.6 ZNF146 PKNOX1 CEBPB JUNB BATF ATF2 ZNF217 IKZF1 HMBOX1 RUNX3 VCAN TMEM167A XRCC4 LOC105379053 GC05P083318
GH05I083306 Enhancer 1.2 FANTOM5 Ensembl ENCODE 1.9 -229.1 -229113 1.4 BACH1 EBF1 BMI1 BATF IRF4 RELA POLR2A NFATC1 ATF7 ETV6 VCAN LOC105379052 TMEM167A XRCC4 GC05P083318 GC05M083273
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM167A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM167A gene promoter:

Genomic Locations for TMEM167A Gene

Genomic Locations for TMEM167A Gene
25,018 bases
Minus strand

Genomic View for TMEM167A Gene

Genes around TMEM167A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM167A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM167A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM167A Gene

Proteins for TMEM167A Gene

  • Protein details for TMEM167A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein kish-A
    Protein Accession:
    Secondary Accessions:
    • Q0P692

    Protein attributes for TMEM167A Gene

    72 amino acids
    Molecular mass:
    8060 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM167A Gene

Post-translational modifications for TMEM167A Gene

Other Protein References for TMEM167A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM167A Gene

Domains & Families for TMEM167A Gene

Gene Families for TMEM167A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM167A Gene


Suggested Antigen Peptide Sequences for TMEM167A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the KISH family.
  • Belongs to the KISH family.
genes like me logo Genes that share domains with TMEM167A: view

Function for TMEM167A Gene

Molecular function for TMEM167A Gene

UniProtKB/Swiss-Prot Function:
Involved in the early part of the secretory pathway.

Phenotypes for TMEM167A Gene

MGI mutant phenotypes for TMEM167A:
inferred from 1 alleles
GenomeRNAi human phenotypes for TMEM167A:
genes like me logo Genes that share phenotypes with TMEM167A: view

Animal Models for TMEM167A Gene

MGI Knock Outs for TMEM167A:

miRNA for TMEM167A Gene

miRTarBase miRNAs that target TMEM167A

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM167A Gene

Localization for TMEM167A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM167A Gene

Golgi apparatus membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM167A gene
Compartment Confidence
extracellular 3
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for TMEM167A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM167A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM167A Gene

Pathways & Interactions for TMEM167A Gene

SuperPathways for TMEM167A Gene

No Data Available

Interacting Proteins for TMEM167A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000424707 for TMEM167A Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM167A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009306 protein secretion IBA --
GO:0046907 intracellular transport IBA --
genes like me logo Genes that share ontologies with TMEM167A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM167A Gene

Drugs & Compounds for TMEM167A Gene

No Compound Related Data Available

Transcripts for TMEM167A Gene

Unigene Clusters for TMEM167A Gene

Transmembrane protein 167A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM167A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP3: - - -

Relevant External Links for TMEM167A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM167A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM167A Gene

Protein differential expression in normal tissues from HIPED for TMEM167A Gene

This gene is overexpressed in Nasal epithelium (37.2) and Bone (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM167A Gene

Protein tissue co-expression partners for TMEM167A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM167A Gene:


SOURCE GeneReport for Unigene cluster for TMEM167A Gene:


Evidence on tissue expression from TISSUES for TMEM167A Gene

  • Nervous system(4.9)
  • Lung(4.3)
  • Liver(3)
genes like me logo Genes that share expression patterns with TMEM167A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM167A Gene

Orthologs for TMEM167A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMEM167A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
LOC100609777 33
  • 99.07 (n)
-- 34
  • 97 (a)
(Canis familiaris)
Mammalia TMEM167A 33 34
  • 97.22 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 97 (a)
-- 34
  • 93 (a)
(Bos Taurus)
Mammalia TMEM167A 33 34
  • 96.3 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM167A 34
  • 94 (a)
(Rattus norvegicus)
Mammalia Tmem167a 33
  • 93.52 (n)
(Mus musculus)
Mammalia Tmem167 33 16 34
  • 93.06 (n)
(Gallus gallus)
Aves TMEM167A 33 34
  • 84.72 (n)
(Anolis carolinensis)
Reptilia TMEM167A 34
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem167a 33
  • 81.94 (n)
Str.6388 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15832 33
(Danio rerio)
Actinopterygii tmem167a 33 34
  • 75.93 (n)
wufa97d03 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5180 33
fruit fly
(Drosophila melanogaster)
Insecta ksh 33 34
  • 65.24 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002087 33
  • 64.29 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KSH1 34
  • 63 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 78 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03465 33
  • 62.05 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7895 33
Species where no ortholog for TMEM167A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM167A Gene

Gene Tree for TMEM167A (if available)
Gene Tree for TMEM167A (if available)

Paralogs for TMEM167A Gene

Paralogs for TMEM167A Gene

(1) SIMAP similar genes for TMEM167A Gene using alignment to 1 proteins: Pseudogenes for TMEM167A Gene

genes like me logo Genes that share paralogs with TMEM167A: view

Variants for TMEM167A Gene

Sequence variations from dbSNP and Humsavar for TMEM167A Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000085104 -- 83,058,705(-) G/A intron_variant
rs1000204405 -- 83,054,130(-) T/A 3_prime_UTR_variant
rs1000323602 -- 83,064,011(-) C/G intron_variant
rs1000355717 -- 83,070,505(-) G/A intron_variant
rs1000393598 -- 83,062,743(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM167A Gene

Variant ID Type Subtype PubMed ID
nsv511108 OTHER complex 20534489
nsv968956 CNV duplication 23825009

Variation tolerance for TMEM167A Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM167A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM167A Gene

Disorders for TMEM167A Gene

Additional Disease Information for TMEM167A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM167A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM167A Gene

Publications for TMEM167A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Phenylmethanesulfonyl fluoride elicits and intensifies the clinical expression of neuropathic insults. (PMID: 1316117) Moretto A … Lotti M (Archives of toxicology 1992) 2 3 58
  3. Gene essentiality and synthetic lethality in haploid human cells. (PMID: 26472760) Blomen VA … Brummelkamp TR (Science (New York, N.Y.) 2015) 3 58
  4. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein JI … Sullivan PF (Nature communications 2014) 3 58
  5. Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance. (PMID: 25057126) Ramos YF … Meulenbelt I (Journal of medical genetics 2014) 3 58

Products for TMEM167A Gene

Sources for TMEM167A Gene

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