TMEM167A Gene
protein-coding GIFtS: 43
GCID: GC05M082348
|
|
transmembrane protein 167A(Previous name: transmembrane protein 167 )
(Previous symbol: TMEM167)
| |
Aliases
for TMEM167A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Transmembrane Protein 167A1 2 3 | | Transmembrane Protein 1671 2 3 | | TMEM1671 2 3 | | FLJ305081 | | MGC239091 | | Protein Kish-A2 |
| External Ids: | HGNC: 283301 | Entrez Gene: 1533392 | Ensembl: ENSG000001746957 | UniProtKB: Q8TBQ93 | | ORGUL members: | |
|---|
| NONCODE:n342663 | |
Export aliases for TMEM167A gene to outside databasesPrevious GC identifers: GC05M082388 GC05M077557
|---|
Summaries
for TMEM167A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KISHA_HUMAN, Q8TBQ9Function: Involved in the early part of the secretory pathway
|
Genomic Views
for TMEM167A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM167A gene promoter:
MEF-2 E4BP4 CBF-C MEF-2A CBF-A CBF-B FOXO1a aMEF-2 FOXO1 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM167A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM167A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q14.2 Ensembl cytogenetic band: 5q14.2 HGNC cytogenetic band: 5q14.2TMEM167A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M082348: view genomic region
(about GC identifiers)
Start:
|
82,348,665 bp from pter |
End:
|
82,373,682 bp from pter |
Size:
|
25,018 bases |
Orientation:
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minus strand |
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Proteins
for TMEM167A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KISHA_HUMAN, Q8TBQ9 (See
protein sequence)Recommended Name: Protein kish-A precursor Size: 72 amino acids; 8060 Da
Subcellular location: Golgi apparatus membrane; Single-pass type I membrane protein
Secondary accessions: Q0P692Explore the universe of human proteins at neXtProt for TMEM167A: NX_Q8TBQ9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TBQ9
TMEM167A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_777569.1
ENSEMBL proteins: ENSP00000424707
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000139 | Golgi membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TMEM167A for ontologies About GeneDecksing
TMEM167A Antibody Products:
Assay Products for TMEM167A: |
Protein
Domains /
Families
for TMEM167A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM167A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TBQ9ProtoNet protein and cluster: Q8TBQ9 UniProtKB/Swiss-Prot: KISHA_HUMAN, Q8TBQ9Similarity: Belongs to the KISH family |
Function
for TMEM167A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KISHA_HUMAN, Q8TBQ9Function: Involved in the early part of the secretory pathway
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM167A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM167A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM167A (NM_174909) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM167A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM167A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM167A |
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Tmem167):
TMEM167A for phenotypes About GeneDecksing
|
Pathways & Interactions
for TMEM167A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM167A
|
Drugs & Compounds
for TMEM167A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM167A
Search CenterWatch for drugs/clinical trials and news about TMEM167A / KISHA
|
Transcripts
for TMEM167A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM167A gene: NM_174909.4 Unigene Cluster for TMEM167A: Transmembrane protein 167A Hs.355606 [show with all ESTs]Unigene Representative Sequence: NM_1749096 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000502346(uc003khx.4) ENST00000511450 ENST00000511118 ENST00000504622
ENST00000509770 ENST00000503892
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM167A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM167A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM167A (NM_174909) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM167A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM167A |
Additional cDNA sequence: AK000174.1 AK055070.1 AK055612.1 AK172803.1 BC026285.1 BC028585.1 BC070122.1 BC107575.1 BX647979.1 15 DOTS entries: DT.101984213 DT.99945748 DT.100784989 DT.92462548 DT.100784987 DT.120875678 DT.120875820 DT.102830243 DT.95279011 DT.100027178 DT.218242 DT.92455369 DT.444657 DT.95180434 DT.95278991 24/562 AceView cDNA sequences (see all 562): CA440875 AV708419 AI915526 AI245206 AI453279 AI741949 CD243268 AI799606 AI499160 BG568176 AA954927 AI215123 BM717462 CB267908 BU735965 CB153558 BQ771696 BC070122 BM828803 AA845250 AA890012 CR600809 CR590885 AA236549
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM167A About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b |
|---|
|
| SP1: | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | | | | |
ECgene alternative splicing isoforms for TMEM167A
|
Expression
for TMEM167A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM167A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACATCTCTG
About this image
See TMEM167A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM167A
SOURCE GeneReport for Unigene cluster: Hs.355606
SABiosciences Custom PCR Arrays for TMEM167A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM167A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM167A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM167A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM167A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM167A |
Orthologs
for TMEM167A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TMEM167A gene from 7/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tmem1671 , 5 |
transmembrane protein 1671, 5 |
93.06(n)1
97.22(a)1 |
|
13 (45.50 cM)5
660741 NM_025335.31 NP_079611.21
900891235 |
chicken
(Gallus gallus) |
Aves |
TMEM167A1 |
transmembrane protein 167A |
84.72(n)
95.83(a) |
|
770790 NM_001113454.2 NP_001106925.1 |
lizard
(Anolis carolinensis) |
Reptilia |
TMEM167A6 |
-- |
93(a) |
1 ↔ 1 |
2(18357629-18363280) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.158322 |
Xenopus laevis transcribed sequence with weak similarity more |
81.25(n) |
|
BJ094584.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufa97d032 |
Transcribed sequence with weak similarity to protein more |
76.68(n) |
|
CB353920.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
ksh1 |
kish |
65.24(n)
74.29(a) |
|
50363 NM_144242.3 NP_652499.2 |
rice
(Oryza sativa) |
Liliopsida |
-- |
transmembrane protein 167 precursor, putative, exp... |
57(a) |
1 ↔ 1 |
5(9194955-9198243) |
ENSEMBL Gene Tree for TMEM167A (if available)
TreeFam Gene Tree for TMEM167A (if available) |
Paralogs
for TMEM167A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM167A gene
- TMEM167B2
1 SIMAP similar gene for TMEM167A using alignment to 1 protein entry: KISHA_HUMAN:TMEM167B
TMEM167A for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TMEM167A
PGOHUM00000233792
|
Genomic Variants
for TMEM167A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM167A (82348665 - 82373682 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM167A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM167A |
|
Disorders
/ Diseases
for TMEM167A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM167A for disorders About GeneDecksing
1  disease for TMEM167A: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: TMEM167A (1 document)
Export disorders for TMEM167A gene to outside databases
|
Publications
for TMEM167A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM167A gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM167A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Phenylmethanesulfonyl fluoride elicits and intensifies the clinical expression of neuropathic insults. (PubMed id 1316117)1, 3 Moretto A....Lotti M. (1992)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. (PubMed id 19942856)2 Wendler F....Munro S. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
|
External Searches for TMEM167A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM167A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM167A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM167A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM167A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM167A gene:
Search GeneIP for patents involving TMEM167A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM167A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM167A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM167A | | | OriGene Protein Over-expression Lysate for TMEM167A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM167A | | OriGene 3'-UTR Clone for TMEM167A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM167A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM167A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM167A | | OriGene Custom Protein Services for TMEM167A | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM167A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM167A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM167A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM167A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM167A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM167A |
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 |
 |
 | | | TMEM167A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM167A |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM167A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM167A |
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