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Aliases for TMEM167A Gene

Aliases for TMEM167A Gene

  • Transmembrane Protein 167A 2 3 4 5
  • Transmembrane Protein 167 2 3 4
  • TMEM167 3 4
  • Protein Kish-A 3

External Ids for TMEM167A Gene

Previous HGNC Symbols for TMEM167A Gene

  • TMEM167

Previous GeneCards Identifiers for TMEM167A Gene

  • GC05M082388
  • GC05M077557
  • GC05M082348

Summaries for TMEM167A Gene

GeneCards Summary for TMEM167A Gene

TMEM167A (Transmembrane Protein 167A) is a Protein Coding gene. An important paralog of this gene is TMEM167B.

UniProtKB/Swiss-Prot for TMEM167A Gene

  • Involved in the early part of the secretory pathway.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM167A Gene

Genomics for TMEM167A Gene

Regulatory Elements for TMEM167A Gene

Enhancers for TMEM167A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G082975 1 ENCODE 5.8 +101.4 101353 2.8 FOXA2 MLX AGO1 ARID4B DMAP1 ZNF48 FOS PAF1 SP3 YY2 ATP6AP1L LOC105379052 TMEM167A ST13P12 GC05M083013
GH05G083368 1.5 FANTOM5 Ensembl ENCODE dbSUPER 2.2 -291.0 -290950 1.6 CTCF PKNOX1 ZNF146 CEBPB JUNB ZNF48 RAD21 GATA2 SCRT2 HMBOX1 VCAN TMEM167A XRCC4 LOC105379053 GC05P083318
GH05G083306 1.4 FANTOM5 Ensembl ENCODE 1.9 -229.1 -229114 1.4 WRNIP1 BMI1 ZNF766 CBX5 FOS RELB ETV6 IKZF2 CREM SMAD5 VCAN LOC105379052 TMEM167A XRCC4 GC05P083318 GC05M083273
GH05G083376 1.4 FANTOM5 Ensembl ENCODE dbSUPER 1.5 -299.6 -299601 2.3 NR2F1 CEBPB FOS RAD21 EP300 ATF2 NFE2L2 VCAN TMEM167A XRCC4 LOC105379053 GC05P083318
GH05G083470 1.7 FANTOM5 ENCODE dbSUPER 1.2 -395.9 -395890 6.4 HNRNPUL1 PKNOX1 FOXA2 CREB3L1 SIN3A FEZF1 ZNF2 ZNF143 ZNF263 SP3 VCAN TMEM167A VCAN-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM167A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM167A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000183397 563 2601 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS

Genomic Location for TMEM167A Gene

Chromosome:
5
Start:
83,052,846 bp from pter
End:
83,077,863 bp from pter
Size:
25,018 bases
Orientation:
Minus strand

Genomic View for TMEM167A Gene

Genes around TMEM167A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM167A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM167A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM167A Gene

Proteins for TMEM167A Gene

  • Protein details for TMEM167A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBQ9-KISHA_HUMAN
    Recommended name:
    Protein kish-A
    Protein Accession:
    Q8TBQ9
    Secondary Accessions:
    • Q0P692

    Protein attributes for TMEM167A Gene

    Size:
    72 amino acids
    Molecular mass:
    8060 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM167A Gene

Post-translational modifications for TMEM167A Gene

  • Ubiquitination at posLast=3636
  • Glycosylation at posLast=3535
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM167A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM167A Gene

Domains & Families for TMEM167A Gene

Protein Domains for TMEM167A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM167A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBQ9

UniProtKB/Swiss-Prot:

KISHA_HUMAN :
  • Belongs to the KISH family.
Family:
  • Belongs to the KISH family.
genes like me logo Genes that share domains with TMEM167A: view

No data available for Gene Families for TMEM167A Gene

Function for TMEM167A Gene

Molecular function for TMEM167A Gene

UniProtKB/Swiss-Prot Function:
Involved in the early part of the secretory pathway.

Phenotypes for TMEM167A Gene

MGI mutant phenotypes for TMEM167A:
inferred from 1 alleles
GenomeRNAi human phenotypes for TMEM167A:
genes like me logo Genes that share phenotypes with TMEM167A: view

Animal Models for TMEM167A Gene

MGI Knock Outs for TMEM167A:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM167A

CRISPR Products

miRNA for TMEM167A Gene

miRTarBase miRNAs that target TMEM167A

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM167A Gene

Localization for TMEM167A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM167A Gene

Golgi apparatus membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM167A gene
Compartment Confidence
extracellular 3
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for TMEM167A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM167A: view

Pathways & Interactions for TMEM167A Gene

SuperPathways for TMEM167A Gene

No Data Available

Interacting Proteins for TMEM167A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000424707%0d%0a9606.ENSP00000371559%0d%0a9606.ENSP00000305654%0d%0a
Selected Interacting proteins: ENSP00000424707 for TMEM167A Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM167A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009306 protein secretion IBA --
GO:0046907 intracellular transport IBA --
genes like me logo Genes that share ontologies with TMEM167A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM167A Gene

Transcripts for TMEM167A Gene

Unigene Clusters for TMEM167A Gene

Transmembrane protein 167A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM167A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2:
SP3: - - -

Relevant External Links for TMEM167A Gene

GeneLoc Exon Structure for
TMEM167A
ECgene alternative splicing isoforms for
TMEM167A

Expression for TMEM167A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM167A Gene

Protein differential expression in normal tissues from HIPED for TMEM167A Gene

This gene is overexpressed in Nasal epithelium (37.2) and Bone (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM167A Gene



Protein tissue co-expression partners for TMEM167A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM167A Gene:

TMEM167A

SOURCE GeneReport for Unigene cluster for TMEM167A Gene:

Hs.355606

Evidence on tissue expression from TISSUES for TMEM167A Gene

  • Nervous system(4.9)
  • Lung(4.3)
  • Liver(3)
genes like me logo Genes that share expression patterns with TMEM167A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM167A Gene

Orthologs for TMEM167A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMEM167A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
OneToMany
LOC100609777 34
  • 99.07 (n)
-- 35
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TMEM167A 34 35
  • 97.22 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 97 (a)
OneToMany
-- 35
  • 93 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TMEM167A 34 35
  • 96.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM167A 35
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem167a 34
  • 93.52 (n)
mouse
(Mus musculus)
Mammalia Tmem167 34 16 35
  • 93.06 (n)
chicken
(Gallus gallus)
Aves TMEM167A 34 35
  • 84.72 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM167A 35
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem167a 34
  • 81.94 (n)
Str.6388 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15832 34
zebrafish
(Danio rerio)
Actinopterygii tmem167a 34 35
  • 75.93 (n)
wufa97d03 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5180 34
fruit fly
(Drosophila melanogaster)
Insecta ksh 34 35
  • 65.24 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002087 34
  • 64.29 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KSH1 35
  • 63 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 78 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU03465 34
  • 62.05 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7895 34
Species where no ortholog for TMEM167A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM167A Gene

ENSEMBL:
Gene Tree for TMEM167A (if available)
TreeFam:
Gene Tree for TMEM167A (if available)

Paralogs for TMEM167A Gene

Paralogs for TMEM167A Gene

(1) SIMAP similar genes for TMEM167A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TMEM167A Gene

genes like me logo Genes that share paralogs with TMEM167A: view

Variants for TMEM167A Gene

Sequence variations from dbSNP and Humsavar for TMEM167A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000085104 -- 83,058,705(+) TTTTT(A/G)AGGAA intron-variant
rs1000204405 -- 83,054,130(+) TAAGA(A/T)GAAGG utr-variant-3-prime
rs1000323602 -- 83,064,011(+) AAAAA(C/G)ATGTA intron-variant, downstream-variant-500B
rs1000355717 -- 83,070,505(+) TATTT(A/G)ATCAT intron-variant
rs1000393598 -- 83,062,743(+) ATAGT(A/G)TCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM167A Gene

Variant ID Type Subtype PubMed ID
nsv511108 OTHER complex 20534489
nsv968956 CNV duplication 23825009

Variation tolerance for TMEM167A Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM167A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM167A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM167A Gene

Disorders for TMEM167A Gene

Relevant External Links for TMEM167A

Genetic Association Database (GAD)
TMEM167A
Human Genome Epidemiology (HuGE) Navigator
TMEM167A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM167A

No disorders were found for TMEM167A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM167A Gene

Publications for TMEM167A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Phenylmethanesulfonyl fluoride elicits and intensifies the clinical expression of neuropathic insults. (PMID: 1316117) Moretto A. … Lotti M. (Arch. Toxicol. 1992) 2 3 64
  3. Gene essentiality and synthetic lethality in haploid human cells. (PMID: 26472760) Blomen V.A. … Brummelkamp T.R. (Science 2015) 3 64
  4. Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance. (PMID: 25057126) Ramos Y.F. … Meulenbelt I. (J. Med. Genet. 2014) 3 64
  5. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein J.I. … Sullivan P.F. (Nat Commun 2014) 3 64

Products for TMEM167A Gene

Sources for TMEM167A Gene

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