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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM165 Gene

protein-coding   GIFtS: 50
GCID: GC04P056262

Transmembrane Protein 165

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 1651 2     CDG2K2
TPA Regulated Locus1 2     FT272
Transmembrane Protein PT272 3     GDT12
Transmembrane Protein TPARL2 3     TMPT272
TPARL2 3     

External Ids:    HGNC: 307601   Entrez Gene: 558582   Ensembl: ENSG000001348517   OMIM: 6147265   UniProtKB: Q9HC073   

Export aliases for TMEM165 gene to outside databases

Previous GC identifers: GC04P055956 GC04P052211


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMEM165 Gene:
This gene encodes a predicted transmembrane protein with a perinuclear Golgi-like distribution in fibroblasts.
Mutations in this gene are associated with the autosomal recessive disorder congenital disorder of glycosylation,
type IIk. Knockdown of this gene's expression causes decreased sialylation in HEK cells and suggests this gene
plays a role in terminal Golgi glycosylation. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Jul 2012)

GeneCards Summary for TMEM165 Gene: 
TMEM165 (transmembrane protein 165) is a protein-coding gene. Diseases associated with TMEM165 include camurati-engelmann disease, and congenital disorder of glycosylation.

UniProtKB/Swiss-Prot: TM165_HUMAN, Q9HC07
Function: May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis.
Therefore, it may play an indirect role in protein glycosylation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_022853.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM165 gene promoter:
         FOXF2   Lmo2   LCR-F1   Evi-1   HEN1   POU2F1   FOXJ2 (long isoform)   POU2F1a   STAT3   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM165 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM165

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM165


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

TMEM165 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM165 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P056262:  view genomic region     (about GC identifiers)

Start:
56,262,090 bp from pter      End:
56,292,342 bp from pter
Size:
30,253 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM165_HUMAN, Q9HC07 (See protein sequence)
Recommended Name: Transmembrane protein 165 precursor  
Size: 324 amino acids; 34906 Da
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein (Probable). Golgi apparatus,
trans-Golgi network membrane. Lysosome membrane. Early endosome membrane. Late endosome membrane
Sequence caution: Sequence=AAF67653.1; Type=Frameshift; Positions=2, 7;
Secondary accessions: A8K3P8 Q9BTN9 Q9NZ34

Explore the universe of human proteins at neXtProt for TMEM165: NX_Q9HC07

Explore proteomics data for TMEM165 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HC07

  • TMEM165 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM165 Protein Expression
    REFSEQ proteins: NP_060945.2  
    ENSEMBL proteins: 
     ENSP00000425449   ENSP00000370736   ENSP00000422639   ENSP00000437816  

    Human Recombinant Protein Products for TMEM165: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMEM165 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005765lysosomal membrane IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0010008endosome membrane IDA--
    GO:0016020membrane ----

    TMEM165 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001727 UPF0016

    Graphical View of Domain Structure for InterPro Entry Q9HC07

    ProtoNet protein and cluster: Q9HC07

    1 Blocks protein domain: IPB001727 Protein of unknown function UPF0016

    UniProtKB/Swiss-Prot: TM165_HUMAN, Q9HC07
    Similarity: Belongs to the GDT1 family


    TMEM165 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TM165_HUMAN, Q9HC07
    Function: May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis.
    Therefore, it may play an indirect role in protein glycosylation

    Phenotypes:
         2 GenomeRNAi human phenotypes for TMEM165:

     Decreased viability with pacli  Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM165 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM165

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM165 
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    miRNA
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    hsa-miR-3671 hsa-miR-892b hsa-miR-187* hsa-miR-181c hsa-miR-3136-5p hsa-miR-1283 hsa-miR-16-1* hsa-miR-181a
    SwitchGear 3'UTR luciferase reporter plasmidTMEM165 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM165


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM165

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/39 Interacting proteins for TMEM165 (Q9HC073 ENSP000003707364) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMS1Q146923, ENSP000003636424I2D: score=3 STRING: ENSP00000363642
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    RBM19Q9Y4C83, ENSP000002617414I2D: score=2 STRING: ENSP00000261741
    ARCN1P484443I2D: score=1 
    ASLP044243I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006487protein N-linked glycosylation IMP--
    GO:0006874cellular calcium ion homeostasis IGI--
    GO:0032472Golgi calcium ion transport IDA--
    GO:0035751regulation of lysosomal lumen pH IMP--

    TMEM165 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM165 (TM165)

    Search CenterWatch for drugs/clinical trials and news about TMEM165 / TM165

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM165 gene: 
    NM_018475.4  

    Unigene Cluster for TMEM165:

    Transmembrane protein 165
    Hs.479766  [show with all ESTs]
    Unigene Representative Sequence: NR_073070
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506198 ENST00000381334(uc003hax.2 uc011bzy.1) ENST00000508404
    ENST00000514070 ENST00000511710 ENST00000502797 ENST00000514904 ENST00000508561
    ENST00000509575 ENST00000506103 ENST00000515591 ENST00000542052
    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM165 (see all 15):
    hsa-miR-3671 hsa-miR-892b hsa-miR-187* hsa-miR-181c hsa-miR-3136-5p hsa-miR-1283 hsa-miR-16-1* hsa-miR-181a
    SwitchGear 3'UTR luciferase reporter plasmidTMEM165 3' UTR sequence
    Inhib. RNA
    Products:
         
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM165
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM165
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    OriGene qPCR primer pairs and template standards for TMEM165
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM165
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM165

    Additional mRNA sequence: 

    AF132746.1 AF183409.1 AK026163.1 AK054712.1 AK123358.1 AK290663.1 AK295289.1 BC003545.1 
    BC104978.1 BC104980.1 BC107582.1 NR_073070.1 

    24/25 DOTS entries (see all 25):

    DT.75181343  DT.100797859  DT.100685206  DT.100797853  DT.95155350  DT.100027591  DT.455304  DT.91909474 
    DT.97817226  DT.85104478  DT.91974933  DT.121219466  DT.97844486  DT.100717391  DT.101983336  DT.121219425 
    DT.92439899  DT.100797856  DT.121219447  DT.121219473  DT.92439897  DT.95241598  DT.100797857  DT.100797858 

    24/336 AceView cDNA sequences (see all 336):

    BF063130 BE168418 AA236413 CB216139 AI343488 BU623789 AA707047 BE675583 
    AA046156 AI762592 CD367216 BF437560 AI742860 BE328796 BF591989 CF272207 
    CF243032 AI335777 AA379786 BM854673 AI337001 AI194062 BC003545 AK026163 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM165 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d
    SP1:              -     -     -                 -     -     -     -                                   -     -                                 
    SP2:                                                              -                                   -     -                                 
    SP3:                                            -     -     -     -                                                                           
    SP4:                                                                                            -                                             
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for TMEM165

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM165 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACAACAAG
    TMEM165 Expression
    About this image


    See TMEM165 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM165

    SOURCE GeneReport for Unigene cluster: Hs.479766

    UniProtKB/Swiss-Prot: TM165_HUMAN, Q9HC07
    Tissue specificity: Ubiquitously expressed

        SABiosciences Custom PCR Arrays for TMEM165
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TMEM165 gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1651 , 5 transmembrane protein 1651, 5 86.79(n)1
    91.95(a)1
      5 (40.56 cM)5
    219821  NM_011626.21  NP_035756.21 
     761838805 
    chicken
    (Gallus gallus)
    Aves TMEM1651 transmembrane protein 165 81.48(n)
    92.86(a)
      428780  XM_426336.3  XP_426336.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1656
    transmembrane protein 165
    67(a)
    1 ↔ 1
    5(104745953-104759160)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ092990.12   -- 79.29(n)    BJ092990.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.26712 Danio rerio transmembrane protein HTP-1 mRNA, complete more 76.13(n)    AF370884.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG425421 CG42542 59.77(n)
    61.67(a)
      8674000  NM_170649.1  NP_731978.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y54F10AL.11 Protein Y54F10AL.1 58.82(n)
    57.25(a)
      175368  NM_065166.3  NP_497567.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GDT1(YBR187W)4
    GDT11
    Putative protein of unknown function; expression is more4
    Gdt1p1
    50.14(n)1
    38.62(a)1
      2(602634-603476)4
    8524851, 4  NP_009746.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G362901 UPF0016 protein 3 50.98(n)
    42.44(a)
      833627  NM_180767.1  NP_851098.1 
    rice
    (Oryza sativa)
    Liliopsida Os.94762 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 80.86(n)    AK071982.1 


    ENSEMBL Gene Tree for TMEM165 (if available)
    TreeFam Gene Tree for TMEM165 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/791 SNPs in TMEM165 are shown (see all 791)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0684474
    Congenital disorder of glycosylation 2K (CDG2K)4--see VAR_0684472 R H mis40--------
    VAR_0684464
    Congenital disorder of glycosylation 2K (CDG2K)4--see VAR_0684462 R C mis40--------
    VAR_0684484
    Congenital disorder of glycosylation 2K (CDG2K)4--see VAR_0684482 G R mis40--------
    rs1997564601,2
    C--52237069(+) AAAAGA/GAAAAA 2 -- int10--------
    rs1891501311,2
    --56162377(+) TCCAGA/GGATGA 2 -- us2k10--------
    rs1400571631,2
    --56162438(+) GTTAGA/GCCTAA 2 -- us2k10--------
    rs1160375441,2
    C,F--56162477(+) CCTAAT/CTGGGT 2 -- us2k12Minor allele frequency- C:0.11WA NA 238
    rs1148553021,2
    F--56162538(+) ATCACA/GAGTGG 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1916166251,2
    --56162559(+) AAACCA/GTGTTC 2 -- us2k10--------
    rs125086941,2
    H--56162578(+) caaacA/Ctgagc 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMEM165 (56262090 - 56292342 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TMEM165:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667161CNV Deletion23128226
    esv2660719CNV Deletion23128226
    esv23054CNV Loss19812545


    Human Gene Mutation Database (HGMD): TMEM165
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614726    OMIM disorders: --

    UniProtKB/Swiss-Prot: TM165_HUMAN, Q9HC07
  • Congenital disorder of glycosylation 2K (CDG2K) [MIM:614727]: An autosomal recessive disorder with a
    variable phenotype. Affected individuals show psychomotor retardation and growth retardation, and most have short
    stature. Other features include dysmorphism, hypotonia, eye abnormalities, acquired microcephaly, hepatomegaly,
    and skeletal dysplasia. Congenital disorders of glycosylation are caused by a defect in glycoprotein biosynthesis
    and characterized by under-glycosylated serum glycoproteins and a wide variety of clinical features. The broad
    spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation,
    and maintenance of cell functions. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 7 diseases for TMEM165:    About MalaCards
    camurati-engelmann disease    congenital disorder of glycosylation    skeletal dysplasias    teratocarcinoma
    microcephaly    short stature    hypotonia

    2 diseases from the University of Copenhagen DISEASES database for TMEM165:
    Congenital disorder of glycosylation     Camurati-Engelmann disease

    TMEM165 for disorders           About GeneDecksing


    Export disorders for TMEM165 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM165 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with TMEM165)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Impact of disease-causing mutations on TMEM165 subcellular localization, a recently identified protein involved in CDG-II. (PubMed id 23575229)1, 2, 3 Rosnoblet C.... Foulquier F. (2013)
    2. TMEM165 deficiency causes a congenital disorder of gly cosylation. (PubMed id 22683087)1, 2, 3 Foulquier F....Matthijs G. (2012)
    3. Newly characterized Golgi-localized family of proteins is involved in calcium and pH homeostasis in yeast and human cells. (PubMed id 23569283)1, 2 Demaegd D.... Morsomme P. (2013)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    7. Messenger RNA expressed in mouse teratocarcinoma stem cells and down-regulated by a tumor-promoting phorbol ester codes for a novel transmembrane protein. (PubMed id 3202867)1, 3 Akagi J....Akagi M. (1988)
    8. Bone dysplasia as a key feature in three patients with a novel congenital disorder of glycosylation (CDG) type II due to a deep intronic splice mutation in TMEM165. (PubMed id 23430531)2 Zeevaert R.... Jaeken J. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55858 HGNC: 30760 AceView: TPARL Ensembl:ENSG00000134851 euGenes: HUgn55858
    ECgene: TMEM165 H-InvDB: TMEM165

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM165 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM165 gene:
    Search GeneIP for patents involving TMEM165

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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