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Aliases for TMEM164 Gene

Aliases for TMEM164 Gene

  • Transmembrane Protein 164 2 3 5
  • RP13-360B22.2 3
  • BB360B22.3 3

External Ids for TMEM164 Gene

Previous GeneCards Identifiers for TMEM164 Gene

  • GC0XP109132
  • GC0XP109245
  • GC0XP098867

Summaries for TMEM164 Gene

GeneCards Summary for TMEM164 Gene

TMEM164 (Transmembrane Protein 164) is a Protein Coding gene.

Additional gene information for TMEM164 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM164 Gene

Genomics for TMEM164 Gene

Regulatory Elements for TMEM164 Gene

Enhancers for TMEM164 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH109958 0.9 ENCODE 59.2 -43.3 -43271 2 HDAC1 ATF1 TBL1XR1 CHAMP1 TCF12 ZNF766 GATA2 ELK1 ATF7 ETV6 TMEM164 GC0XM109995 GC0XM109994 GC0XM109993 GC0XP109871
GH0XH110001 1.1 ENCODE 40.1 +1.0 975 4 HDGF PKNOX1 ARNT ZNF2 ZNF766 ZNF143 ZNF548 SP3 ZNF592 MEF2D TMEM164 AMMECR1 GC0XP110056
GH0XH109953 0.6 ENCODE 46 -48.5 -48507 1 JUN HMBOX1 REST ETV6 BATF ZBTB40 TMEM164 GC0XM109993 GC0XM109994 GC0XM109995 GC0XP109871
GH0XH110085 1.6 FANTOM5 Ensembl ENCODE 12.3 +85.6 85633 5 FOXA2 SIN3A FEZF1 BRCA1 TCF12 ZNF766 FOS RUNX3 SREBF1 NFIL3 TMEM164 MIR3978 LOC101928589
GH0XH110014 0.6 Ensembl ENCODE 25.1 +13.2 13207 2 CREB1 TMEM164 GC0XP110056
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM164 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM164 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247967 787 2001 HDGF PKNOX1 ARNT GLI4 ZNF2 GLIS2 ZNF143 ZNF548 RUNX3 SP3

Genomic Location for TMEM164 Gene

Chromosome:
X
Start:
110,002,413 bp from pter
End:
110,184,038 bp from pter
Size:
181,626 bases
Orientation:
Plus strand

Genomic View for TMEM164 Gene

Genes around TMEM164 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM164 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM164 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM164 Gene

Proteins for TMEM164 Gene

  • Protein details for TMEM164 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5U3C3-TM164_HUMAN
    Recommended name:
    Transmembrane protein 164
    Protein Accession:
    Q5U3C3
    Secondary Accessions:
    • B3KSQ8
    • F5H2P2

    Protein attributes for TMEM164 Gene

    Size:
    297 amino acids
    Molecular mass:
    33508 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM164 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM164 Gene

Post-translational modifications for TMEM164 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM164 Gene

Domains & Families for TMEM164 Gene

Gene Families for TMEM164 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM164 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM164 Gene

Graphical View of Domain Structure for InterPro Entry

Q5U3C3

UniProtKB/Swiss-Prot:

TM164_HUMAN :
  • Belongs to the TMEM164 family.
Family:
  • Belongs to the TMEM164 family.
genes like me logo Genes that share domains with TMEM164: view

Function for TMEM164 Gene

genes like me logo Genes that share phenotypes with TMEM164: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM164 Gene

Localization for TMEM164 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM164 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM164 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM164 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM164: view

Pathways & Interactions for TMEM164 Gene

SuperPathways for TMEM164 Gene

No Data Available

Interacting Proteins for TMEM164 Gene

Selected Interacting proteins: Q5U3C3-TM164_HUMAN for TMEM164 Gene via IID

Gene Ontology (GO) - Biological Process for TMEM164 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM164 Gene

Drugs & Compounds for TMEM164 Gene

No Compound Related Data Available

Transcripts for TMEM164 Gene

Unigene Clusters for TMEM164 Gene

Transmembrane protein 164:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM164 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2: - - - - -
SP3: - -
SP4: -

Relevant External Links for TMEM164 Gene

GeneLoc Exon Structure for
TMEM164
ECgene alternative splicing isoforms for
TMEM164

Expression for TMEM164 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM164 Gene

Protein differential expression in normal tissues from HIPED for TMEM164 Gene

This gene is overexpressed in Breast (50.8) and Platelet (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM164 Gene



Protein tissue co-expression partners for TMEM164 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM164 Gene:

TMEM164

SOURCE GeneReport for Unigene cluster for TMEM164 Gene:

Hs.496572

Evidence on tissue expression from TISSUES for TMEM164 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with TMEM164: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM164 Gene

Orthologs for TMEM164 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM164 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM164 33 34
  • 97.55 (n)
dog
(Canis familiaris)
Mammalia TMEM164 33 34
  • 97.31 (n)
rat
(Rattus norvegicus)
Mammalia Tmem164 33
  • 96.17 (n)
mouse
(Mus musculus)
Mammalia Tmem164 33 16 34
  • 95.95 (n)
chimpanzee
(Pan troglodytes)
Mammalia TMEM164 33 34
  • 92.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM164 34
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM164 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM164 33 34
  • 74.37 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 72 (a)
OneToMany
-- 34
  • 54 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem164 33
  • 71.61 (n)
Str.6835 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.2869 33
zebrafish
(Danio rerio)
Actinopterygii TMEM164 34
  • 70 (a)
OneToOne
LOC100332120 33
  • 65.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14591 33 34
  • 52.3 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012707 33
  • 51.06 (n)
worm
(Caenorhabditis elegans)
Secernentea C35C5.10 33 34
  • 48.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9623 34
  • 43 (a)
OneToOne
Species where no ortholog for TMEM164 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM164 Gene

ENSEMBL:
Gene Tree for TMEM164 (if available)
TreeFam:
Gene Tree for TMEM164 (if available)

Paralogs for TMEM164 Gene

No data available for Paralogs for TMEM164 Gene

Variants for TMEM164 Gene

Sequence variations from dbSNP and Humsavar for TMEM164 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_035671 A colorectal cancer sample
rs1000000065 -- 110,098,264(+) GAGTG(C/G)TTTTC intron-variant
rs1000029946 -- 110,155,853(+) TTGGC(C/T)TCATT intron-variant
rs1000048254 -- 110,088,266(+) CCCAG(A/T)GCTCA intron-variant
rs1000080222 -- 110,156,443(+) TAATT(A/G)TTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM164 Gene

Variant ID Type Subtype PubMed ID
esv1372383 CNV insertion 17803354

Variation tolerance for TMEM164 Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM164 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM164

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM164 Gene

Disorders for TMEM164 Gene

Relevant External Links for TMEM164

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM164

No disorders were found for TMEM164 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM164 Gene

Publications for TMEM164 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for TMEM164 Gene

Sources for TMEM164 Gene

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