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Aliases for TMEM164 Gene

Aliases for TMEM164 Gene

  • Transmembrane Protein 164 2 3 5
  • RP13-360B22.2 3
  • BB360B22.3 3

External Ids for TMEM164 Gene

Previous GeneCards Identifiers for TMEM164 Gene

  • GC0XP109132
  • GC0XP109245
  • GC0XP098867

Summaries for TMEM164 Gene

GeneCards Summary for TMEM164 Gene

TMEM164 (Transmembrane Protein 164) is a Protein Coding gene. Diseases associated with TMEM164 include Non-Syndromic X-Linked Intellectual Disability.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM164 Gene

Genomics for TMEM164 Gene

Regulatory Elements for TMEM164 Gene

Enhancers for TMEM164 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF109958 0.2 ENCODE 59.2 -43.3 -43271 2.0 HDAC1 ATF1 TBL1XR1 CHAMP1 GATA2 ETV6 CREM CEBPB MBD2 MEF2D TMEM164 GC0XM109993 GC0XM109994 GC0XM109995 GC0XP109871
GH0XF109953 0.6 Ensembl ENCODE 46 -48.5 -48507 1.7 JUN HMBOX1 REST ZBTB40 TMEM164 GC0XM109995 GC0XM109994 GC0XM109993 GC0XP109871
GH0XF110001 0.2 ENCODE 40.1 +1.0 975 4.5 HDGF PKNOX1 ZNF2 ZNF143 ZNF548 KLF13 ZNF263 SP3 TBX21 ZNF592 TMEM164 GC0XP110056
GH0XF110014 1 Ensembl ENCODE 25 +13.2 13207 2.8 TMEM164 GC0XP110056
GH0XF110007 0.8 Ensembl ENCODE 24.2 +5.3 5294 1.4 SMARCA4 POLR2A ZNF133 SPI1 TMEM164 GC0XP110056
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM164 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM164 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001491029 1087 3401 HDGF PKNOX1 GLI4 ZNF2 GLIS2 ZNF143 ZNF548 ZNF263 SP3 NCOA1

Genomic Location for TMEM164 Gene

Chromosome:
X
Start:
110,002,413 bp from pter
End:
110,184,038 bp from pter
Size:
181,626 bases
Orientation:
Plus strand

Genomic View for TMEM164 Gene

Genes around TMEM164 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM164 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM164 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM164 Gene

Proteins for TMEM164 Gene

  • Protein details for TMEM164 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5U3C3-TM164_HUMAN
    Recommended name:
    Transmembrane protein 164
    Protein Accession:
    Q5U3C3
    Secondary Accessions:
    • B3KSQ8
    • F5H2P2

    Protein attributes for TMEM164 Gene

    Size:
    297 amino acids
    Molecular mass:
    33508 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM164 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM164 Gene

Post-translational modifications for TMEM164 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM164 Gene

Domains & Families for TMEM164 Gene

Protein Domains for TMEM164 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM164 Gene

Graphical View of Domain Structure for InterPro Entry

Q5U3C3

UniProtKB/Swiss-Prot:

TM164_HUMAN :
  • Belongs to the TMEM164 family.
Family:
  • Belongs to the TMEM164 family.
genes like me logo Genes that share domains with TMEM164: view

No data available for Gene Families for TMEM164 Gene

Function for TMEM164 Gene

genes like me logo Genes that share phenotypes with TMEM164: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM164 Gene

Localization for TMEM164 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM164 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM164 Gene COMPARTMENTS Subcellular localization image for TMEM164 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM164 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM164: view

Pathways & Interactions for TMEM164 Gene

SuperPathways for TMEM164 Gene

No Data Available

Interacting Proteins for TMEM164 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361138%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000361138 Q5U3C3-TM164_HUMAN for TMEM164 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM164 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM164 Gene

Transcripts for TMEM164 Gene

Unigene Clusters for TMEM164 Gene

Transmembrane protein 164:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM164 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2: - - - - -
SP3: - -
SP4: -

Relevant External Links for TMEM164 Gene

GeneLoc Exon Structure for
TMEM164
ECgene alternative splicing isoforms for
TMEM164

Expression for TMEM164 Gene

mRNA expression in normal human tissues for TMEM164 Gene

Protein differential expression in normal tissues from HIPED for TMEM164 Gene

This gene is overexpressed in Breast (50.8) and Platelet (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM164 Gene



Protein tissue co-expression partners for TMEM164 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM164 Gene:

TMEM164

SOURCE GeneReport for Unigene cluster for TMEM164 Gene:

Hs.496572
genes like me logo Genes that share expression patterns with TMEM164: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM164 Gene

Orthologs for TMEM164 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM164 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM164 34 35
  • 97.55 (n)
dog
(Canis familiaris)
Mammalia TMEM164 34 35
  • 97.31 (n)
rat
(Rattus norvegicus)
Mammalia Tmem164 34
  • 96.17 (n)
mouse
(Mus musculus)
Mammalia Tmem164 34 16 35
  • 95.95 (n)
chimpanzee
(Pan troglodytes)
Mammalia TMEM164 34 35
  • 92.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM164 35
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM164 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM164 34 35
  • 74.37 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 72 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem164 34
  • 71.61 (n)
Str.6835 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.2869 34
zebrafish
(Danio rerio)
Actinopterygii TMEM164 35
  • 70 (a)
OneToOne
LOC100332120 34
  • 65.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14591 34 35
  • 52.3 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012707 34
  • 51.06 (n)
worm
(Caenorhabditis elegans)
Secernentea C35C5.10 34 35
  • 48.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9623 35
  • 43 (a)
OneToOne
Species where no ortholog for TMEM164 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM164 Gene

ENSEMBL:
Gene Tree for TMEM164 (if available)
TreeFam:
Gene Tree for TMEM164 (if available)

Paralogs for TMEM164 Gene

No data available for Paralogs for TMEM164 Gene

Variants for TMEM164 Gene

Sequence variations from dbSNP and Humsavar for TMEM164 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_035671 A colorectal cancer sample
rs111263122 -- 110,180,493(+) CCCCC(-/G)CCCCG intron-variant
rs111310914 -- 110,124,654(+) ATGTA(A/G)TGGAT intron-variant
rs111312659 -- 110,181,423(+) GCATC(A/G)GAGTA intron-variant
rs111402949 -- 110,165,755(+) TCTTC(C/T)CTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM164 Gene

Variant ID Type Subtype PubMed ID
esv1372383 CNV insertion 17803354

Variation tolerance for TMEM164 Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM164 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM164

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM164 Gene

Disorders for TMEM164 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM164 Gene - From: DISEASES

Disorder Aliases PubMed IDs
non-syndromic x-linked intellectual disability
  • mrx
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM164

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM164
genes like me logo Genes that share disorders with TMEM164: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM164 Gene

Publications for TMEM164 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for TMEM164 Gene

Sources for TMEM164 Gene

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