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Aliases for TMEM163 Gene

Aliases for TMEM163 Gene

  • Transmembrane Protein 163 2 3
  • DC29 3
  • SV31 3

External Ids for TMEM163 Gene

Previous GeneCards Identifiers for TMEM163 Gene

  • GC02M134930
  • GC02M135213
  • GC02M127206

Summaries for TMEM163 Gene

GeneCards Summary for TMEM163 Gene

TMEM163 (Transmembrane Protein 163) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM163 Gene

  • May bind zinc and other divalent cations and recruit them to vesicular organelles.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM163 Gene

Genomics for TMEM163 Gene

Regulatory Elements for TMEM163 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM163 Gene

Start:
134,455,759 bp from pter
End:
134,719,001 bp from pter
Size:
263,243 bases
Orientation:
Minus strand

Genomic View for TMEM163 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM163 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM163 Gene

Proteins for TMEM163 Gene

  • Protein details for TMEM163 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC26-TM163_HUMAN
    Recommended name:
    Transmembrane protein 163
    Protein Accession:
    Q8TC26
    Secondary Accessions:
    • Q53QM3
    • Q53SV7
    • Q69YH3
    • Q9UFG3

    Protein attributes for TMEM163 Gene

    Size:
    289 amino acids
    Molecular mass:
    31469 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH10592.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM163 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM163 Gene

Proteomics data for TMEM163 Gene at MOPED

Post-translational modifications for TMEM163 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM163 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM163 Gene

Domains for TMEM163 Gene

Protein Domains for TMEM163 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM163 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TC26

UniProtKB/Swiss-Prot:

TM163_HUMAN :
  • Q8TC26
Family:
  • Belongs to the TMEM163 family.
genes like me logo Genes that share domains with TMEM163: view

No data available for Gene Families for TMEM163 Gene

Function for TMEM163 Gene

Molecular function for TMEM163 Gene

UniProtKB/Swiss-Prot Function: May bind zinc and other divalent cations and recruit them to vesicular organelles.

Gene Ontology (GO) - Molecular Function for TMEM163 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding ISS --
genes like me logo Genes that share ontologies with TMEM163: view

Phenotypes for TMEM163 Gene

GenomeRNAi human phenotypes for TMEM163:
genes like me logo Genes that share phenotypes with TMEM163: view

Animal Model Products

CRISPR Products

miRNA for TMEM163 Gene

miRTarBase miRNAs that target TMEM163

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM163 Gene

Localization for TMEM163 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM163 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Early endosome membrane. Note=Glutamatergic synaptic vesicles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM163 Gene COMPARTMENTS Subcellular localization image for TMEM163 gene
Compartment Confidence
endosome 4
plasma membrane 3
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM163 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030054 cell junction IEA --
GO:0030285 integral component of synaptic vesicle membrane ISS --
GO:0030672 synaptic vesicle membrane IEA --
GO:0031901 early endosome membrane ISS --
genes like me logo Genes that share ontologies with TMEM163: view

Pathways for TMEM163 Gene

SuperPathways for TMEM163 Gene

No Data Available

Interacting Proteins for TMEM163 Gene

Gene Ontology (GO) - Biological Process for TMEM163 Gene

None

No data available for Pathways by source for TMEM163 Gene

Transcripts for TMEM163 Gene

mRNA/cDNA for TMEM163 Gene

Unigene Clusters for TMEM163 Gene

Transmembrane protein 163:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM163

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM163 Gene

No ASD Table

Relevant External Links for TMEM163 Gene

GeneLoc Exon Structure for
TMEM163
ECgene alternative splicing isoforms for
TMEM163

Expression for TMEM163 Gene

mRNA expression in normal human tissues for TMEM163 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM163 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (6.7), Brain - Cerebellum (5.8), and Pancreas (5.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM163 Gene

SOURCE GeneReport for Unigene cluster for TMEM163 Gene Hs.369471

genes like me logo Genes that share expressions with TMEM163: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM163 Gene

Orthologs for TMEM163 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM163 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM163 35
  • 99.77 (n)
  • 100 (a)
TMEM163 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM163 35
  • 91.99 (n)
  • 94.77 (a)
TMEM163 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM163 35
  • 93.82 (n)
  • 99.1 (a)
TMEM163 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem163 35
  • 84.03 (n)
  • 88.19 (a)
Tmem163 16
Tmem163 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM163 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem163 35
  • 84.95 (n)
  • 87.85 (a)
chicken
(Gallus gallus)
Aves TMEM163 35
  • 77.6 (n)
  • 86.96 (a)
TMEM163 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM163 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem163 35
  • 76.48 (n)
  • 83.47 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem163a 36
  • 68 (a)
OneToMany
tmem163b 35
  • 72.34 (n)
  • 79.15 (a)
tmem163b 36
  • 67 (a)
OneToMany
Species with no ortholog for TMEM163:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM163 Gene

ENSEMBL:
Gene Tree for TMEM163 (if available)
TreeFam:
Gene Tree for TMEM163 (if available)

Paralogs for TMEM163 Gene

No data available for Paralogs for TMEM163 Gene

Variants for TMEM163 Gene

Sequence variations from dbSNP and Humsavar for TMEM163 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs472299 -- 134,469,386(+) AGCTA(G/T)GTGAC intron-variant
rs474031 -- 134,485,604(+) cctcg(A/T)tctgt intron-variant
rs475921 -- 134,485,802(+) AGAAA(C/G)ACTAG intron-variant
rs478675 -- 134,470,079(+) GAggc(C/T)gggcg intron-variant
rs479297 -- 134,526,457(+) TCGGA(C/G)AAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM163 Gene

Variant ID Type Subtype PubMed ID
nsv834385 CNV Gain 17160897
esv9502 CNV Loss 19470904
esv2720857 CNV Deletion 23290073
esv2720858 CNV Deletion 23290073
esv2676369 CNV Deletion 23128226
esv2662661 CNV Deletion 23128226
esv2674764 CNV Deletion 23128226
esv2720859 CNV Deletion 23290073
esv24078 CNV Gain+Loss 19812545
nsv821400 CNV Deletion 20802225
esv1185737 CNV Insertion 17803354
esv1203818 CNV Deletion 17803354
esv1198411 CNV Deletion 17803354
esv2595055 CNV Deletion 19546169

Relevant External Links for TMEM163 Gene

HapMap Linkage Disequilibrium report
TMEM163

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM163 Gene

Disorders for TMEM163 Gene

Relevant External Links for TMEM163

Genetic Association Database (GAD)
TMEM163
Human Genome Epidemiology (HuGE) Navigator
TMEM163
genes like me logo Genes that share disorders with TMEM163: view

No data available for UniProtKB/Swiss-Prot for TMEM163 Gene

Publications for TMEM163 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Identification and characterization of SV31, a novel synaptic vesicle membrane protein and potential transporter. (PMID: 17623043) BurrAc J. … Volknandt W. (J. Neurochem. 2007) 2 3
  4. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3
  5. Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21. (PMID: 23209189) Tabassum R. … Bharadwaj D. (Diabetes 2013) 3

Products for TMEM163 Gene

  • antibodies-online peptides for TMEM163
  • antibodies-online antibodies for TMEM163
  • antibodies-online kits for TMEM163

Sources for TMEM163 Gene

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