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Aliases for TMEM163 Gene

Aliases for TMEM163 Gene

  • Transmembrane Protein 163 2 3 5
  • DC29 3
  • SV31 3

External Ids for TMEM163 Gene

Previous GeneCards Identifiers for TMEM163 Gene

  • GC02M134930
  • GC02M135213
  • GC02M127206

Summaries for TMEM163 Gene

GeneCards Summary for TMEM163 Gene

TMEM163 (Transmembrane Protein 163) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM163 Gene

  • May bind zinc and other divalent cations and recruit them to vesicular organelles.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM163 Gene

Genomics for TMEM163 Gene

Regulatory Elements for TMEM163 Gene

Enhancers for TMEM163 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F134669 1.6 FANTOM5 Ensembl ENCODE 25.7 +65.9 65889 2.6 KLF1 HLF CEBPB FEZF1 REST ZNF843 ARID1B KDM1A MAFK TMEM163 CCNT2 LOC105373629 GC02P134502
GH02F134677 1.3 FANTOM5 Ensembl ENCODE 23.7 +57.3 57324 2.6 BCOR ZNF146 MAX ZMYM3 TMEM163 LOC105373629 GC02P134502
GH02F134668 1.3 FANTOM5 Ensembl ENCODE 23.1 +67.5 67524 0.6 TCF7 TMEM163 CCNT2 LOC105373629 GC02P134502
GH02F134678 1.1 Ensembl 23 +59.2 59224 0.4 GABPA TMEM163 LOC105373629 GC02P134502
GH02F134782 0.5 Ensembl 21.2 -46.5 -46477 0.2 CTCF ZNF654 PKNOX1 TEAD1 HLF CEBPB MIER2 CEBPG RAD21 TEAD3 TMEM163 GC02P134795 GC02M134743
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM163 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM163 Gene

Chromosome:
2
Start:
134,455,759 bp from pter
End:
134,736,424 bp from pter
Size:
280,666 bases
Orientation:
Minus strand

Genomic View for TMEM163 Gene

Genes around TMEM163 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM163 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM163 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM163 Gene

Proteins for TMEM163 Gene

  • Protein details for TMEM163 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC26-TM163_HUMAN
    Recommended name:
    Transmembrane protein 163
    Protein Accession:
    Q8TC26
    Secondary Accessions:
    • Q53QM3
    • Q53SV7
    • Q69YH3
    • Q9UFG3

    Protein attributes for TMEM163 Gene

    Size:
    289 amino acids
    Molecular mass:
    31469 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH10592.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM163 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM163 Gene

Post-translational modifications for TMEM163 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM163 Gene

No data available for DME Specific Peptides for TMEM163 Gene

Domains & Families for TMEM163 Gene

Protein Domains for TMEM163 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM163 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TC26

UniProtKB/Swiss-Prot:

TM163_HUMAN :
  • Belongs to the TMEM163 family.
Family:
  • Belongs to the TMEM163 family.
genes like me logo Genes that share domains with TMEM163: view

No data available for Gene Families for TMEM163 Gene

Function for TMEM163 Gene

Molecular function for TMEM163 Gene

UniProtKB/Swiss-Prot Function:
May bind zinc and other divalent cations and recruit them to vesicular organelles.

Gene Ontology (GO) - Molecular Function for TMEM163 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA,ISS --
genes like me logo Genes that share ontologies with TMEM163: view
genes like me logo Genes that share phenotypes with TMEM163: view

Animal Model Products

miRNA for TMEM163 Gene

miRTarBase miRNAs that target TMEM163

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM163 Gene

Localization for TMEM163 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM163 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Early endosome membrane. Note=Glutamatergic synaptic vesicles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM163 Gene COMPARTMENTS Subcellular localization image for TMEM163 gene
Compartment Confidence
endosome 4
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM163 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0030285 integral component of synaptic vesicle membrane IEA,ISS --
GO:0030672 synaptic vesicle membrane IEA --
genes like me logo Genes that share ontologies with TMEM163: view

Pathways & Interactions for TMEM163 Gene

SuperPathways for TMEM163 Gene

No Data Available

Interacting Proteins for TMEM163 Gene

Gene Ontology (GO) - Biological Process for TMEM163 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM163 Gene

Transcripts for TMEM163 Gene

Unigene Clusters for TMEM163 Gene

Transmembrane protein 163:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM163 Gene

No ASD Table

Relevant External Links for TMEM163 Gene

GeneLoc Exon Structure for
TMEM163
ECgene alternative splicing isoforms for
TMEM163

Expression for TMEM163 Gene

mRNA expression in normal human tissues for TMEM163 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM163 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.7), Brain - Cerebellum (x5.8), and Pancreas (x5.3).

Protein differential expression in normal tissues from HIPED for TMEM163 Gene

This gene is overexpressed in Frontal cortex (15.9), Pancreas (14.5), Fetal Brain (12.7), and Platelet (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM163 Gene



Protein tissue co-expression partners for TMEM163 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM163 Gene:

TMEM163

SOURCE GeneReport for Unigene cluster for TMEM163 Gene:

Hs.369471
genes like me logo Genes that share expression patterns with TMEM163: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM163 Gene

Orthologs for TMEM163 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM163 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM163 34 35
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia TMEM163 34 35
  • 93.82 (n)
cow
(Bos Taurus)
Mammalia TMEM163 34 35
  • 91.99 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM163 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 85 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem163 34
  • 84.95 (n)
mouse
(Mus musculus)
Mammalia Tmem163 34 16 35
  • 84.03 (n)
chicken
(Gallus gallus)
Aves TMEM163 34 35
  • 77.6 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM163 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem163 34
  • 76.48 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem163b 34 35
  • 72.34 (n)
tmem163a 35
  • 68 (a)
OneToMany
Species where no ortholog for TMEM163 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM163 Gene

ENSEMBL:
Gene Tree for TMEM163 (if available)
TreeFam:
Gene Tree for TMEM163 (if available)

Paralogs for TMEM163 Gene

No data available for Paralogs for TMEM163 Gene

Variants for TMEM163 Gene

Sequence variations from dbSNP and Humsavar for TMEM163 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1001984 -- 134,463,753(+) TGGAA(A/T)GGGAG intron-variant
rs10164986 -- 134,710,815(+) CCTGC(C/T)AACAC intron-variant
rs10165205 -- 134,695,849(+) agttc(C/G)agacc intron-variant
rs10167037 -- 134,529,286(+) agatc(A/C)cgcca intron-variant
rs10168723 -- 134,521,199(+) tcacc(A/G)agtta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM163 Gene

Variant ID Type Subtype PubMed ID
dgv2046n106 CNV deletion 24896259
dgv2253e59 CNV duplication 20981092
esv1185737 CNV insertion 17803354
esv1198411 CNV deletion 17803354
esv1203818 CNV deletion 17803354
esv24078 CNV gain+loss 19812545
esv2595055 CNV deletion 19546169
esv2662661 CNV deletion 23128226
esv2674764 CNV deletion 23128226
esv2676369 CNV deletion 23128226
esv2720857 CNV deletion 23290073
esv2720858 CNV deletion 23290073
esv2720859 CNV deletion 23290073
esv3560183 CNV deletion 23714750
esv3592555 CNV loss 21293372
esv3592556 CNV loss 21293372
esv3592557 CNV loss 21293372
esv3592558 CNV loss 21293372
esv3592559 CNV loss 21293372
esv3592560 CNV loss 21293372
esv9502 CNV loss 19470904
nsv1004271 CNV loss 25217958
nsv1004843 CNV gain 25217958
nsv1009691 CNV gain 25217958
nsv1118883 CNV deletion 24896259
nsv1128818 CNV duplication 24896259
nsv1146003 CNV duplication 26484159
nsv821400 CNV deletion 20802225
nsv834385 CNV gain 17160897
nsv953185 CNV deletion 24416366

Variation tolerance for TMEM163 Gene

Residual Variation Intolerance Score: 41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM163 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM163

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM163 Gene

Disorders for TMEM163 Gene

Relevant External Links for TMEM163

Genetic Association Database (GAD)
TMEM163
Human Genome Epidemiology (HuGE) Navigator
TMEM163
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM163

No disorders were found for TMEM163 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM163 Gene

Publications for TMEM163 Gene

  1. Identification and characterization of SV31, a novel synaptic vesicle membrane protein and potential transporter. (PMID: 17623043) BurrAc J. … Volknandt W. (J. Neurochem. 2007) 2 3 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. (PMID: 24262325) Dichgans M. … . (Stroke 2014) 3 64
  5. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. (PMID: 25064009) Nalls M.A. … Singleton A.B. (Nat. Genet. 2014) 3 64

Products for TMEM163 Gene

Sources for TMEM163 Gene

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