TMEM161B Gene
protein-coding GIFtS: 43
GCID: GC05M087527
|
|
transmembrane protein 161B
| |
Aliases
for TMEM161B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 161B1 2 | | MGC332141 | | FLB33422 | | PRO13132 |
Export aliases for TMEM161B gene to outside databasesPrevious GC identifer: GC05M082694 |
Summaries
for TMEM161B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM161B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM161B gene promoter:
STAT5B TBP Elk-1 Sp1 Lmo2 Egr-4 RORalpha1 NRF-2 TFIID ZIC2/Zic2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM161B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM161B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q14.3 Ensembl cytogenetic band: 5q14.3 HGNC cytogenetic band: 5q14.3TMEM161B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M087527: view genomic region
(about GC identifiers)
Start:
|
87,485,450 bp from pter |
End:
|
87,565,293 bp from pter |
Size:
|
79,844 bases |
Orientation:
|
minus strand |
|
Proteins
for TMEM161B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T161B_HUMAN, Q8NDZ6 (See
protein sequence)Recommended Name: Transmembrane protein 161B Size: 487 amino acids; 55482 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q5CZH7 Q6UWQ6Alternative splicing: 3 isoforms: Q8NDZ6-1 Q8NDZ6-2 Q8NDZ6-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TMEM161B: NX_Q8NDZ6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NDZ6
TMEM161B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_699185.1
ENSEMBL proteins: ENSP00000426354 ENSP00000421805 ENSP00000423380 ENSP00000296595 ENSP00000421733 ENSP00000425991 ENSP00000421498 ENSP00000427312 ENSP00000424200
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM161B for ontologies About GeneDecksing
TMEM161B Antibody Products:
Assay Products for TMEM161B: |
Protein
Domains /
Families
for TMEM161B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM161B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8NDZ6ProtoNet protein and cluster: Q8NDZ6 UniProtKB/Swiss-Prot: T161B_HUMAN, Q8NDZ6Similarity: Belongs to the TMEM161 family |
Function
for TMEM161B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM161B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM161B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM161B (NM_153354) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM161B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM161B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM161B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
-- | -- |
TMEM161B for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TMEM161B:
|
Pathways & Interactions
for TMEM161B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM161B
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015074 | DNA integration |
-- | -- |
TMEM161B for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM161B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM161B
Search CenterWatch for drugs/clinical trials and news about TMEM161B / T161B
|
Transcripts
for TMEM161B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM161B gene: NM_153354.3 Unigene Cluster for TMEM161B: Transmembrane protein 161B Hs.379972 [show with all ESTs]Unigene Representative Sequence: BX64734515 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000514135 ENST00000511087(uc010jax.3) ENST00000510089 ENST00000296595(uc011ctx.2 uc003kjc.3 uc011cty.2)
ENST00000506536 ENST00000511218 ENST00000512429 ENST00000515293 ENST00000507872
ENST00000509387(uc011ctz.1) ENST00000503755 ENST00000513487 ENST00000515477
ENST00000503943 ENST00000503194
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM161B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM161B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM161B (NM_153354) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM161B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM161B |
Additional cDNA sequence: AK129894.1 AK299896.1 AK300006.1 AK300893.1 AK301091.1 AY358693.1 BC037287.2 BX647345.1 10 DOTS entries: DT.431388 DT.40226754 DT.97812792 DT.100815272 DT.92064078 DT.120866353 DT.449891 DT.91683736 DT.95356641 DT.120866307 24/91 AceView cDNA sequences (see all 91): AI890023 AI689412 AI290046 CR595175 BM728124 N53094 AI985771 AI470712 CB851067 AI570193 AY358693 AA600374 AW139360 BF512356 BM696511 AW207895 T57856 AW130696 CA313210 BX647345 CD639899 AI289112 AA740768 AI348525
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM161B About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM161B
|
Expression
for TMEM161B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM161B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTAGGGGA
About this image
See TMEM161B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM161B
SOURCE GeneReport for Unigene cluster: Hs.379972
SABiosciences Custom PCR Arrays for TMEM161B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM161B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM161B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM161B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM161B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM161B |
Orthologs
for TMEM161B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM161B gene from 7/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tmem161b1 , 5 |
transmembrane protein 161B1, 5 |
91.31(n)1
95.07(a)1 |
|
13 (44.20 cM)5
727451 NM_175187.51 NP_780396.21
842222965 |
chicken
(Gallus gallus) |
Aves |
TMEM161B1 |
transmembrane protein 161B |
84.05(n)
89.9(a) |
|
426919 XM_424528.3 XP_424528.3 |
lizard
(Anolis carolinensis) |
Reptilia |
TMEM161B6 |
-- |
86(a) |
1 ↔ 1 |
2(21333687-21349550) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.150302 |
Transcribed sequence with weak similarity to protein more |
80.21(n) |
|
AL963083.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc31d042 |
Danio rerio cDNA clone MGC63626 IMAGE5603604, complete more |
75.21(n) |
|
BC055170.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG76381 |
CG7638 |
49.21(n)
42.44(a) |
|
39250 NM_140182.2 NP_648439.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y87G2A.131 |
Protein Y87G2A.13 |
43.3(n)
29.46(a) |
|
173230 NM_060984.3 NP_493385.2 |
ENSEMBL Gene Tree for TMEM161B (if available)
TreeFam Gene Tree for TMEM161B (if available) |
Paralogs
for TMEM161B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM161B gene
- TMEM161A2
1 SIMAP similar gene for TMEM161B using alignment to 8 protein entries: T161B_HUMAN (see all proteins):TMEM161A
TMEM161B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TMEM161B
PGOHUM00000251264
|
Genomic Variants
for TMEM161B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM161B (87485450 - 87565293 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM161B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM161B |
|
Disorders
/ Diseases
for TMEM161B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM161B for disorders About GeneDecksing
1  disease for TMEM161B: About MalaCardsbruxism
Human Genome Epidemiology (HuGE) Navigator: TMEM161B (3 documents)
Export disorders for TMEM161B gene to outside databases
|
Publications
for TMEM161B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM161B gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM161B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for TMEM161B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM161B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM161B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM161B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM161B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM161B gene:
Search GeneIP for patents involving TMEM161B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM161B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM161B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM161B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM161B | | OriGene 3'-UTR Clone for TMEM161B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM161B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM161B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM161B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM161B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM161B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM161B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM161B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM161B |
| |
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 |
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 | | | TMEM161B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM161B |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM161B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM161B |
|
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|
|
