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Aliases for TMEM161B Gene

Aliases for TMEM161B Gene

  • Transmembrane Protein 161B 2 3 5
  • FLB3342 3
  • PRO1313 3

External Ids for TMEM161B Gene

Previous GeneCards Identifiers for TMEM161B Gene

  • GC05M087527
  • GC05M082694
  • GC05M087487

Summaries for TMEM161B Gene

GeneCards Summary for TMEM161B Gene

TMEM161B (Transmembrane Protein 161B) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is TMEM161A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM161B Gene

Genomics for TMEM161B Gene

Regulatory Elements for TMEM161B Gene

Enhancers for TMEM161B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G088671 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.7 -405.5 -405457 7.0 ATF1 ARNT ZNF133 SIN3A FEZF1 ZNF2 GLIS2 ELK1 KLF7 ZNF548 TMEM161B MEF2C MEF2C-AS1 MEF2C-AS2 MIR9-2
GH05G088140 1.2 Ensembl ENCODE 12.7 +128.1 128114 1.7 HDGF PKNOX1 ZNF2 YY1 GLIS2 ZNF143 KLF7 ZNF548 ZNF263 SP3 TMEM161B MEF2C-AS2 LINC00461 MIR9-2 ENSG00000250555 ENSG00000250377 LOC105379070 GC05P088219
GH05G088845 1.2 ENCODE dbSUPER 12.7 -576.0 -576008 1.0 HDGF PKNOX1 ARID4B ZNF2 YY1 GLIS2 CBX5 KLF7 ZNF548 ZNF263 TMEM161B MEF2C-AS1 ENSG00000250377
GH05G088657 0.6 dbSUPER 13.3 -388.9 -388877 1.1 ZNF316 ZNF26 MAFG CBX2 EMSY MAFK TMEM161B LINC00461 ENSG00000250555 ENSG00000250377 GC05P088664 ENSG00000250705
GH05G087745 0.4 ENCODE 13.3 +522.6 522618 2.1 JUND ZNF26 TMEM161B GC05P087735 GC05M087850
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM161B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM161B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000183630 576 2201 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for TMEM161B Gene

Chromosome:
5
Start:
88,185,575 bp from pter
End:
88,269,476 bp from pter
Size:
83,902 bases
Orientation:
Minus strand

Genomic View for TMEM161B Gene

Genes around TMEM161B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM161B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM161B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM161B Gene

Proteins for TMEM161B Gene

  • Protein details for TMEM161B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDZ6-T161B_HUMAN
    Recommended name:
    Transmembrane protein 161B
    Protein Accession:
    Q8NDZ6
    Secondary Accessions:
    • Q5CZH7
    • Q6UWQ6

    Protein attributes for TMEM161B Gene

    Size:
    487 amino acids
    Molecular mass:
    55482 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM161B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM161B Gene

Post-translational modifications for TMEM161B Gene

  • Glycosylation at Asn34, isoforms=2, 3135, and Asn203
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM161B Gene

Domains & Families for TMEM161B Gene

Protein Domains for TMEM161B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM161B Gene

Graphical View of Domain Structure for InterPro Entry

Q8NDZ6

UniProtKB/Swiss-Prot:

T161B_HUMAN :
  • Belongs to the TMEM161 family.
Family:
  • Belongs to the TMEM161 family.
genes like me logo Genes that share domains with TMEM161B: view

No data available for Gene Families for TMEM161B Gene

Function for TMEM161B Gene

Phenotypes for TMEM161B Gene

MGI mutant phenotypes for TMEM161B:
inferred from 1 alleles
GenomeRNAi human phenotypes for TMEM161B:
genes like me logo Genes that share phenotypes with TMEM161B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM161B

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM161B Gene

Localization for TMEM161B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM161B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM161B gene
Compartment Confidence
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TMEM161B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM161B: view

Pathways & Interactions for TMEM161B Gene

SuperPathways for TMEM161B Gene

No Data Available

Interacting Proteins for TMEM161B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296595%0d%0a9606.ENSP00000307259%0d%0a
Selected Interacting proteins: ENSP00000296595 Q8NDZ6-T161B_HUMAN for TMEM161B Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM161B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015074 DNA integration IEA --
genes like me logo Genes that share ontologies with TMEM161B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM161B Gene

Drugs & Compounds for TMEM161B Gene

No Compound Related Data Available

Transcripts for TMEM161B Gene

Unigene Clusters for TMEM161B Gene

Transmembrane protein 161B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM161B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - -
SP2: - - -
SP3:
SP4:
SP5:

Relevant External Links for TMEM161B Gene

GeneLoc Exon Structure for
TMEM161B
ECgene alternative splicing isoforms for
TMEM161B

Expression for TMEM161B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM161B Gene

Protein differential expression in normal tissues from HIPED for TMEM161B Gene

This gene is overexpressed in Heart (55.7) and Retina (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM161B Gene



Protein tissue co-expression partners for TMEM161B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM161B Gene:

TMEM161B

SOURCE GeneReport for Unigene cluster for TMEM161B Gene:

Hs.379972
genes like me logo Genes that share expression patterns with TMEM161B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM161B Gene

Orthologs for TMEM161B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM161B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM161B 34 35
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia TMEM161B 34 35
  • 95.89 (n)
cow
(Bos Taurus)
Mammalia TMEM161B 34 35
  • 95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM161B 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem161b 34 16 35
  • 91.31 (n)
rat
(Rattus norvegicus)
Mammalia Tmem161b 34
  • 91.3 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM161B 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM161B 34 35
  • 83.54 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM161B 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem161b 34
  • 78.14 (n)
Str.15030 34
zebrafish
(Danio rerio)
Actinopterygii tmem161b 34 35
  • 69.44 (n)
wufc31d04 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6252 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004945 34
  • 50.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7638 34 35
  • 48.87 (n)
worm
(Caenorhabditis elegans)
Secernentea Y87G2A.13 34 35
  • 42.73 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToMany
Species where no ortholog for TMEM161B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM161B Gene

ENSEMBL:
Gene Tree for TMEM161B (if available)
TreeFam:
Gene Tree for TMEM161B (if available)

Paralogs for TMEM161B Gene

Paralogs for TMEM161B Gene

(1) SIMAP similar genes for TMEM161B Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for TMEM161B Gene

genes like me logo Genes that share paralogs with TMEM161B: view

Variants for TMEM161B Gene

Sequence variations from dbSNP and Humsavar for TMEM161B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000047986 -- 88,226,973(+) TTTTT(A/T)AAAAC intron-variant, upstream-variant-2KB
rs1000081214 -- 88,250,885(+) AATTG(C/T)CTGAT intron-variant
rs1000083978 -- 88,205,579(+) ATTTT(C/T)ATTTT intron-variant
rs1000111495 -- 88,191,497(+) AAAAA(C/T)AACCA intron-variant
rs1000146926 -- 88,256,136(+) ACAAA(C/T)CATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM161B Gene

Variant ID Type Subtype PubMed ID
nsv473243 CNV novel sequence insertion 20440878
nsv830384 CNV gain 17160897
nsv830385 CNV gain 17160897

Variation tolerance for TMEM161B Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.63; 65.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM161B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM161B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM161B Gene

Disorders for TMEM161B Gene

Relevant External Links for TMEM161B

Genetic Association Database (GAD)
TMEM161B
Human Genome Epidemiology (HuGE) Navigator
TMEM161B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM161B

No disorders were found for TMEM161B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM161B Gene

Publications for TMEM161B Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Genetic loci for retinal arteriolar microcirculation. (PMID: 23776548) Sim X. … Wong T.Y. (PLoS ONE 2013) 3 64

Products for TMEM161B Gene

Sources for TMEM161B Gene

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