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Aliases for TMEM161A Gene

Aliases for TMEM161A Gene

  • Transmembrane Protein 161A 2 3 5
  • Adaptive Response To Oxidative Stress Protein 29 3 4
  • AROS-29 3 4

External Ids for TMEM161A Gene

Previous GeneCards Identifiers for TMEM161A Gene

  • GC19M019231
  • GC19M018794

Summaries for TMEM161A Gene

GeneCards Summary for TMEM161A Gene

TMEM161A (Transmembrane Protein 161A) is a Protein Coding gene. An important paralog of this gene is TMEM161B.

UniProtKB/Swiss-Prot for TMEM161A Gene

  • May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM161A Gene

Genomics for TMEM161A Gene

Regulatory Elements for TMEM161A Gene

Enhancers for TMEM161A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM161A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM161A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM161A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM161A Gene

19,119,169 bp from pter
19,138,554 bp from pter
19,386 bases
Minus strand

Genomic View for TMEM161A Gene

Genes around TMEM161A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM161A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM161A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM161A Gene

Proteins for TMEM161A Gene

  • Protein details for TMEM161A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 161A
    Protein Accession:
    Secondary Accessions:
    • B3KUE0
    • G5E9M6
    • Q7L2Y1

    Protein attributes for TMEM161A Gene

    479 amino acids
    Molecular mass:
    53602 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM161A Gene


neXtProt entry for TMEM161A Gene

Proteomics data for TMEM161A Gene at MOPED

Post-translational modifications for TMEM161A Gene

No data available for DME Specific Peptides for TMEM161A Gene

Domains & Families for TMEM161A Gene

Protein Domains for TMEM161A Gene


Suggested Antigen Peptide Sequences for TMEM161A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM161 family.
  • Belongs to the TMEM161 family.
genes like me logo Genes that share domains with TMEM161A: view

No data available for Gene Families for TMEM161A Gene

Function for TMEM161A Gene

Molecular function for TMEM161A Gene

UniProtKB/Swiss-Prot Function:
May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis.
UniProtKB/Swiss-Prot Induction:
Up-regulated in cells which display transient adaptation to mild oxidative stress by treatment with diethylmaleate, a glutathione-depleting agent. Also induced by retinoic acid.
genes like me logo Genes that share phenotypes with TMEM161A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM161A

CRISPR Products

miRNA for TMEM161A Gene

miRTarBase miRNAs that target TMEM161A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM161A Gene

Localization for TMEM161A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM161A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM161A Gene COMPARTMENTS Subcellular localization image for TMEM161A gene
Compartment Confidence
plasma membrane 3
cytosol 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM161A Gene

Pathways & Interactions for TMEM161A Gene

SuperPathways for TMEM161A Gene

No Data Available

Interacting Proteins for TMEM161A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000162044 Q9NX61-T161A_HUMAN for TMEM161A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TMEM161A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034599 cellular response to oxidative stress IDA 16551573
GO:0034644 cellular response to UV IDA 16551573
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP 16551573
genes like me logo Genes that share ontologies with TMEM161A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM161A Gene

Drugs & Compounds for TMEM161A Gene

No Compound Related Data Available

Transcripts for TMEM161A Gene

Unigene Clusters for TMEM161A Gene

Transmembrane protein 161A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM161A Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - -
SP6: -
SP7: - -
SP8: - -

Relevant External Links for TMEM161A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM161A Gene

mRNA expression in normal human tissues for TMEM161A Gene

Protein differential expression in normal tissues from HIPED for TMEM161A Gene

This gene is overexpressed in Lung (25.8), Plasma (15.4), Heart (10.3), and Liver (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMEM161A Gene

SOURCE GeneReport for Unigene cluster for TMEM161A Gene Hs.631629

genes like me logo Genes that share expression patterns with TMEM161A: view

Protein tissue co-expression partners for TMEM161A Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM161A Gene

Orthologs for TMEM161A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM161A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM161A 35
  • 86.68 (n)
  • 91 (a)
TMEM161A 36
  • 88 (a)
(Canis familiaris)
Mammalia TMEM161A 35
  • 85.59 (n)
  • 87.27 (a)
TMEM161A 36
  • 80 (a)
(Mus musculus)
Mammalia Tmem161a 35
  • 82.88 (n)
  • 82.88 (a)
Tmem161a 16
Tmem161a 36
  • 83 (a)
(Pan troglodytes)
Mammalia TMEM161A 35
  • 99.65 (n)
  • 99.58 (a)
TMEM161A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tmem161a 35
  • 81.87 (n)
  • 83.05 (a)
(Monodelphis domestica)
Mammalia TMEM161A 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM161A 36
  • 61 (a)
(Gallus gallus)
Aves TMEM161A 35
  • 71 (n)
  • 64.15 (a)
TMEM161A 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem161a 35
  • 61.52 (n)
  • 58.46 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18468 35
(Danio rerio)
Actinopterygii tmem161a 35
  • 61.13 (n)
  • 58.19 (a)
tmem161a 36
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7638 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea Y87G2A.13 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for TMEM161A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM161A Gene

Gene Tree for TMEM161A (if available)
Gene Tree for TMEM161A (if available)

Paralogs for TMEM161A Gene

Paralogs for TMEM161A Gene

(1) SIMAP similar genes for TMEM161A Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TMEM161A: view

Variants for TMEM161A Gene

Sequence variations from dbSNP and Humsavar for TMEM161A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_036537 A breast cancer sample
rs7408268 -- 19,131,509(+) atata(C/T)acaca intron-variant
rs7408301 -- 19,131,768(+) tgatc(C/G)acctg intron-variant
rs8099994 -- 19,127,780(+) aaaaa(A/T)aaatt intron-variant
rs12983351 -- 19,131,168(+) tgagc(C/T)taaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM161A Gene

Variant ID Type Subtype PubMed ID
nsv833779 CNV Loss 17160897

Variation tolerance for TMEM161A Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM161A Gene

Disorders for TMEM161A Gene

Relevant External Links for TMEM161A

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM161A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM161A Gene

Publications for TMEM161A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. AROS-29 is involved in adaptive response to oxidative stress. (PMID: 16551573) Montesano Gesualdi N. … Esposito F. (Free Radic. Res. 2006) 3

Products for TMEM161A Gene

Sources for TMEM161A Gene