TMEM161A Gene
protein-coding GIFtS: 41
GCID: GC19M019231
|
|
transmembrane protein 161A
| |
Aliases
for TMEM161A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 161A1 2 | | FLJ204221 | | FLJ396451 | | AROS-292 |
Export aliases for TMEM161A gene to outside databasesPrevious GC identifers: GC19M019092 GC19M018794 |
Summaries
for TMEM161A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM161A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM161A gene promoter:
HFH-3 p53 FOXI1 E2F-1 E2F CP2 STAT3 Msx-1 NF-E2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM161A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM161A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.11TMEM161A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M019231: view genomic region
(about GC identifiers)
Start:
|
19,229,978 bp from pter |
End:
|
19,249,322 bp from pter |
Size:
|
19,345 bases |
Orientation:
|
minus strand |
|
Proteins
for TMEM161A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T161A_HUMAN, Q9NX61 (See
protein sequence)Recommended Name: Transmembrane protein 161A precursor Size: 479 amino acids; 53602 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B3KUE0 G5E9M6 Q7L2Y1Alternative splicing: 2 isoforms: Q9NX61-1 Q9NX61-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TMEM161A: NX_Q9NX61
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NX61
TMEM161A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001243695.1 NP_060284.1
ENSEMBL proteins: ENSP00000404208 ENSP00000162044 ENSP00000467300 ENSP00000465840 ENSP00000467649 ENSP00000466773 ENSP00000465215 ENSP00000467793
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM161A for ontologies About GeneDecksing
TMEM161A Antibody Products:
Assay Products for TMEM161A: |
Protein
Domains /
Families
for TMEM161A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM161A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NX61ProtoNet protein and cluster: Q9NX61 UniProtKB/Swiss-Prot: T161A_HUMAN, Q9NX61Similarity: Belongs to the TMEM161 family |
Function
for TMEM161A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM161A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM161A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM161A (NM_017814) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM161A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM161A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM161A |
|
Pathways & Interactions
for TMEM161A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM161A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for TMEM161A (Q9NX613 ENSP000001620444) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
TMEM161A for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM161A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM161A
Search CenterWatch for drugs/clinical trials and news about TMEM161A / T161A
|
Transcripts
for TMEM161A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM161A gene (2 alternative transcripts): NM_001256766.1 NM_017814.2 Unigene Cluster for TMEM161A: Transmembrane protein 161A Hs.631629 [show with all ESTs]Unigene Representative Sequence: AK09696416 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000450333(uc002nli.3) ENST00000587406 ENST00000162044(uc002nlg.3)
ENST00000589448 ENST00000587583 ENST00000591443 ENST00000587925 ENST00000587096
ENST00000591031 ENST00000587985 ENST00000585829 ENST00000590216 ENST00000592369
ENST00000587915 ENST00000592147 ENST00000586357
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM161A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM161A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM161A (NM_017814) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM161A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM161A |
Additional cDNA sequence: AK000429.1 AK096964.1 AK225424.1 AY358088.1 BC005210.1 BC016478.2 13 DOTS entries: DT.100822483 DT.100774795 DT.111198 DT.95207371 DT.92429020 DT.100822489 DT.100763338 DT.121441686 DT.121441695 DT.92429022 DT.92429025 DT.100697613 DT.100758687 24/234 AceView cDNA sequences (see all 234): CA488682 BU557390 CR597925 BU150538 BQ063217 BU556645 CR600373 BM560021 AA865956 BX401706 CR592471 CR610030 BM928038 BI256890 BU553926 AL702419 BX343000 BP351685 CR624962 BU857813 CR614146 CR602833 BF725966 BM543920
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM161A (see all 9) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c |
|---|
|
| SP1: | | | | | - | | | | - | | | | - | | | | - | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | |
| SP2: | | | | | - | | | | - | | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM161A
|
Expression
for TMEM161A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM161A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCGATTTTTA
About this image
See TMEM161A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM161A
SOURCE GeneReport for Unigene cluster: Hs.631629
SABiosciences Custom PCR Arrays for TMEM161A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM161A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM161A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM161A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM161A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM161A |
Orthologs
for TMEM161A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM161A gene from 5/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008572641 |
transmembrane protein 161A-like |
71(n)
64.15(a) |
|
100857264 XM_003642880.1 XP_003642928.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.184682 |
Xenopus laevis transcribed sequence with moderate similarity more |
87.25(n) |
|
BG347824.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
tmem161a1 |
transmembrane protein 161A |
61.13(n)
58.19(a) |
|
492692 NM_001044317.1 NP_001037782.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG76386 |
-- |
34(a) |
1 → many |
3L(11102790-11105217) |
worm
(Caenorhabditis elegans) |
Secernentea |
Y87G2A.136 |
Protein Y87G2A.13 |
24(a) |
1 → many |
I(13598607-13603384) |
ENSEMBL Gene Tree for TMEM161A (if available)
TreeFam Gene Tree for TMEM161A (if available) |
Paralogs
for TMEM161A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM161A gene
- TMEM161B2
1 SIMAP similar gene for TMEM161A using alignment to 7 protein entries: T161A_HUMAN (see all proteins):TMEM161B
TMEM161A for paralogs About GeneDecksing
|
Genomic Variants
for TMEM161A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM161A (19229978 - 19249322 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM161A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM161A |
|
Disorders
/ Diseases
for TMEM161A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TMEM161A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM161A gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with TMEM161A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- AROS-29 is involved in adaptive response to oxidative stress. (PubMed id 16551573)1 Montesano Gesualdi N....Esposito F. (2006)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Automated yeast two-hybrid screening for nuclear rece ptor-interacting proteins. (PubMed id 15604093)1 Albers M....Koegl M. (2005)
|
External Searches for TMEM161A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM161A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM161A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM161A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM161A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM161A gene:
Search GeneIP for patents involving TMEM161A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM161A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM161A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM161A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM161A | | | OriGene Protein Over-expression Lysate for TMEM161A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM161A | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM161A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM161A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM161A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM161A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM161A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM161A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM161A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM161A |
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 | | | TMEM161A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM161A |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM161A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM161A |
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