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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM160 Gene

protein-coding   GIFtS: 39
GCID: GC19M047549

Transmembrane Protein 160

  Search for TMEM160
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 1601 2

External Ids:    HGNC: 260421   Entrez Gene: 549582   Ensembl: ENSG000001307487   UniProtKB: Q9NX003   

Export aliases for TMEM160 gene to outside databases

Previous GC identifers: GC19M052242 GC19M043973


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM160 Gene: 
TMEM160 (transmembrane protein 160) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM160 gene promoter:
         USF1   MIF-1   XBP-1   AP-2gamma   Arnt   c-Ets-1   Roaz   USF-1   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM160 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM160

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM160


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

TMEM160 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM160 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M047549:  view genomic region     (about GC identifiers)

Start:
47,549,165 bp from pter      End:
47,551,888 bp from pter
Size:
2,724 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM160_HUMAN, Q9NX00 (See protein sequence)
Recommended Name: Transmembrane protein 160  
Size: 188 amino acids; 19658 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q9BU41

Explore the universe of human proteins at neXtProt for TMEM160: NX_Q9NX00

Explore proteomics data for TMEM160 at MOPED 

TMEM160 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TMEM160 Protein Expression

REFSEQ proteins: NP_060324.1  
ENSEMBL proteins: 
 ENSP00000253047  

Human Recombinant Protein Products for TMEM160: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IEA--
GO:0016021integral to membrane IEA--

TMEM160 for ontologies           About GeneDecksing



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Cloud-Clone Corp. ELISAs for TMEM160 
Cloud-Clone Corp. CLIAs for TMEM160


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR026801 TMEM160

Graphical View of Domain Structure for InterPro Entry Q9NX00

ProtoNet protein and cluster: Q9NX00

UniProtKB/Swiss-Prot: TM160_HUMAN, Q9NX00
Similarity: Belongs to the TMEM160 family


TMEM160 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 GenomeRNAi human phenotype for TMEM160:
 Decreased nuclei size in G2M 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM160 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM160

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM160

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/9 Interacting proteins for TMEM160 (Q9NX003 ENSP000002530474) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
InteractantInteraction Details
GeneCardExternal ID(s)
KBTBD7Q8WVZ93, ENSP000003687974I2D: score=3 STRING: ENSP00000368797
KEAP1Q141453, ENSP000001711114I2D: score=2 STRING: ENSP00000171111
SQSTM1Q135013, ENSP000003744554I2D: score=2 STRING: ENSP00000374455
GABARAPO951663, ENSP000003068664I2D: score=1 STRING: ENSP00000306866
MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=3 STRING: ENSP00000268607
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM160 (TM160)

Search CenterWatch for drugs/clinical trials and news about TMEM160 / TM160

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM160 gene: 
NM_017854.1  

Unigene Cluster for TMEM160:

Transmembrane protein 160
Hs.105606  [show with all ESTs]
Unigene Representative Sequence: BQ673305
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000253047(uc002pfz.3)
miRNA
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                     Customized lentivirus expression plasmids for stable overexpression of TMEM160 
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Additional mRNA sequence: 

AK000519.1 BC002907.2 

2 DOTS entries:

DT.107357  DT.100711639 

24/75 AceView cDNA sequences (see all 75):

BI964001 BM127634 AI500262 BI963735 CB107311 CK906219 CD673753 BM967091 
BM053127 BM128575 AI571368 AK000519 AW473473 BF434884 NM_017854 CA439706 
BM128356 AI479711 CA432976 CB156622 AI929750 BG575189 CK906218 BU528876 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM160 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGGCAGCTGG
TMEM160 Expression
About this image


See TMEM160 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM160

SOURCE GeneReport for Unigene cluster: Hs.105606
    SABiosciences Custom PCR Arrays for TMEM160
Primer
Products:
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM160
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM160

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TMEM160 gene from 2/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmem1601 , 5 transmembrane protein 1601, 5 84.4(n)1
94.15(a)1
  7 (9.13 cM)5
690941  NM_026938.11  NP_081214.11 
 164527795 
zebrafish
(Danio rerio)
Actinopterygii Dr.177832 Transcribed sequence with weak similarity to protein more 71.91(n)    BQ131917.1 


ENSEMBL Gene Tree for TMEM160 (if available)
TreeFam Gene Tree for TMEM160 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TMEM160 gene

TMEM160 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for TMEM160
PGOHUM00000237038


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/128 SNPs in TMEM160 are shown (see all 128)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0306004
----see VAR_0306002 G S mis40--------
rs18624981,2
C,F,H--47549565(+) GGAGCA/GAAGCC 1 -- int18Minor allele frequency- G:0.04NS NA WA 1010
rs735665371,2
C,F--47549602(+) AGGGCC/AGTGCC 1 -- int13Minor allele frequency- A:0.13WA NA 240
rs1178707721,2
F--47549730(+) AGAATG/CGGGGT 1 -- int11Minor allele frequency- C:0.03NA 120
rs18624991,2
C,F,A,H--47549791(+) AGGGCG/AGGTGA 1 -- int122Minor allele frequency- A:0.46EA NS NA WA CSA 3844
rs1876800201,2
C--47549804(+) GGGGCC/TCTGCA 1 -- int10--------
rs2011441571,2
C--47549829(+) GGGGCA/GAGAGG 1 -- int10--------
rs2005628091,2
--47549926(+) ATTGCA/GGAACC 2 R C mis10--------
rs735665381,2
C,F--47549962(+) GACATG/AGGGGG 1 -- int14Minor allele frequency- A:0.14WA CSA NA 242
rs1926025011,2
C--47549980(+) TCACCC/TCCAAC 1 -- int10--------

HapMap Linkage Disequilibrium report for TMEM160 (47549165 - 47551888 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for TMEM160:    About this table     
Variant IDTypeSubtypePubMed ID
nsv2512CNV Insertion18451855
dgv3962n71CNV Loss21882294
nsv912193CNV Loss21882294
nsv912192CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TMEM160 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM160)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  4. Why do cellular proteins linked to K63-polyubiquitin c hains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (2013)
  5. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
  6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
  7. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1 Speliotes E.K....Loos R.J. (2010)
  8. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
  9. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 54958 HGNC: 26042 AceView: FLJ20512 Ensembl:ENSG00000130748 euGenes: HUgn54958
ECgene: TMEM160 H-InvDB: TMEM160

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TMEM160 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TMEM160 gene:
Search GeneIP for patents involving TMEM160

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM160
 Browse SwitchGear 3'UTR luciferase reporter plasmids for TMEM160
 SwitchGear Promoter luciferase reporter plasmids for TMEM160
 Search ThermoFisher Antibodies for TMEM160
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM160
 inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM160
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM160
Customized:
 lentivirus for stable overexpression of TMEM160
 lentivirus expression plasmids for stable overexpression of TMEM160
 adenovirus for overexpression of TMEM160
 Search LSBio for Antibodies for TMEM160
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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