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TMEM160 Gene

protein-coding   GIFtS: 42
GCID: GC19M047549

Transmembrane Protein 160

  Search for TMEM160
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 1601 2

External Ids:    HGNC: 260421   Entrez Gene: 549582   Ensembl: ENSG000001307487   UniProtKB: Q9NX003   

Export aliases for TMEM160 gene to outside databases

Previous GC identifers: GC19M052242 GC19M043973


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM160 Gene:
TMEM160 (transmembrane protein 160) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM160 gene promoter:
         USF1   MIF-1   XBP-1   AP-2gamma   Arnt   c-Ets-1   Roaz   USF-1   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM160 promoter sequence
   Search Chromatin IP Primers for TMEM160

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM160


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

TMEM160 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM160 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M047549:  view genomic region     (about GC identifiers)

Start:
47,549,165 bp from pter      End:
47,551,888 bp from pter
Size:
2,724 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM160_HUMAN, Q9NX00 (See protein sequence)
Recommended Name: Transmembrane protein 160  
Size: 188 amino acids; 19658 Da
Secondary accessions: Q9BU41

Explore the universe of human proteins at neXtProt for TMEM160: NX_Q9NX00

Explore proteomics data for TMEM160 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMEM160 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060324.1  
    ENSEMBL proteins: 
     ENSP00000253047  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026801 TMEM160

    Graphical View of Domain Structure for InterPro Entry Q9NX00

    ProtoNet protein and cluster: Q9NX00

    UniProtKB/Swiss-Prot: TM160_HUMAN, Q9NX00
    Similarity: Belongs to the TMEM160 family


    TMEM160 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for TMEM160:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM160
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM160_HUMAN, Q9NX00: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    endoplasmic reticulum1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0016021integral component of membrane IEA--

    TMEM160 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM160
    Interactions:

        Search GeneGlobe Interaction Network for TMEM160

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for TMEM160 (Q9NX003 ENSP000002530474) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KBTBD7Q8WVZ93, ENSP000003687974I2D: score=3 STRING: ENSP00000368797
    KEAP1Q141453, ENSP000001711114I2D: score=2 STRING: ENSP00000171111
    SQSTM1Q135013, ENSP000003744554I2D: score=2 STRING: ENSP00000374455
    GABARAPO951663, ENSP000003068664I2D: score=1 STRING: ENSP00000306866
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=3 STRING: ENSP00000268607
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM160 (TM160)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM160 gene: 
    NM_017854.1  

    Unigene Cluster for TMEM160:

    Transmembrane protein 160
    Hs.105606  [show with all ESTs]
    Unigene Representative Sequence: BQ673305
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000253047(uc002pfz.3)
    miRNA
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    Additional mRNA sequence: 

    AK000519.1 BC002907.2 

    2 DOTS entries:

    DT.107357  DT.100711639 

    Selected AceView cDNA sequences (see all 75):

    BI963735 BF434884 BM127634 AI500262 CK906219 AK000519 CB156622 BI964001 
    CD673753 AI571368 CA439706 BM128356 CB107311 BM128575 BM967091 AI479711 
    AW473473 CA432976 BM053127 NM_017854 BG774995 BE257238 BI758256 AI767097 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM160 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCAGCTGG
    TMEM160 Expression
    About this image

    TMEM160 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM160 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.105606
        Custom PCR Arrays for TMEM160
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM160

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM160 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1601 , 5 transmembrane protein 1601, 5 84.4(n)1
    94.15(a)1
      7 (9.13 cM)5
    690941  NM_026938.11  NP_081214.11 
     164527795 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.177832 Transcribed sequence with weak similarity to protein more 71.91(n)    BQ131917.1 


    ENSEMBL Gene Tree for TMEM160 (if available)
    TreeFam Gene Tree for TMEM160 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM160 gene

    TMEM160 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TMEM160
    PGOHUM00000237038


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM160 (see all 128)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18624981,2
    C,F,H--47549565(+) GGAGCA/GAAGCC 1 -- int18Minor allele frequency- G:0.04NS NA WA 1010
    rs735665371,2
    C,F--47549602(+) AGGGCC/AGTGCC 1 -- int13Minor allele frequency- A:0.13WA NA 240
    rs1178707721,2
    F--47549730(+) AGAATG/CGGGGT 1 -- int11Minor allele frequency- C:0.03NA 120
    rs18624991,2
    C,F,A,H--47549791(+) AGGGCG/AGGTGA 1 -- int122Minor allele frequency- A:0.46EA NS NA WA CSA 3844
    rs1876800201,2
    C--47549804(+) GGGGCC/TCTGCA 1 -- int10--------
    rs2011441571,2
    C--47549829(+) GGGGCA/GAGAGG 1 -- int10--------
    rs2005628091,2
    --47549926(+) ATTGCA/GGAACC 2 R C mis10--------
    rs735665381,2
    C,F--47549962(+) GACATG/AGGGGG 1 -- int14Minor allele frequency- A:0.14WA CSA NA 242
    rs1926025011,2
    C--47549980(+) TCACCC/TCCAAC 1 -- int10--------
    rs104114851,2
    C--47549990(+) CCCTAC/TCTCCT 1 -- int13Minor allele frequency- T:0.11CSA WA NA 239

    HapMap Linkage Disequilibrium report for TMEM160 (47549165 - 47551888 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TMEM160:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2512CNV Insertion18451855
    dgv3962n71CNV Loss21882294
    nsv912193CNV Loss21882294
    nsv912192CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM160 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMEM160)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    5. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1 Speliotes E.K....Loos R.J. (Nat. Genet. 2010)
    8. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (Nature 2010)
    9. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54958 HGNC: 26042 AceView: FLJ20512 Ensembl:ENSG00000130748 euGenes: HUgn54958
    ECgene: TMEM160 H-InvDB: TMEM160

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM160 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM160 gene:
    Search GeneIP for patents involving TMEM160

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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