TMEM159 Gene
protein-coding GIFtS: 44
GCID: GC16P021169
|
|
transmembrane protein 159
| |
Aliases
for TMEM159 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 1591 2 3 | | Promethin1 | | PROMETHIN2 |
Export aliases for TMEM159 gene to outside databasesPrevious GC identifers: GC16P021078 GC16P019705 |
Summaries
for TMEM159 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM159 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM159 gene promoter:
p53 Pax-6 Brachyury HNF-3beta POU2F1 POU2F1a POU2F1b IRF-7A PPAR-gamma2 POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM159
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM159 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p12 Ensembl cytogenetic band: 16p12.3 HGNC cytogenetic band: 16p12.2TMEM159 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P021169: view genomic region
(about GC identifiers)
Start:
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21,169,698 bp from pter |
End:
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21,191,937 bp from pter |
Size:
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22,240 bases |
Orientation:
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plus strand |
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Proteins
for TMEM159 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM159_HUMAN, Q96B96 (See
protein sequence)Recommended Name: Promethin Size: 161 amino acids; 17522 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A6NMA9 O00323Explore the universe of human proteins at neXtProt for TMEM159: NX_Q96B96
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96B96
TMEM159 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065155.3
ENSEMBL proteins: ENSP00000461828 ENSP00000233047 ENSP00000459481 ENSP00000261388 ENSP00000409879 ENSP00000460687 ENSP00000461826 ENSP00000460102
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM159 for ontologies About GeneDecksing
TMEM159 Antibody Products:
Assay Products for TMEM159: |
Protein
Domains /
Families
for TMEM159 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96B96 UniProtKB/Swiss-Prot: TM159_HUMAN, Q96B96Similarity: Belongs to the TMEM159 family |
Function
for TMEM159 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM159 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM159
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM159 (NM_020422) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM159 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM159 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM159 |
|
Pathways & Interactions
for TMEM159 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM159
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
4 Interacting proteins for TMEM159 (Q96B962, 3 ENSP000002330474) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TMEM159 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM159
Search CenterWatch for drugs/clinical trials and news about TMEM159 / TM159
|
Transcripts
for TMEM159 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM159 gene: NM_020422.4 Unigene Cluster for TMEM159: Transmembrane protein 159 Hs.258212 [show with all ESTs]Unigene Representative Sequence: NM_0204229 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000573487 ENST00000233047(uc002dig.4 uc010vbf.2 uc002dih.4)
ENST00000572258 ENST00000574092 ENST00000261388(uc002dif.4) ENST00000451578
ENST00000572599 ENST00000577162 ENST00000573688
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM159 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM159
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM159 (NM_020422) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM159 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM159 |
Additional cDNA sequence: AF070596.1 AK074667.1 AK293557.1 AY212918.1 BC015812.1 BX647512.1 8 DOTS entries: DT.114285 DT.100788617 DT.91737345 DT.100788620 DT.91737361 DT.100788619 DT.100732754 DT.91737359 24/151 AceView cDNA sequences (see all 151): BX339274 AI291803 BU947538 AA807413 BF940501 BQ953550 Z38799 CB158506 BU789678 AA953509 AA905252 AA947241 BM924035 AW405043 BX282506 BF449015 AA804885 BU071096 AI676077 AA808195 F08702 AW401798 BP354699 BU624832
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM159 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | - | | | | | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM159
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Expression
for TMEM159 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM159 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAACAAAA
About this image
See TMEM159 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM159
SOURCE GeneReport for Unigene cluster: Hs.258212
UniProtKB/Swiss-Prot: TM159_HUMAN, Q96B96Tissue specificity: Expressed at high levels in the heart and skeletal muscle. Expressed at low levels in kidney, smallintestine, lung and liver
SABiosciences Custom PCR Arrays for TMEM159
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM159
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM159 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM159 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM159 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM159 |
Orthologs
for TMEM159 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TMEM159 gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for TMEM159 (if available)
TreeFam Gene Tree for TMEM159 (if available) |
Paralogs
for TMEM159 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM159 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM159 (21169698 - 21191937 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TMEM159
2 CNVs: 7094 4931
1 Indel: 11107 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM159 |
|
Disorders
/ Diseases
for TMEM159 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TMEM159 for disorders About MalaCards
TMEM159 for disorders About GeneDecksing
OMIM gene information: 611304
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: TMEM159 (1 document)
Export disorders for TMEM159 gene to outside databases
|
Publications
for TMEM159 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM159 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with TMEM159) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liver. (PubMed id 15589683)1, 2, 3 Yu S....Reddy J.K. (2004)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Large-scale identification of human genes implicated in epidermal barrier function. (PubMed id 17562024)1 Toulza E.... Guerrin M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
|
External Searches for TMEM159 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM159 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM159 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM159 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM159 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM159 gene:
Search GeneIP for patents involving TMEM159
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM159 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM159 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM159 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM159 | | | OriGene Protein Over-expression Lysate for TMEM159 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM159 | | OriGene 3'-UTR Clone for TMEM159 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM159 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM159 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM159 | | OriGene Custom Protein Services for TMEM159 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM159 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM159 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM159 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM159 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM159 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM159 |
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 |  |  |  | |
| | | | Search Tocris compounds for TMEM159 |
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 | | | TMEM159 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM159 |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM159 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM159 |
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