Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM159 Gene

Aliases for TMEM159 Gene

  • Transmembrane Protein 159 2 3 4 5
  • Promethin 3

External Ids for TMEM159 Gene

Previous GeneCards Identifiers for TMEM159 Gene

  • GC16P021078
  • GC16P019705
  • GC16P021169

Summaries for TMEM159 Gene

GeneCards Summary for TMEM159 Gene

TMEM159 (Transmembrane Protein 159) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM159 Gene

Genomics for TMEM159 Gene

Regulatory Elements for TMEM159 Gene

Enhancers for TMEM159 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TMEM159 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM159 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM159 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM159 Gene

21,158,377 bp from pter
21,180,616 bp from pter
22,240 bases
Plus strand

Genomic View for TMEM159 Gene

Genes around TMEM159 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM159 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM159 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM159 Gene

Proteins for TMEM159 Gene

  • Protein details for TMEM159 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NMA9
    • B4DEC1
    • O00323

    Protein attributes for TMEM159 Gene

    161 amino acids
    Molecular mass:
    17522 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM159 Gene


neXtProt entry for TMEM159 Gene

Post-translational modifications for TMEM159 Gene

  • Glycosylation at Asn 29 and Asn 141
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM159 Gene

Domains & Families for TMEM159 Gene

Protein Domains for TMEM159 Gene


Suggested Antigen Peptide Sequences for TMEM159 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM159 family.
  • Belongs to the TMEM159 family.
genes like me logo Genes that share domains with TMEM159: view

No data available for Gene Families for TMEM159 Gene

Function for TMEM159 Gene

Gene Ontology (GO) - Molecular Function for TMEM159 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TMEM159: view

Phenotypes for TMEM159 Gene

genes like me logo Genes that share phenotypes with TMEM159: view

Animal Model Products

CRISPR Products

miRNA for TMEM159 Gene

miRTarBase miRNAs that target TMEM159

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM159 Gene

Localization for TMEM159 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM159 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM159 Gene COMPARTMENTS Subcellular localization image for TMEM159 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM159 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM159: view

Pathways & Interactions for TMEM159 Gene

SuperPathways for TMEM159 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM159 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM159 Gene

Drugs & Compounds for TMEM159 Gene

No Compound Related Data Available

Transcripts for TMEM159 Gene

Unigene Clusters for TMEM159 Gene

Transmembrane protein 159:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM159 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - -
SP2: - - -
SP3: - -
SP5: - - - -
SP6: - - -
SP7: -

Relevant External Links for TMEM159 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM159 Gene

mRNA expression in normal human tissues for TMEM159 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM159 Gene

This gene is overexpressed in Heart (25.1), Bone (9.8), and Lung (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM159 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM159 Gene:


SOURCE GeneReport for Unigene cluster for TMEM159 Gene:


mRNA Expression by UniProt/SwissProt for TMEM159 Gene:

Tissue specificity: Expressed at high levels in the heart and skeletal muscle. Expressed at low levels in kidney, small intestine, lung and liver.
genes like me logo Genes that share expression patterns with TMEM159: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for TMEM159 Gene

Orthologs for TMEM159 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM159 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TMEM159 34
  • 83.85 (n)
  • 75.78 (a)
TMEM159 35
  • 66 (a)
(Mus musculus)
Mammalia Tmem159 34
  • 79.54 (n)
  • 71.52 (a)
Tmem159 16
Tmem159 35
  • 70 (a)
(Pan troglodytes)
Mammalia TMEM159 34
  • 99.38 (n)
  • 98.14 (a)
TMEM159 35
  • 85 (a)
(Rattus norvegicus)
Mammalia Tmem159 34
  • 80.17 (n)
  • 72.15 (a)
(Bos Taurus)
Mammalia TMEM159 35
  • 63 (a)
(Monodelphis domestica)
Mammalia TMEM159 35
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM159 35
  • 60 (a)
(Gallus gallus)
Aves TMEM159 34
  • 58.84 (n)
  • 48.48 (a)
TMEM159 35
  • 43 (a)
(Anolis carolinensis)
Reptilia TMEM159 35
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486925 34
  • 56.98 (n)
  • 47.97 (a)
Species where no ortholog for TMEM159 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM159 Gene

Gene Tree for TMEM159 (if available)
Gene Tree for TMEM159 (if available)

Paralogs for TMEM159 Gene

No data available for Paralogs for TMEM159 Gene

Variants for TMEM159 Gene

Sequence variations from dbSNP and Humsavar for TMEM159 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1046480 - 21,174,063(+) GTTTG(A/G)GCTTC intron-variant, nc-transcript-variant, reference, missense
rs1063087 - 21,179,532(+) GCAGA(A/C)TTCGA nc-transcript-variant, reference, missense, utr-variant-3-prime
rs35345508 - 21,174,033(+) GTGGC(C/T)TCTCA intron-variant, nc-transcript-variant, reference, missense
rs9302392 -- 21,170,304(+) ggccT(A/G)TAGTG intron-variant
rs9302393 -- 21,172,718(+) GAAAT(A/C)TGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM159 Gene

Variant ID Type Subtype PubMed ID
esv33128 CNV loss 17666407
esv33636 CNV loss 17666407
nsv436835 CNV insertion 17901297
nsv457444 CNV loss 19166990
nsv571622 CNV loss 21841781
nsv571623 CNV gain 21841781
nsv833166 CNV gain+loss 17160897

Variation tolerance for TMEM159 Gene

Residual Variation Intolerance Score: 60.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM159 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM159 Gene

Disorders for TMEM159 Gene

Relevant External Links for TMEM159

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM159 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM159 Gene

Publications for TMEM159 Gene

  1. Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liver. (PMID: 15589683) Yu S. … Reddy J.K. (Biochimie 2004) 2 3 4 65
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3 65
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3 65
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65

Products for TMEM159 Gene

Sources for TMEM159 Gene