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Aliases for TMEM159 Gene

Aliases for TMEM159 Gene

  • Transmembrane Protein 159 2 3 4
  • Promethin 3

External Ids for TMEM159 Gene

Previous GeneCards Identifiers for TMEM159 Gene

  • GC16P021078
  • GC16P019705
  • GC16P021169

Summaries for TMEM159 Gene

GeneCards Summary for TMEM159 Gene

TMEM159 (Transmembrane Protein 159) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM159 Gene

Genomics for TMEM159 Gene

Regulatory Elements for TMEM159 Gene

Genomic Location for TMEM159 Gene

21,158,377 bp from pter
21,180,616 bp from pter
22,240 bases
Plus strand

Genomic View for TMEM159 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM159 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM159 Gene

Proteins for TMEM159 Gene

  • Protein details for TMEM159 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NMA9
    • B4DEC1
    • O00323

    Protein attributes for TMEM159 Gene

    161 amino acids
    Molecular mass:
    17522 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM159 Gene


neXtProt entry for TMEM159 Gene

Proteomics data for TMEM159 Gene at MOPED

Post-translational modifications for TMEM159 Gene

  • Glycosylation at Asn29 and Asn141
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM159 Gene

Domains for TMEM159 Gene

Protein Domains for TMEM159 Gene


Suggested Antigen Peptide Sequences for TMEM159 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96B96
  • Belongs to the TMEM159 family.
genes like me logo Genes that share domains with TMEM159: view

No data available for Gene Families for TMEM159 Gene

Function for TMEM159 Gene

Gene Ontology (GO) - Molecular Function for TMEM159 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TMEM159: view

miRNA for TMEM159 Gene

miRTarBase miRNAs that target TMEM159

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM159 Gene

Localization for TMEM159 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM159 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM159 Gene COMPARTMENTS Subcellular localization image for TMEM159 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM159 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM159: view

Pathways for TMEM159 Gene

SuperPathways for TMEM159 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM159 Gene


No data available for Pathways by source for TMEM159 Gene

Transcripts for TMEM159 Gene

Unigene Clusters for TMEM159 Gene

Transmembrane protein 159:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM159 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - -
SP2: - - -
SP3: - -
SP5: - - - -
SP6: - - -
SP7: -

Relevant External Links for TMEM159 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM159 Gene

mRNA expression in normal human tissues for TMEM159 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM159 Gene

SOURCE GeneReport for Unigene cluster for TMEM159 Gene Hs.258212

mRNA Expression by UniProt/SwissProt for TMEM159 Gene

Tissue specificity: Expressed at high levels in the heart and skeletal muscle. Expressed at low levels in kidney, small intestine, lung and liver.
genes like me logo Genes that share expressions with TMEM159: view

No data available for mRNA differential expression in normal tissues for TMEM159 Gene

Orthologs for TMEM159 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM159 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM159 35
  • 99.38 (n)
  • 98.14 (a)
TMEM159 36
  • 85 (a)
(Bos Taurus)
Mammalia TMEM159 36
  • 63 (a)
(Canis familiaris)
Mammalia TMEM159 35
  • 83.85 (n)
  • 75.78 (a)
TMEM159 36
  • 66 (a)
(Mus musculus)
Mammalia Tmem159 35
  • 79.54 (n)
  • 71.52 (a)
Tmem159 16
Tmem159 36
  • 70 (a)
(Monodelphis domestica)
Mammalia TMEM159 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM159 36
  • 60 (a)
(Rattus norvegicus)
Mammalia Tmem159 35
  • 80.17 (n)
  • 72.15 (a)
(Gallus gallus)
Aves TMEM159 35
  • 58.84 (n)
  • 48.48 (a)
TMEM159 36
  • 43 (a)
(Anolis carolinensis)
Reptilia TMEM159 36
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486925 35
  • 56.98 (n)
  • 47.97 (a)
Species with no ortholog for TMEM159:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM159 Gene

Gene Tree for TMEM159 (if available)
Gene Tree for TMEM159 (if available)

Paralogs for TMEM159 Gene

No data available for Paralogs for TMEM159 Gene

Variants for TMEM159 Gene

Sequence variations from dbSNP and Humsavar for TMEM159 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs909083 -- 21,180,777(+) CTCGC(A/G)ATAGA downstream-variant-500B
rs1046480 - 21,174,063(+) GTTTG(A/G)GCTTC missense, reference, intron-variant
rs1063087 - 21,179,532(+) GCAGA(A/C)TTCGA reference, missense, utr-variant-3-prime
rs1270168 -- 21,169,614(+) agatt(C/T)tgtat intron-variant
rs1270169 -- 21,172,061(+) TACTT(C/T)CTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM159 Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV Insertion 17901297
nsv457444 CNV Loss 19166990
nsv833166 CNV Gain+Loss 17160897
esv33636 CNV Loss 17666407
esv33128 CNV Loss 17666407

Relevant External Links for TMEM159 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM159 Gene

Disorders for TMEM159 Gene

Relevant External Links for TMEM159

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TMEM159: view

No data available for UniProtKB/Swiss-Prot for TMEM159 Gene

Publications for TMEM159 Gene

  1. Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liver. (PMID: 15589683) Yu S. … Reddy J.K. (Biochimie 2004) 2 3 4
  2. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for TMEM159 Gene

Sources for TMEM159 Gene

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