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Aliases for TMEM159 Gene

Aliases for TMEM159 Gene

  • Transmembrane Protein 159 2 3 4 5
  • Promethin 3

External Ids for TMEM159 Gene

Previous GeneCards Identifiers for TMEM159 Gene

  • GC16P021078
  • GC16P019705
  • GC16P021169

Summaries for TMEM159 Gene

GeneCards Summary for TMEM159 Gene

TMEM159 (Transmembrane Protein 159) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM159 Gene

Genomics for TMEM159 Gene

Regulatory Elements for TMEM159 Gene

Enhancers for TMEM159 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G021187 1.3 Ensembl ENCODE 17.3 +30.1 30144 1.4 ARNT ARID4B SIN3A ZNF48 TCF12 ZNF143 FOS JUNB MXD4 REST TMEM159 DNAH3 ENSG00000262983 GC16P021165
GH16G021156 1.1 Ensembl ENCODE 18.6 -1.5 -1476 0.6 ELF3 ZSCAN4 ARID4B KLF17 ZNF2 RAD21 RFX5 ZNF366 ZNF143 IKZF2 TMEM159 PIR41433
GH16G020849 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -307.2 -307241 3.1 ARNT SIN3A ARID4B ZNF2 YY1 SLC30A9 GATA2 ZNF143 DEK MXD4 THUMPD1 DCUN1D3 LYRM1 TMEM159 DNAH3 PIR58963
GH16G021157 1 ENCODE 18.7 +0.7 713 2.6 WRNIP1 ARID4B SIN3A GLI4 ZNF48 ZBTB7B GLIS2 ELK1 FOS KLF13 TMEM159 DNAH3
GH16G020864 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -291.9 -291877 3.6 PKNOX1 ATF1 ARID4B SIN3A FEZF1 ZNF48 YY1 TCF12 ZNF121 GATA2 ACSM3 THUMPD1 DCUN1D3 LYRM1 DNAH3 TMEM159 PIR58963
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM159 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM159 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000084301 823 1601 WRNIP1 ARID4B SIN3A GLI4 ZNF48 ZBTB7B GLIS2 ELK1 FOS KLF13

Genomic Location for TMEM159 Gene

Chromosome:
16
Start:
21,158,377 bp from pter
End:
21,180,616 bp from pter
Size:
22,240 bases
Orientation:
Plus strand

Genomic View for TMEM159 Gene

Genes around TMEM159 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM159 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM159 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM159 Gene

Proteins for TMEM159 Gene

  • Protein details for TMEM159 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B96-TM159_HUMAN
    Recommended name:
    Promethin
    Protein Accession:
    Q96B96
    Secondary Accessions:
    • A6NMA9
    • B4DEC1
    • O00323

    Protein attributes for TMEM159 Gene

    Size:
    161 amino acids
    Molecular mass:
    17522 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM159 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM159 Gene

Post-translational modifications for TMEM159 Gene

  • Glycosylation at Asn29 and Asn141
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM159 Gene

Domains & Families for TMEM159 Gene

Protein Domains for TMEM159 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM159 Gene

Graphical View of Domain Structure for InterPro Entry

Q96B96

UniProtKB/Swiss-Prot:

TM159_HUMAN :
  • Belongs to the TMEM159 family.
Family:
  • Belongs to the TMEM159 family.
genes like me logo Genes that share domains with TMEM159: view

No data available for Gene Families for TMEM159 Gene

Function for TMEM159 Gene

Gene Ontology (GO) - Molecular Function for TMEM159 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TMEM159: view

Phenotypes for TMEM159 Gene

genes like me logo Genes that share phenotypes with TMEM159: view

Animal Model Products

CRISPR Products

miRNA for TMEM159 Gene

miRTarBase miRNAs that target TMEM159

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM159 Gene

Localization for TMEM159 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM159 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM159 gene
Compartment Confidence
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM159 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM159: view

Pathways & Interactions for TMEM159 Gene

SuperPathways for TMEM159 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM159 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM159 Gene

Drugs & Compounds for TMEM159 Gene

No Compound Related Data Available

Transcripts for TMEM159 Gene

Unigene Clusters for TMEM159 Gene

Transmembrane protein 159:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM159 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - -
SP2: - - -
SP3: - -
SP4:
SP5: - - - -
SP6: - - -
SP7: -

Relevant External Links for TMEM159 Gene

GeneLoc Exon Structure for
TMEM159
ECgene alternative splicing isoforms for
TMEM159

Expression for TMEM159 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM159 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM159 Gene

This gene is overexpressed in Heart (25.1), Bone (9.8), and Lung (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM159 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM159 Gene:

TMEM159

SOURCE GeneReport for Unigene cluster for TMEM159 Gene:

Hs.258212

mRNA Expression by UniProt/SwissProt for TMEM159 Gene:

Q96B96-TM159_HUMAN
Tissue specificity: Expressed at high levels in the heart and skeletal muscle. Expressed at low levels in kidney, small intestine, lung and liver.

Evidence on tissue expression from TISSUES for TMEM159 Gene

  • Heart(4.4)
  • Nervous system(4.4)
  • Skin(4.3)
genes like me logo Genes that share expression patterns with TMEM159: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM159 Gene

Orthologs for TMEM159 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM159 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM159 34 35
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia TMEM159 34 35
  • 83.85 (n)
rat
(Rattus norvegicus)
Mammalia Tmem159 34
  • 80.17 (n)
mouse
(Mus musculus)
Mammalia Tmem159 34 16 35
  • 79.54 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM159 35
  • 65 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM159 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM159 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM159 34 35
  • 58.84 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM159 35
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486925 34
  • 56.98 (n)
Species where no ortholog for TMEM159 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM159 Gene

ENSEMBL:
Gene Tree for TMEM159 (if available)
TreeFam:
Gene Tree for TMEM159 (if available)

Paralogs for TMEM159 Gene

No data available for Paralogs for TMEM159 Gene

Variants for TMEM159 Gene

Sequence variations from dbSNP and Humsavar for TMEM159 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000094392 -- 21,171,653(+) GCCTC(A/C)GGGTG intron-variant
rs1000104829 -- 21,165,139(+) CTTTC(A/T)CTTTG intron-variant
rs1000658086 -- 21,169,299(+) TCTGC(A/G)TTTCC intron-variant
rs1000819565 -- 21,175,943(+) TCTTG(C/G)TGTGT intron-variant
rs1000877952 -- 21,156,707(+) TTTTT(A/T)ACCCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM159 Gene

Variant ID Type Subtype PubMed ID
esv33128 CNV loss 17666407
esv33636 CNV loss 17666407
nsv436835 CNV insertion 17901297
nsv457444 CNV loss 19166990
nsv571622 CNV loss 21841781
nsv571623 CNV gain 21841781
nsv833166 CNV gain+loss 17160897

Variation tolerance for TMEM159 Gene

Residual Variation Intolerance Score: 60.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM159 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM159

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM159 Gene

Disorders for TMEM159 Gene

Relevant External Links for TMEM159

Genetic Association Database (GAD)
TMEM159
Human Genome Epidemiology (HuGE) Navigator
TMEM159
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM159

No disorders were found for TMEM159 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM159 Gene

Publications for TMEM159 Gene

  1. Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liver. (PMID: 15589683) Yu S. … Reddy J.K. (Biochimie 2004) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3 64
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3 64
  5. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N. … Vidal M. (Cell 2015) 3 64

Products for TMEM159 Gene

Sources for TMEM159 Gene

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