Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM158 Gene

Aliases for TMEM158 Gene

  • Transmembrane Protein 158 (Gene/Pseudogene) 2 3
  • 40 KDa BINP-Binding Protein 3 4
  • Ras Induced Senescence 1 2 3
  • P40BBP 3 4
  • RIS1 3 4
  • Brain Injury-Derived Neurotrophic Peptide (BINP) Binding Protein 3
  • Ras-Induced Senescence Protein 1 4
  • Brain Specific Binding Protein 3
  • Transmembrane Protein 158 2
  • BINP Receptor 3
  • HBBP 4
  • BBP 3

External Ids for TMEM158 Gene

Summaries for TMEM158 Gene

Entrez Gene Summary for TMEM158 Gene

  • Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway. An allelic polymorphism in this gene results in both functional and non-functional (frameshifted) alleles; the reference genome represents the functional allele. [provided by RefSeq, Jul 2015]

GeneCards Summary for TMEM158 Gene

TMEM158 (Transmembrane Protein 158 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with TMEM158 include brain injury. GO annotations related to this gene include peptide binding.

UniProtKB/Swiss-Prot for TMEM158 Gene

  • Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.

Gene Wiki entry for TMEM158 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM158 Gene

Genomics for TMEM158 Gene

Regulatory Elements for TMEM158 Gene

Genomic Location for TMEM158 Gene

45,224,464 bp from pter
45,226,322 bp from pter
1,859 bases
Minus strand

Genomic View for TMEM158 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM158 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM158 Gene

Proteins for TMEM158 Gene

  • Protein details for TMEM158 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 158
    Protein Accession:
    Secondary Accessions:
    • Q6PFW5
    • Q9Y4M1

    Protein attributes for TMEM158 Gene

    300 amino acids
    Molecular mass:
    30404 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM158 Gene


neXtProt entry for TMEM158 Gene

Proteomics data for TMEM158 Gene at MOPED

Post-translational modifications for TMEM158 Gene

Other Protein References for TMEM158 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM158 Gene

Domains & Families for TMEM158 Gene

Protein Domains for TMEM158 Gene


Suggested Antigen Peptide Sequences for TMEM158 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM158 family.
  • Belongs to the TMEM158 family.
genes like me logo Genes that share domains with TMEM158: view

No data available for Gene Families for TMEM158 Gene

Function for TMEM158 Gene

Molecular function for TMEM158 Gene

UniProtKB/Swiss-Prot Function:
Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.
UniProtKB/Swiss-Prot Induction:
Up-regulated during Ras-induced senesence.

Gene Ontology (GO) - Molecular Function for TMEM158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042277 peptide binding IEA --
genes like me logo Genes that share ontologies with TMEM158: view

Phenotypes for TMEM158 Gene

genes like me logo Genes that share phenotypes with TMEM158: view

Animal Models for TMEM158 Gene

MGI Knock Outs for TMEM158:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TMEM158 Gene

Localization for TMEM158 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM158 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM158 Gene COMPARTMENTS Subcellular localization image for TMEM158 gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for TMEM158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM158: view

Pathways & Interactions for TMEM158 Gene

SuperPathways for TMEM158 Gene

No Data Available

Interacting Proteins for TMEM158 Gene

Selected Interacting proteins: Q8WZ71-TM158_HUMAN for TMEM158 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMEM158 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM158 Gene

Drugs & Compounds for TMEM158 Gene

No Compound Related Data Available

Transcripts for TMEM158 Gene

mRNA/cDNA for TMEM158 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(82) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM158 Gene

Transmembrane protein 158 (gene/pseudogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM158 Gene

No ASD Table

Relevant External Links for TMEM158 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM158 Gene

mRNA expression in normal human tissues for TMEM158 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM158 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.0), Brain - Caudate (basal ganglia) (x6.5), Brain - Putamen (basal ganglia) (x6.5), and Uterus (x5.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMEM158 Gene

SOURCE GeneReport for Unigene cluster for TMEM158 Gene Hs.740403

genes like me logo Genes that share expression patterns with TMEM158: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM158 Gene

Orthologs for TMEM158 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM158 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM158 35
  • 93.3 (n)
  • 93.16 (a)
TMEM158 36
  • 94 (a)
(Mus musculus)
Mammalia Tmem158 35
  • 88.99 (n)
  • 88.99 (a)
Tmem158 16
Tmem158 36
  • 89 (a)
(Pan troglodytes)
Mammalia TMEM158 35
  • 99.44 (n)
  • 99.33 (a)
TMEM158 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmem158 35
  • 88.69 (n)
  • 89.43 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM158 36
  • 58 (a)
(Gallus gallus)
Aves TMEM158 35
  • 81.43 (n)
  • 79.29 (a)
(Anolis carolinensis)
Reptilia TMEM158 36
  • 60 (a)
(Danio rerio)
Actinopterygii LOC100148963 35
  • 63.37 (n)
  • 58.42 (a)
Species with no ortholog for TMEM158:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM158 Gene

Gene Tree for TMEM158 (if available)
Gene Tree for TMEM158 (if available)

Paralogs for TMEM158 Gene

No data available for Paralogs for TMEM158 Gene

Variants for TMEM158 Gene

Sequence variations from dbSNP and Humsavar for TMEM158 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs33749 -- 45,225,063(+) GAGTC(C/T)CCGGC utr-variant-3-prime
rs33750 -- 45,225,566(+) cggcC(A/G)GTGCG reference, synonymous-codon
rs33751 -- 45,226,624(+) CTTAG(C/T)GCTAC upstream-variant-2KB
rs33752 -- 45,227,641(+) TACTA(A/T)CAGTG upstream-variant-2KB
rs33753 -- 45,228,073(+) TGCAG(C/G/T)GGGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM158 Gene

Variant ID Type Subtype PubMed ID
nsv3793 CNV Insertion 18451855

Variation tolerance for TMEM158 Gene

Gene Damage Index Score: 0.11; 2.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM158 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM158 Gene

Disorders for TMEM158 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM158 Gene - From: GeneCards

Disorder Aliases PubMed IDs
brain injury
- elite association

Relevant External Links for TMEM158

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMEM158: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM158 Gene

Publications for TMEM158 Gene

  1. Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence. (PMID: 11822868) Barradas M. … Serrano M. (Exp. Cell Res. 2002) 2 23 67
  2. Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas. (PMID: 16280139) Silva J. … Bonilla F. (Mutat. Res. 2006) 23 67
  3. RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis. (PMID: 16737913) Iglesias D. … GonzA!lez-Aguilera J.J. (Cancer Genet. Cytogenet. 2006) 23 67
  4. Identification and molecular cloning of a novel brain-specific receptor protein that binds to brain injury-derived neurotrophic peptide. Possible role for neuronal survival. (PMID: 11399754) Hama T. … Nara K. (J. Biol. Chem. 2001) 2 67
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 67

Products for TMEM158 Gene

Sources for TMEM158 Gene

Back to Top