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Aliases for TMEM158 Gene

Aliases for TMEM158 Gene

  • Transmembrane Protein 158 (Gene/Pseudogene) 2 3 5
  • 40 KDa BINP-Binding Protein 3 4
  • Transmembrane Protein 158 2 3
  • Ras Induced Senescence 1 2 3
  • P40BBP 3 4
  • RIS1 3 4
  • Brain Injury-Derived Neurotrophic Peptide (BINP) Binding Protein 3
  • Ras-Induced Senescence Protein 1 4
  • Brain Specific Binding Protein 3
  • BINP Receptor 3
  • HBBP 4
  • BBP 3

External Ids for TMEM158 Gene

Summaries for TMEM158 Gene

Entrez Gene Summary for TMEM158 Gene

  • Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway. An allelic polymorphism in this gene results in both functional and non-functional (frameshifted) alleles; the reference genome represents the functional allele. [provided by RefSeq, Jul 2015]

GeneCards Summary for TMEM158 Gene

TMEM158 (Transmembrane Protein 158 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with TMEM158 include Brain Injury. GO annotations related to this gene include peptide binding.

UniProtKB/Swiss-Prot for TMEM158 Gene

  • Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.

Gene Wiki entry for TMEM158 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM158 Gene

Genomics for TMEM158 Gene

Regulatory Elements for TMEM158 Gene

Enhancers for TMEM158 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F045346 0.4 FANTOM5 20.8 -120.2 -120212 0.1 SMARCE1 L3MBTL2 NR4A1 CEBPB MAFG ZEB2 CEBPG IRF9 ATF3 POLR2A TMEM158 CDCP1 LOC105377062 GC03M045381
GH03F045117 1.8 FANTOM5 Ensembl ENCODE 17.8 +103.3 103334 10.7 HDGF PKNOX1 SIN3A FEZF1 ZNF766 FOS DEK ZHX2 REST TBX21 LIMD1 TMEM158 SACM1L CDCP1 RNU5B-3P CLEC3B XCR1 ENSG00000202268 ZNF502 LOC105377059
GH03F045043 1.3 FANTOM5 Ensembl ENCODE 11 +182.4 182358 1.3 HDAC1 PKNOX1 ATF1 NFRKB SIN3A RAD21 SIRT6 FOS SMARCA5 ZEB2 SACM1L EXOSC7 TMEM158 CDCP1 ENSG00000202268 LARS2-AS1 RNU5B-3P LOC105377059
GH03F045040 0.8 Ensembl ENCODE 11 +184.6 184622 2.2 ARNT TBL1XR1 WRNIP1 NFRKB ZNF2 RAD21 ZNF143 FOS CREM SMARCA5 EXOSC7 CLEC3B TMEM158 LARS2-AS1 CDCP1 LIMD1 ZNF660 ENSG00000202268 RNU5B-3P LOC105377059
GH03F045165 1.6 FANTOM5 Ensembl ENCODE 10.9 +58.0 58028 5.4 HDGF ARNT SIN3A FEZF1 CBX5 FOS DEK REST SMARCB1 SREBF1 CDCP1 SACM1L TMEM158 ENSG00000202268 LARS2-AS1 SLC6A20 LIMD1 RPS24P8 LOC101928636
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM158 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM158 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TMEM158 Gene

45,224,464 bp from pter
45,226,322 bp from pter
1,859 bases
Minus strand

Genomic View for TMEM158 Gene

Genes around TMEM158 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM158 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM158 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM158 Gene

Proteins for TMEM158 Gene

  • Protein details for TMEM158 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 158
    Protein Accession:
    Secondary Accessions:
    • Q6PFW5
    • Q9Y4M1

    Protein attributes for TMEM158 Gene

    300 amino acids
    Molecular mass:
    30404 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM158 Gene


neXtProt entry for TMEM158 Gene

Post-translational modifications for TMEM158 Gene

Other Protein References for TMEM158 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM158 Gene

Domains & Families for TMEM158 Gene

Protein Domains for TMEM158 Gene


Suggested Antigen Peptide Sequences for TMEM158 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM158 family.
  • Belongs to the TMEM158 family.
genes like me logo Genes that share domains with TMEM158: view

No data available for Gene Families for TMEM158 Gene

Function for TMEM158 Gene

Molecular function for TMEM158 Gene

UniProtKB/Swiss-Prot Function:
Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.
UniProtKB/Swiss-Prot Induction:
Up-regulated during Ras-induced senesence.

Gene Ontology (GO) - Molecular Function for TMEM158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042277 peptide binding IEA --
genes like me logo Genes that share ontologies with TMEM158: view
genes like me logo Genes that share phenotypes with TMEM158: view

Animal Models for TMEM158 Gene

MGI Knock Outs for TMEM158:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM158 Gene

Localization for TMEM158 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM158 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM158 Gene COMPARTMENTS Subcellular localization image for TMEM158 gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for TMEM158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM158: view

Pathways & Interactions for TMEM158 Gene

SuperPathways for TMEM158 Gene

No Data Available

Interacting Proteins for TMEM158 Gene

Selected Interacting proteins: Q8WZ71-TM158_HUMAN for TMEM158 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMEM158 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM158 Gene

Transcripts for TMEM158 Gene

mRNA/cDNA for TMEM158 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(82) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM158 Gene

Transmembrane protein 158 (gene/pseudogene):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM158 Gene

No ASD Table

Relevant External Links for TMEM158 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM158 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM158 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM158 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.0), Brain - Caudate (basal ganglia) (x6.5), Brain - Putamen (basal ganglia) (x6.5), and Uterus (x5.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM158 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM158 Gene:


SOURCE GeneReport for Unigene cluster for TMEM158 Gene:

genes like me logo Genes that share expression patterns with TMEM158: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMEM158 Gene

Orthologs for TMEM158 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM158 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM158 34 35
  • 99.44 (n)
(Bos Taurus)
Mammalia TMEM158 34 35
  • 93.3 (n)
(Mus musculus)
Mammalia Tmem158 34 16 35
  • 88.99 (n)
(Rattus norvegicus)
Mammalia Tmem158 34
  • 88.69 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM158 35
  • 58 (a)
(Gallus gallus)
Aves TMEM158 34
  • 81.43 (n)
(Anolis carolinensis)
Reptilia TMEM158 35
  • 60 (a)
(Danio rerio)
Actinopterygii LOC100148963 34
  • 63.37 (n)
Species where no ortholog for TMEM158 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM158 Gene

Gene Tree for TMEM158 (if available)
Gene Tree for TMEM158 (if available)

Paralogs for TMEM158 Gene

No data available for Paralogs for TMEM158 Gene

Variants for TMEM158 Gene

Sequence variations from dbSNP and Humsavar for TMEM158 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs111529604 -- 45,226,182(+) GCGGA(A/G)GCGGT utr-variant-5-prime
rs111851031 -- 45,228,072(+) TGCAG(-/C)GGGGG upstream-variant-2KB
rs112317578 -- 45,226,183(+) CGGAG(A/G)CGGTG utr-variant-5-prime
rs113328738 -- 45,224,543(+) ACTGG(A/C)TAGAT utr-variant-3-prime
rs113354957 -- 45,224,844(+) GGAGT(A/C)GGGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM158 Gene

Variant ID Type Subtype PubMed ID
esv3893691 CNV gain 25118596
nsv1008836 CNV gain 25217958
nsv1073221 CNV deletion 25765185
nsv1112825 CNV deletion 24896259
nsv3793 CNV insertion 18451855

Variation tolerance for TMEM158 Gene

Gene Damage Index Score: 0.11; 2.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM158 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM158 Gene

Disorders for TMEM158 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM158 Gene - From: GeneCards

Disorder Aliases PubMed IDs
brain injury
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM158

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMEM158: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM158 Gene

Publications for TMEM158 Gene

  1. Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence. (PMID: 11822868) Barradas M. … Serrano M. (Exp. Cell Res. 2002) 2 3 4 22 64
  2. Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas. (PMID: 16280139) Silva J. … Bonilla F. (Mutat. Res. 2006) 3 22 64
  3. RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis. (PMID: 16737913) Iglesias D. … GonzA!lez-Aguilera J.J. (Cancer Genet. Cytogenet. 2006) 3 22 64
  4. Identification and molecular cloning of a novel brain-specific receptor protein that binds to brain injury-derived neurotrophic peptide. Possible role for neuronal survival. (PMID: 11399754) Hama T. … Nara K. (J. Biol. Chem. 2001) 2 3 64
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3 64

Products for TMEM158 Gene

Sources for TMEM158 Gene

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