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TMEM158 Gene

protein-coding   GIFtS: 39
GCID: GC03M045241

Transmembrane Protein 158 (Gene/Pseudogene)

(Previous name: transmembrane protein 158)
  See TMEM158-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 158 (Gene/Pseudogene)1 2     BBP2
Transmembrane Protein 1581 2     BINP Receptor2
Ras Induced Senescence 11 2     Brain Injury-Derived Neurotrophic Peptide (BINP) Binding Protein2
40 KDa BINP-Binding Protein2 3     Brain Specific Binding Protein2
RIS12 3     HBBP3
p40BBP2 3     Ras-Induced Senescence Protein 13

External Ids:    HGNC: 302931   Entrez Gene: 259072   Ensembl: ENSG000002499927   UniProtKB: Q8WZ713   

Export aliases for TMEM158 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMEM158 Gene:
Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of
replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway,
but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface
receptor proposed to function in a neuronal survival pathway. (provided by RefSeq, Jul 2008)

GeneCards Summary for TMEM158 Gene:
TMEM158 (transmembrane protein 158 (gene/pseudogene)) is a protein-coding gene. Diseases associated with TMEM158 include ductal carcinoma in situ, and brain injury. GO annotations related to this gene include peptide binding.

UniProtKB/Swiss-Prot: TM158_HUMAN, Q8WZ71
Function: Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide (By
similarity)

Gene Wiki entry for TMEM158 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM158 gene promoter:
         HOXA9   HOXA9B   NF-1/L   NF-1   CUTL1   Meis-1b   C/EBPalpha   PPAR-alpha   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TMEM158

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM158


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

TMEM158 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM158 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M045241:  view genomic region     (about GC identifiers)

Start:
45,265,956 bp from pter      End:
45,267,814 bp from pter
Size:
1,859 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM158_HUMAN, Q8WZ71 (See protein sequence)
Recommended Name: Transmembrane protein 158 precursor  
Size: 300 amino acids; 30404 Da
Secondary accessions: Q6PFW5 Q9Y4M1
Alternative splicing: 2 isoforms:  Q8WZ71-1   Q8WZ71-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM158: NX_Q8WZ71

Explore proteomics data for TMEM158 at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • Glycosylation2 at Asn75

  • See TMEM158 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056259.2  
    ENSEMBL proteins: 
     ENSP00000422431  

    TMEM158 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8WZ71

    UniProtKB/Swiss-Prot: TM158_HUMAN, Q8WZ71
    Similarity: Belongs to the TMEM158 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TM158_HUMAN, Q8WZ71
    Function: Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide (By
    similarity)
    Induction: Up-regulated during Ras-induced senesence

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042277peptide binding IEA--
         
    Find genes that share ontologies with TMEM158           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TMEM158:
     Decreased Salmonella enterica   Increased cell number in S 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tmem158):
     tumorigenesis 

    Find genes that share phenotypes with TMEM158           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tmem158tm1Srn for TMEM158

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM158
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    Selected qRT-PCR Assays for microRNAs that regulate TMEM158 (see all 14):
    hsa-miR-3671 hsa-miR-516b hsa-miR-520d-5p hsa-miR-7-2* hsa-miR-765 hsa-miR-3120-3p hsa-miR-548aa hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidTMEM158 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM158


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM158_HUMAN, Q8WZ71: Membrane; Multi-pass membrane protein (Potential)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMEM158           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM158
    Interactions:

        Search GeneGlobe Interaction Network for TMEM158

    1 Interacting protein for TMEM158 (Q8WZ713) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB1P055563I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM158 (TM158)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM158 gene: 
    NM_015444.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000503771(uc011baf.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TMEM158 (see all 14):
    hsa-miR-3671 hsa-miR-516b hsa-miR-520d-5p hsa-miR-7-2* hsa-miR-765 hsa-miR-3120-3p hsa-miR-548aa hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidTMEM158 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMEM158
    Clone
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TMEM158
      QuantiFast Probe-based Assays in human, mouse, rat TMEM158

    Selected AceView cDNA sequences (see all 82):

    BM782399 AA127069 BF062629 BQ000094 AI201885 BU619384 AI205532 CR615050 
    CR593631 AI675138 AL080235 AA987586 AI453785 BG910829 BF726477 AA195741 
    CR591255 CR621614 NM_015444 AW117286 BF003089 BU627971 AI480231 C02149 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM158 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAGGATTT
    TMEM158 Expression
    About this image


    TMEM158 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)
             Striatum
     
     Limb (Muscoskeletal System)
     
     Uterus (Reproductive System)
    TMEM158 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM158 Protein Expression
        Custom PCR Arrays for TMEM158
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TMEM158
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM158

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM158 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1581 , 5 transmembrane protein 1581, 5 88.99(n)1
    88.99(a)1
      9 (73.92 cM)5
    723091  NM_001002267.21  NP_001002267.21 
     1232590585 
    chicken
    (Gallus gallus)
    Aves TMEM1581 transmembrane protein 158 81.43(n)
    79.29(a)
      776186  XM_001235309.3  XP_001235310.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1586
    transmembrane protein 158 (gene/pseudogene)
    60(a)
    1 ↔ 1
    GL343611.1(126057-132079)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001489631 transmembrane protein 158-like 63.37(n)
    58.42(a)
      100148963  XM_005173447.1  XP_005173504.1 


    ENSEMBL Gene Tree for TMEM158 (if available)
    TreeFam Gene Tree for TMEM158 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM158 (see all 65)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1144244031,2
    F--45265481(+) ATCTTT/ATTAAA 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs76446691,2
    C--45265535(+) TTTGGA/GATGTG 1 -- ds50012Minor allele frequency- G:0.00NA 4
    rs1393384571,2
    --45265655(+) ATGCTG/TGCCTG 1 -- ds50010--------
    rs1439849641,2
    --45265774(+) GATGCA/CAGACA 1 -- ds50010--------
    rs1133287381,2
    C--45266035(+) ACTGGA/CTAGAT 1 -- ut310--------
    rs1133549571,2
    C,F--45266336(+) GGAGTC/AGGGCA 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs728685741,2
    C,F--45266342(+) GGGCAG/AGGGGA 1 -- ut312Minor allele frequency- A:0.14WA 120
    rs1161930011,2
    C,F--45266400(+) GCTGCG/CATCCC 1 -- ut311Minor allele frequency- C:0.04WA 118
    rs1443461531,2
    C--45266431(+) AACATC/TTGCTT 1 -- ut310--------
    rs67917451,2
    C,F--45266478(+) AAAGGC/GGCTGG 1 -- ut311Minor allele frequency- G:0.04EA 120

    HapMap Linkage Disequilibrium report for TMEM158 (45265956 - 45267814 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TMEM158:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3793CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TMEM158
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM158

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for TMEM158:    
    About MalaCards
    ductal carcinoma in situ    brain injury


    Find genes that share disorders with TMEM158           About GenesLikeMe

    Genetic Association Database (GAD): TMEM158

    Export disorders for TMEM158 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM158 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with TMEM158)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence. (PubMed id 11822868)1, 2, 3, 9 Barradas M.... Serrano M. (Exp. Cell Res. 2002)
    2. Identification and molecular cloning of a novel brain-specific receptor protein that binds to brain injury-derived neurotrophic peptide. Possible role for neuronal survival. (PubMed id 11399754)1, 3 Hama T....Nara K. (J. Biol. Chem. 2001)
    3. Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas. (PubMed id 16280139)1, 9 Silva J....Bonilla F. (Mutat. Res. 2006)
    4. RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis. (PubMed id 16737913)1, 9 Iglesias D....GonzA!lez-Aguilera J.J. (Cancer Genet. Cytogenet. 2006)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    6. Target genes of the WNT/beta-catenin pathway in Wilms tumors. (PubMed id 16575872)1 Zirn B....Gessler M. (amp 2006)
    7. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    8. Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth properties and gene expression. (PubMed id 16083501)1 Sussan T.E....Reeves R.H. (Mol. Cancer 2005)
    9. Microdissection and SAGE as a combined tool to reveal gene expression in ductal carcinoma in situ of the breast. (PubMed id 15486950)1 Verlinden I....Michiels L. (Mol. Carcinog. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25907 HGNC: 30293 AceView: RIS1 Ensembl:ENSG00000249992 euGenes: HUgn25907
    ECgene: TMEM158 H-InvDB: TMEM158

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM158 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM158 gene:
    Search GeneIP for patents involving TMEM158

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM158
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     Search Addgene for plasmids for TMEM158
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      eBioscience FlowRNA Probe Sets
           
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