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Aliases for TMEM158 Gene

Aliases for TMEM158 Gene

  • Transmembrane Protein 158 (Gene/Pseudogene) 2 3 5
  • 40 KDa BINP-Binding Protein 3 4
  • Transmembrane Protein 158 2 3
  • Ras Induced Senescence 1 2 3
  • P40BBP 3 4
  • RIS1 3 4
  • Brain Injury-Derived Neurotrophic Peptide (BINP) Binding Protein 3
  • Ras-Induced Senescence Protein 1 4
  • Brain Specific Binding Protein 3
  • BINP Receptor 3
  • HBBP 4
  • BBP 3

External Ids for TMEM158 Gene

Summaries for TMEM158 Gene

Entrez Gene Summary for TMEM158 Gene

  • Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway. An allelic polymorphism in this gene results in both functional and non-functional (frameshifted) alleles; the reference genome represents the functional allele. [provided by RefSeq, Jul 2015]

GeneCards Summary for TMEM158 Gene

TMEM158 (Transmembrane Protein 158 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with TMEM158 include Brain Injury. Gene Ontology (GO) annotations related to this gene include peptide binding.

UniProtKB/Swiss-Prot for TMEM158 Gene

  • Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.

Gene Wiki entry for TMEM158 Gene

Additional gene information for TMEM158 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM158 Gene

Genomics for TMEM158 Gene

GeneHancer (GH) Regulatory Elements for TMEM158 Gene

Promoters and enhancers for TMEM158 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I045223 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 558.2 +1.1 1147 3.3 ATF1 RB1 SREBF2 ARID4B SIN3A RAD21 ZNF335 EGR1 ZNF143 ATF7 TMEM158 LINC00694 CXCR6 LOC101928636
GH03I045117 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.8 +103.3 103333 10.7 HDGF PKNOX1 ARNT SIN3A ATF7 FOS ZNF623 ZNF592 ATF4 GMEB1 RN7SL145P ZNF852 LIMD1 ZNF502 ZNF445 TMEM158 ZNF197 FYCO1 CDCP1 RNU5B-3P
GH03I045165 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +58.1 58078 5.3 HDGF PKNOX1 SIN3A FEZF1 POLR2B ZNF766 FOS REST SMARCB1 ZNF592 CDCP1 TMEM158 ENSG00000202268 LARS2-AS1 SLC6A20 LIMD1 RPS24P8 LOC101928636
GH03I045052 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +166.8 166793 13.7 HDGF PKNOX1 ARNT YY1 POLR2B ZNF766 E2F8 ZNF143 FOS REST ZNF502 ZNF852 RN7SL145P CLEC3B ZNF35 CDCP1 ZNF197 ZNF660 EXOSC7 RNU5B-3P
GH03I045130 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +90.3 90331 11.1 HDGF PKNOX1 SMAD1 ARNT POLR2B ZNF766 CBX5 E2F8 FOS REST ZNF502 ZNF852 RN7SL145P ZNF35 ZNF197 RNU5B-3P CLEC3B TMEM158 SACM1L ZDHHC3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM158 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM158 gene promoter:

Genomic Locations for TMEM158 Gene

Genomic Locations for TMEM158 Gene
1,859 bases
Minus strand

Genomic View for TMEM158 Gene

Genes around TMEM158 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM158 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM158 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM158 Gene

Proteins for TMEM158 Gene

  • Protein details for TMEM158 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 158
    Protein Accession:
    Secondary Accessions:
    • Q6PFW5
    • Q9Y4M1

    Protein attributes for TMEM158 Gene

    300 amino acids
    Molecular mass:
    30404 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM158 Gene


neXtProt entry for TMEM158 Gene

Post-translational modifications for TMEM158 Gene

Other Protein References for TMEM158 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM158 Gene

Domains & Families for TMEM158 Gene

Gene Families for TMEM158 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM158 Gene


Suggested Antigen Peptide Sequences for TMEM158 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM158 family.
  • Belongs to the TMEM158 family.
genes like me logo Genes that share domains with TMEM158: view

Function for TMEM158 Gene

Molecular function for TMEM158 Gene

UniProtKB/Swiss-Prot Function:
Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.
UniProtKB/Swiss-Prot Induction:
Up-regulated during Ras-induced senescence.

Phenotypes From GWAS Catalog for TMEM158 Gene

Gene Ontology (GO) - Molecular Function for TMEM158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042277 peptide binding IEA --
genes like me logo Genes that share ontologies with TMEM158: view
genes like me logo Genes that share phenotypes with TMEM158: view

Animal Models for TMEM158 Gene

MGI Knock Outs for TMEM158:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM158 Gene

Localization for TMEM158 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM158 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM158 gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for TMEM158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM158: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM158 Gene

Pathways & Interactions for TMEM158 Gene

SuperPathways for TMEM158 Gene

No Data Available

Interacting Proteins for TMEM158 Gene

Selected Interacting proteins: Q8WZ71-TM158_HUMAN for TMEM158 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMEM158 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM158 Gene

Drugs & Compounds for TMEM158 Gene

No Compound Related Data Available

Transcripts for TMEM158 Gene

mRNA/cDNA for TMEM158 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(82) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM158 Gene

Transmembrane protein 158 (gene/pseudogene):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM158 Gene

No ASD Table

Relevant External Links for TMEM158 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM158 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM158 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM158 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.0), Brain - Caudate (basal ganglia) (x6.5), Brain - Putamen (basal ganglia) (x6.5), and Uterus (x5.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM158 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM158 Gene:


SOURCE GeneReport for Unigene cluster for TMEM158 Gene:


Evidence on tissue expression from TISSUES for TMEM158 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TMEM158: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM158 Gene

Orthologs for TMEM158 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM158 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM158 33 34
  • 99.44 (n)
(Bos Taurus)
Mammalia TMEM158 33 34
  • 93.3 (n)
(Mus musculus)
Mammalia Tmem158 33 16 34
  • 88.99 (n)
(Rattus norvegicus)
Mammalia Tmem158 33
  • 88.69 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM158 34
  • 58 (a)
(Gallus gallus)
Aves TMEM158 33
  • 81.43 (n)
(Anolis carolinensis)
Reptilia TMEM158 34
  • 60 (a)
(Danio rerio)
Actinopterygii LOC100148963 33
  • 63.37 (n)
Species where no ortholog for TMEM158 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM158 Gene

Gene Tree for TMEM158 (if available)
Gene Tree for TMEM158 (if available)

Paralogs for TMEM158 Gene

No data available for Paralogs for TMEM158 Gene

Variants for TMEM158 Gene

Sequence variations from dbSNP and Humsavar for TMEM158 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1002375286 -- 45,227,695(-) T/C upstream_transcript_variant
rs1002404270 -- 45,228,118(-) G/A upstream_transcript_variant
rs1003338694 -- 45,226,420(-) G/A upstream_transcript_variant
rs1003409116 -- 45,226,597(-) G/C upstream_transcript_variant
rs1003575968 -- 45,226,931(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM158 Gene

Variant ID Type Subtype PubMed ID
esv3893691 CNV gain 25118596
nsv1008836 CNV gain 25217958
nsv1073221 CNV deletion 25765185
nsv1112825 CNV deletion 24896259
nsv3793 CNV insertion 18451855

Variation tolerance for TMEM158 Gene

Gene Damage Index Score: 0.11; 2.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM158 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM158 Gene

Disorders for TMEM158 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM158 Gene - From: GeneCards

Disorder Aliases PubMed IDs
brain injury
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM158

genes like me logo Genes that share disorders with TMEM158: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM158 Gene

Publications for TMEM158 Gene

  1. Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence. (PMID: 11822868) Barradas M … Serrano M (Experimental cell research 2002) 2 3 4 22 58
  2. RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis. (PMID: 16737913) Iglesias D … González-Aguilera JJ (Cancer genetics and cytogenetics 2006) 3 22 58
  3. Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas. (PMID: 16280139) Silva J … Bonilla F (Mutation research 2006) 3 22 58
  4. Identification and molecular cloning of a novel brain-specific receptor protein that binds to brain injury-derived neurotrophic peptide. Possible role for neuronal survival. (PMID: 11399754) Hama T … Nara K (The Journal of biological chemistry 2001) 2 3 58
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 58

Products for TMEM158 Gene

Sources for TMEM158 Gene

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