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TMEM156 Gene

protein-coding   GIFtS: 43
GCID: GC04M038968

Transmembrane Protein 156

  Search for TMEM156
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 1561 2

External Ids:    HGNC: 262601   Entrez Gene: 800082   Ensembl: ENSG000001218957   UniProtKB: Q8N6143   

Export aliases for TMEM156 gene to outside databases

Previous GC identifers: GC04M038644 GC04M038293


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM156 Gene:
TMEM156 (transmembrane protein 156) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006238.12  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM156 gene promoter:
         IRF-1   HNF-3beta   HEN1   CREB   POU2F1   deltaCREB   POU2F1b   POU2F1a   POU2F1c   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM156 promoter sequence
   Search Chromatin IP Primers for TMEM156

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM156


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p14

TMEM156 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM156 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M038968:  view genomic region     (about GC identifiers)

Start:
38,968,365 bp from pter      End:
39,034,542 bp from pter
Size:
66,178 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM156_HUMAN, Q8N614 (See protein sequence)
Recommended Name: Transmembrane protein 156  
Size: 296 amino acids; 34323 Da
Secondary accessions: Q9H5N9

Explore the universe of human proteins at neXtProt for TMEM156: NX_Q8N614

Explore proteomics data for TMEM156 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn45, Asn156

  • See TMEM156 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079219.1  
    ENSEMBL proteins: 
     ENSP00000371364   ENSP00000343758  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8N614


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for TMEM156:
     Elongated cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM156
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    hsa-miR-587 hsa-miR-659 hsa-miR-218-1*
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM156_HUMAN, Q8N614: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMEM156           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM156
    Interactions:

        Search GeneGlobe Interaction Network for TMEM156

    1 Interacting protein for TMEM156 (Q8N6143) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2CAP677753I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM156 (TM156)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM156 gene: 
    NM_024943.1  

    Unigene Cluster for TMEM156:

    Transmembrane protein 156
    Hs.374147  [show with all ESTs]
    Unigene Representative Sequence: BC030803
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381938(uc003gto.3 uc010ifj.3) ENST00000344606 ENST00000372489
    ENST00000495029
    miRNA
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    hsa-miR-587 hsa-miR-659 hsa-miR-218-1*
    SwitchGear 3'UTR luciferase reporter plasmidTMEM156 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK026888.1 BC030803.1 BC060512.1 

    4 DOTS entries:

    DT.86858986  DT.425622  DT.92420642  DT.423382 

    Selected AceView cDNA sequences (see all 36):

    NM_024943 BI712375 AK026888 BP337153 BG611522 BC060512 BU941213 BG611295 
    BU194262 BP335420 AU279400 BG779674 BG177227 BC030803 BM746590 BP336732 
    BX092007 BG779050 BE677537 BP336530 BI712608 BP337808 AW402403 BF669308 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM156    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                -                 -     -                                       
    SP2:                                -           -     -     -                                       
    SP3:                                -                                                               
    SP4:                                -                       -                                       
    SP5:                                                                                                


    ECgene alternative splicing isoforms for TMEM156

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM156 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTCAAGGG
    TMEM156 Expression
    About this image


    TMEM156 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
    TMEM156 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM156 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.374147
        Custom PCR Arrays for TMEM156
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM156

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM156 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1561 , 5 transmembrane protein 1561, 5 74.44(n)1
    57.52(a)1
      5 (33.58 cM)5
    2430251  XM_006504245.11  XP_006504308.11 
     650543475 
    chicken
    (Gallus gallus)
    Aves TMEM1561 transmembrane protein 156 51.97(n)
    28.82(a)
      426317  XM_004936117.1  XP_004936174.1 


    ENSEMBL Gene Tree for TMEM156 (if available)
    TreeFam Gene Tree for TMEM156 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM156 (see all 1660)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1386597511,2
    --38859421(+) TGTTTC/TAGAGG 1 -- int10--------
    rs100037551,2
    C,F,A,H--38859444(+) ggtttT/Gattac 1 -- int112Minor allele frequency- G:0.10NS EA NA WA 1310
    rs1413912271,2
    C--38859445(+) GTTTTA/GTTACC 1 -- int10--------
    rs1469864241,2
    --38859468(+) GAAAGC/GTGGCA 1 -- int10--------
    rs14735781,2
    C,F,O,A,H--38859479(+) AAGGAA/GGGTCA 1 -- int122Minor allele frequency- G:0.19MN NS EA NA WA 2528
    rs1381067961,2
    C--38859524(+) CAAATC/TCTTCA 1 -- int10--------
    rs1435777341,2
    --38859544(+) ATTCAA/GTTTGC 1 -- int10--------
    rs1921096051,2
    --38859551(+) TTGCCA/GAGGTG 1 -- int10--------
    rs1855254641,2
    --38859566(+) ATTTTG/TGGGCA 1 -- int10--------
    rs1903593521,2
    C--38859574(+) GCAGCA/GTGTCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for TMEM156 (38968365 - 39034542 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for TMEM156:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2389788CNV Deletion18987734
    esv3383CNV Deletion18987735
    esv2727454CNV Deletion23290073
    esv1006603CNV Deletion20482838
    esv2727453CNV Deletion23290073
    esv2493459CNV Deletion19546169
    esv2576383CNV Deletion19546169
    nsv461337CNV Loss19166990
    esv6492CNV Loss19470904
    nsv291693CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM156 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMEM156)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80008 HGNC: 26260 AceView: FLJ23235 Ensembl:ENSG00000121895 euGenes: HUgn80008
    ECgene: TMEM156 H-InvDB: TMEM156

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM156 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM156 gene:
    Search GeneIP for patents involving TMEM156

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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