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Aliases for TMEM156 Gene

Aliases for TMEM156 Gene

  • Transmembrane Protein 156 2 3 5

External Ids for TMEM156 Gene

Previous GeneCards Identifiers for TMEM156 Gene

  • GC04M038644
  • GC04M038293

Summaries for TMEM156 Gene

GeneCards Summary for TMEM156 Gene

TMEM156 (Transmembrane Protein 156) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM156 Gene

Genomics for TMEM156 Gene

Regulatory Elements for TMEM156 Gene

Enhancers for TMEM156 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G039024 1.4 Ensembl ENCODE dbSUPER 14.8 +5.8 5810 4.3 PKNOX1 TBL1XR1 ARNT NFRKB ZNF766 POLR3A CBX5 ZNF143 ETV6 CEBPB TMEM156 ENSG00000249685 KLHL5 WDR19 GC04P038912
GH04G039035 1.3 FANTOM5 Ensembl ENCODE 14.7 -4.1 -4104 3.3 HDGF EBF1 TEAD3 EED SCRT2 FOS ETV6 RELB IKZF2 HLF ENSG00000249685 TMEM156 ENSG00000249207 WDR19 KLHL5
GH04G039029 1.2 ENCODE dbSUPER 15 +0.9 871 4.3 HDGF ATF1 PKNOX1 WRNIP1 YY1 GATA2 CBX5 ZNF143 FOS CAVIN1 TMEM156 ENSG00000249685 WDR19 GC04P038912
GH04G038983 1.3 Ensembl ENCODE dbSUPER 12.3 +47.6 47603 2.8 ELF3 FOXA2 ZSCAN4 THRB ZNF48 IKZF2 CREM JUNB ZEB2 NFIL3 KLHL5 TMEM156 ENSG00000249207 ENSG00000249685 MIR574 FAM114A1 RNU6-32P RFC1 RPL9 GC04P038912
GH04G039040 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.3 -11.6 -11648 8.1 HDGF PKNOX1 FOXA2 MLX WRNIP1 SIN3A ARID4B YY1 ZNF766 FOS ENSG00000249685 ZBTB12BP ENSG00000250568 KLHL5 TMEM156 TLR1 TLR6 KLF3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM156 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM156 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000309575 822 601 HDGF GATA2 CBX5 FOS CAVIN1 JUNB TBX21 ZNF592 MEF2D SMARCA4
ENSR00000167587 1922 1201 HDGF ATF1 PKNOX1 WRNIP1 YY1 GATA2 CBX5 ZNF143 FOS JUNB

Genomic Location for TMEM156 Gene

Chromosome:
4
Start:
38,966,016 bp from pter
End:
39,032,922 bp from pter
Size:
66,907 bases
Orientation:
Minus strand

Genomic View for TMEM156 Gene

Genes around TMEM156 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM156 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM156 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM156 Gene

Proteins for TMEM156 Gene

  • Protein details for TMEM156 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N614-TM156_HUMAN
    Recommended name:
    Transmembrane protein 156
    Protein Accession:
    Q8N614
    Secondary Accessions:
    • Q9H5N9

    Protein attributes for TMEM156 Gene

    Size:
    296 amino acids
    Molecular mass:
    34323 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM156 Gene

Post-translational modifications for TMEM156 Gene

  • Glycosylation at isoforms=45 and Asn156
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM156 Gene

Domains & Families for TMEM156 Gene

Protein Domains for TMEM156 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM156 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM156: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM156 Gene

Function for TMEM156 Gene

genes like me logo Genes that share phenotypes with TMEM156: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM156

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM156 Gene

Localization for TMEM156 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM156 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM156 gene
Compartment Confidence
plasma membrane 2
extracellular 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM156 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM156: view

Pathways & Interactions for TMEM156 Gene

SuperPathways for TMEM156 Gene

No Data Available

Interacting Proteins for TMEM156 Gene

Gene Ontology (GO) - Biological Process for TMEM156 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM156 Gene

Drugs & Compounds for TMEM156 Gene

No Compound Related Data Available

Transcripts for TMEM156 Gene

Unigene Clusters for TMEM156 Gene

Transmembrane protein 156:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM156 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -
SP2: - - - -
SP3: -
SP4: - -
SP5:

Relevant External Links for TMEM156 Gene

GeneLoc Exon Structure for
TMEM156
ECgene alternative splicing isoforms for
TMEM156

Expression for TMEM156 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM156 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM156 Gene

This gene is overexpressed in Spleen (x8.0) and Whole Blood (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of TMEM156 Gene:

TMEM156

SOURCE GeneReport for Unigene cluster for TMEM156 Gene:

Hs.374147

Evidence on tissue expression from TISSUES for TMEM156 Gene

  • Muscle(4.1)
genes like me logo Genes that share expression patterns with TMEM156: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM156 Gene

Orthologs for TMEM156 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM156 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM156 34 35
  • 99.1 (n)
dog
(Canis familiaris)
Mammalia TMEM156 34 35
  • 84.18 (n)
cow
(Bos Taurus)
Mammalia TMEM156 34 35
  • 83.51 (n)
rat
(Rattus norvegicus)
Mammalia Tmem156 34
  • 76.28 (n)
mouse
(Mus musculus)
Mammalia Tmem156 34 16 35
  • 74.44 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM156 35
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM156 35
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM156 34 35
  • 51.97 (n)
Species where no ortholog for TMEM156 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM156 Gene

ENSEMBL:
Gene Tree for TMEM156 (if available)
TreeFam:
Gene Tree for TMEM156 (if available)

Paralogs for TMEM156 Gene

No data available for Paralogs for TMEM156 Gene

Variants for TMEM156 Gene

Sequence variations from dbSNP and Humsavar for TMEM156 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000032425 -- 39,008,669(+) TGGAA(A/C)CTCAA intron-variant
rs1000040262 -- 38,984,521(+) TACCC(A/G)TGTTA intron-variant
rs10001298 -- 39,005,146(+) ccact(C/T)atatg intron-variant
rs1000140782 -- 39,019,693(+) AAAAA(-/TTATATATATAT)TTATG intron-variant
rs1000146074 -- 39,031,776(+) CTACT(C/T)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM156 Gene

Variant ID Type Subtype PubMed ID
dgv2773n106 CNV deletion 24896259
esv1006603 CNV deletion 20482838
esv2389788 CNV deletion 18987734
esv2493459 CNV deletion 19546169
esv2576383 CNV deletion 19546169
esv2727453 CNV deletion 23290073
esv2727454 CNV deletion 23290073
esv3383 CNV loss 18987735
esv3435084 CNV insertion 20981092
esv3563733 CNV deletion 23714750
esv3600270 CNV loss 21293372
esv3600272 CNV loss 21293372
esv6492 CNV loss 19470904
nsv1149844 CNV deletion 26484159
nsv291693 CNV deletion 16902084
nsv461337 CNV loss 19166990
nsv594011 CNV loss 21841781
nsv594012 CNV loss 21841781
nsv956861 CNV deletion 24416366

Variation tolerance for TMEM156 Gene

Residual Variation Intolerance Score: 88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.16; 90.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM156 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM156

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM156 Gene

Disorders for TMEM156 Gene

Relevant External Links for TMEM156

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM156

No disorders were found for TMEM156 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM156 Gene

Publications for TMEM156 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for TMEM156 Gene

Sources for TMEM156 Gene

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