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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM155 Gene

protein-coding   GIFtS: 35
GCID: GC04M122680

Transmembrane Protein 155

  Search for TMEM155
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 1551 2
Protein TMEM1552

External Ids:    HGNC: 264181   Entrez Gene: 1323322   Ensembl: ENSG000001641127   UniProtKB: Q4W5P63   

Export aliases for TMEM155 gene to outside databases

Previous GC identifers: GC04M122899 GC04M118407


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM155 Gene: 
TMEM155 (transmembrane protein 155) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM155 gene promoter:
         TBP   Nkx3-1 v4   AML1a   Egr-1   AP-4   IRF-2   CP2   IRF-7A   MRF-2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM155 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM155

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM155


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q27   Ensembl cytogenetic band:  4q27   HGNC cytogenetic band: 4q27

TMEM155 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM155 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M122680:  view genomic region     (about GC identifiers)

Start:
122,680,085 bp from pter      End:
122,686,582 bp from pter
Size:
6,498 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM155_HUMAN, Q4W5P6 (See protein sequence)
Recommended Name: Protein TMEM155 precursor  
Size: 130 amino acids; 14221 Da
Subcellular location: Secreted (Potential)
Secondary accessions: D3DNW9 Q96NI2

Explore the universe of human proteins at neXtProt for TMEM155: NX_Q4W5P6

Explore proteomics data for TMEM155 at MOPED 

TMEM155 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TMEM155 Protein Expression

REFSEQ proteins: NP_689612.2  
ENSEMBL proteins: 
 ENSP00000377919   ENSP00000336987   ENSP00000377917   ENSP00000422869  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

TMEM155 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q4W5P6


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM155

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM155 (TM155)

Search CenterWatch for drugs/clinical trials and news about TMEM155 / TM155

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM155 gene: 
NM_152399.2  

Unigene Cluster for TMEM155:

Transmembrane protein 155
Hs.27524  [show with all ESTs]
Unigene Representative Sequence: BC059365
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000394396 ENST00000461198 ENST00000337677(uc003idx.1) ENST00000394394
ENST00000513254 ENST00000514885 ENST00000505198 ENST00000506551
miRNA
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SwitchGear 3'UTR luciferase reporter plasmidTMEM155 3' UTR sequence
Inhib. RNA
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                     Customized lentivirus expression plasmids for stable overexpression of TMEM155 
Primer
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM155

Additional mRNA sequence: 

AK055396.1 AK310583.1 BC047657.1 BC059365.1 

6 DOTS entries:

DT.210340  DT.121237542  DT.91962243  DT.100702327  DT.121237546  DT.91977739 

24/38 AceView cDNA sequences (see all 38):

AA693810 BQ011176 AA699314 H10362 CR608317 BI757990 Z39835 AL575833 
AA972788 NM_152399 BX359598 BC059365 AK055396 AW594645 BE552284 AI184773 
Z43772 AW188040 BC047657 N93749 BI553307 AI918675 BF673779 AL552582 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM155    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:              -                 -                     
SP2:                                                      


ECgene alternative splicing isoforms for TMEM155

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM155 expression in normal human tissues (normalized intensities)      TMEM155 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGAAATGGC
TMEM155 Expression
About this image


TMEM155 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/4 selected tissues (see all 4) fully expand
 
 Epidermis (Integumentary System)
         Detroit 551
 
 Eye (Sensory Organs)
         Human Keratocyte (HK)   
 
 Fibroblast
         Detroit 551
 
 Brain (Nervous System)

See TMEM155 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM155

SOURCE GeneReport for Unigene cluster: Hs.27524
    SABiosciences Custom PCR Arrays for TMEM155
Primer
Products:
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM155
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM155

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and chimp.

Orthologs for TMEM155 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM1551 transmembrane protein 155 98.72(n)
97.69(a)
  741271  XM_003310462.1  XP_003310510.1 


ENSEMBL Gene Tree for TMEM155 (if available)
TreeFam Gene Tree for TMEM155 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/84 SNPs in TMEM155 are shown (see all 84)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1487864691,2
--122679587(+) GAGAAA/TGCAAT 1 -- ds50010--------
rs1161266641,2
C,F--122679833(+) AGTGTG/AATGAA 1 -- ds50011Minor allele frequency- A:0.04WA 118
rs1424554911,2
--122679958(+) ATTGGA/CATATA 1 -- ds50010--------
rs1162866791,2
F--122679985(+) AGTAAA/GTTTAA 1 -- ds50011Minor allele frequency- G:0.03WA 118
rs1464051321,2
--122680036(+) TGACCA/GTTAAC 1 -- ds50010--------
rs119378611,2
C,F,H--122680075(+) AAAAGC/TCACAT 1 -- ds500114Minor allele frequency- T:0.14NS NA WA 1910
rs729139851,2
C,F--122680183(+) AGCTGC/TCACAA 1 -- ut311Minor allele frequency- T:0.50WA 2
rs1827658991,2
--122680262(+) TGACTA/GGGAAC 1 -- ut310--------
rs1889760931,2
--122680395(+) TGCAAC/TATATA 1 -- ut310--------
rs1931329991,2
--122680702(+) CATGTA/GCCTAT 1 -- ut310--------

HapMap Linkage Disequilibrium report for TMEM155 (122680085 - 122686582 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for TMEM155:    About this table     
Variant IDTypeSubtypePubMed ID
nsv508309CNV Loss20534489

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TMEM155 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM155)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 132332 HGNC: 26418 AceView: FLJ30834 Ensembl:ENSG00000164112 euGenes: HUgn132332
ECgene: TMEM155 H-InvDB: TMEM155

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TMEM155 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TMEM155 gene:
Search GeneIP for patents involving TMEM155

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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