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TMEM155 Gene

protein-coding   GIFtS: 38
GCID: GC04M122680

Transmembrane Protein 155

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transmembrane Protein 1551 2
Protein TMEM1552

External Ids:    HGNC: 264181   Entrez Gene: 1323322   Ensembl: ENSG000001641127   UniProtKB: Q4W5P63   
ORGUL members:         

Export aliases for TMEM155 gene to outside databases

Previous GC identifers: GC04M122899 GC04M118407


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM155 Gene:
TMEM155 (transmembrane protein 155) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM155 gene promoter:
         TBP   Nkx3-1 v4   AML1a   Egr-1   AP-4   IRF-2   CP2   IRF-7A   MRF-2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM155 promoter sequence
   Search Chromatin IP Primers for TMEM155

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM155


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q27   Ensembl cytogenetic band:  4q27   HGNC cytogenetic band: 4q27

TMEM155 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM155 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M122680:  view genomic region     (about GC identifiers)

Start:
122,680,085 bp from pter      End:
122,686,582 bp from pter
Size:
6,498 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TM155_HUMAN, Q4W5P6 (See protein sequence)
Recommended Name: Protein TMEM155 precursor  
Size: 130 amino acids; 14221 Da
Secondary accessions: D3DNW9 Q96NI2

Explore the universe of human proteins at neXtProt for TMEM155: NX_Q4W5P6

Explore proteomics data for TMEM155 at MOPED


See TMEM155 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_689612.2  
ENSEMBL proteins: 
 ENSP00000377919   ENSP00000336987   ENSP00000377917   ENSP00000422869  

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antibodies-online kits for TMEM155 (2 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q4W5P6


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM155
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miRNA
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hsa-mir-335-5p (MIRT016889)

Block miRNA regulation of human, mouse, rat TMEM155 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate TMEM155 (see all 12):
hsa-miR-34c-3p hsa-miR-3671 hsa-miR-1290 hsa-miR-767-3p hsa-miR-646 hsa-miR-4294 hsa-miR-182* hsa-miR-629*
SwitchGear 3'UTR luciferase reporter plasmidTMEM155 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TM155_HUMAN, Q4W5P6: Secreted (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

Find genes that share ontologies with TMEM155           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM155
Interactions:

    Search GeneGlobe Interaction Network for TMEM155

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TMEM155 (TM155)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TMEM155 gene: 
NM_152399.2  

Unigene Cluster for TMEM155:

Transmembrane protein 155
Hs.27524  [show with all ESTs]
Unigene Representative Sequence: BC059365
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000394396 ENST00000461198 ENST00000337677(uc003idx.1) ENST00000394394
ENST00000513254 ENST00000514885 ENST00000505198 ENST00000506551
miRNA
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Selected qRT-PCR Assays for microRNAs that regulate TMEM155 (see all 12):
hsa-miR-34c-3p hsa-miR-3671 hsa-miR-1290 hsa-miR-767-3p hsa-miR-646 hsa-miR-4294 hsa-miR-182* hsa-miR-629*
SwitchGear 3'UTR luciferase reporter plasmidTMEM155 3' UTR sequence
Inhib. RNA
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GenScript: all cDNA clones in your preferred vector: TMEM155 (NM_152399)
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Primer
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  QuantiFast Probe-based Assays in human, mouse, rat TMEM155

Additional mRNA sequence: 

AK055396.1 AK310583.1 BC047657.1 BC059365.1 

6 DOTS entries:

DT.210340  DT.121237542  DT.91962243  DT.100702327  DT.121237546  DT.91977739 

Selected AceView cDNA sequences (see all 38):

H10362 BI757990 AA693810 BQ011176 CR608317 AA699314 Z39835 BC059365 
AA972788 BC047657 AK055396 AW188040 AI184773 AL575833 Z43772 BE552284 
NM_152399 BX359598 AW594645 AL552582 AI221736 BX359599 N93749 BG700563 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM155    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:              -                 -                     
SP2:                                                      


ECgene alternative splicing isoforms for TMEM155

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMEM155 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGAAATGGC
TMEM155 Expression
About this image


TMEM155 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Fibroblasts
         Detroit 551
 
 Epidermis (Integumentary System)
         Detroit 551
TMEM155 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TMEM155 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.27524
    Custom PCR Arrays for TMEM155
Primer
Products:
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM155

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of mammals.

Orthologs for TMEM155 gene from Selected species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia TMEM1551 transmembrane protein 155 85(n)
70.71(a)
  102155771  XM_005642428.1  XP_005642485.1 


ENSEMBL Gene Tree for TMEM155 (if available)
TreeFam Gene Tree for TMEM155 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TMEM155 (see all 84)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1487864691,2
--122679587(+) GAGAAA/TGCAAT 1 -- ds50010--------
rs1161266641,2
C,F--122679833(+) AGTGTG/AATGAA 1 -- ds50011Minor allele frequency- A:0.04WA 118
rs1424554911,2
--122679958(+) ATTGGA/CATATA 1 -- ds50010--------
rs1162866791,2
F--122679985(+) AGTAAA/GTTTAA 1 -- ds50011Minor allele frequency- G:0.03WA 118
rs1464051321,2
--122680036(+) TGACCA/GTTAAC 1 -- ds50010--------
rs119378611,2
C,F,H--122680075(+) AAAAGC/TCACAT 1 -- ds500114Minor allele frequency- T:0.14NS NA WA 1910
rs729139851,2
C,F--122680183(+) AGCTGC/TCACAA 1 -- ut311Minor allele frequency- T:0.50WA 2
rs1827658991,2
--122680262(+) TGACTA/GGGAAC 1 -- ut310--------
rs1889760931,2
--122680395(+) TGCAAC/TATATA 1 -- ut310--------
rs1931329991,2
--122680702(+) CATGTA/GCCTAT 1 -- ut310--------

HapMap Linkage Disequilibrium report for TMEM155 (122680085 - 122686582 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for TMEM155:    About this table    
Variant IDTypeSubtypePubMed ID
nsv508309CNV Loss20534489

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TMEM155
DNA2.0 Custom Variant and Variant Library Synthesis for TMEM155

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TMEM155 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TMEM155)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 132332 HGNC: 26418 AceView: FLJ30834 Ensembl:ENSG00000164112 euGenes: HUgn132332
ECgene: TMEM155 H-InvDB: TMEM155

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TMEM155 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TMEM155 gene:
Search GeneIP for patents involving TMEM155

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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