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Aliases for TMEM154 Gene

Aliases for TMEM154 Gene

  • Transmembrane Protein 154 2 3

External Ids for TMEM154 Gene

Summaries for TMEM154 Gene

GeneCards Summary for TMEM154 Gene

TMEM154 (Transmembrane Protein 154) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM154 Gene

Genomics for TMEM154 Gene

Genomic Location for TMEM154 Gene

Start:
152,618,632 bp from pter
End:
152,680,165 bp from pter
Size:
61,534 bases
Orientation:
Minus strand

Genomic View for TMEM154 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM154 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM154 Gene

Regulatory Elements for TMEM154 Gene

Proteins for TMEM154 Gene

  • Protein details for TMEM154 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P9G4-TM154_HUMAN
    Recommended name:
    Transmembrane protein 154
    Protein Accession:
    Q6P9G4
    Secondary Accessions:
    • Q8WUT7
    • Q96MQ8

    Protein attributes for TMEM154 Gene

    Size:
    183 amino acids
    Molecular mass:
    20498 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM154 Gene

Proteomics data for TMEM154 Gene at MOPED

Post-translational modifications for TMEM154 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr53 and Thr57

Other Protein References for TMEM154 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM154 Gene

Domains for TMEM154 Gene

Protein Domains for TMEM154 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with TMEM154: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM154 Gene

Function for TMEM154 Gene

Phenotypes for TMEM154 Gene

GenomeRNAi human phenotypes for TMEM154:
genes like me logo Genes that share phenotypes with TMEM154: view

miRNA for TMEM154 Gene

miRTarBase miRNAs that target TMEM154

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM154 Gene

Localization for TMEM154 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM154 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM154 Gene COMPARTMENTS Subcellular localization image for TMEM154 gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM154 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM154: view

Pathways for TMEM154 Gene

SuperPathways for TMEM154 Gene

No Data Available

Interacting Proteins for TMEM154 Gene

Gene Ontology (GO) - Biological Process for TMEM154 Gene

None

No data available for Pathways by source for TMEM154 Gene

Transcripts for TMEM154 Gene

Unigene Clusters for TMEM154 Gene

Transmembrane protein 154:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM154 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for TMEM154 Gene

GeneLoc Exon Structure for
TMEM154
ECgene alternative splicing isoforms for
TMEM154

Expression for TMEM154 Gene

mRNA expression in normal human tissues for TMEM154 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM154 Gene

This gene is overexpressed in Whole Blood (15.8), Esophagus - Mucosa (8.6), Skin - Not Sun Exposed (Suprapubic) (6.0), and Skin - Sun Exposed (Lower leg) (5.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM154 Gene

SOURCE GeneReport for Unigene cluster for TMEM154 Gene Hs.518900

genes like me logo Genes that share expressions with TMEM154: view

Orthologs for TMEM154 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM154 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 100 (a)
OneToMany
TMEM154 36
  • 99.64 (n)
  • 99.45 (a)
TMEM154 37
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TMEM154 36
  • 80.8 (n)
  • 72.78 (a)
TMEM154 37
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem154 36
  • 73.11 (n)
  • 65.19 (a)
Tmem154 16
Tmem154 37
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM154 37
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem154 36
  • 69.06 (n)
  • 57.49 (a)
chicken
(Gallus gallus)
Aves TMEM154 37
  • 37 (a)
OneToOne
Species with no ortholog for TMEM154:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM154 Gene

ENSEMBL:
Gene Tree for TMEM154 (if available)
TreeFam:
Gene Tree for TMEM154 (if available)

Paralogs for TMEM154 Gene

No data available for Paralogs for TMEM154 Gene

Variants for TMEM154 Gene

Sequence variations from dbSNP and Humsavar for TMEM154 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2068185 -- 152,677,136(-) TGAGC(A/G)TAGTT intron-variant
rs3922934 -- 152,626,885(-) TCAGA(G/T)ATTTA utr-variant-3-prime
rs3924584 -- 152,669,813(+) ATTCA(A/G)AAACA intron-variant
rs3935569 -- 152,644,686(+) TCAGA(C/T)CAGAT intron-variant
rs3936131 -- 152,641,602(+) AAAAC(A/G)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM154 Gene

Variant ID Type Subtype PubMed ID
dgv671n27 CNV Gain 19166990
nsv521115 CNV Loss 19592680
nsv461690 CNV Gain 19166990

Relevant External Links for TMEM154 Gene

HapMap Linkage Disequilibrium report
TMEM154

Disorders for TMEM154 Gene

Relevant External Links for TMEM154

Genetic Association Database (GAD)
TMEM154
genes like me logo Genes that share disorders with TMEM154: view

No data available for UniProtKB/Swiss-Prot for TMEM154 Gene

Publications for TMEM154 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. (PMID: 24509480) . … Morris A.P. (Nat. Genet. 2014) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TMEM154 Gene

Sources for TMEM154 Gene

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