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Aliases for TMEM154 Gene

Aliases for TMEM154 Gene

  • Transmembrane Protein 154 2 3 5

External Ids for TMEM154 Gene

Previous GeneCards Identifiers for TMEM154 Gene

  • GC04M153766
  • GC04M153547
  • GC04M149273

Summaries for TMEM154 Gene

GeneCards Summary for TMEM154 Gene

TMEM154 (Transmembrane Protein 154) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM154 Gene

Genomics for TMEM154 Gene

Regulatory Elements for TMEM154 Gene

Enhancers for TMEM154 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F152678 0.9 FANTOM5 29.1 +1.7 1748 0.4 TMEM154 FBXW7 ARFIP1 GC04P152678 LOC105377495
GH04F152707 1 Ensembl ENCODE 17.4 -29.3 -29264 3.5 ZIC2 ZNF316 GATA3 CTBP1 POLR2A NFYB ETV6 FOS NR2F6 MAFK TMEM154 LOC105377494 GC04M152697 GC04M152705
GH04F152700 1.1 Ensembl ENCODE 12 -20.3 -20253 0.5 PKNOX1 POLR2A PBX2 TMEM154 GC04M152697 GC04M152705
GH04F152656 0.2 Ensembl 11.5 +24.1 24065 0.2 CTCF ZFHX2 NFIA NRF1 RAD21 EGR2 TMEM154 LOC105377494 RPS14P6
GH04F152655 0.7 Ensembl 11.5 +24.7 24665 0.2 ADNP RAD21 TMEM154 LOC105377494 RPS14P6
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM154 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM154 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001252223 565 1201 HDGF HDAC1 PKNOX1 ATF1 TBL1XR1 ZBTB40 EGR1 ETV6 CREM SMAD5

Genomic Location for TMEM154 Gene

Chromosome:
4
Start:
152,618,632 bp from pter
End:
152,680,165 bp from pter
Size:
61,534 bases
Orientation:
Minus strand

Genomic View for TMEM154 Gene

Genes around TMEM154 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM154 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM154 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM154 Gene

Proteins for TMEM154 Gene

  • Protein details for TMEM154 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P9G4-TM154_HUMAN
    Recommended name:
    Transmembrane protein 154
    Protein Accession:
    Q6P9G4
    Secondary Accessions:
    • Q8WUT7
    • Q96MQ8

    Protein attributes for TMEM154 Gene

    Size:
    183 amino acids
    Molecular mass:
    20498 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM154 Gene

Post-translational modifications for TMEM154 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM154 Gene

No data available for DME Specific Peptides for TMEM154 Gene

Domains & Families for TMEM154 Gene

Protein Domains for TMEM154 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM154 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM154: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM154 Gene

Function for TMEM154 Gene

genes like me logo Genes that share phenotypes with TMEM154: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM154 Gene

Localization for TMEM154 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM154 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM154 Gene COMPARTMENTS Subcellular localization image for TMEM154 gene
Compartment Confidence
plasma membrane 3
extracellular 2
nucleus 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM154 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM154: view

Pathways & Interactions for TMEM154 Gene

SuperPathways for TMEM154 Gene

No Data Available

Interacting Proteins for TMEM154 Gene

Gene Ontology (GO) - Biological Process for TMEM154 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM154 Gene

Transcripts for TMEM154 Gene

Unigene Clusters for TMEM154 Gene

Transmembrane protein 154:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM154 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for TMEM154 Gene

GeneLoc Exon Structure for
TMEM154
ECgene alternative splicing isoforms for
TMEM154

Expression for TMEM154 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM154 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM154 Gene

This gene is overexpressed in Whole Blood (x15.8), Esophagus - Mucosa (x8.6), Skin - Not Sun Exposed (Suprapubic) (x6.0), and Skin - Sun Exposed (Lower leg) (x5.6).

Protein differential expression in normal tissues from HIPED for TMEM154 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM154 Gene



Protein tissue co-expression partners for TMEM154 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM154 Gene:

TMEM154

SOURCE GeneReport for Unigene cluster for TMEM154 Gene:

Hs.518900
genes like me logo Genes that share expression patterns with TMEM154: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM154 Gene

Orthologs for TMEM154 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM154 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
OneToMany
TMEM154 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia TMEM154 34 35
  • 80.8 (n)
mouse
(Mus musculus)
Mammalia Tmem154 34 16 35
  • 73.11 (n)
rat
(Rattus norvegicus)
Mammalia Tmem154 34
  • 69.06 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM154 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM154 35
  • 37 (a)
OneToOne
Species where no ortholog for TMEM154 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM154 Gene

ENSEMBL:
Gene Tree for TMEM154 (if available)
TreeFam:
Gene Tree for TMEM154 (if available)

Paralogs for TMEM154 Gene

No data available for Paralogs for TMEM154 Gene

Variants for TMEM154 Gene

Sequence variations from dbSNP and Humsavar for TMEM154 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10003323 -- 152,649,301(+) ATCGA(A/T)TCCGA intron-variant
rs10008259 -- 152,668,713(+) CAGGG(G/T)CTTGG intron-variant
rs10010565 -- 152,668,911(+) CAGAT(A/C)CCTAA intron-variant
rs10013570 -- 152,675,542(+) gaatc(A/G)cttga intron-variant
rs10014045 -- 152,670,197(+) TTCTC(C/T)GCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM154 Gene

Variant ID Type Subtype PubMed ID
dgv1035e214 CNV gain 21293372
dgv671n27 CNV gain 19166990
esv2763399 CNV gain 21179565
esv3602708 CNV gain 21293372
nsv461690 CNV gain 19166990
nsv521115 CNV loss 19592680
nsv595743 CNV gain 21841781
nsv595744 CNV gain 21841781

Variation tolerance for TMEM154 Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM154 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM154

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM154 Gene

Disorders for TMEM154 Gene

Relevant External Links for TMEM154

Genetic Association Database (GAD)
TMEM154
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM154

No disorders were found for TMEM154 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM154 Gene

Publications for TMEM154 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The type 2 diabetes risk allele of TMEM154-rs6813195 associates with decreased beta cell function in a study of 6,486 Danes. (PMID: 25799151) Harder M.N. … Hansen T. (PLoS ONE 2015) 3 64
  4. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. (PMID: 24509480) . … Morris A.P. (Nat. Genet. 2014) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for TMEM154 Gene

Sources for TMEM154 Gene

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