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Aliases for TMEM154 Gene

Aliases for TMEM154 Gene

  • Transmembrane Protein 154 2 3

External Ids for TMEM154 Gene

Previous GeneCards Identifiers for TMEM154 Gene

  • GC04M153766
  • GC04M153547
  • GC04M149273

Summaries for TMEM154 Gene

GeneCards Summary for TMEM154 Gene

TMEM154 (Transmembrane Protein 154) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM154 Gene

Genomics for TMEM154 Gene

Regulatory Elements for TMEM154 Gene

Genomic Location for TMEM154 Gene

Chromosome:
4
Start:
152,618,632 bp from pter
End:
152,680,165 bp from pter
Size:
61,534 bases
Orientation:
Minus strand

Genomic View for TMEM154 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for TMEM154 Gene

Proteins for TMEM154 Gene

  • Protein details for TMEM154 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P9G4-TM154_HUMAN
    Recommended name:
    Transmembrane protein 154
    Protein Accession:
    Q6P9G4
    Secondary Accessions:
    • Q8WUT7
    • Q96MQ8

    Protein attributes for TMEM154 Gene

    Size:
    183 amino acids
    Molecular mass:
    20498 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM154 Gene

Proteomics data for TMEM154 Gene at MOPED

Post-translational modifications for TMEM154 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM154 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM154 Gene

Domains & Families for TMEM154 Gene

Protein Domains for TMEM154 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM154 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM154: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM154 Gene

Function for TMEM154 Gene

genes like me logo Genes that share phenotypes with TMEM154: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM154

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM154 Gene

Localization for TMEM154 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM154 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM154 Gene COMPARTMENTS Subcellular localization image for TMEM154 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for TMEM154 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM154: view

Pathways & Interactions for TMEM154 Gene

SuperPathways for TMEM154 Gene

No Data Available

Interacting Proteins for TMEM154 Gene

Gene Ontology (GO) - Biological Process for TMEM154 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM154 Gene

Drugs & Compounds for TMEM154 Gene

No Compound Related Data Available

Transcripts for TMEM154 Gene

Unigene Clusters for TMEM154 Gene

Transmembrane protein 154:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM154

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM154 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for TMEM154 Gene

GeneLoc Exon Structure for
TMEM154
ECgene alternative splicing isoforms for
TMEM154

Expression for TMEM154 Gene

mRNA expression in normal human tissues for TMEM154 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM154 Gene

This gene is overexpressed in Whole Blood (x15.8), Esophagus - Mucosa (x8.6), Skin - Not Sun Exposed (Suprapubic) (x6.0), and Skin - Sun Exposed (Lower leg) (x5.6).

Protein differential expression in normal tissues from HIPED for TMEM154 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM154 Gene



SOURCE GeneReport for Unigene cluster for TMEM154 Gene Hs.518900

genes like me logo Genes that share expression patterns with TMEM154: view

Protein tissue co-expression partners for TMEM154 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM154 Gene

Orthologs for TMEM154 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM154 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TMEM154 35
  • 80.8 (n)
  • 72.78 (a)
TMEM154 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem154 35
  • 73.11 (n)
  • 65.19 (a)
Tmem154 16
Tmem154 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM154 35
  • 99.64 (n)
  • 99.45 (a)
-- 36
  • 100 (a)
OneToMany
TMEM154 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem154 35
  • 69.06 (n)
  • 57.49 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM154 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM154 36
  • 37 (a)
OneToOne
Species with no ortholog for TMEM154:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM154 Gene

ENSEMBL:
Gene Tree for TMEM154 (if available)
TreeFam:
Gene Tree for TMEM154 (if available)

Paralogs for TMEM154 Gene

No data available for Paralogs for TMEM154 Gene

Variants for TMEM154 Gene

Sequence variations from dbSNP and Humsavar for TMEM154 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_031755 -

Structural Variations from Database of Genomic Variants (DGV) for TMEM154 Gene

Variant ID Type Subtype PubMed ID
dgv671n27 CNV Gain 19166990
nsv521115 CNV Loss 19592680
nsv461690 CNV Gain 19166990

Variation tolerance for TMEM154 Gene

Residual Variation Intolerance Score: 57.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM154 Gene

HapMap Linkage Disequilibrium report
TMEM154

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM154 Gene

Disorders for TMEM154 Gene

Relevant External Links for TMEM154

Genetic Association Database (GAD)
TMEM154
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM154
genes like me logo Genes that share disorders with TMEM154: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM154 Gene

Publications for TMEM154 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. (PMID: 24509480) . … Morris A.P. (Nat. Genet. 2014) 67
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 67
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for TMEM154 Gene

Sources for TMEM154 Gene

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