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TMEM154 Gene

protein-coding   GIFtS: 43
GCID: GC04M153547

Transmembrane Protein 154

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 1541 2

External Ids:    HGNC: 264891   Entrez Gene: 2017992   Ensembl: ENSG000001700067   UniProtKB: Q6P9G43   

Export aliases for TMEM154 gene to outside databases

Previous GC identifers: GC04M153766 GC04M149273


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM154 Gene:
TMEM154 (transmembrane protein 154) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM154 gene promoter:
         SRF   C/EBPbeta   AML1a   ATF-2   SRF (504 AA)   CUTL1   AP-2gamma   C/EBPalpha   SRY   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM154 promoter sequence
   Search Chromatin IP Primers for TMEM154

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM154


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.3   Ensembl cytogenetic band:  4q31.3   HGNC cytogenetic band: 4q31.3

TMEM154 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM154 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M153547:  view genomic region     (about GC identifiers)

Start:
153,539,784 bp from pter      End:
153,601,317 bp from pter
Size:
61,534 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM154_HUMAN, Q6P9G4 (See protein sequence)
Recommended Name: Transmembrane protein 154 precursor  
Size: 183 amino acids; 20498 Da
Secondary accessions: Q8WUT7 Q96MQ8

Explore the universe of human proteins at neXtProt for TMEM154: NX_Q6P9G4

Explore proteomics data for TMEM154 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr53, Thr57
  • Modification sites at PhosphoSitePlus

  • See TMEM154 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689893.1  
    ENSEMBL proteins: 
     ENSP00000302144   ENSP00000422156  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028064 TMEM154

    Graphical View of Domain Structure for InterPro Entry Q6P9G4

    ProtoNet protein and cluster: Q6P9G4


    Find genes that share domains with TMEM154           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for TMEM154:
     Increased cell number in S and 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM154
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    Selected qRT-PCR Assays for microRNAs that regulate TMEM154 (see all 24):
    hsa-miR-495 hsa-miR-4251 hsa-miR-15a hsa-miR-570 hsa-miR-877* hsa-miR-424 hsa-miR-580 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidTMEM154 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM154_HUMAN, Q6P9G4: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMEM154           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM154
    Interactions:

        Search GeneGlobe Interaction Network for TMEM154

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM154 (TM154)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM154 gene: 
    NM_152680.2  

    Unigene Cluster for TMEM154:

    Transmembrane protein 154
    Hs.518900  [show with all ESTs]
    Unigene Representative Sequence: NM_152680
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304385(uc003imw.2) ENST00000510252 ENST00000504064
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TMEM154 (see all 24):
    hsa-miR-495 hsa-miR-4251 hsa-miR-15a hsa-miR-570 hsa-miR-877* hsa-miR-424 hsa-miR-580 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidTMEM154 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TMEM154
      QuantiFast Probe-based Assays in human, mouse, rat TMEM154

    Additional mRNA sequence: 

    AK056590.1 AK296694.1 AK309319.1 BC019600.1 BC060775.1 

    7 DOTS entries:

    DT.310131  DT.101969645  DT.91808501  DT.91725167  DT.92048897  DT.95342722  DT.95116666 

    Selected AceView cDNA sequences (see all 37):

    AA336885 AL597461 AA337864 BM549074 NM_152680 AI263515 BX115221 BC060775 
    BC019600 AA321529 BG548436 AA809311 BX490096 CD701701 AW081455 AA909635 
    AA729904 BU688947 AA806283 BP337644 AK056590 BG288308 BP355820 AA251925 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM154    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
    SP1:                    -                 -           -                                 
    SP2:                                      -           -                                 
    SP3:                    -                                                               
    SP4:                                                                                    


    ECgene alternative splicing isoforms for TMEM154

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM154 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATTGAGTT
    TMEM154 Expression
    About this image


    TMEM154 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Epidermis (Integumentary System)
    TMEM154 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM154 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518900
        Custom PCR Arrays for TMEM154
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM154

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM154 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1541 , 5 transmembrane protein 1541, 5 73.11(n)1
    65.19(a)1
      3 (37.70 cM)5
    3207821  NM_177260.21  NP_796234.11 
     846661925 
    chicken
    (Gallus gallus)
    Aves TMEM1546
    transmembrane protein 154
    37(a)
    1 ↔ 1
    4(33309104-33320854)


    ENSEMBL Gene Tree for TMEM154 (if available)
    TreeFam Gene Tree for TMEM154 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM154 (see all 1141)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1430252641,2
    C--153331743(+) GCTCAC/TGCCTG 1 -- int10--------
    rs1461629611,2
    --153331898(+) CATAAC/TTAGGA 1 -- int10--------
    rs1154681391,2
    F--153331914(+) AAAAAC/GTATGA 1 -- int11Minor allele frequency- G:0.03WA 118
    rs793882721,2
    F--153332064(+) CACCAT/CTGGGT 1 -- int11Minor allele frequency- C:0.06WA 118
    rs757176741,2
    C--153332102(+) TATTTA/CTTAAA 1 -- ut310--------
    rs1147222451,2
    F--153332170(+) ATGTAC/TGAAAA 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs1924196731,2
    --153332178(+) AAATGC/TAATCA 1 -- ut310--------
    rs42908781,2
    C,F,H--153332270(+) TTTTGT/GTTTTT 1 -- ut3111Minor allele frequency- G:0.07NA WA CSA EA 373
    rs43127391,2
    C,H--153332287(+) TTTTTC/TTAACA 1 -- ut3110Minor allele frequency- T:0.06NA WA CSA EA 372
    rs580152361,2
    C,F--153332320(+) GTTTGG/TGTTTA 1 -- ut312Minor allele frequency- T:0.06WA 120

    HapMap Linkage Disequilibrium report for TMEM154 (153539784 - 153601317 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TMEM154:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv521115CNV Loss19592680
    nsv461690CNV Gain19166990
    dgv671n27CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with TMEM154           About GenesLikeMe

    Genetic Association Database (GAD): TMEM154

    Export disorders for TMEM154 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM154 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMEM154)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 201799 HGNC: 26489 AceView: FLJ32028 Ensembl:ENSG00000170006 euGenes: HUgn201799
    ECgene: TMEM154 H-InvDB: TMEM154

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM154 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM154 gene:
    Search GeneIP for patents involving TMEM154

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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