TMEM151B Gene
protein-coding GIFtS: 37
GCID: GC06P044239
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transmembrane protein 151B(Previous names: chromosome 6 open reading frame 137, transmembrane protein...)
(Previous symbols: C6orf137, TMEM193)
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Aliases
for TMEM151B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 151B1 2 | | Transmembrane Protein 1931 2 3 | | C6orf1371 2 3 | | TMEM1931 2 3 | | BA444E17.51 | | Chromosome 6 Open Reading Frame 1371 |
Export aliases for TMEM151B gene to outside databasesPrevious GC identifers: GC06P044349 GC06P043960 |
Summaries
for TMEM151B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM151B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM151B gene promoter:
ISGF-3 Elk-1 GATA-3 p300 E47 Egr-4 Egr-2 RORalpha1 MZF-1 c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM151B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM151B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21.1TMEM151B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P044239: view genomic region
(about GC identifiers)
Start:
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44,238,203 bp from pter |
End:
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44,346,694 bp from pter |
Size:
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108,492 bases |
Orientation:
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plus strand |
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Proteins
for TMEM151B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T151B_HUMAN, Q8IW70 (See
protein sequence)Recommended Name: Transmembrane protein 151B Size: 566 amino acids; 61506 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=CAI20104.1; Type=Erroneous initiation; Sequence=CAI20105.1; Type=Erroneous gene modelprediction; Sequence=CAI40748.1; Type=Erroneous initiation;
Secondary accessions: Q5T9V7Alternative splicing: 2 isoforms: Q8IW70-1 Q8IW70-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TMEM151B: NX_Q8IW70
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IW70
TMEM151B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001131032.1
ENSEMBL proteins: ENSP00000393161 ENSP00000409337 ENSP00000424257
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016021 | integral to membrane |
IEA | -- |
TMEM151B for ontologies About GeneDecksing
TMEM151B Antibody Products:
Assay Products for TMEM151B: |
Protein
Domains /
Families
for TMEM151B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM151B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IW70ProtoNet protein and cluster: Q8IW70 UniProtKB/Swiss-Prot: T151B_HUMAN, Q8IW70Similarity: Belongs to the TMEM151 family |
Function
for TMEM151B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM151B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM151B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM151B (NM_001137560) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM151B | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM151B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM151B |
|
Pathways & Interactions
for TMEM151B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM151B
|
Drugs & Compounds
for TMEM151B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM151B
Search CenterWatch for drugs/clinical trials and news about TMEM151B / T151B
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Transcripts
for TMEM151B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM151B gene (2 alternative transcripts): NM_001039704.1 NM_001137560.1 Unigene Cluster for TMEM151B: Transmembrane protein 151B Hs.632851 [show with all ESTs]Unigene Representative Sequence: NM_0011375603 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000451188(uc003oxh.2) ENST00000438774(uc003oxf.2) ENST00000505802(uc003oxg.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM151B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM151B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM151B (NM_001137560) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM151B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM151B |
Additional cDNA sequence: AK094365.1 AK124502.1 AK126839.1 AL833884.1 L35592.1 4 DOTS entries: DT.101964568 DT.101954396 DT.121344584 DT.97794224 24/97 AceView cDNA sequences (see all 97): AA400703 F02279 AA349867 F09448 AI298456 NM_145026 AL833884 AA400657 BX096175 BE208625 BF439722 F04849 F10562 AK058171 AI684638 CK003094 AW293645 BV192293 CD657142 BE671218 Z42467 T31215 T31253 BE046886
GeneLoc Exon Structure
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Expression
for TMEM151B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM151B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTCCTGGGG
About this image
See TMEM151B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM151B
SOURCE GeneReport for Unigene cluster: Hs.632851
SABiosciences Custom PCR Arrays for TMEM151B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM151B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM151B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM151B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM151B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM151B |
Orthologs
for TMEM151B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM151B gene from 6/13 species (see all 13) About this table
ENSEMBL Gene Tree for TMEM151B (if available)
TreeFam Gene Tree for TMEM151B (if available) |
Paralogs
for TMEM151B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM151B gene
- TMEM151A2
1 SIMAP similar gene for TMEM151B using alignment to 2 protein entries: T151B_HUMAN (see all proteins):TMEM151A
TMEM151B for paralogs About GeneDecksing
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Genomic Variants
for TMEM151B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM151B (44238203 - 44346694 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM151B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM151B |
|
Disorders
/ Diseases
for TMEM151B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM151B for disorders About GeneDecksing
1  disease for TMEM151B: About MalaCardspelizaeus-merzbacher disease
Human Genome Epidemiology (HuGE) Navigator: TMEM151B (1 document)
Export disorders for TMEM151B gene to outside databases
|
Publications
for TMEM151B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM151B gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM151B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1 Hosgood H.D....Lan Q. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
- False association of human ESTs. (PubMed id 7894479)1 Tsai J.Y....Silver L.M. (1994)
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External Searches for TMEM151B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TMEM151B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing TMEM151B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM151B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM151B | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TMEM151B gene:
Search GeneIP for patents involving TMEM151B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM151B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM151B | | | OriGene Protein Over-expression Lysate for TMEM151B | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for TMEM151B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM151B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM151B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM151B | | OriGene Custom Protein Services for TMEM151B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM151B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM151B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM151B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM151B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM151B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM151B |
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 | | | TMEM151B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM151B |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM151B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM151B |
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