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Aliases for TMEM151B Gene

Aliases for TMEM151B Gene

  • Transmembrane Protein 151B 2 3 5
  • Transmembrane Protein 193 2 3 4
  • C6orf137 3 4
  • TMEM193 3 4
  • Chromosome 6 Open Reading Frame 137 2
  • BA444E17.5 3

External Ids for TMEM151B Gene

Previous HGNC Symbols for TMEM151B Gene

  • C6orf137
  • TMEM193

Previous GeneCards Identifiers for TMEM151B Gene

  • GC06P044349
  • GC06P044239
  • GC06P043960

Summaries for TMEM151B Gene

GeneCards Summary for TMEM151B Gene

TMEM151B (Transmembrane Protein 151B) is a Protein Coding gene. An important paralog of this gene is TMEM151A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM151B Gene

Genomics for TMEM151B Gene

Regulatory Elements for TMEM151B Gene

Genomic Location for TMEM151B Gene

Chromosome:
6
Start:
44,270,466 bp from pter
End:
44,307,506 bp from pter
Size:
37,041 bases
Orientation:
Plus strand

Genomic View for TMEM151B Gene

Genes around TMEM151B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM151B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM151B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM151B Gene

Proteins for TMEM151B Gene

  • Protein details for TMEM151B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IW70-T151B_HUMAN
    Recommended name:
    Transmembrane protein 151B
    Protein Accession:
    Q8IW70
    Secondary Accessions:
    • Q5T9V7

    Protein attributes for TMEM151B Gene

    Size:
    566 amino acids
    Molecular mass:
    61506 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI20104.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI20105.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40748.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM151B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM151B Gene

Proteomics data for TMEM151B Gene at MOPED

Post-translational modifications for TMEM151B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM151B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM151B Gene

Domains & Families for TMEM151B Gene

Protein Domains for TMEM151B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM151B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IW70

UniProtKB/Swiss-Prot:

T151B_HUMAN :
  • Belongs to the TMEM151 family.
Family:
  • Belongs to the TMEM151 family.
genes like me logo Genes that share domains with TMEM151B: view

No data available for Gene Families for TMEM151B Gene

Function for TMEM151B Gene

Phenotypes for TMEM151B Gene

genes like me logo Genes that share phenotypes with TMEM151B: view

Animal Models for TMEM151B Gene

MGI Knock Outs for TMEM151B:

Animal Model Products

CRISPR Products

miRNA for TMEM151B Gene

miRTarBase miRNAs that target TMEM151B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM151B Gene

Localization for TMEM151B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM151B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM151B Gene COMPARTMENTS Subcellular localization image for TMEM151B gene
Compartment Confidence
plasma membrane 3
peroxisome 2

No data available for Gene Ontology (GO) - Cellular Components for TMEM151B Gene

Pathways & Interactions for TMEM151B Gene

SuperPathways for TMEM151B Gene

No Data Available

Interacting Proteins for TMEM151B Gene

Gene Ontology (GO) - Biological Process for TMEM151B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM151B Gene

Drugs & Compounds for TMEM151B Gene

No Compound Related Data Available

Transcripts for TMEM151B Gene

mRNA/cDNA for TMEM151B Gene

Unigene Clusters for TMEM151B Gene

Transmembrane protein 151B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM151B Gene

No ASD Table

Relevant External Links for TMEM151B Gene

GeneLoc Exon Structure for
TMEM151B
ECgene alternative splicing isoforms for
TMEM151B

Expression for TMEM151B Gene

mRNA expression in normal human tissues for TMEM151B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM151B Gene

This gene is overexpressed in Bone (42.7) and Adipocyte (24.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM151B Gene



SOURCE GeneReport for Unigene cluster for TMEM151B Gene Hs.632851

genes like me logo Genes that share expression patterns with TMEM151B: view

Protein tissue co-expression partners for TMEM151B Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM151B Gene

Orthologs for TMEM151B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM151B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM151B 35
  • 91.39 (n)
  • 95.51 (a)
dog
(Canis familiaris)
Mammalia TMEM151B 35
  • 94.26 (n)
  • 96.94 (a)
TMEM151B 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem151b 35
  • 90.23 (n)
  • 95.09 (a)
Tmem151b 16
Tmem151b 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM151B 35
  • 99.11 (n)
  • 99.81 (a)
TMEM151B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem151b 35
  • 89.6 (n)
  • 95.09 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM151B 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves C6ORF137 35
  • 76 (n)
  • 77.8 (a)
-- 36
  • 77 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tmem151b 35
  • 67.49 (n)
  • 70.84 (a)
si:ch73-387g8.1 36
  • 68 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ZK1067.4 36
  • 31 (a)
OneToMany
Species with no ortholog for TMEM151B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM151B Gene

ENSEMBL:
Gene Tree for TMEM151B (if available)
TreeFam:
Gene Tree for TMEM151B (if available)

Paralogs for TMEM151B Gene

Paralogs for TMEM151B Gene

(1) SIMAP similar genes for TMEM151B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM151B: view

Variants for TMEM151B Gene

Sequence variations from dbSNP and Humsavar for TMEM151B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs170510 -- 44,276,865(-) CCCAA(C/G)GCGGG utr-variant-3-prime
rs12943 -- 44,279,029(+) CTTAG(C/T)GGAAG utr-variant-3-prime
rs325017 -- 44,278,312(+) TGGGC(A/C/G/T)GGGGA utr-variant-3-prime
rs325018 -- 44,278,193(+) GAGTG(A/C/G/T)GAGGG utr-variant-3-prime
rs325019 -- 44,277,586(-) GCACA(C/G)GTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM151B Gene

Variant ID Type Subtype PubMed ID
nsv885851 CNV Loss 21882294
nsv462936 CNV Loss 19166990
dgv6843n71 CNV Loss 21882294
nsv524398 CNV Loss 19592680
nsv885857 CNV Loss 21882294

Variation tolerance for TMEM151B Gene

Gene Damage Index Score: 1.50; 29.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM151B Gene

HapMap Linkage Disequilibrium report
TMEM151B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM151B Gene

Disorders for TMEM151B Gene

Relevant External Links for TMEM151B

Genetic Association Database (GAD)
TMEM151B
Human Genome Epidemiology (HuGE) Navigator
TMEM151B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM151B

No disorders were found for TMEM151B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM151B Gene

Publications for TMEM151B Gene

  1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 48 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  5. False association of human ESTs. (PMID: 7894479) Tsai J.Y. … Silver L.M. (Nat. Genet. 1994) 3

Products for TMEM151B Gene

Sources for TMEM151B Gene

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