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Aliases for TMEM151A Gene

Aliases for TMEM151A Gene

  • Transmembrane Protein 151A 2 3 5
  • Transmembrane Protein 151 2 3
  • TMEM151 3 4

External Ids for TMEM151A Gene

Previous HGNC Symbols for TMEM151A Gene

  • TMEM151

Previous GeneCards Identifiers for TMEM151A Gene

  • GC11P065819
  • GC11P066059
  • GC11P062384

Summaries for TMEM151A Gene

GeneCards Summary for TMEM151A Gene

TMEM151A (Transmembrane Protein 151A) is a Protein Coding gene. An important paralog of this gene is TMEM151B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM151A Gene

Genomics for TMEM151A Gene

Regulatory Elements for TMEM151A Gene

Enhancers for TMEM151A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F066324 1.6 FANTOM5 Ensembl ENCODE 11.7 +35.0 34986 5.4 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 RIN1 ACTN3 YIF1A TMEM151A LOC100505504 SLC29A2 ENSG00000255320 PACS1 ENSG00000201733 CTSF
GH11F066311 1.5 FANTOM5 ENCODE 11.4 +23.5 23464 8.3 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YBX1 RIN1 CTSW BRMS1 TMEM151A YIF1A LOC102724064 ENSG00000255320 PACS1 ENSG00000254458 CD248
GH11F066386 1.1 Ensembl ENCODE 10.4 +94.5 94531 0.8 PKNOX1 CBX3 RAD21 ZNF121 ZNF143 CREM THAP11 ZNF654 CEBPB MIER2 LOC100505504 NPAS4 ENSG00000201733 PELI3 MRPL11 DPP3 LOC101928069 YIF1A TMEM151A KLC2
GH11F066321 0.9 Ensembl ENCODE 11.4 +30.6 30632 1.4 ELF3 CTCF ZNF366 NR2F1 REST ZNF644 RAD21 THAP11 RIN1 BRMS1 TMEM151A YIF1A LOC102724064 ENSG00000255320 PACS1 CD248 ENSG00000254756
GH11F066078 1.6 FANTOM5 Ensembl ENCODE 6.4 -209.9 -209939 7.7 HDGF PKNOX1 SIN3A YBX1 FEZF1 ZNF121 CBX5 GATA2 ZNF143 FOS ENSG00000255320 SF3B2 SIPA1 PACS1 CST6 BANF1 EIF1AD SART1 MAP3K11 AP5B1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM151A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM151A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001769354 130 801 CBX3 JUND CREM ZBTB7A ATF2 ZBTB26

Genomic Location for TMEM151A Gene

Chromosome:
11
Start:
66,291,870 bp from pter
End:
66,296,664 bp from pter
Size:
4,795 bases
Orientation:
Plus strand

Genomic View for TMEM151A Gene

Genes around TMEM151A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM151A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM151A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM151A Gene

Proteins for TMEM151A Gene

  • Protein details for TMEM151A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4L1-T151A_HUMAN
    Recommended name:
    Transmembrane protein 151A
    Protein Accession:
    Q8N4L1
    Secondary Accessions:
    • Q8ND14

    Protein attributes for TMEM151A Gene

    Size:
    468 amino acids
    Molecular mass:
    51278 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM151A Gene

Post-translational modifications for TMEM151A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM151A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM151A Gene

Domains & Families for TMEM151A Gene

Protein Domains for TMEM151A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM151A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4L1

UniProtKB/Swiss-Prot:

T151A_HUMAN :
  • Belongs to the TMEM151 family.
Family:
  • Belongs to the TMEM151 family.
genes like me logo Genes that share domains with TMEM151A: view

No data available for Gene Families for TMEM151A Gene

Function for TMEM151A Gene

genes like me logo Genes that share phenotypes with TMEM151A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM151A Gene

Localization for TMEM151A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM151A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM151A gene
Compartment Confidence
plasma membrane 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for TMEM151A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM151A: view

Pathways & Interactions for TMEM151A Gene

SuperPathways for TMEM151A Gene

No Data Available

Interacting Proteins for TMEM151A Gene

Gene Ontology (GO) - Biological Process for TMEM151A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM151A Gene

Transcripts for TMEM151A Gene

mRNA/cDNA for TMEM151A Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(41) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM151A Gene

Transmembrane protein 151A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM151A Gene

No ASD Table

Relevant External Links for TMEM151A Gene

GeneLoc Exon Structure for
TMEM151A
ECgene alternative splicing isoforms for
TMEM151A

Expression for TMEM151A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM151A Gene

mRNA differential expression in normal tissues according to GTEx for TMEM151A Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.5), Brain - Substantia nigra (x5.9), Brain - Hippocampus (x4.9), and Brain - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for TMEM151A Gene

This gene is overexpressed in Spinal cord (39.2) and Colon (22.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM151A Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM151A Gene:

TMEM151A

SOURCE GeneReport for Unigene cluster for TMEM151A Gene:

Hs.399779
genes like me logo Genes that share expression patterns with TMEM151A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMEM151A Gene

Orthologs for TMEM151A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM151A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM151A 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia TMEM151A 35
  • 98 (a)
OneToOne
LOC483713 34
  • 91.45 (n)
cow
(Bos Taurus)
Mammalia TMEM151A 34 35
  • 93.02 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM151A 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem151a 34 16 35
  • 86.89 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911978 34
  • 86.47 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC793560 34
  • 63.8 (n)
TMEM151A (1 of 2) 35
  • 43 (a)
OneToMany
tmem151a 35
  • 42 (a)
OneToMany
Dr.14563 34
worm
(Caenorhabditis elegans)
Secernentea ZK1067.4 34 35
  • 42.99 (n)
Species where no ortholog for TMEM151A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM151A Gene

ENSEMBL:
Gene Tree for TMEM151A (if available)
TreeFam:
Gene Tree for TMEM151A (if available)

Paralogs for TMEM151A Gene

Paralogs for TMEM151A Gene

(1) SIMAP similar genes for TMEM151A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM151A: view

Variants for TMEM151A Gene

Sequence variations from dbSNP and Humsavar for TMEM151A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs112089750 -- 66,291,677(+) ACCAG(C/T)TCAAG upstream-variant-2KB
rs112148750 -- 66,295,266(+) GCCAC(A/G)GTGGA reference, synonymous-codon
rs112242593 -- 66,293,207(+) GCTGT(G/T)CTCCC intron-variant
rs11227451 -- 66,291,562(+) GCTTA(A/C)CTCTG upstream-variant-2KB
rs11227452 -- 66,291,634(+) CGAGG(A/G)TTTTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM151A Gene

Variant ID Type Subtype PubMed ID
nsv555223 CNV loss 21841781
esv32849 CNV gain 17666407

Variation tolerance for TMEM151A Gene

Gene Damage Index Score: 1.18; 23.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM151A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM151A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM151A Gene

Disorders for TMEM151A Gene

Relevant External Links for TMEM151A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM151A

No disorders were found for TMEM151A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM151A Gene

Publications for TMEM151A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 64

Products for TMEM151A Gene

Sources for TMEM151A Gene

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