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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM151A Gene

protein-coding   GIFtS: 38
GCID: GC11P066059

Transmembrane Protein 151A

(Previous name: transmembrane protein 151)
(Previous symbol: TMEM151)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 151A1 2
TMEM1511 2 3
Transmembrane Protein 1511 2

External Ids:    HGNC: 284971   Entrez Gene: 2564722   Ensembl: ENSG000001792927   UniProtKB: Q8N4L13   

Export aliases for TMEM151A gene to outside databases

Previous GC identifers: GC11P065819 GC11P062384


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM151A Gene: 
TMEM151A (transmembrane protein 151A) is a protein-coding gene. Diseases associated with TMEM151A include pelizaeus-merzbacher disease. An important paralog of this gene is ENSG00000272442.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM151A gene promoter:
         AhR   Pbx1a   NRSF form 1   Tal-1beta   LCR-F1   NRSF form 2   RORalpha2   E47   c-Ets-1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM151A promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM151A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM151A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.2

TMEM151A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM151A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P066059:  view genomic region     (about GC identifiers)

Start:
66,059,341 bp from pter      End:
66,064,135 bp from pter
Size:
4,795 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T151A_HUMAN, Q8N4L1 (See protein sequence)
Recommended Name: Transmembrane protein 151A  
Size: 468 amino acids; 51278 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q8ND14

Explore the universe of human proteins at neXtProt for TMEM151A: NX_Q8N4L1

Explore proteomics data for TMEM151A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N4L1

  • TMEM151A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM151A Protein Expression
    REFSEQ proteins: NP_694998.1  
    ENSEMBL proteins: 
     ENSP00000326244  

    Human Recombinant Protein Products for TMEM151A: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    TMEM151A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026767 Tmem151

    Graphical View of Domain Structure for InterPro Entry Q8N4L1

    ProtoNet protein and cluster: Q8N4L1

    UniProtKB/Swiss-Prot: T151A_HUMAN, Q8N4L1
    Similarity: Belongs to the TMEM151 family


    TMEM151A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM151A 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM151A 
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    SwitchGear 3'UTR luciferase reporter plasmidTMEM151A 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM151A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM151A (T151A)

    Search CenterWatch for drugs/clinical trials and news about TMEM151A / T151A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM151A gene: 
    NM_153266.3  

    Unigene Cluster for TMEM151A:

    Transmembrane protein 151A
    Hs.399779  [show with all ESTs]
    Unigene Representative Sequence: BC033898
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000327259(uc001ohl.3)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidTMEM151A 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM151A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM151A
    Sirion Biotech Customized lentivirus for stable overexpression of TMEM151A 
                         Customized lentivirus expression plasmids for stable overexpression of TMEM151A 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM151A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM151A

    Additional mRNA sequence: 

    AL834459.1 BC033898.2 BC035477.1 

    1 DOTS entry:

    DT.91656100 

    24/41 AceView cDNA sequences (see all 41):

    NM_153266 BC035477 BM727563 BC033898 AL834459 BM709262 BU732410 BE792000 
    BX116640 BM546679 BI820366 BI756162 CA433623 AL523646 BI457430 BM564651 
    BF507635 BF568366 AL523645 BM666807 BM695019 BX366057 BM681779 BI490232 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM151A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCCCAGGC
    TMEM151A Expression
    About this image


    See TMEM151A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM151A

    SOURCE GeneReport for Unigene cluster: Hs.399779
        SABiosciences Custom PCR Arrays for TMEM151A
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM151A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMEM151A gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem151a1 , 5 transmembrane protein 151A1, 5 86.89(n)1
    97.44(a)1
      19 (4.24 cM)5
    3811991  NM_001001885.11  NP_001001885.11 
     50708595 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.145632 Transcribed sequence with weak similarity to protein more 76.41(n)    BI703488.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK1067.46
    Transmembrane protein 151 homolog
    27(a)
    1 → many
    II(9210376-9213097)


    ENSEMBL Gene Tree for TMEM151A (if available)
    TreeFam Gene Tree for TMEM151A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMEM151A gene
    ENSG000002724422  TMEM151B2  
    1 SIMAP similar gene for TMEM151A using alignment to 1 protein entry:     T151A_HUMAN:
    TMEM151B

    TMEM151A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/117 SNPs in TMEM151A are shown (see all 117)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs681308281,2
    C--66058843(+) AAAACTG/-AGGTT 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs763461101,2
    C,F--66058912(+) CCAGCC/GTGCCT 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs1866153561,2
    --66058961(+) GACTCC/GTCACG 1 -- us2k10--------
    rs1402230791,2
    --66059104(+) TCGAGA/GGTTTT 1 -- us2k10--------
    rs112274521,2
    C--66059105(+) CGAGGG/ATTTTA 1 -- us2k14Minor allele frequency- A:0.19WA NA EA 360
    rs1120897501,2
    C--66059148(+) ACCAGC/TTCAAG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1155124381,2
    F--66059209(+) GCGGGG/AGCTTC 1 -- us2k11Minor allele frequency- A:0.13WA 118
    rs1434634791,2
    --66059425(+) CCCTCC/GGTGCT 1 -- ut510--------
    rs1388231111,2
    C--66059570(+) GCGCT-/GGGGGG 1 -- int10--------
    rs1509347571,2
    --66059642(+) GGGCTA/GAGGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for TMEM151A (66059341 - 66064135 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TMEM151A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897772CNV Loss21882294
    dgv1187n71CNV Loss21882294
    nsv897779CNV Loss21882294
    dgv1188n71CNV Loss21882294
    esv32849CNV Gain17666407

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for TMEM151A:    About MalaCards
    pelizaeus-merzbacher disease    


    TMEM151A for disorders           About GeneDecksing


    Export disorders for TMEM151A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM151A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEM151A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    5. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 256472 HGNC: 28497 AceView: MGC33486 Ensembl:ENSG00000179292 euGenes: HUgn256472
    ECgene: TMEM151A H-InvDB: TMEM151A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM151A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM151A gene:
    Search GeneIP for patents involving TMEM151A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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