TMEM151A Gene
protein-coding GIFtS: 41
GCID: GC11P066059
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transmembrane protein 151A(Previous name: transmembrane protein 151 )
(Previous symbol: TMEM151)
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Aliases
for TMEM151A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 151A1 2 | | TMEM1511 2 3 | | Transmembrane Protein 1511 2 | | MGC334861 |
Export aliases for TMEM151A gene to outside databasesPrevious GC identifers: GC11P065819 GC11P062384 |
Summaries
for TMEM151A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM151A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM151A gene promoter:
AhR Pbx1a NRSF form 1 Tal-1beta LCR-F1 NRSF form 2 RORalpha2 E47 c-Ets-1 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM151A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM151A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.2 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13.2TMEM151A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P066059: view genomic region
(about GC identifiers)
Start:
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66,059,341 bp from pter |
End:
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66,064,135 bp from pter |
Size:
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4,795 bases |
Orientation:
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plus strand |
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Proteins
for TMEM151A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T151A_HUMAN, Q8N4L1 (See
protein sequence)Recommended Name: Transmembrane protein 151A Size: 468 amino acids; 51278 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q8ND14Explore the universe of human proteins at neXtProt for TMEM151A: NX_Q8N4L1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N4L1
TMEM151A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_694998.1
ENSEMBL proteins: ENSP00000326244
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016021 | integral to membrane |
IEA | -- |
TMEM151A for ontologies About GeneDecksing
TMEM151A Antibody Products:
Assay Products for TMEM151A: |
Protein
Domains /
Families
for TMEM151A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM151A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N4L1ProtoNet protein and cluster: Q8N4L1 UniProtKB/Swiss-Prot: T151A_HUMAN, Q8N4L1Similarity: Belongs to the TMEM151 family |
Function
for TMEM151A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM151A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM151A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM151A (NM_153266) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM151A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM151A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM151A |
|
Pathways & Interactions
for TMEM151A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM151A
|
Drugs & Compounds
for TMEM151A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM151A
Search CenterWatch for drugs/clinical trials and news about TMEM151A / T151A
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Transcripts
for TMEM151A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM151A gene: NM_153266.3 Unigene Cluster for TMEM151A: Transmembrane protein 151A Hs.399779 [show with all ESTs]Unigene Representative Sequence: BC0338981 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000327259(uc001ohl.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM151A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM151A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM151A (NM_153266) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM151A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM151A |
Additional cDNA sequence: AL834459.1 BC033898.2 BC035477.1 1 DOTS entry: DT.91656100 24/41 AceView cDNA sequences (see all 41): BM709262 AL834459 BC035477 BC033898 NM_153266 BM727563 BX116640 BX403337 BG222611 BI490232 BI756162 BI457430 BF507635 BE792000 CA433623 BM546679 AL523646 BI820366 BM564651 BF568366 AL523645 BM666807 BU732410 BM695019
GeneLoc Exon Structure
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Expression
for TMEM151A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM151A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGCCCAGGC
About this image
See TMEM151A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM151A
SOURCE GeneReport for Unigene cluster: Hs.399779
SABiosciences Custom PCR Arrays for TMEM151A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM151A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM151A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM151A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM151A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM151A |
Orthologs
for TMEM151A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM151A gene from 3/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.145632 |
Transcribed sequence with weak similarity to protein more |
76.41(n) |
|
BI703488.1 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
17(a) |
1 → many |
Group9.3(33096-37197) |
worm
(Caenorhabditis elegans) |
Secernentea |
ZK1067.46 |
Transmembrane protein 151 homolog |
27(a) |
1 → many |
II(9210316-9213037) |
ENSEMBL Gene Tree for TMEM151A (if available)
TreeFam Gene Tree for TMEM151A (if available) |
Paralogs
for TMEM151A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM151A gene
- TMEM151B2
1 SIMAP similar gene for TMEM151A using alignment to 1 protein entry: T151A_HUMAN:TMEM151B
TMEM151A for paralogs About GeneDecksing
|
Genomic Variants
for TMEM151A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM151A (66059341 - 66064135 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMEM151A
1 CNV: 6936 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM151A |
|
Disorders
/ Diseases
for TMEM151A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM151A for disorders About GeneDecksing
1  disease for TMEM151A: About MalaCardspelizaeus-merzbacher disease
Export disorders for TMEM151A gene to outside databases
|
Publications
for TMEM151A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM151A gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM151A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for TMEM151A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TMEM151A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing TMEM151A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM151A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM151A | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TMEM151A gene:
Search GeneIP for patents involving TMEM151A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM151A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM151A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM151A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM151A | | | OriGene Protein Over-expression Lysate for TMEM151A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM151A | | OriGene 3'-UTR Clone for TMEM151A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM151A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM151A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TMEM151A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM151A | | OriGene Custom Protein Services for TMEM151A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM151A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM151A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM151A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM151A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM151A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM151A |
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 | | | TMEM151A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM151A |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM151A |
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