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TMEM150C Gene

protein-coding   GIFtS: 38
GCID: GC04M083405

Transmembrane Protein 150C

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 150C1 2

External Ids:    HGNC: 372631   Entrez Gene: 4410272   Ensembl: ENSG000002492427   UniProtKB: B9EJG83   

Export aliases for TMEM150C gene to outside databases

Previous GC identifers: GC04M083625 GC04M079146


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM150C Gene:
TMEM150C (transmembrane protein 150C) is a protein-coding gene. An important paralog of this gene is TMEM150A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TMEM150C
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TMEM150C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM150C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.22   Ensembl cytogenetic band:  4q21.22   HGNC cytogenetic band: 4q21.22

TMEM150C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM150C gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M083405:  view genomic region     (about GC identifiers)

Start:
83,404,323 bp from pter      End:
83,483,510 bp from pter
Size:
79,188 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: T150C_HUMAN, B9EJG8 (See protein sequence)
Recommended Name: Transmembrane protein 150C  
Size: 249 amino acids; 27887 Da
Sequence caution: Sequence=BAH12581.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B7Z4J5 B7Z4L3 B7Z692 B7Z6X6
Alternative splicing: 2 isoforms:  B9EJG8-1   B9EJG8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM150C: NX_B9EJG8

Explore proteomics data for TMEM150C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMEM150C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073975.1  
    ENSEMBL proteins: 
     ENSP00000420919   ENSP00000403438   ENSP00000421812   ENSP00000414988  

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    antibodies-online kits for TMEM150C (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR019402 Frag1/DRAM/Sfk1
     IPR027315 DRAM/TMEM150

    Graphical View of Domain Structure for InterPro Entry B9EJG8

    ProtoNet protein and cluster: B9EJG8

    UniProtKB/Swiss-Prot: T150C_HUMAN, B9EJG8
    Similarity: Belongs to the DRAM/TMEM150 family


    Find genes that share domains with TMEM150C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TMEM150C

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TMEM150C (see all 23):
    hsa-miR-448 hsa-miR-517a hsa-miR-1224-3p hsa-miR-517c hsa-miR-1271 hsa-miR-517b hsa-miR-218 hsa-miR-23a
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM150C

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T150C_HUMAN, B9EJG8: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMEM150C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM150C
    Interactions:

        Search GeneGlobe Interaction Network for TMEM150C

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM150C (T150C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM150C gene: 
    NM_001080506.1  

    Unigene Cluster for TMEM150C:

    Transmembrane protein 150C
    Hs.507676  [show with all ESTs]
    Unigene Representative Sequence: AK023055
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000515780 ENST00000449862(uc003hmy.1 uc011ccj.1) ENST00000508701
    ENST00000454948
    miRNA
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    hsa-miR-448 hsa-miR-517a hsa-miR-1224-3p hsa-miR-517c hsa-miR-1271 hsa-miR-517b hsa-miR-218 hsa-miR-23a
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM150C
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TMEM150C
      QuantiFast Probe-based Assays in human, mouse, rat TMEM150C

    Additional mRNA sequence: 

    AK023055.1 AK297434.1 AK297512.1 AK299942.1 AK301116.1 BC052613.1 BC147019.1 BC147027.1 

    15 DOTS entries:

    DT.210234  DT.102841544  DT.91782228  DT.121267590  DT.408054  DT.100742261  DT.100749240  DT.100749249 
    DT.100749272  DT.100749323  DT.91782213  DT.91782227  DT.91949128  DT.95320945  DT.99926814 

    Selected AceView cDNA sequences (see all 42):

    AA825354 BU679345 AA599064 AI619704 AI698261 BC052613 AI933703 BX445921 
    AW118721 BF508344 AI281035 CA431740 D81855 AI418232 BE855829 BF509310 
    BQ711654 AU118042 AW498715 AU130068 AW300364 AK023055 BX103325 AI088709 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM150C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCAAAGAAA
    TMEM150C Expression
    About this image


    TMEM150C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    TMEM150C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM150C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.507676
        Custom PCR Arrays for TMEM150C
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TMEM150C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM150C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM150C gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem150c1 , 5 transmembrane protein 150C1, 5 87.28(n)1
    95.98(a)1
      5 (48.46 cM)5
    2315031  NM_182841.11  NP_878261.11 
     1000778725 
    chicken
    (Gallus gallus)
    Aves TMEM150C1 transmembrane protein 150C 80.19(n)
    90.76(a)
      422599  XM_420558.4  XP_420558.4 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM150C6
    transmembrane protein 150C
    85(a)
    1 ↔ 1
    5(42941954-42982430)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmem150c1 transmembrane protein 150C 73.92(n)
    76.61(a)
      100487151  XM_002936457.2  XP_002936503.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmem150c1 transmembrane protein 150C 68.43(n)
    66.67(a)
      100003020  XM_005155549.1  XP_005155606.1 


    ENSEMBL Gene Tree for TMEM150C (if available)
    TreeFam Gene Tree for TMEM150C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM150C gene
    TMEM150A2  TMEM150B2  
    1 SIMAP similar gene for TMEM150C using alignment to 3 protein entries:     T150C_HUMAN (see all proteins):
    TMEM150B

    Find genes that share paralogs with TMEM150C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM150C (see all 1447)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs68298501,2
    C,A--83405125(+) TTTTTA/GGTAGA 1 -- ds50013Minor allele frequency- G:0.17WA NA EA 242
    rs68537181,2
    C,F--83405232(+) gagccC/Tcacac 1 -- ds50012Minor allele frequency- T:0.08WA 120
    rs595168861,2
    F--83405237(+) CCACAC/TCCAGC 1 -- ds50011Minor allele frequency- T:0.09WA 118
    rs68186771,2
    C,F,A,H--83405383(+) CTGCTC/TTTCTT 1 -- ds500125Minor allele frequency- N:0.00NS EA NA WA CSA 1427
    rs1812915561,2
    --83405546(+) CCAAAC/TTTGAA 1 -- ds50010--------
    rs1995304371,2
    C--83405564(+) TAATCA/CAAAAA 1 -- ds50010--------
    rs46934461,2
    C--83405958(+) CTTGTT/ACCAGG 1 -- ut312Minor allele frequency- A:0.04WA EA 122
    rs1850672371,2
    --83406042(+) ACAGCA/GGCGGG 1 -- ut310--------
    rs1465293671,2
    --83406047(+) GGCGGG/TCTTTG 1 -- ut310--------
    rs1404668831,2
    --83406112(+) ACAACA/GATGAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TMEM150C (83404323 - 83483510 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TMEM150C:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv28726CNV Loss19812545
    nsv829988CNV Loss17160897
    nsv829989CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TMEM150C
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM150C gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMEM150C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 441027 HGNC: 37263 AceView: LOC441027 Ensembl:ENSG00000249242 euGenes: HUgn441027
    ECgene: TMEM150C H-InvDB: TMEM150C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM150C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM150C gene:
    Search GeneIP for patents involving TMEM150C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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