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Aliases for TMEM150C Gene

Aliases for TMEM150C Gene

  • Transmembrane Protein 150C 2 3 5
  • Tentonin 3 2 3
  • TTN3 3

External Ids for TMEM150C Gene

Previous GeneCards Identifiers for TMEM150C Gene

  • GC04M083625
  • GC04M083405
  • GC04M079146

Summaries for TMEM150C Gene

Entrez Gene Summary for TMEM150C Gene

  • This gene encodes a transmembrane protein component of a mechanosensitve ion channel that is activated by mechanical stimuli in various cell types and confers slowly adapting, mechanically activated currents in dorsal root ganglion neurons. Mechanically activated ion channels are sensors that are critical for hearing, touch, pain, and blood pressure regulation. [provided by RefSeq, Jul 2017]

GeneCards Summary for TMEM150C Gene

TMEM150C (Transmembrane Protein 150C) is a Protein Coding gene. Diseases associated with TMEM150C include Malignant Hemangioma and Chromosome 4Q21 Deletion Syndrome. An important paralog of this gene is TMEM150B.

Additional gene information for TMEM150C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM150C Gene

Genomics for TMEM150C Gene

Regulatory Elements for TMEM150C Gene

Enhancers for TMEM150C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H082742 1.3 Ensembl ENCODE dbSUPER 16.4 -183.8 -183822 6 TBP NFIB GLIS2 EGR1 ZNF143 FOS EGR2 SMAD5 GTF2B CEBPB HNRNPD TMEM150C SCD5 MIR575 PIR47609
GH04H082715 1.1 Ensembl ENCODE dbSUPER 16.7 -153.9 -153861 1 SOX13 SCRT1 NFIL3 GATA3 SCRT2 CREB1 BCL6 TMEM150C MIR575 PIR47609
GH04H082733 1 Ensembl ENCODE dbSUPER 15.7 -171.4 -171383 1 JUND FOS MAFK TMEM150C SCD5 MIR575 PIR47609
GH04H082741 0.8 ENCODE dbSUPER 17.7 -179.1 -179056 0 SOX13 GATAD2A TFAP4 HNF4A ZNF644 TMEM150C MIR575 PIR47609
GH04H082739 1.3 Ensembl ENCODE dbSUPER 10.8 -177.0 -177045 0 GTF2F1 CTCF TBL1XR1 ARNT SIN3A RAD21 FOXM1 HIC1 CC2D1A EGR1 TMEM150C SCD5 MIR575 PIR47609
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM150C on UCSC Golden Path with GeneCards custom track

Promoters for TMEM150C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000170006 457 1001 CTCF ZNF384 ZBTB8A FOXM1 ZNF366 ZNF610 GLIS1 ZBTB20 EZH2

Genomic Location for TMEM150C Gene

Chromosome:
4
Start:
82,483,170 bp from pter
End:
82,562,357 bp from pter
Size:
79,188 bases
Orientation:
Minus strand

Genomic View for TMEM150C Gene

Genes around TMEM150C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM150C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM150C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM150C Gene

Proteins for TMEM150C Gene

  • Protein details for TMEM150C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B9EJG8-T150C_HUMAN
    Recommended name:
    Transmembrane protein 150C
    Protein Accession:
    B9EJG8
    Secondary Accessions:
    • B7Z4J5
    • B7Z4L3
    • B7Z692
    • B7Z6X6

    Protein attributes for TMEM150C Gene

    Size:
    249 amino acids
    Molecular mass:
    27887 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAH12581.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM150C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM150C Gene

Post-translational modifications for TMEM150C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM150C Gene

No data available for DME Specific Peptides for TMEM150C Gene

Domains & Families for TMEM150C Gene

Gene Families for TMEM150C Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM150C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM150C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B9EJG8

UniProtKB/Swiss-Prot:

T150C_HUMAN :
  • Belongs to the DRAM/TMEM150 family.
Family:
  • Belongs to the DRAM/TMEM150 family.
genes like me logo Genes that share domains with TMEM150C: view

Function for TMEM150C Gene

Phenotypes From GWAS Catalog for TMEM150C Gene

Gene Ontology (GO) - Molecular Function for TMEM150C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008381 mechanically-gated ion channel activity IEA --
genes like me logo Genes that share ontologies with TMEM150C: view

Phenotypes for TMEM150C Gene

GenomeRNAi human phenotypes for TMEM150C:
genes like me logo Genes that share phenotypes with TMEM150C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM150C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM150C Gene

Localization for TMEM150C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM150C Gene

Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Note=Localizes at the plasma membrane. A portion co-localizes with LAMP1 lysosomal marker (PubMed:25608530). {ECO:0000269 PubMed:25608530}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM150C gene
Compartment Confidence
plasma membrane 5
lysosome 5

Gene Ontology (GO) - Cellular Components for TMEM150C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane TAS 25608530
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IDA 25608530
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM150C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM150C Gene

Pathways & Interactions for TMEM150C Gene

SuperPathways for TMEM150C Gene

No Data Available

Interacting Proteins for TMEM150C Gene

Gene Ontology (GO) - Biological Process for TMEM150C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019230 proprioception ISS --
GO:0034220 ion transmembrane transport IEA --
GO:0071260 cellular response to mechanical stimulus ISS --
genes like me logo Genes that share ontologies with TMEM150C: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM150C Gene

Drugs & Compounds for TMEM150C Gene

No Compound Related Data Available

Transcripts for TMEM150C Gene

Unigene Clusters for TMEM150C Gene

Transmembrane protein 150C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM150C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM150C Gene

No ASD Table

Relevant External Links for TMEM150C Gene

GeneLoc Exon Structure for
TMEM150C
ECgene alternative splicing isoforms for
TMEM150C

Expression for TMEM150C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM150C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM150C Gene

This gene is overexpressed in Adrenal Gland (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of TMEM150C Gene:

TMEM150C

SOURCE GeneReport for Unigene cluster for TMEM150C Gene:

Hs.507676

Evidence on tissue expression from TISSUES for TMEM150C Gene

  • Nervous system(4.3)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with TMEM150C: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM150C Gene

Orthologs for TMEM150C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM150C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM150C 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia TMEM150C 33 34
  • 93.98 (n)
cow
(Bos Taurus)
Mammalia TMEM150C 33 34
  • 93.31 (n)
rat
(Rattus norvegicus)
Mammalia Tmem150c 33
  • 88.09 (n)
mouse
(Mus musculus)
Mammalia Tmem150c 33 16 34
  • 87.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM150C 34
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM150C 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM150C 33 34
  • 80.19 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM150C 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem150c 33
  • 73.92 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem150c 33 34
  • 68.43 (n)
Species where no ortholog for TMEM150C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM150C Gene

ENSEMBL:
Gene Tree for TMEM150C (if available)
TreeFam:
Gene Tree for TMEM150C (if available)

Paralogs for TMEM150C Gene

Paralogs for TMEM150C Gene

(1) SIMAP similar genes for TMEM150C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMEM150C: view

Variants for TMEM150C Gene

Sequence variations from dbSNP and Humsavar for TMEM150C Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000029670 -- 82,528,846(+) GCCTC(A/G)GCCTC intron-variant
rs1000044853 -- 82,523,290(+) CAGTC(A/G)GGTGT intron-variant
rs1000065033 -- 82,530,295(+) GCTCA(A/C)GCCTG intron-variant
rs10001408 -- 82,507,270(+) TAATG(C/T)ACAAT intron-variant
rs1000160956 -- 82,535,679(+) GACCT(C/G)GGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM150C Gene

Variant ID Type Subtype PubMed ID
esv28726 CNV loss 19812545
nsv1074731 CNV deletion 25765185
nsv1126693 CNV deletion 24896259
nsv1140350 OTHER inversion 24896259
nsv829988 CNV loss 17160897
nsv829989 CNV loss 17160897
nsv966293 CNV duplication 23825009

Variation tolerance for TMEM150C Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM150C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM150C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM150C Gene

Disorders for TMEM150C Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMEM150C Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
malignant hemangioma
chromosome 4q21 deletion syndrome
  • 4q21 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM150C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM150C
genes like me logo Genes that share disorders with TMEM150C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM150C Gene

Publications for TMEM150C Gene

  1. Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function. (PMID: 27321926) Hong GS … Oh U (Neuron 2016) 2 3 60
  2. Plasticity of PI4KIIIα interactions at the plasma membrane. (PMID: 25608530) Chung J … De Camilli P (EMBO reports 2015) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Evidence for Mechanosensitive Channel Activity of Tentonin 3/TMEM150C. (PMID: 28426962) Hong GS … Oh U (Neuron 2017) 3 60
  5. Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization. (PMID: 28426961) Dubin AE … Patapoutian A (Neuron 2017) 3 60

Products for TMEM150C Gene

Sources for TMEM150C Gene

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