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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMEM150C Gene

protein-coding GIFtS: 37
GCID: GC04M083405

transmembrane protein 150C

Search for TMEM150C
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transmembrane Protein 150C¹ ²
FLJ12993¹

External Ids:	HGNC: 37263¹	Entrez Gene: 441027²	Ensembl: ENSG00000249242⁷	UniProtKB: B9EJG8³

Export aliases for TMEM150C gene to outside databases

Previous GC identifers: GC04M083625 GC04M079146

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for TMEM150C
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM150C

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.22 Ensembl cytogenetic band: 4q21.22 HGNC cytogenetic band: 4q21.22

TMEM150C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM150C gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M083405: view genomic region (about GC identifiers)

Start:	83,405,604 bp from pter	End:	83,483,510 bp from pter
Size:	77,907 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: T150C_HUMAN, B9EJG8 (See protein sequence)

Recommended Name: Transmembrane protein 150C

Size: 249 amino acids; 27887 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Sequence caution: Sequence=BAH12581.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: B7Z4J5 B7Z4L3 B7Z692 B7Z6X6

Alternative splicing: 2 isoforms: B9EJG8-1 B9EJG8-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM150C: NX_B9EJG8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_B9EJG8

TMEM150C Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001073975.1

ENSEMBL proteins:

ENSP00000403438 ENSP00000420919 ENSP00000421812 ENSP00000414988

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

TMEM150C for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TMEM150C for domains About GeneDecksing

1 InterPro domain/family:

IPR019402 Frag1/DRAM/Sfk1

Graphical View of Domain Structure for InterPro Entry B9EJG8

ProtoNet protein and cluster: B9EJG8

UniProtKB/Swiss-Prot: T150C_HUMAN, B9EJG8

Similarity: Belongs to the DRAM/TMEM150 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TMEM150C

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMEM150C

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for TMEM150C gene:

NM_001080506.1

Unigene Cluster for TMEM150C:

Transmembrane protein 150C

Hs.507676 [show with all ESTs]

Unigene Representative Sequence: AK023055

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000449862(uc003hmy.1 uc011ccj.1) ENST00000515780 ENST00000508701

ENST00000454948

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Additional cDNA sequence:

AK023055.1 AK297434.1 AK297512.1 AK299942.1 AK301116.1 BC052613.1 BC147019.1 BC147027.1

15 DOTS entries:

DT.210234 DT.102841544 DT.91782228 DT.121267590 DT.408054 DT.100742261 DT.100749240 DT.100749249

DT.100749272 DT.100749323 DT.91782213 DT.91782227 DT.91949128 DT.95320945 DT.99926814

24/42 AceView cDNA sequences (see all 42):

BX445921 BU679345 AI698261 AW118721 AI619704 AA599064 AI933703 BF508344

AA825354 CA431740 BC052613 AI281035 AA340534 AI978713 BX357863 AW300364

AU130068 BX103325 AI418232 AK023055 BF508608 AW498715 BE855829 AU118042

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM150C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCAAAGAAA

About this image

TMEM150C expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TMEM150C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM150C

SOURCE GeneReport for Unigene cluster: Hs.507676

SABiosciences Custom PCR Arrays for TMEM150C

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TMEM150C gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TMEM150C¹	transmembrane protein 150C	80.19(n) 90.76(a)		422599 XM_420558.3 XP_420558.3
zebrafish (Danio rerio)	Actinopterygii	tmem150c¹	transmembrane protein 150C	68.43(n) 66.67(a)		100003020 XM_001342631.4 XP_001342667.2
fruit fly (Drosophila melanogaster)	Insecta	CG4025⁶	--	22(a)	1 → many	X(1970999-1972488)
worm (Caenorhabditis elegans)	Secernentea	C33A11.2⁶	--	20(a)	1 → many	X(15365925-15369931)

ENSEMBL Gene Tree for TMEM150C (if available)
TreeFam Gene Tree for TMEM150C (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TMEM150C gene

DRAM2² TMEM150A² DRAM1² TMEM150B²

1 SIMAP similar gene for TMEM150C using alignment to 3 protein entries: T150C_HUMAN (see all proteins):

TMEM150B

TMEM150C for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6829850^1,2	C,A	--	83405125(+)	`TTTTTA/GGTAGA`	1	--	ds500¹		3		WA NA EA	242
rs6853718^1,2	C	--	83405232(+)	`gagccC/Tcacac`	1	--	ds500¹		2		WA	120
rs59516886^1,2	F	--	83405237(+)	`CCACAC/TCCAGC`	1	--	ds500¹		1		WA	118
rs6818677^1,2	C,F,A,H	--	83405383(+)	`CTGCTC/TTTCTT`	1	--	ds500¹		25		NS EA NA WA CSA	1427
rs181291556^1,2		--	83405546(+)	`CCAAAC/TTTGAA`	1	--	ds500¹		0	--	--	--	--
rs199530437^1,2	C	--	83405564(+)	`TAATCA/CAAAAA`	1	--	ds500¹		0	--	--	--	--
rs34966322^1,2	C	--	83405565(+)	`AAAAA-/ACCCTA`	1	--	ds500¹		0	--	--	--	--
rs4693446^1,2	C	--	83405958(+)	`CTTGTT/ACCAGG`	1	--	ut3¹		2		WA EA	122
rs185067237^1,2		--	83406042(+)	`ACAGCA/GGCGGG`	1	--	ut3¹		0	--	--	--	--
rs146529367^1,2		--	83406047(+)	`GGCGGG/TCTTTG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TMEM150C (83405604 - 83483510 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMEM150C
1 Indel: 68757

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMEM150C gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM150C)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 441027	HGNC: 37263	AceView: LOC441027	Ensembl:ENSG00000249242	euGenes: HUgn441027
ECgene: TMEM150C	H-InvDB: TMEM150C

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TMEM150C	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMEM150C gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TMEM150C gene:
Search GeneIP for patents involving TMEM150C

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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TMEM150C Gene

transmembrane protein 150C

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TMEM150C Gene

transmembrane protein 150C

Aliasesfor TMEM150C gene

Summariesfor TMEM150C gene

Genomic Viewsfor TMEM150C gene

Proteinsfor TMEM150C gene

Protein Domains /Familiesfor TMEM150C gene

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for TMEM150C gene

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for TMEM150C gene

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for TMEM150C gene

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for TMEM150C gene

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for TMEM150C gene

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for TMEM150C gene

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