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Aliases for TMEM150C Gene

Aliases for TMEM150C Gene

  • Transmembrane Protein 150C 2 3 5
  • Tentonin 3 2 3
  • TTN3 3

External Ids for TMEM150C Gene

Previous GeneCards Identifiers for TMEM150C Gene

  • GC04M083625
  • GC04M083405
  • GC04M079146

Summaries for TMEM150C Gene

GeneCards Summary for TMEM150C Gene

TMEM150C (Transmembrane Protein 150C) is a Protein Coding gene. Diseases associated with TMEM150C include Chromosome 4Q21 Deletion Syndrome. An important paralog of this gene is TMEM150B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM150C Gene

Genomics for TMEM150C Gene

Regulatory Elements for TMEM150C Gene

Enhancers for TMEM150C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G082742 1.4 Ensembl ENCODE dbSUPER 16.4 -183.8 -183822 6.8 TBP NFIB GLIS2 GATA4 EGR1 ZNF143 FOS BCLAF1 KDM4B EGR2 TMEM150C SCD5 MIR575 PIR47609
GH04G082715 1.2 Ensembl ENCODE dbSUPER 16.7 -153.9 -153861 1.9 SOX13 SCRT1 PKNOX1 CEBPB ATF2 GATA3 SCRT2 CREB1 BCL6 ZBTB33 TMEM150C MIR575 PIR47609
GH04G082701 0.9 dbSUPER 20.2 -136.2 -136179 2.1 MLX ARID4B SIN3A TCF12 GATA2 FOS MAFF SMARCA4 HMBOX1 NR2C1 TMEM150C MIR575 GPAT3 PQLC1P2 PIR47609
GH04G082700 0.9 dbSUPER 20.2 -136.0 -136031 2.3 MLX ARID4B SIN3A TCF12 GATA2 FOS MAFF SMARCA4 HMBOX1 NR2C1 TMEM150C MIR575 GPAT3 PQLC1P2 PIR47609
GH04G082699 0.9 dbSUPER 20.2 -136.0 -135981 2.7 MLX ARID4B SIN3A TCF12 GATA2 FOS MAFF SMARCA4 HMBOX1 NR2C1 TMEM150C MIR575 GPAT3 PQLC1P2 PIR47609
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM150C on UCSC Golden Path with GeneCards custom track

Promoters for TMEM150C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000170006 73 1001 CTCF SUZ12 ZNF384 ZBTB8A RBBP5 FOXM1 ZNF610 POLR2A ZNF366 GLIS1

Genomic Location for TMEM150C Gene

Chromosome:
4
Start:
82,483,170 bp from pter
End:
82,562,357 bp from pter
Size:
79,188 bases
Orientation:
Minus strand

Genomic View for TMEM150C Gene

Genes around TMEM150C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM150C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM150C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM150C Gene

Proteins for TMEM150C Gene

  • Protein details for TMEM150C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B9EJG8-T150C_HUMAN
    Recommended name:
    Transmembrane protein 150C
    Protein Accession:
    B9EJG8
    Secondary Accessions:
    • B7Z4J5
    • B7Z4L3
    • B7Z692
    • B7Z6X6

    Protein attributes for TMEM150C Gene

    Size:
    249 amino acids
    Molecular mass:
    27887 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAH12581.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM150C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM150C Gene

Post-translational modifications for TMEM150C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM150C Gene

No data available for DME Specific Peptides for TMEM150C Gene

Domains & Families for TMEM150C Gene

Protein Domains for TMEM150C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM150C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B9EJG8

UniProtKB/Swiss-Prot:

T150C_HUMAN :
  • Belongs to the DRAM/TMEM150 family.
Family:
  • Belongs to the DRAM/TMEM150 family.
genes like me logo Genes that share domains with TMEM150C: view

No data available for Gene Families for TMEM150C Gene

Function for TMEM150C Gene

Phenotypes for TMEM150C Gene

GenomeRNAi human phenotypes for TMEM150C:
genes like me logo Genes that share phenotypes with TMEM150C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM150C Gene

Localization for TMEM150C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM150C Gene

Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Note=Localizes at the plasma membrane. A portion co-localizes with LAMP1 lysosomal marker (PubMed:25608530). {ECO:0000269 PubMed:25608530}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM150C gene
Compartment Confidence
plasma membrane 5
lysosome 5

Gene Ontology (GO) - Cellular Components for TMEM150C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane TAS 25608530
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IDA 25608530
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM150C: view

Pathways & Interactions for TMEM150C Gene

SuperPathways for TMEM150C Gene

No Data Available

Interacting Proteins for TMEM150C Gene

Gene Ontology (GO) - Biological Process for TMEM150C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM150C Gene

Transcripts for TMEM150C Gene

Unigene Clusters for TMEM150C Gene

Transmembrane protein 150C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM150C Gene

No ASD Table

Relevant External Links for TMEM150C Gene

GeneLoc Exon Structure for
TMEM150C
ECgene alternative splicing isoforms for
TMEM150C

Expression for TMEM150C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM150C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM150C Gene

This gene is overexpressed in Adrenal Gland (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of TMEM150C Gene:

TMEM150C

SOURCE GeneReport for Unigene cluster for TMEM150C Gene:

Hs.507676

Evidence on tissue expression from TISSUES for TMEM150C Gene

  • Nervous system(4.3)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with TMEM150C: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM150C Gene

Orthologs for TMEM150C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM150C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM150C 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia TMEM150C 34 35
  • 93.98 (n)
cow
(Bos Taurus)
Mammalia TMEM150C 34 35
  • 93.31 (n)
rat
(Rattus norvegicus)
Mammalia Tmem150c 34
  • 88.09 (n)
mouse
(Mus musculus)
Mammalia Tmem150c 34 16 35
  • 87.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM150C 35
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM150C 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM150C 34 35
  • 80.19 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM150C 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem150c 34
  • 73.92 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem150c 34 35
  • 68.43 (n)
Species where no ortholog for TMEM150C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM150C Gene

ENSEMBL:
Gene Tree for TMEM150C (if available)
TreeFam:
Gene Tree for TMEM150C (if available)

Paralogs for TMEM150C Gene

Paralogs for TMEM150C Gene

(1) SIMAP similar genes for TMEM150C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMEM150C: view

Variants for TMEM150C Gene

Sequence variations from dbSNP and Humsavar for TMEM150C Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000029670 -- 82,528,846(+) GCCTC(A/G)GCCTC intron-variant
rs1000044853 -- 82,523,290(+) CAGTC(A/G)GGTGT intron-variant
rs1000065033 -- 82,530,295(+) GCTCA(A/C)GCCTG intron-variant
rs10001408 -- 82,507,270(+) TAATG(C/T)ACAAT intron-variant
rs1000160956 -- 82,535,679(+) GACCT(C/G)GGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM150C Gene

Variant ID Type Subtype PubMed ID
esv28726 CNV loss 19812545
nsv1074731 CNV deletion 25765185
nsv1126693 CNV deletion 24896259
nsv1140350 OTHER inversion 24896259
nsv829988 CNV loss 17160897
nsv829989 CNV loss 17160897
nsv966293 CNV duplication 23825009

Variation tolerance for TMEM150C Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM150C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM150C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM150C Gene

Disorders for TMEM150C Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM150C Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chromosome 4q21 deletion syndrome
  • 4q21 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM150C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM150C
genes like me logo Genes that share disorders with TMEM150C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM150C Gene

Publications for TMEM150C Gene

  1. Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function. (PMID: 27321926) Hong G.S. … Oh U. (Neuron 2016) 2 3 64
  2. Plasticity of PI4KIIIalpha interactions at the plasma membrane. (PMID: 25608530) Chung J. … De Camilli P. (EMBO Rep. 2015) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for TMEM150C Gene

Sources for TMEM150C Gene

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