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TMEM150B Gene

protein-coding   GIFtS: 39
GCID: GC19M055824

Transmembrane Protein 150B

(Previous name: transmembrane protein 224)
(Previous symbol: TMEM224)
  Search for TMEM150B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 150B1 2
Transmembrane Protein 2241 2 3
TMEM2241 2 3
hCG16514762
Transmembrane Protein LOC2844172

External Ids:    HGNC: 344151   Entrez Gene: 2844172   Ensembl: ENSG000001800617   UniProtKB: A6NC513   

Export aliases for TMEM150B gene to outside databases

Previous GC identifers: GC19M060519 GC19M052146


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMEM150B Gene:
This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of
membrane-spanning proteins. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Aug
2013)

GeneCards Summary for TMEM150B Gene:
TMEM150B (transmembrane protein 150B) is a protein-coding gene. An important paralog of this gene is TMEM150A.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TMEM150B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TMEM150B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM150B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

TMEM150B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM150B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M055824:  view genomic region     (about GC identifiers)

Start:
55,824,169 bp from pter      End:
55,845,416 bp from pter
Size:
21,248 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: T150B_HUMAN, A6NC51 (See protein sequence)
Recommended Name: Transmembrane protein 150B precursor  
Size: 233 amino acids; 25701 Da
Secondary accessions: B7ZW71

Explore the universe of human proteins at neXtProt for TMEM150B: NX_A6NC51

Explore proteomics data for TMEM150B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn30

  • See TMEM150B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001078957.1  NP_001268940.1  

    ENSEMBL proteins: 
     ENSP00000320757   ENSP00000468745   ENSP00000466957   ENSP00000465672   ENSP00000465815  
     ENSP00000466297   ENSP00000412658  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR019402 Frag1/DRAM/Sfk1
     IPR027315 DRAM/TMEM150

    Graphical View of Domain Structure for InterPro Entry A6NC51

    ProtoNet protein and cluster: A6NC51

    UniProtKB/Swiss-Prot: T150B_HUMAN, A6NC51
    Similarity: Belongs to the DRAM/TMEM150 family


    TMEM150B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM150B
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T150B_HUMAN, A6NC51: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    TMEM150B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM150B
    Interactions:

        Search GeneGlobe Interaction Network for TMEM150B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM150B (T150B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM150B gene (2 alternative transcripts): 
    NM_001085488.2  NM_001282011.1  

    Unigene Cluster for TMEM150B:

    Transmembrane protein 150B
    Hs.382625  [show with all ESTs]
    Unigene Representative Sequence: BC020862
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326652(uc010yfu.1 uc010yfv.1 uc002qki.3) ENST00000592603
    ENST00000586609 ENST00000585918 ENST00000592731 ENST00000591570 ENST00000592891
    ENST00000438693(uc010esw.1 uc010yfw.1)
    miRNA
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    Additional mRNA sequence: 

    BC020862.1 BC171893.1 BC171901.1 BC171904.1 

    4 DOTS entries:

    DT.91943190  DT.101970693  DT.121505329  DT.97815280 

    5 AceView cDNA sequences:

    BM922629 BM712598 BC020862 BF934961 BG400141 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM150B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
    SP1:                                                                  
    SP2:              -     -                       -                     


    ECgene alternative splicing isoforms for TMEM150B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM150B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTGTTCG
    TMEM150B Expression
    About this image

    TMEM150B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM150B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.382625
        Custom PCR Arrays for TMEM150B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM150B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM150B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem150b1 , 5 transmembrane protein 150B1, 5 76.78(n)1
    75.36(a)1
      7 (2.72 cM)5
    3304601  NM_001142792.11  NP_001136264.11 
     47068325 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM150B6
    transmembrane protein 150B
    41(a)
    1 ↔ 1
    GL343329.1(1276642-1286186)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.133812 Xenopus laevis transcribed sequence with weak similarity more 72.69(n)    BJ061647.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1232441 zgc:123244 53.14(n)
    43.4(a)
      556933  NM_001037381.1  NP_001032458.1 


    ENSEMBL Gene Tree for TMEM150B (if available)
    TreeFam Gene Tree for TMEM150B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM150B gene
    TMEM150A2  TMEM150C2  
    2 SIMAP similar genes for TMEM150B using alignment to 5 protein entries:     T150B_HUMAN (see all proteins):
    DRAM2    TMEM150C

    TMEM150B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM150B (see all 344)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1388523011,2
    --52160907(+) GGATTA/GCAGGT 1 -- us2k10--------
    rs1916445971,2
    C--52160913(+) CAGGTC/GAGAGC 1 -- us2k10--------
    rs1843198731,2
    --52160999(+) CACATC/TGGGCA 1 -- us2k10--------
    rs2005522491,2
    C--55824454(+) GCTACC/TGTGAC 1 -- int10--------
    rs1834021731,2
    --55824504(+) TGGGCA/GGAGGC 1 -- int10--------
    rs799248021,2
    C,F--55824549(+) TCCCCC/TGTAGC 1 -- int11Minor allele frequency- T:0.02EA 120
    rs48066591,2
    C,F,A,H--55824586(+) TCTCCG/AATGCT 1 -- int120Minor allele frequency- A:0.33NS EA NA WA CSA 2342
    rs48066601,2
    C,F,A,H--55824634(+) TTTCCT/CTTGCG 1 -- int124Minor allele frequency- C:0.30NS EA NA WA CSA 2530
    rs48066611,2
    C,F,A,H--55824661(+) TTGCAA/TTCCTA 1 -- int131Minor allele frequency- T:0.34NA NS EA WA CSA 2901
    rs722392811,2
    C--55824818(+) CGGAC-/TGTGTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TMEM150B (55824169 - 55845416 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TMEM150B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912457CNV Loss21882294
    nsv912459CNV Loss21882294
    dgv4016n71CNV Loss21882294
    nsv912460CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    TMEM150B for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMEM150B

    Export disorders for TMEM150B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM150B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMEM150B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PubMed id 22267201)1, 4 Stolk L....Lunetta K.L. (Nat. Genet. 2012)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    3. A genome-wide association study of early menopause and the combined impact of identified variants. (PubMed id 23307926)1 Perry J.R....Murray A. (Hum. Mol. Genet. 2013)
    4. Loci at chromosomes 13, 19 and 20 influence age at natural menopause. (PubMed id 19448619)1 Stolk L....Uitterlinden A.G. (Nat. Genet. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284417 HGNC: 34415 AceView: LOC284417 Ensembl:ENSG00000180061 euGenes: HUgn284417
    ECgene: TMEM150B H-InvDB: TMEM150B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM150B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM150B gene:
    Search GeneIP for patents involving TMEM150B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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