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Aliases for TMEM150B Gene

Aliases for TMEM150B Gene

  • Transmembrane Protein 150B 2 3
  • Transmembrane Protein 224 2 3 4
  • TMEM224 3 4
  • Transmembrane Protein LOC284417 3
  • HCG1651476 3

External Ids for TMEM150B Gene

Previous HGNC Symbols for TMEM150B Gene

  • TMEM224

Previous GeneCards Identifiers for TMEM150B Gene

  • GC19M060519
  • GC19M055824
  • GC19M052146

Summaries for TMEM150B Gene

Entrez Gene Summary for TMEM150B Gene

  • This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for TMEM150B Gene

TMEM150B (Transmembrane Protein 150B) is a Protein Coding gene. An important paralog of this gene is TMEM150A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM150B Gene

Genomics for TMEM150B Gene

Genomic Location for TMEM150B Gene

Start:
55,312,285 bp from pter
End:
55,334,048 bp from pter
Size:
21,764 bases
Orientation:
Minus strand

Genomic View for TMEM150B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM150B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM150B Gene

No data available for Regulatory Elements for TMEM150B Gene

Proteins for TMEM150B Gene

  • Protein details for TMEM150B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NC51-T150B_HUMAN
    Recommended name:
    Transmembrane protein 150B
    Protein Accession:
    A6NC51
    Secondary Accessions:
    • B7ZW71

    Protein attributes for TMEM150B Gene

    Size:
    233 amino acids
    Molecular mass:
    25701 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM150B Gene

Proteomics data for TMEM150B Gene at MOPED

Post-translational modifications for TMEM150B Gene

Other Protein References for TMEM150B Gene

No data available for DME Specific Peptides for TMEM150B Gene

Domains for TMEM150B Gene

Protein Domains for TMEM150B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM150B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NC51

UniProtKB/Swiss-Prot:

T150B_HUMAN :
  • A6NC51
Family:
  • Belongs to the DRAM/TMEM150 family.
genes like me logo Genes that share domains with TMEM150B: view

No data available for Gene Families for TMEM150B Gene

Function for TMEM150B Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM150B Gene

Localization for TMEM150B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM150B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM150B Gene COMPARTMENTS Subcellular localization image for TMEM150B gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM150B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM150B: view

Pathways for TMEM150B Gene

SuperPathways for TMEM150B Gene

No Data Available

Interacting Proteins for TMEM150B Gene

Gene Ontology (GO) - Biological Process for TMEM150B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030262 apoptotic nuclear changes IBA --
genes like me logo Genes that share ontologies with TMEM150B: view

No data available for Pathways by source for TMEM150B Gene

Transcripts for TMEM150B Gene

mRNA/cDNA for TMEM150B Gene

(4) Additional mRNA sequences :
(11) REFSEQ mRNAs :
(5) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM150B Gene

Transmembrane protein 150B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM150B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TMEM150B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM150B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1:
SP2: - - -

Relevant External Links for TMEM150B Gene

GeneLoc Exon Structure for
TMEM150B
ECgene alternative splicing isoforms for
TMEM150B

Expression for TMEM150B Gene

mRNA expression in normal human tissues for TMEM150B Gene

mRNA differential expression in normal tissues according to GTEx for TMEM150B Gene

This gene is overexpressed in Whole Blood (12.1), Small Intestine - Terminal Ileum (9.5), and Colon - Transverse (4.9).

SOURCE GeneReport for Unigene cluster for TMEM150B Gene Hs.382625

genes like me logo Genes that share expressions with TMEM150B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for TMEM150B Gene

Orthologs for TMEM150B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM150B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM150B 35
  • 99.14 (n)
  • 99.14 (a)
TMEM150B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM150B 35
  • 80.11 (n)
  • 76.39 (a)
TMEM150B 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM150B 35
  • 84.27 (n)
  • 76.64 (a)
TMEM150B 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem150b 35
  • 76.78 (n)
  • 75.36 (a)
Tmem150b 16
Tmem150b 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM150B 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM150B 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem150b 35
  • 76.32 (n)
  • 73.83 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM150B 36
  • 41 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13381 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10343 35
tmem150b 35
  • 58.37 (n)
  • 53.17 (a)
zebrafish
(Danio rerio)
Actinopterygii TMEM150B 36
  • 40 (a)
OneToOne
zgc:123244 35
  • 53.14 (n)
  • 43.4 (a)
Species with no ortholog for TMEM150B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM150B Gene

ENSEMBL:
Gene Tree for TMEM150B (if available)
TreeFam:
Gene Tree for TMEM150B (if available)

Paralogs for TMEM150B Gene

Paralogs for TMEM150B Gene

Selected SIMAP similar genes for TMEM150B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM150B: view

Variants for TMEM150B Gene

Sequence variations from dbSNP and Humsavar for TMEM150B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs734517 -- 55,321,708(+) TCCAG(A/C)CTGGA intron-variant
rs734518 -- 55,321,516(+) GTCTT(A/G)GGTCT intron-variant
rs897794 -- 55,320,208(+) CCACC(A/C)AGAAC intron-variant
rs897795 -- 55,320,209(+) CACCA(A/C)GAACT intron-variant
rs897796 -- 55,320,221(+) CTGGG(A/G)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM150B Gene

Variant ID Type Subtype PubMed ID
dgv4016n71 CNV Loss 21882294
nsv912457 CNV Loss 21882294
nsv912459 CNV Loss 21882294
nsv912460 CNV Loss 21882294

Relevant External Links for TMEM150B Gene

HapMap Linkage Disequilibrium report
TMEM150B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM150B Gene

Disorders for TMEM150B Gene

Relevant External Links for TMEM150B

Genetic Association Database (GAD)
TMEM150B
genes like me logo Genes that share disorders with TMEM150B: view

No data available for UniProtKB/Swiss-Prot for TMEM150B Gene

Publications for TMEM150B Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  2. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L. … Lunetta K.L. (Nat. Genet. 2012) 3 48
  3. A genome-wide association study of early menopause and the combined impact of identified variants. (PMID: 23307926) Perry J.R. … Murray A. (Hum. Mol. Genet. 2013) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Loci at chromosomes 13, 19 and 20 influence age at natural menopause. (PMID: 19448619) Stolk L. … Uitterlinden A.G. (Nat. Genet. 2009) 3

Products for TMEM150B Gene

Sources for TMEM150B Gene

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