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Aliases for TMEM150B Gene

Aliases for TMEM150B Gene

  • Transmembrane Protein 150B 2 3 4 5
  • Transmembrane Protein 224 2 3 4
  • Protein DRAM-3 3 4
  • Tentonin 2 2 3
  • TMEM224 3 4
  • Modulator Of Macroautophagy TMEM150B 3
  • Transmembrane Protein LOC284417 3
  • HCG1651476 3
  • DRAM3 3
  • TTN2 3

External Ids for TMEM150B Gene

Previous HGNC Symbols for TMEM150B Gene

  • TMEM224

Previous GeneCards Identifiers for TMEM150B Gene

  • GC19M060519
  • GC19M055824
  • GC19M052146
  • GC19M055313

Summaries for TMEM150B Gene

Entrez Gene Summary for TMEM150B Gene

  • This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for TMEM150B Gene

TMEM150B (Transmembrane Protein 150B) is a Protein Coding gene. An important paralog of this gene is TMEM150A.

UniProtKB/Swiss-Prot for TMEM150B Gene

  • Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (PubMed:25929859). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (PubMed:25929859). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (PubMed:25929859).

Additional gene information for TMEM150B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM150B Gene

Genomics for TMEM150B Gene

GeneHancer (GH) Regulatory Elements for TMEM150B Gene

Promoters and enhancers for TMEM150B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I055320 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 561.7 +10.7 10722 5.7 BACH1 ZNF384 CEBPG E4F1 ZNF316 POLR2A SCRT2 NFE2 MAFK CREM TMEM150B FCAR FAM71E2 IL11 TMEM190 BRSK1 HSPBP1 PPP6R1 TMEM238 RPL28
GH19I055333 Enhancer 0.9 ENCODE 550.8 -0.1 -60 1.4 FOXA2 ARID4B FEZF1 DMAP1 ZNF48 ETS1 SLC30A9 FOS ATF7 ZHX2 TMEM150B KMT5C
GH19I055300 Promoter/Enhancer 1.4 Ensembl ENCODE 12.3 +32.2 32201 2 SIN3A ZBTB7B POLR2B GLIS2 ZNF207 ZNF143 ATF7 RUNX3 KLF13 SP3 TMEM86B TMEM150B KMT5C HSPBP1 PPP6R1 RPL28 TMEM238 UBE2S TMEM190 ZNF628
GH19I055304 Enhancer 0.8 ENCODE 12.3 +29.6 29580 0.2 ATF1 ZNF76 DEAF1 ZBTB40 ETS1 ZNF766 ZNF143 SMARCC2 CREM THAP11 TMEM150B KMT5C HSPBP1 BRSK1 PPP6R1 RPL28 TMEM238 UBE2S TMEM190 ZNF628
GH19I055307 Enhancer 0.8 ENCODE 12.3 +28.4 28390 0.2 ATF1 ZNF76 SIN3A DEAF1 ZBTB40 ETS1 ZNF335 ZNF766 ZNF143 SMARCC2 TMEM150B KMT5C BRSK1 HSPBP1 PPP6R1 TMEM238 RPL28 UBE2S TMEM190 ZNF628
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM150B on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM150B Gene

Genomic Locations for TMEM150B Gene
chr19:55,308,886-55,334,048
(GRCh38/hg38)
Size:
25,163 bases
Orientation:
Minus strand
chr19:55,824,169-55,845,416
(GRCh37/hg19)

Genomic View for TMEM150B Gene

Genes around TMEM150B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM150B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM150B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM150B Gene

Proteins for TMEM150B Gene

  • Protein details for TMEM150B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NC51-T150B_HUMAN
    Recommended name:
    Modulator of macroautophagy TMEM150B
    Protein Accession:
    A6NC51
    Secondary Accessions:
    • B7ZW71

    Protein attributes for TMEM150B Gene

    Size:
    233 amino acids
    Molecular mass:
    25701 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM150B Gene

Post-translational modifications for TMEM150B Gene

No data available for DME Specific Peptides for TMEM150B Gene

Domains & Families for TMEM150B Gene

Gene Families for TMEM150B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM150B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM150B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NC51

UniProtKB/Swiss-Prot:

T150B_HUMAN :
  • Belongs to the DRAM/TMEM150 family.
Family:
  • Belongs to the DRAM/TMEM150 family.
genes like me logo Genes that share domains with TMEM150B: view

Function for TMEM150B Gene

Molecular function for TMEM150B Gene

UniProtKB/Swiss-Prot Function:
Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (PubMed:25929859). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (PubMed:25929859). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (PubMed:25929859).
UniProtKB/Swiss-Prot Induction:
Is not markedly up- or down-regulated by DNA damage, nutrient deprivation or by exposure to TNF-alpha and IFN-gamma (PubMed:25929859).

Phenotypes From GWAS Catalog for TMEM150B Gene

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM150B Gene

Localization for TMEM150B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM150B Gene

Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Note=Localizes mainly at the plasma membrane where it concentrates at actin-rich focal adhesions (PubMed:25608530, PubMed:25929859). {ECO:0000269 PubMed:25608530, ECO:0000269 PubMed:25929859}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM150B gene
Compartment Confidence
plasma membrane 5
lysosome 3
endosome 3

Gene Ontology (GO) - Cellular Components for TMEM150B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane IEA --
GO:0005764 lysosome IBA --
GO:0005768 endosome IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IDA 25608530
genes like me logo Genes that share ontologies with TMEM150B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM150B Gene

Pathways & Interactions for TMEM150B Gene

SuperPathways for TMEM150B Gene

No Data Available

Interacting Proteins for TMEM150B Gene

Gene Ontology (GO) - Biological Process for TMEM150B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
genes like me logo Genes that share ontologies with TMEM150B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM150B Gene

Drugs & Compounds for TMEM150B Gene

No Compound Related Data Available

Transcripts for TMEM150B Gene

mRNA/cDNA for TMEM150B Gene

(13) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM150B Gene

Transmembrane protein 150B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM150B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1:
SP2: - - -

Relevant External Links for TMEM150B Gene

GeneLoc Exon Structure for
TMEM150B
ECgene alternative splicing isoforms for
TMEM150B

Expression for TMEM150B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM150B Gene

mRNA differential expression in normal tissues according to GTEx for TMEM150B Gene

This gene is overexpressed in Whole Blood (x12.1), Small Intestine - Terminal Ileum (x9.5), and Colon - Transverse (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of TMEM150B Gene:

TMEM150B

SOURCE GeneReport for Unigene cluster for TMEM150B Gene:

Hs.382625

mRNA Expression by UniProt/SwissProt for TMEM150B Gene:

A6NC51-T150B_HUMAN
Tissue specificity: Highly expressed in the colon and lung with comparatively high levels also detectable in the lymph nodes, placenta, duodenum, peripheral blood mononuclear cells and spleen (PubMed:25929859).

Evidence on tissue expression from TISSUES for TMEM150B Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TMEM150B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM150B Gene

Orthologs for TMEM150B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM150B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM150B 33 34
  • 99.14 (n)
dog
(Canis familiaris)
Mammalia TMEM150B 33 34
  • 84.27 (n)
cow
(Bos Taurus)
Mammalia TMEM150B 33 34
  • 80.11 (n)
mouse
(Mus musculus)
Mammalia Tmem150b 33 16 34
  • 76.78 (n)
rat
(Rattus norvegicus)
Mammalia Tmem150b 33
  • 76.32 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM150B 34
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM150B 34
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM150B 34
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem150b 33
  • 58.37 (n)
Str.10343 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13381 33
zebrafish
(Danio rerio)
Actinopterygii zgc:123244 33
  • 53.14 (n)
TMEM150B 34
  • 40 (a)
OneToOne
Species where no ortholog for TMEM150B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM150B Gene

ENSEMBL:
Gene Tree for TMEM150B (if available)
TreeFam:
Gene Tree for TMEM150B (if available)

Paralogs for TMEM150B Gene

Paralogs for TMEM150B Gene

(2) SIMAP similar genes for TMEM150B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM150B: view

Variants for TMEM150B Gene

Sequence variations from dbSNP and Humsavar for TMEM150B Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000146373 -- 55,327,737(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000172205 -- 55,312,723(-) G/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000656340 -- 55,323,030(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000724467 -- 55,333,468(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000822973 -- 55,330,697(-) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM150B Gene

Variant ID Type Subtype PubMed ID
nsv953624 CNV deletion 24416366

Variation tolerance for TMEM150B Gene

Residual Variation Intolerance Score: 68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM150B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM150B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM150B Gene

Disorders for TMEM150B Gene

Additional Disease Information for TMEM150B

No disorders were found for TMEM150B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM150B Gene

Publications for TMEM150B Gene

  1. Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function. (PMID: 27321926) Hong GS … Oh U (Neuron 2016) 2 3 58
  2. Plasticity of PI4KIIIα interactions at the plasma membrane. (PMID: 25608530) Chung J … De Camilli P (EMBO reports 2015) 3 4 58
  3. DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose. (PMID: 25929859) Mrschtik M … Ryan KM (Cell death and differentiation 2015) 3 4 58
  4. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L … Lunetta KL (Nature genetics 2012) 3 44 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58

Products for TMEM150B Gene

Sources for TMEM150B Gene

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