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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM150A Gene

protein-coding   GIFtS: 43
GCID: GC02M085825

transmembrane protein 150A

(Previous name: transmembrane protein 150 )
(Previous symbol: TMEM150)
  Search for TMEM150A
in our new
 Human Malady Compendium 
Biological research products
for TMEM150A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transmembrane Protein 150A1 2
Transmembrane Protein 1501 2 3
TMEM1501 2 3
TM6P11 2
FLJ900241
Fasting-Inducible Integral Membrane Protein TM6P12

External Ids:    HGNC: 246771   Entrez Gene: 1293032   Ensembl: ENSG000001688907   UniProtKB: Q86TG13   
ORGUL members:         
NONCODE:n409080    

Export aliases for TMEM150A gene to outside databases

Previous GC identifers: GC02M085680 GC02M085723


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: T150A_HUMAN, Q86TG1
Function: Possible role in fasting-induced catabolism (By similarity)

Gene Wiki entry for TMEM150A (TMEM150)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TMEM150A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM150A promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM150A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM150A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

TMEM150A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM150A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M085825:  view genomic region     (about GC identifiers)

Start:
85,825,670 bp from pter      End:
85,830,319 bp from pter
Size:
4,650 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: T150A_HUMAN, Q86TG1 (See protein sequence)
Recommended Name: Transmembrane protein 150A precursor  
Size: 271 amino acids; 28835 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: A8K764 B7WPQ9 D6W5L2 Q8N2R6
Alternative splicing: 2 isoforms:  Q86TG1-1   Q86TG1-2   

Explore the universe of human proteins at neXtProt for TMEM150A: NX_Q86TG1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86TG1

  • TMEM150A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001026908.1  
    ENSEMBL proteins: 
     ENSP00000302715   ENSP00000334708   ENSP00000387292   ENSP00000409224   ENSP00000388247  
     ENSP00000394945   ENSP00000401631  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 3): TMEM150A
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    Novus Biologicals TMEM150A Protein
    Novus Biologicals TMEM150A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TMEM150A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--


    TMEM150A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TMEM150A


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TMEM150A for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019402 Frag1/DRAM/Sfk1

    Graphical View of Domain Structure for InterPro Entry Q86TG1

    ProtoNet protein and cluster: Q86TG1

    UniProtKB/Swiss-Prot: T150A_HUMAN, Q86TG1
    Similarity: Belongs to the DRAM/TMEM150 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: T150A_HUMAN, Q86TG1
    Function: Possible role in fasting-induced catabolism (By similarity)

    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM150A (see all 17):
    hsa-miR-194* hsa-miR-1263 hsa-miR-548k hsa-miR-1184 hsa-miR-124 hsa-miR-3622b-3p hsa-miR-506 hsa-miR-18b*
    SwitchGear 3'UTR luciferase reporter plasmidTMEM150A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM150A (see all 4)
    OriGene shRNA RFP: TMEM150A
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    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM150A

    1 GenomeRNAi human phenotype for TMEM150A:
     Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM150A

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009056catabolic process IEA--


    TMEM150A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM150A
    Search CenterWatch for drugs/clinical trials and news about TMEM150A / T150A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM150A gene (2 alternative transcripts): 
    NM_153342.2  NM_001031738.2  

    Unigene Cluster for TMEM150A:

    Transmembrane protein 150A
    Hs.591559  [show with all ESTs]
    Unigene Representative Sequence: NM_001031738
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306353(uc002spz.2) ENST00000431593(uc002spx.2) ENST00000334462(uc002spy.2)
    ENST00000444380 ENST00000409668 ENST00000463363 ENST00000422458 ENST00000451147
    ENST00000417791 ENST00000425160 ENST00000433956 ENST00000455852

    miRNA
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    OriGene 3'-UTR Clone: TMEM150A
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM150A
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM150A (see all 17):
    hsa-miR-194* hsa-miR-1263 hsa-miR-548k hsa-miR-1184 hsa-miR-124 hsa-miR-3622b-3p hsa-miR-506 hsa-miR-18b*
    SwitchGear 3'UTR luciferase reporter plasmidTMEM150A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM150A (see all 4)
    OriGene shRNA RFP: TMEM150A
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM150A
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM150A (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM150A
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    Additional cDNA sequence: 

    AK074505.1 AK291879.1 BC050466.1 BX647409.1 NR_033179.1 

    14 DOTS entries:

    DT.95078425  DT.100816884  DT.420581  DT.97804596  DT.92023417  DT.100816878  DT.100816879  DT.120979895 
    DT.91777722  DT.100727615  DT.120979884  DT.95078421  DT.95078422  DT.70101995 

    24/129 AceView cDNA sequences (see all 129):

    AK098152 BF569907 CR614257 AI339443 AL542052 AW024548 BX357928 AI381786 
    BX097104 CR595341 BX367160 CR590255 CR600054 BP377766 CD105754 BI830894 
    BM745257 C20837 AI891097 BC050466 AI379416 BQ188244 BI912834 BQ932038 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM150A (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e
    SP1:              -     -           -           -     -           -     -     -                                         -                           
    SP2:              -     -           -           -     -           -     -     -     -                                   -                           
    SP3:                    -           -           -     -           -     -     -                                                                     
    SP4:                                -           -     -           -     -     -                                                                     
    SP5:                                                  -           -     -     -                                                                     


    ECgene alternative splicing isoforms for TMEM150A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM150A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    TMEM150A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TMEM150A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM150A

    SOURCE GeneReport for Unigene cluster: Hs.591559
        SABiosciences Custom PCR Arrays for TMEM150A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM150A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMEM150A gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TMEM150A6
    Uncharacterized protein
    55(a)
    1 ↔ 1
    6(18014516-18019326)
    lizard
    (Anolis carolinensis)
    Reptilia TMEM150A6
    --
    78(a)
    1 ↔ 1
    GL343608.1(135295-144160)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.154652 Xenopus laevis transcribed sequence with weak similarity more 76.4(n)    CA788608.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc662422 hypothetical protein MGC66242 78.27(n)   393483  BC055560.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG40256
    --
    26(a)
    1 → many
    X(1970999-1972488)
    worm
    (Caenorhabditis elegans)
    Secernentea C33A11.26
    --
    21(a)
    1 → many
    X(15365925-15369931)


    ENSEMBL Gene Tree for TMEM150A (if available)
    TreeFam Gene Tree for TMEM150A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMEM150A gene
    DRAM22  DRAM12  TMEM150C2  TMEM150B2  

    TMEM150A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/43 NCBI SNPs in TMEM150A are shown (see all 43    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs31980891,2
    C,F,H,--85825337(+) CTTTTT/CGCTCC 2 -- int18Minor allele frequency- C:0.11MN NS WA CSA NA EA 764
    rs1457593621,2
    --85825340(+) TTTGCA/TCCATT 2 -- int10--------
    rs1386880811,2
    --85825357(+) GCCACC/TTTTAA 2 -- int10--------
    rs1844054641,2
    --85825372(+) TTAAAG/TTTGCT 2 -- int10--------
    rs1426180051,2
    --85825440(+) ACTCTC/GAGTGG 2 -- int10--------
    rs103021,2
    C,--85825575(+) CACTCA/GGCACT 2 -- int15Minor allele frequency- G:0.16WA NA EA 362
    rs1502638301,2
    --85825639(+) TCAGGC/TCCCCC 2 -- int10--------
    rs1899295951,2
    --85825694(+) AATATA/TAAAAA 2 -- ut31 nc-transcript-variant0--------
    rs1129645631,2
    F--85826035(+) GCCCAG/CTCCTC 2 -- nc-transcript-variantut311Minor allele frequency- C:0.50CSA 4
    rs1820932861,2
    --85826041(+) TCCTCC/TATGGC 2 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for TMEM150A (85825670 - 85830319 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TMEM150A: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM150A
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM150A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM150A gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with TMEM150A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Identification of a new gene (rat TM6P1) encoding a fasting-inducible, integral membrane protein with six transmembrane domains. (PubMed id 10858565)1, 3 Zhang J....Underwood L.E. (2000)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    6. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 129303 HGNC: 24677 AceView: FLJ90024 Ensembl:ENSG00000168890 euGenes: HUgn129303
    ECgene: TMEM150A H-InvDB: TMEM150A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM150A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM150A gene:
    Search GeneIP for patents involving TMEM150A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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