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Aliases for TMEM150A Gene

Aliases for TMEM150A Gene

  • Transmembrane Protein 150A 2 3 5
  • Transmembrane Protein 150 2 3 4
  • TMEM150 3 4
  • Fasting-Inducible Integral Membrane Protein TM6P1 3
  • TM6P1 3

External Ids for TMEM150A Gene

Previous HGNC Symbols for TMEM150A Gene

  • TMEM150

Previous GeneCards Identifiers for TMEM150A Gene

  • GC02M085680
  • GC02M085825
  • GC02M085723

Summaries for TMEM150A Gene

GeneCards Summary for TMEM150A Gene

TMEM150A (Transmembrane Protein 150A) is a Protein Coding gene. An important paralog of this gene is TMEM150B.

UniProtKB/Swiss-Prot for TMEM150A Gene

  • Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex (PubMed:25608530). Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:25608530). May also play a role in fasting-induced catabolism (By similarity).

Gene Wiki entry for TMEM150A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM150A Gene

Genomics for TMEM150A Gene

Regulatory Elements for TMEM150A Gene

Enhancers for TMEM150A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM150A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM150A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM150A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM150A Gene

Chromosome:
2
Start:
85,598,547 bp from pter
End:
85,603,196 bp from pter
Size:
4,650 bases
Orientation:
Minus strand

Genomic View for TMEM150A Gene

Genes around TMEM150A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM150A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM150A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM150A Gene

Proteins for TMEM150A Gene

  • Protein details for TMEM150A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TG1-T150A_HUMAN
    Recommended name:
    Transmembrane protein 150A
    Protein Accession:
    Q86TG1
    Secondary Accessions:
    • A8K764
    • B7WPQ9
    • D6W5L2
    • Q8N2R6

    Protein attributes for TMEM150A Gene

    Size:
    271 amino acids
    Molecular mass:
    28835 Da
    Quaternary structure:
    • Interacts (via C-terminal cytoplasmic tail) with PI4KA.

    Alternative splice isoforms for TMEM150A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM150A Gene

Proteomics data for TMEM150A Gene at MOPED

Post-translational modifications for TMEM150A Gene

  • Glycosylation at Asn 37 and Asn 41
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM150A Gene

No data available for DME Specific Peptides for TMEM150A Gene

Domains & Families for TMEM150A Gene

Protein Domains for TMEM150A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM150A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86TG1

UniProtKB/Swiss-Prot:

T150A_HUMAN :
  • Belongs to the DRAM/TMEM150 family.
Family:
  • Belongs to the DRAM/TMEM150 family.
genes like me logo Genes that share domains with TMEM150A: view

No data available for Gene Families for TMEM150A Gene

Function for TMEM150A Gene

Molecular function for TMEM150A Gene

UniProtKB/Swiss-Prot Function:
Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex (PubMed:25608530). Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:25608530). May also play a role in fasting-induced catabolism (By similarity).
genes like me logo Genes that share phenotypes with TMEM150A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM150A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM150A Gene

Localization for TMEM150A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM150A Gene

Cell membrane; Multi-pass membrane protein. Note=Localizes mainly at the plasma membrane; only a minor fraction localizes on intracellular structures (PubMed:25608530). {ECO:0000269 PubMed:25608530}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM150A Gene COMPARTMENTS Subcellular localization image for TMEM150A gene
Compartment Confidence
plasma membrane 5
lysosome 3
vacuole 3
nucleus 2

Gene Ontology (GO) - Cellular Components for TMEM150A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IDA 25608530
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM150A: view

Pathways & Interactions for TMEM150A Gene

SuperPathways for TMEM150A Gene

No Data Available

Interacting Proteins for TMEM150A Gene

Gene Ontology (GO) - Biological Process for TMEM150A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046854 phosphatidylinositol phosphorylation IMP 25608530
GO:0090002 establishment of protein localization to plasma membrane IDA 25608530
genes like me logo Genes that share ontologies with TMEM150A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM150A Gene

Drugs & Compounds for TMEM150A Gene

No Compound Related Data Available

Transcripts for TMEM150A Gene

Unigene Clusters for TMEM150A Gene

Transmembrane protein 150A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM150A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - - - -
SP11: - - - - - - -
SP12: - - - -
SP13: - - - - -
SP14: - -

Relevant External Links for TMEM150A Gene

GeneLoc Exon Structure for
TMEM150A
ECgene alternative splicing isoforms for
TMEM150A

Expression for TMEM150A Gene

mRNA expression in normal human tissues for TMEM150A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM150A Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM150A Gene



SOURCE GeneReport for Unigene cluster for TMEM150A Gene Hs.591559

genes like me logo Genes that share expression patterns with TMEM150A: view

Protein tissue co-expression partners for TMEM150A Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM150A Gene

Orthologs for TMEM150A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM150A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM150A 35
  • 88.31 (n)
  • 92.62 (a)
TMEM150A 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM150A 35
  • 89.91 (n)
  • 90.77 (a)
TMEM150A 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem150a 35
  • 89.05 (n)
  • 91.51 (a)
Tmem150a 16
Tmem150a 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM150A 35
  • 99.63 (n)
  • 100 (a)
TMEM150A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem150a 35
  • 89.54 (n)
  • 92.25 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM150A 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM150A 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM150A 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM150A 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem150a 35
  • 70.23 (n)
  • 70.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15465 35
zebrafish
(Danio rerio)
Actinopterygii zgc66242 35
zgc:66242 35
  • 68.27 (n)
  • 69.74 (a)
tmem150a 36
  • 64 (a)
OneToMany
TMEM150A (1 of 4) 36
  • 64 (a)
OneToMany
TMEM150A (2 of 4) 36
  • 30 (a)
OneToMany
TMEM150A (4 of 4) 36
  • 53 (a)
OneToMany
Species with no ortholog for TMEM150A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM150A Gene

ENSEMBL:
Gene Tree for TMEM150A (if available)
TreeFam:
Gene Tree for TMEM150A (if available)

Paralogs for TMEM150A Gene

Paralogs for TMEM150A Gene

genes like me logo Genes that share paralogs with TMEM150A: view

Variants for TMEM150A Gene

Sequence variations from dbSNP and Humsavar for TMEM150A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1044157 -- 85,599,111(-) CCCAC(C/T)TCAAC nc-transcript-variant, reference, missense
rs1044158 -- 85,599,009(-) TATTT(C/T)GTACC nc-transcript-variant, utr-variant-3-prime
rs3198089 -- 85,598,214(+) CTTTT(C/T)GCTCC downstream-variant-500B
rs10302 -- 85,598,452(+) CACTC(A/G)GCACT downstream-variant-500B
rs11891495 -- 85,599,598(+) GGGGC(A/G)GTGGC nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TMEM150A Gene

Variant ID Type Subtype PubMed ID
dgv4202n71 CNV Loss 21882294

Variation tolerance for TMEM150A Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM150A Gene

Disorders for TMEM150A Gene

Relevant External Links for TMEM150A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM150A

No disorders were found for TMEM150A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM150A Gene

Publications for TMEM150A Gene

  1. Plasticity of PI4KIIIalpha interactions at the plasma membrane. (PMID: 25608530) Chung J. … De Camilli P. (EMBO Rep. 2015) 3 4 67
  2. Identification of a new gene (rat TM6P1) encoding a fasting-inducible, integral membrane protein with six transmembrane domains. (PMID: 10858565) Zhang J. … Underwood L.E. (Biochim. Biophys. Acta 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for TMEM150A Gene

Sources for TMEM150A Gene

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