Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM14C Gene

Aliases for TMEM14C Gene

  • Transmembrane Protein 14C 2 3 5
  • C6orf53 3 4
  • Chromosome 6 Open Reading Frame 53 2
  • BA421M1.6 3
  • HSPC194 3
  • MSTP073 3
  • NET26 3

External Ids for TMEM14C Gene

Previous HGNC Symbols for TMEM14C Gene

  • C6orf53

Previous GeneCards Identifiers for TMEM14C Gene

  • GC06P010832
  • GC06P010833
  • GC06P010598

Summaries for TMEM14C Gene

GeneCards Summary for TMEM14C Gene

TMEM14C (Transmembrane Protein 14C) is a Protein Coding gene. An important paralog of this gene is TMEM14B.

UniProtKB/Swiss-Prot for TMEM14C Gene

  • Required for normal heme biosynthesis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM14C Gene

Genomics for TMEM14C Gene

Regulatory Elements for TMEM14C Gene

Enhancers for TMEM14C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G010398 3.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 4.2 -313.0 -313021 22.9 CREB3L1 AGO1 FEZF1 ZNF143 ZNF548 ZNF263 SP3 MEF2D ZNF610 GLIS1 RNA5SP203 TFAP2A PAK1IP1 TMEM14C TMEM14B C6orf52 TFAP2A-AS1
GH06G010719 1.4 ENCODE dbSUPER 6.6 -0.2 -150 6.7 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 SP3 ENSG00000272097 TMEM14C PAK1IP1 C6orf52
GH06G010642 1.2 Ensembl ENCODE 6.1 -79.6 -79615 1.0 ATF1 PKNOX1 TCF12 GATA2 TBX21 SMARCA4 PBX2 HMBOX1 NBN NR2C1 TMEM14C PIR56839 LOC105374924
GH06G011611 1.2 Ensembl ENCODE dbSUPER 4.3 +891.4 891449 5.2 JUN BHLHE40 ZFP37 MNT EP300 ZNF274 JUND GATA2 POLR2A SCRT2 TMEM170B TMEM14C ENSG00000271897 ENSG00000277473
GH06G010440 1.4 FANTOM5 Ensembl ENCODE 3 -281.2 -281160 1.9 TBP CTCF PKNOX1 MXI1 TAF1 JUN MAX SIN3A CEBPG RAD21 TFAP2A TMEM14C TMEM14B PAK1IP1 GCNT2 MIR5689 MRPL48P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM14C on UCSC Golden Path with GeneCards custom track

Promoters for TMEM14C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000193031 385 1401 HNRNPUL1 HDGF PKNOX1 CREB3L1 MLX ARNT AGO1 ARID4B SIN3A DMAP1

Genomic Location for TMEM14C Gene

Chromosome:
6
Start:
10,722,915 bp from pter
End:
10,731,129 bp from pter
Size:
8,215 bases
Orientation:
Plus strand

Genomic View for TMEM14C Gene

Genes around TMEM14C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM14C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM14C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM14C Gene

Proteins for TMEM14C Gene

  • Protein details for TMEM14C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0S9-TM14C_HUMAN
    Recommended name:
    Transmembrane protein 14C
    Protein Accession:
    Q9P0S9
    Secondary Accessions:
    • Q5T4I6

    Protein attributes for TMEM14C Gene

    Size:
    112 amino acids
    Molecular mass:
    11565 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TMEM14C Gene

neXtProt entry for TMEM14C Gene

Post-translational modifications for TMEM14C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM14C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM14C Gene

Domains & Families for TMEM14C Gene

Protein Domains for TMEM14C Gene

Suggested Antigen Peptide Sequences for TMEM14C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P0S9

UniProtKB/Swiss-Prot:

TM14C_HUMAN :
  • Belongs to the TMEM14 family.
Family:
  • Belongs to the TMEM14 family.
genes like me logo Genes that share domains with TMEM14C: view

No data available for Gene Families for TMEM14C Gene

Function for TMEM14C Gene

Molecular function for TMEM14C Gene

UniProtKB/Swiss-Prot Function:
Required for normal heme biosynthesis.

Gene Ontology (GO) - Molecular Function for TMEM14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM14C: view
genes like me logo Genes that share phenotypes with TMEM14C: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM14C

CRISPR Products

miRNA for TMEM14C Gene

miRTarBase miRNAs that target TMEM14C

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM14C Gene

Localization for TMEM14C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM14C Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM14C gene
Compartment Confidence
mitochondrion 4
extracellular 2
plasma membrane 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TMEM14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with TMEM14C: view

Pathways & Interactions for TMEM14C Gene

SuperPathways for TMEM14C Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006783 heme biosynthetic process IEA --
genes like me logo Genes that share ontologies with TMEM14C: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM14C Gene

Transcripts for TMEM14C Gene

Unigene Clusters for TMEM14C Gene

Transmembrane protein 14C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM14C Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h ·
SP1: - - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - -
SP9: - - - - - - -
SP10: -
SP11: - - - - - - - - -

ExUns: 7i
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TMEM14C Gene

GeneLoc Exon Structure for
TMEM14C
ECgene alternative splicing isoforms for
TMEM14C

Expression for TMEM14C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM14C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM14C Gene

This gene is overexpressed in Nasal epithelium (40.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM14C Gene



Protein tissue co-expression partners for TMEM14C Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM14C Gene:

TMEM14C

SOURCE GeneReport for Unigene cluster for TMEM14C Gene:

Hs.519557

Evidence on tissue expression from TISSUES for TMEM14C Gene

  • Skin(4.9)
  • Blood(4.1)
  • Pancreas(3.1)
  • Nervous system(2.5)
  • Eye(2.2)
  • Heart(2.2)
  • Kidney(2.2)
  • Lung(2.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with TMEM14C: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM14C Gene

Orthologs for TMEM14C Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM14C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM14C 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia TMEM14C 34
  • 87.39 (n)
-- 35
  • 85 (a)
ManyToMany
-- 35
  • 69 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tmem14c 34
  • 83.78 (n)
cow
(Bos Taurus)
Mammalia TMEM14C 34 35
  • 83.48 (n)
mouse
(Mus musculus)
Mammalia Tmem14c 34 16 35
  • 82.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 71 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 37 (a)
OneToMany
chicken
(Gallus gallus)
Aves TMEM14C 34
  • 75.08 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 69 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem14c 34
  • 73.46 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem14ca 34 35
  • 72.82 (n)
tmem14cb 35
  • 51 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5532 35
  • 46 (a)
OneToMany
Species where no ortholog for TMEM14C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM14C Gene

ENSEMBL:
Gene Tree for TMEM14C (if available)
TreeFam:
Gene Tree for TMEM14C (if available)

Paralogs for TMEM14C Gene

Paralogs for TMEM14C Gene

(4) SIMAP similar genes for TMEM14C Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TMEM14C Gene

genes like me logo Genes that share paralogs with TMEM14C: view

Variants for TMEM14C Gene

Sequence variations from dbSNP and Humsavar for TMEM14C Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000075062 -- 10,730,890(+) AGCTT(A/G)ATTCT utr-variant-3-prime
rs1000227508 -- 10,720,930(+) CTGCT(C/T)CACAG upstream-variant-2KB
rs1000462406 -- 10,722,636(+) TGCAG(A/C)CCCCG upstream-variant-2KB
rs1000743943 -- 10,723,195(+) CATTC(C/G)TGCGG utr-variant-5-prime
rs1000760717 -- 10,721,305(+) AAACA(C/T)ACCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM14C Gene

Variant ID Type Subtype PubMed ID
esv2663502 CNV deletion 23128226
esv3608082 CNV gain 21293372
nsv462631 CNV gain 19166990
nsv470800 CNV gain 18288195
nsv520853 CNV loss 19592680
nsv600979 CNV gain 21841781
nsv966670 CNV duplication 23825009

Variation tolerance for TMEM14C Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 21.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM14C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM14C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM14C Gene

Disorders for TMEM14C Gene

Relevant External Links for TMEM14C

Genetic Association Database (GAD)
TMEM14C
Human Genome Epidemiology (HuGE) Navigator
TMEM14C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM14C

No disorders were found for TMEM14C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM14C Gene

Publications for TMEM14C Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Nuclear membrane proteins with potential disease links found by subtractive proteomics. (PMID: 12958361) Schirmer E.C. … Gerace L. (Science 2003) 2 3 64
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64

Products for TMEM14C Gene

Sources for TMEM14C Gene

Content
Loading form....