Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TMEM14C Gene

protein-coding   GIFtS: 50
GCID: GC06P010723

Transmembrane Protein 14C

(Previous name: chromosome 6 open reading frame 53)
(Previous symbol: C6orf53)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transmembrane Protein 14C1 2
C6orf531 2 3
Chromosome 6 Open Reading Frame 531
MSTP0732
NET262
bA421M1.62

External Ids:    HGNC: 209521   Entrez Gene: 515222   Ensembl: ENSG000001118437   OMIM: 6153185   UniProtKB: Q9P0S93   
ORGUL members:         

Export aliases for TMEM14C gene to outside databases

Previous GC identifers: GC06P010832 GC06P010833 GC06P010598


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TMEM14C Gene:
TMEM14C (transmembrane protein 14C) is a protein-coding gene. Diseases associated with TMEM14C include malaria, and cerebritis. An important paralog of this gene is TMEM14B.

UniProtKB/Swiss-Prot: TM14C_HUMAN, Q9P0S9
Function: Required for normal heme biosynthesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM14C gene promoter:
         STAT1   Tal-1   Pax-6   MyoD   LUN-1   CUTL1   GATA-1   E47   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM14C promoter sequence
   Search Chromatin IP Primers for TMEM14C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM14C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p24.2   Ensembl cytogenetic band:  6p24.2   HGNC cytogenetic band: 6p24.1

TMEM14C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM14C gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P010723:  view genomic region     (about GC identifiers)

Start:
10,723,148 bp from pter      End:
10,731,362 bp from pter
Size:
8,215 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TM14C_HUMAN, Q9P0S9 (See protein sequence)
Recommended Name: Transmembrane protein 14C  
Size: 112 amino acids; 11565 Da
1 PDB 3D structure from and Proteopedia for TMEM14C:
2LOS (3D)    
Secondary accessions: Q5T4I6

Explore the universe of human proteins at neXtProt for TMEM14C: NX_Q9P0S9

Explore proteomics data for TMEM14C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMEM14C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001158730.1  NP_057546.1  

    ENSEMBL proteins: 
     ENSP00000229563   ENSP00000444561  

    TMEM14C Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TMEM14C
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TMEM14C
    GenScript Custom Purified and Recombinant Proteins Services for TMEM14C
    Novus Biologicals TMEM14C Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMEM14C

    TMEM14C Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TMEM14C
    Search for Antibodies for TMEM14C at Abcam
    Cloud-Clone Corp. Antibodies for TMEM14C
    Search ThermoFisher Antibodies for TMEM14C
    Search LSBio for Antibodies for TMEM14C

    TMEM14C Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TMEM14C
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMEM14C
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMEM14C
    Cloud-Clone Corp. CLIAs for TMEM14C


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR005349 UPF0136_TM

    Graphical View of Domain Structure for InterPro Entry Q9P0S9

    ProtoNet protein and cluster: Q9P0S9

    1 Blocks protein domain: IPB005349 Protein of unknown function UPF0136

    UniProtKB/Swiss-Prot: TM14C_HUMAN, Q9P0S9
    Similarity: Belongs to the UPF0136 (TMEM14) family


    TMEM14C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TM14C_HUMAN, Q9P0S9
    Function: Required for normal heme biosynthesis (By similarity)

    Phenotypes:
         5 GenomeRNAi human phenotypes for TMEM14C:

     Cell cycle / mitosis defect  Decreased POU5F1-GFP protein e  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM14C
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM14C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM14C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM14C

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMEM14C:
    hsa-mir-744-5p (MIRT037572)

    Block miRNA regulation of human, mouse, rat TMEM14C using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TMEM14C:
    hsa-miR-3143 hsa-miR-3145-3p
    SwitchGear 3'UTR luciferase reporter plasmidTMEM14C 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMEM14C
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM14C

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMEM14C

    Clone
    Products:
         
    OriGene clones in human, mouse for TMEM14C (see all 13)
    OriGene ORF clones in mouse, rat for TMEM14C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM14C (NM_016462)
    Sino Biological Human cDNA Clone for TMEM14C
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM14C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM14C

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TMEM14C
    Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM14C 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM14C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TM14C_HUMAN, Q9P0S9: Mitochondrion membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    extracellular2
    cytosol1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0031966mitochondrial membrane IEA--

    TMEM14C for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM14C
    Interactions:

        Search GeneGlobe Interaction Network for TMEM14C

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for TMEM14C (Q9P0S93 ENSP000002295634) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC34P494273, ENSP000002155744I2D: score=1 STRING: ENSP00000215574
    CREB3O438893I2D: score=1 
    RCHY1ENSP000003212394STRING: ENSP00000321239
    RSG1ENSP000003647494STRING: ENSP00000364749
    IMMTENSP000003872624STRING: ENSP00000387262
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006783heme biosynthetic process IEA--

    TMEM14C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM14C (TM14C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TMEM14C gene (2 alternative transcripts): 
    NM_001165258.1  NM_016462.3  

    Unigene Cluster for TMEM14C:

    Transmembrane protein 14C
    Hs.519557  [show with all ESTs]
    Unigene Representative Sequence: BE908369
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229563 ENST00000466421 ENST00000467415 ENST00000495549 ENST00000541412(uc010joq.2 uc003mzh.3 uc021ylj.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMEM14C using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TMEM14C:
    hsa-miR-3143 hsa-miR-3145-3p
    SwitchGear 3'UTR luciferase reporter plasmidTMEM14C 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMEM14C
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM14C
    Clone
    Products:
         
    OriGene clones in human, mouse for TMEM14C (see all 13)
    OriGene ORF clones in mouse, rat for TMEM14C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM14C (NM_016462)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM14C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM14C
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMEM14C
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM14C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM14C
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM14C
      QuantiFast Probe-based Assays in human, mouse, rat TMEM14C

    Additional mRNA sequence: 

    AF151028.1 AF164962.1 AK223462.1 AK309591.1 AK310191.1 BC002496.2 BC010086.2 

    16 DOTS entries:

    DT.419950  DT.100827185  DT.100827189  DT.100827181  DT.40132990  DT.92452631  DT.95262803  DT.97854830 
    DT.121397360  DT.121397469  DT.91950006  DT.92452623  DT.92452638  DT.99960630  DT.121397502  DT.87017216 

    Selected AceView cDNA sequences (see all 663):

    CF454595 BU627524 BM510901 BM127107 AL557695 AW239079 AA846240 CD722677 
    AW337755 BG681183 AI088520 CR626492 BU948171 CB528523 BU543180 BG254889 
    CR593270 CB177191 CA777519 CR594179 BQ935722 BM887873 CA306707 BU948332 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMEM14C (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h ·
    SP1:                                      -     -                       -                 -                                                                     
    SP2:                                                                    -                 -                                                                     
    SP3:                                      -                             -                 -                                                                     
    SP4:                                      -     -                       -                 -                                                                     
    SP5:                                      -     -                       -                 -                 -                                                   

    ExUns: 7i
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for TMEM14C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TMEM14C expression in normal human tissues (normalized intensities)      TMEM14C embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTACAAACC
    TMEM14C Expression
    About this image


    TMEM14C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Eye (Sensory Organs)
             Retina
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
    TMEM14C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM14C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.519557
        Custom PCR Arrays for TMEM14C
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TMEM14C
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM14C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM14C
    QuantiTect SYBR Green Assays in human, mouse, rat TMEM14C
    QuantiFast Probe-based Assays in human, mouse, rat TMEM14C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM14C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TMEM14C gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem14c1 , 5 transmembrane protein 14C1, 5 82.88(n)1
    85.59(a)1
      13 (20.25 cM)5
    661541  NM_025387.31  NP_079663.11 
     410162505 
    chicken
    (Gallus gallus)
    Aves TMEM14C1 transmembrane protein 14C 75.08(n)
    73.79(a)
      420851  XM_418940.4  XP_418940.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    69(a)
    1 → many
    GL343209.1(2583459-2588653)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ068667.12   -- 75.08(n)    BJ068667.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ285704.12   -- 74.77(n)    BQ285704.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55326
    --
    46(a)
    1 → many
    2R(19640264-19640929)


    ENSEMBL Gene Tree for TMEM14C (if available)
    TreeFam Gene Tree for TMEM14C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TMEM14C gene
    TMEM14B2  TMEM14A2  
    4 SIMAP similar genes for TMEM14C using alignment to 1 protein entry:     TM14C_HUMAN:
    TMEM14D    TMEM14B    TMEM14A    TMEM14E

    TMEM14C for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TMEM14C
    PGOHUM00000236899 PGOHUM00000247539


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TMEM14C (see all 459)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs44016591,2
    C,F,H--10721169(+) cacagC/Ggccca 2 -- us2k13Minor allele frequency- G:0.40NA WA CSA 5
    rs45606381,2
    C,F,H--10721182(+) cccatC/Taacca 2 -- us2k13Minor allele frequency- T:0.50NA WA CSA 6
    rs1879160661,2
    --10721224(+) CAGGAC/TTGGAA 2 -- us2k10--------
    rs1509372421,2
    --10721232(+) GAAGGC/TAGCTC 2 -- us2k10--------
    rs1420277831,2
    C--10721238(+) AGCTCC/TACCTG 2 -- us2k10--------
    rs1926958711,2
    --10721241(+) TCCACC/TTGCAG 2 -- us2k10--------
    rs2017014551,2
    C--10721241(+) CCACC-/ATGCAG 2 -- us2k10--------
    rs1459001541,2
    --10721265(+) TCCACC/TGGGTG 2 -- us2k10--------
    rs1822546791,2
    --10721277(+) AGCCAA/GCTGGG 2 -- us2k10--------
    rs1135091891,2
    F--10721285(+) GGGTTG/AAGTCT 2 -- us2k11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for TMEM14C (10723148 - 10731362 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TMEM14C:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663502CNV Deletion23128226
    nsv520853CNV Loss19592680
    nsv462631CNV Gain19166990
    nsv470800CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM14C
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM14C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 615318    OMIM disorders: --

    2 diseases for TMEM14C:    About MalaCards
    malaria    cerebritis


    TMEM14C for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMEM14C
    Human Genome Epidemiology (HuGE) Navigator: TMEM14C (1 document)

    Export disorders for TMEM14C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TMEM14C gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with TMEM14C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Nuclear membrane proteins with potential disease links found by subtractive proteomics. (PubMed id 12958361)1, 3 Schirmer E.C.... Gerace L. (Science 2003)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Facile backbone structure determination of human membrane proteins by NMR spectroscopy. (PubMed id 22609626)2 Klammt C.... Choe S. (Nat. Methods 2012)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Biochemical and computational analysis of LNX1 interacting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (PLoS ONE 2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51522 HGNC: 20952 AceView: TMEM14CandTMEM14B Ensembl:ENSG00000111843 euGenes: HUgn51522
    ECgene: TMEM14C H-InvDB: TMEM14C

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TMEM14C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TMEM14C gene:
    Search GeneIP for patents involving TMEM14C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TMEM14C  
     OriGene qPCR primer pairs and template standards for TMEM14C   OriGene Protein Over-expression Lysate for TMEM14C  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TMEM14C  
     OriGene qSTAR qPCR primer pairs in human, mouse for TMEM14C   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TMEM14C   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TMEM14C   OriGene Custom Protein Services for TMEM14C  

     
     
     Block miRNA regulation of human, mouse, rat TMEM14C using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TMEM14C
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM14C Predesigned siRNA for gene silencing in human, mouse, rat TMEM14C
     QuantiFast Probe-based Assays in human, mouse, rat TMEM14C QuantiTect SYBR Green Assays in human, mouse, rat TMEM14C
     Custom PCR Arrays for TMEM14C Search Chromatin IP Primers for TMEM14C
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM14C  Search GeneGlobe Interaction Network for TMEM14C
     Regulatory tfbs in TMEM14C promoter
     GenScript Custom Purified and Recombinant Proteins Services for TMEM14C GenScript cDNA clones with any tag delivered in your preferred vector for TMEM14C
     GenScript Custom Assay Services for TMEM14C GenScript Custom overexpressing Cell Line Services for TMEM14C
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TMEM14C (TM14C)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TMEM14C
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TMEM14C lysates
     Search for Antibodies for TMEM14C at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TMEM14C
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TMEM14C
     Antibodies for TMEM14C
     ELISAs for TMEM14C
     CLIAs for TMEM14C



     Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM14C
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM14C
     SwitchGear 3'UTR luciferase reporter plasmids for TMEM14C
     SwitchGear Promoter luciferase reporter plasmids for TMEM14C
     Search ThermoFisher Antibodies for TMEM14C
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM14C
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM14C
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM14C
     Search LSBio for Antibodies for TMEM14C
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TMEM14C gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4