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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMEM14C Gene

protein-coding GIFtS: 46
GCID: GC06P010723

transmembrane protein 14C

(Previous name: chromosome 6 open reading frame 53 )
(Previous symbol: C6orf53)

Search for TMEM14C
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transmembrane Protein 14C¹ ²		HSPC194¹
C6orf53¹ ² ³		Chromosome 6 Open Reading Frame 53¹
NET26¹ ²		MSTP073²
BA421M1.6¹

External Ids:	HGNC: 20952¹	Entrez Gene: 51522²	Ensembl: ENSG00000111843⁷	UniProtKB: Q9P0S9³

Export aliases for TMEM14C gene to outside databases

Previous GC identifers: GC06P010832 GC06P010833 GC06P010598

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TM14C_HUMAN, Q9P0S9

Function: Required for normal heme biosynthesis (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TMEM14C gene promoter:
STAT1 Tal-1 Pax-6 MyoD LUN-1 CUTL1 GATA-1 E47 PPAR-gamma1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM14C promoter sequence

Search SABiosciences Chromatin IP Primers for TMEM14C

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM14C

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p24.2 Ensembl cytogenetic band: 6p24.2 HGNC cytogenetic band: 6p24.1

TMEM14C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM14C gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P010723: view genomic region (about GC identifiers)

Start:	10,723,148 bp from pter	End:	10,731,362 bp from pter
Size:	8,215 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TM14C_HUMAN, Q9P0S9 (See protein sequence)

Recommended Name: Transmembrane protein 14C

Size: 112 amino acids; 11565 Da

Subcellular location: Mitochondrion membrane; Multi-pass membrane protein (By similarity)

1 PDB 3D structure from and Proteopedia for TMEM14C:

2LOS (3D)

Secondary accessions: Q5T4I6

Explore the universe of human proteins at neXtProt for TMEM14C: NX_Q9P0S9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P0S9

TMEM14C Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001158730.1 NP_057546.1

ENSEMBL proteins:

ENSP00000229563 ENSP00000444561

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals TMEM14C Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TMEM14C

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--
GO:0031966	mitochondrial membrane	IEA	--

TMEM14C for ontologies About GeneDecksing

TMEM14C Antibody Products:

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	Search for Antibodies for TMEM14C at Abcam
	Uscn Antibodies for TMEM14C
	Search ThermoFisher Antibodies for TMEM14C

Assay Products for TMEM14C:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TMEM14C
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TMEM14C

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TMEM14C for domains About GeneDecksing

1 InterPro domain/family:

IPR005349 UPF0136_TM

Graphical View of Domain Structure for InterPro Entry Q9P0S9

ProtoNet protein and cluster: Q9P0S9

1 Blocks protein family: IPB005349 Protein of unknown function UPF0136

UniProtKB/Swiss-Prot: TM14C_HUMAN, Q9P0S9

Similarity: Belongs to the UPF0136 (TMEM14) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TM14C_HUMAN, Q9P0S9

Function: Required for normal heme biosynthesis (By similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TMEM14C Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM14C
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM14C:
		hsa-miR-3143 hsa-miR-3145-3p
		SwitchGear 3'UTR luciferase reporter plasmid: TMEM14C 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM14C (see all 7) OriGene shRNA RFP: TMEM14C OriGene siRNA: TMEM14C
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM14C

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TMEM14C

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM14C (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM14C (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TMEM14C (NM_016462)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM14C
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM14C

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TMEM14C
		Search LifeMap BioReagents cell lines for TMEM14C

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM14C

5 GenomeRNAi human phenotypes for TMEM14C:

Cell cycle / mitosis defect	Decreased POU5F1-GFP protein e	Downregulation of NF-kappaB pa	Downregulation of NF-kappaB pa
Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMEM14C

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for TMEM14C (Q9P0S9³ ENSP00000229563⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDC34	P49427³, ENSP00000215574⁴	I2D: score=1 STRING: ENSP00000215574
CREB3	O43889³	I2D: score=1
RCHY1	ENSP00000321239⁴	STRING: ENSP00000321239
RSG1	ENSP00000364749⁴	STRING: ENSP00000364749

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006783	heme biosynthetic process	IEA	--

TMEM14C for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM14C
Search CenterWatch for drugs/clinical trials and news about TMEM14C / TM14C

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM14C gene (2 alternative transcripts):

NM_001165258.1 NM_016462.3

Unigene Cluster for TMEM14C:

Transmembrane protein 14C

Hs.519557 [show with all ESTs]

Unigene Representative Sequence: BE908369

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000229563 ENST00000466421 ENST00000467415 ENST00000495549 ENST00000541412(uc010joq.2 uc003mzh.3 uc021ylj.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TMEM14C Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM14C
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM14C:
		hsa-miR-3143 hsa-miR-3145-3p
		SwitchGear 3'UTR luciferase reporter plasmid: TMEM14C 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM14C (see all 7) OriGene shRNA RFP: TMEM14C OriGene siRNA: TMEM14C
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM14C

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM14C (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM14C (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TMEM14C (NM_016462)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM14C
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM14C

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM14C Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TMEM14C
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM14C
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM14C

Additional cDNA sequence:

AF151028.1 AF164962.1 AK223462.1 AK309591.1 AK310191.1 BC002496.2 BC010086.2

16 DOTS entries:

DT.419950 DT.100827185 DT.100827189 DT.100827181 DT.40132990 DT.92452631 DT.95262803 DT.97854830

DT.121397360 DT.121397469 DT.91950006 DT.92452623 DT.92452638 DT.99960630 DT.121397502 DT.87017216

24/663 AceView cDNA sequences (see all 663):

AI873685 CR625322 BU948060 CR623943 BI762652 AA326688 CA944770 CR621789

AI631124 BU633040 BM764385 AW261898 BM888344 BI755167 BM781841 AA830816

BU688113 AI142474 AI423011 AI493197 AA570008 AI887408 CB528523 BM661517

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM14C (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	·	2c	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f	·	7g	·	7h	·
SP1:													-		-								-						-
SP2:																							-						-
SP3:													-										-						-
SP4:													-		-								-						-
SP5:													-		-								-						-						-

ExUns:	7i
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for TMEM14C

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM14C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTACAAACC

About this image

TMEM14C expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Eye

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TMEM14C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM14C

SOURCE GeneReport for Unigene cluster: Hs.519557

SABiosciences Custom PCR Arrays for TMEM14C

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM14C Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TMEM14C
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM14C
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM14C

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM14C

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TMEM14C gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TMEM14C¹	transmembrane protein 14C	75.58(n) 75.25(a)		420851 XM_418940.3 XP_418940.1
lizard (Anolis carolinensis)	Reptilia	--	--	68(a)	1 → many	GL343209.1(2583459-2588647)
African clawed frog (Xenopus laevis)	Amphibia	BJ068667.1²	--	75.08(n)		BJ068667.1
zebrafish (Danio rerio)	Actinopterygii	BQ285704.1²	--	74.77(n)		BQ285704.1
fruit fly (Drosophila melanogaster)	Insecta	CG5532¹	CG5532	50.65(n) 51.96(a)		37761 NM_137982.3 NP_611826.1

ENSEMBL Gene Tree for TMEM14C (if available)
TreeFam Gene Tree for TMEM14C (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TMEM14C gene

TMEM14E² TMEM14B² TMEM14A²

4 SIMAP similar genes for TMEM14C using alignment to 1 protein entry: TM14C_HUMAN:

TMEM14D TMEM14B TMEM14A TMEM14E

TMEM14C for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for TMEM14C
PGOHUM00000236899 PGOHUM00000247539

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4401659^1,2	C,F,H,	--	10721169(+)	`cacagC/Ggccca`	2	--	us2k¹		3		NA WA CSA	5
rs4560638^1,2	C,F,H,	--	10721182(+)	`cccatC/Taacca`	2	--	us2k¹		3		NA WA CSA	6
rs187916066^1,2		--	10721224(+)	`CAGGAC/TTGGAA`	2	--	us2k¹		0	--	--	--	--
rs150937242^1,2		--	10721232(+)	`GAAGGC/TAGCTC`	2	--	us2k¹		0	--	--	--	--
rs142027783^1,2		--	10721238(+)	`AGCTCC/TACCTG`	2	--	us2k¹		0	--	--	--	--
rs192695871^1,2		--	10721241(+)	`TCCACC/TTGCAG`	2	--	us2k¹		0	--	--	--	--
rs201701455^1,2		--	10721241(+)	`CCACC-/ATGCAG`	2	--	us2k¹		0	--	--	--	--
rs145900154^1,2		--	10721265(+)	`TCCACC/TGGGTG`	2	--	us2k¹		0	--	--	--	--
rs182254679^1,2		--	10721277(+)	`AGCCAA/GCTGGG`	2	--	us2k¹		0	--	--	--	--
rs113509189^1,2		--	10721285(+)	`GGGTTG/AAGTCT`	2	--	us2k¹		1		CSA	2

HapMap Linkage Disequilibrium report for TMEM14C (10723148 - 10731362 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM14C: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM14C

DNA2.0 Custom Variant and Variant Library Synthesis for TMEM14C

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMEM14C for disorders About MalaCards

TMEM14C for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: TMEM14C (1 document)

Export disorders for TMEM14C gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMEM14C gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TMEM14C)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2, 3} Zhang Q.-H.... Chen Z. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Nuclear membrane proteins with potential disease links found by subtractive proteomics. (PubMed id 12958361)^{1, 3} Schirmer E.C....Gerace L. (2003)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Biochemical and computational analysis of LNX1 interac ting proteins. (PubMed id 22087225)¹ Wolting C.D....McGlade C.J. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
Discovery of genes essential for heme biosynthesis th rough large-scale gene expression analysis. (PubMed id 19656490)¹ Nilsson R....Mootha V.K. (2009)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)² Mungall A.J.... Beck S. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51522	HGNC: 20952	AceView: TMEM14CandTMEM14B	Ensembl:ENSG00000111843	euGenes: HUgn51522
ECgene: TMEM14C	H-InvDB: TMEM14C

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TMEM14C	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMEM14C gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TMEM14C gene:
Search GeneIP for patents involving TMEM14C

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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	Browse OriGene Antibodies		OriGene shRNA RFP for TMEM14C
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM14C		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM14C
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM14C
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	GenScript Custom Purified and Recombinant Proteins Services for TMEM14C		GenScript cDNA clones with any tag delivered in your preferred vector for TMEM14C
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM14C

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM14C

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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TMEM14C Gene

transmembrane protein 14C

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TMEM14C Gene

transmembrane protein 14C

Aliasesfor TMEM14C gene

Summariesfor TMEM14C gene

Genomic Viewsfor TMEM14C gene

Proteinsfor TMEM14C gene

Protein Domains /Familiesfor TMEM14C gene

Functionfor TMEM14C gene

Pathways & Interactionsfor TMEM14C gene

Drugs & Compoundsfor TMEM14C gene

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Expression for TMEM14C gene

Orthologsfor TMEM14C gene

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Genomic Variantsfor TMEM14C gene

Disorders / Diseasesfor TMEM14C gene

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External Searches for TMEM14C gene

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for TMEM14C gene

Genomic Views
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for TMEM14C gene

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for TMEM14C gene

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for TMEM14C gene

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Expression
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Orthologs
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for TMEM14C gene

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