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Aliases for TMEM14B Gene

Aliases for TMEM14B Gene

  • Transmembrane Protein 14B 2 3

External Ids for TMEM14B Gene

Previous GeneCards Identifiers for TMEM14B Gene

  • GC06P010810
  • GC06P010856
  • GC06P010624

Summaries for TMEM14B Gene

GeneCards Summary for TMEM14B Gene

TMEM14B (Transmembrane Protein 14B) is a Protein Coding gene. An important paralog of this gene is TMEM14C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM14B Gene

Genomics for TMEM14B Gene

Regulatory Elements for TMEM14B Gene

Genomic Location for TMEM14B Gene

Start:
10,747,759 bp from pter
End:
10,852,753 bp from pter
Size:
104,995 bases
Orientation:
Plus strand

Genomic View for TMEM14B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM14B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM14B Gene

Proteins for TMEM14B Gene

  • Protein details for TMEM14B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUH8-TM14B_HUMAN
    Recommended name:
    Transmembrane protein 14B
    Protein Accession:
    Q9NUH8
    Secondary Accessions:
    • Q5THN7
    • Q5THN8
    • Q96IX7
    • Q9BVN8

    Protein attributes for TMEM14B Gene

    Size:
    114 amino acids
    Molecular mass:
    12078 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM14B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM14B Gene

Proteomics data for TMEM14B Gene at MOPED

Post-translational modifications for TMEM14B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM14B Gene

Domains for TMEM14B Gene

Protein Domains for TMEM14B Gene

Suggested Antigen Peptide Sequences for TMEM14B Gene

Graphical View of Domain Structure for InterPro Entry

Q9NUH8

UniProtKB/Swiss-Prot:

TM14B_HUMAN :
  • Q9NUH8
Family:
  • Belongs to the TMEM14 family.
genes like me logo Genes that share domains with TMEM14B: view

No data available for Gene Families for TMEM14B Gene

Function for TMEM14B Gene

genes like me logo Genes that share phenotypes with TMEM14B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM14B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM14B Gene

Localization for TMEM14B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM14B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM14B Gene COMPARTMENTS Subcellular localization image for TMEM14B gene
Compartment Confidence
extracellular 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMEM14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM14B: view

Pathways for TMEM14B Gene

SuperPathways for TMEM14B Gene

No Data Available

Interacting Proteins for TMEM14B Gene

Gene Ontology (GO) - Biological Process for TMEM14B Gene

None

No data available for Pathways by source for TMEM14B Gene

Transcripts for TMEM14B Gene

Unigene Clusters for TMEM14B Gene

Transmembrane protein 14B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM14B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM14B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - - - -
SP6: - - -
SP7:
SP8: - - -

Relevant External Links for TMEM14B Gene

GeneLoc Exon Structure for
TMEM14B
ECgene alternative splicing isoforms for
TMEM14B

Expression for TMEM14B Gene

mRNA expression in normal human tissues for TMEM14B Gene

SOURCE GeneReport for Unigene cluster for TMEM14B Gene Hs.95600

genes like me logo Genes that share expressions with TMEM14B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for TMEM14B Gene

Orthologs for TMEM14B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM14B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM14B 35
  • 99.71 (n)
  • 99.12 (a)
TMEM14B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM14C 36
  • 68 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 60 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 31 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tmem14c 36
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tmem14ca 36
  • 58 (a)
ManyToMany
tmem14cb 36
  • 46 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5532 36
  • 39 (a)
OneToMany
Species with no ortholog for TMEM14B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM14B Gene

ENSEMBL:
Gene Tree for TMEM14B (if available)
TreeFam:
Gene Tree for TMEM14B (if available)

Paralogs for TMEM14B Gene

Paralogs for TMEM14B Gene

genes like me logo Genes that share paralogs with TMEM14B: view

Variants for TMEM14B Gene

Sequence variations from dbSNP and Humsavar for TMEM14B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs561325 -- 10,758,090(+) CCCCT(G/T)GATGG intron-variant
rs565905 -- 10,758,583(+) AGTCT(A/G)GTGGA intron-variant
rs1046010 -- 10,756,544(+) GGACT(C/G)ATGAA utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1046427 -- 10,751,146(+) CCGTC(C/T)CTGGC intron-variant, reference, synonymous-codon
rs1233893 -- 10,752,650(+) caggg(G/T)ttttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM14B Gene

Variant ID Type Subtype PubMed ID
nsv462631 CNV Gain 19166990
nsv470800 CNV Gain 18288195
esv2663502 CNV Deletion 23128226
esv2731586 CNV Deletion 23290073
esv2677566 CNV Deletion 23128226

Relevant External Links for TMEM14B Gene

HapMap Linkage Disequilibrium report
TMEM14B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM14B Gene

Disorders for TMEM14B Gene

No disorders were found for TMEM14B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TMEM14B Gene

Publications for TMEM14B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4

Products for TMEM14B Gene

Sources for TMEM14B Gene

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