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Aliases for TMEM14B Gene

Aliases for TMEM14B Gene

  • Transmembrane Protein 14B 2 3

External Ids for TMEM14B Gene

Summaries for TMEM14B Gene

GeneCards Summary for TMEM14B Gene

TMEM14B (Transmembrane Protein 14B) is a Protein Coding gene. An important paralog of this gene is TMEM14C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM14B Gene

Genomics for TMEM14B Gene

Genomic Location for TMEM14B Gene

10,747,759 bp from pter
10,852,753 bp from pter
104,995 bases
Plus strand

Genomic View for TMEM14B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM14B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM14B Gene

Regulatory Elements for TMEM14B Gene

Proteins for TMEM14B Gene

  • Protein details for TMEM14B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 14B
    Protein Accession:
    Secondary Accessions:
    • Q5THN7
    • Q5THN8
    • Q96IX7
    • Q9BVN8

    Protein attributes for TMEM14B Gene

    114 amino acids
    Molecular mass:
    12078 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM14B Gene


neXtProt entry for TMEM14B Gene

Proteomics data for TMEM14B Gene at MOPED

Post-translational modifications for TMEM14B Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM14B Gene

Domains for TMEM14B Gene

Protein Domains for TMEM14B Gene


  • Belongs to the TMEM14 family.:
    • Q9NUH8
genes like me logo Genes that share domains with TMEM14B: view

No data available for Gene Families for TMEM14B Gene

Function for TMEM14B Gene

genes like me logo Genes that share phenotypes with TMEM14B: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM14B Gene

Localization for TMEM14B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM14B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM14B Gene COMPARTMENTS Subcellular localization image for TMEM14B gene
Compartment Confidence
extracellular 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMEM14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM14B: view

Pathways for TMEM14B Gene

SuperPathways for TMEM14B Gene

No Data Available

Interacting Proteins for TMEM14B Gene

Gene Ontology (GO) - Biological Process for TMEM14B Gene


No data available for Pathways by source for TMEM14B Gene

Transcripts for TMEM14B Gene

Unigene Clusters for TMEM14B Gene

Transmembrane protein 14B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM14B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - - - -
SP6: - - -
SP8: - - -

Relevant External Links for TMEM14B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM14B Gene

mRNA expression in normal human tissues for TMEM14B Gene

SOURCE GeneReport for Unigene cluster for TMEM14B Gene Hs.95600

genes like me logo Genes that share expressions with TMEM14B: view

Orthologs for TMEM14B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM14B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM14B 36
  • 99.71 (n)
  • 99.12 (a)
TMEM14B 37
  • 99 (a)
(Bos Taurus)
Mammalia TMEM14C 37
  • 68 (a)
(Canis familiaris)
Mammalia -- 37
  • 60 (a)
-- 37
  • 71 (a)
(Mus musculus)
Mammalia Tmem14c 37
  • 71 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 31 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 62 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 62 (a)
(Danio rerio)
Actinopterygii tmem14ca 37
  • 58 (a)
tmem14cb 37
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5532 37
  • 39 (a)
Species with no ortholog for TMEM14B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM14B Gene

Gene Tree for TMEM14B (if available)
Gene Tree for TMEM14B (if available)

Paralogs for TMEM14B Gene

Paralogs for TMEM14B Gene

genes like me logo Genes that share paralogs with TMEM14B: view

Variants for TMEM14B Gene

Sequence variations from dbSNP and Humsavar for TMEM14B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs561325 -- 10,758,090(+) CCCCT(G/T)GATGG intron-variant
rs565905 -- 10,758,583(+) AGTCT(A/G)GTGGA intron-variant
rs1046010 -- 10,756,544(+) GGACT(C/G)ATGAA utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1046427 -- 10,751,146(+) CCGTC(C/T)CTGGC intron-variant, reference, synonymous-codon
rs1233893 -- 10,752,650(+) caggg(G/T)ttttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM14B Gene

Variant ID Type Subtype PubMed ID
nsv462631 CNV Gain 19166990
nsv470800 CNV Gain 18288195
esv2663502 CNV Deletion 23128226
esv2731586 CNV Deletion 23290073
esv2677566 CNV Deletion 23128226

Relevant External Links for TMEM14B Gene

HapMap Linkage Disequilibrium report

Disorders for TMEM14B Gene

No disorders were found for TMEM14B Gene.

No data available for UniProtKB/Swiss-Prot for TMEM14B Gene

Publications for TMEM14B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4

Products for TMEM14B Gene

Sources for TMEM14B Gene

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