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Aliases for TMEM14B Gene

Aliases for TMEM14B Gene

  • Transmembrane Protein 14B 2 3 5

External Ids for TMEM14B Gene

Previous GeneCards Identifiers for TMEM14B Gene

  • GC06P010810
  • GC06P010856
  • GC06P010624

Summaries for TMEM14B Gene

GeneCards Summary for TMEM14B Gene

TMEM14B (Transmembrane Protein 14B) is a Protein Coding gene. An important paralog of this gene is TMEM14C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM14B Gene

Genomics for TMEM14B Gene

Regulatory Elements for TMEM14B Gene

Promoters for TMEM14B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM14B on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM14B Gene

Chromosome:
6
Start:
10,747,759 bp from pter
End:
10,852,753 bp from pter
Size:
104,995 bases
Orientation:
Plus strand

Genomic View for TMEM14B Gene

Genes around TMEM14B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM14B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM14B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM14B Gene

Proteins for TMEM14B Gene

  • Protein details for TMEM14B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUH8-TM14B_HUMAN
    Recommended name:
    Transmembrane protein 14B
    Protein Accession:
    Q9NUH8
    Secondary Accessions:
    • Q5THN7
    • Q5THN8
    • Q96IX7
    • Q9BVN8

    Protein attributes for TMEM14B Gene

    Size:
    114 amino acids
    Molecular mass:
    12078 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM14B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM14B Gene

Proteomics data for TMEM14B Gene at MOPED

Post-translational modifications for TMEM14B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM14B Gene

Domains & Families for TMEM14B Gene

Protein Domains for TMEM14B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM14B Gene

Graphical View of Domain Structure for InterPro Entry

Q9NUH8

UniProtKB/Swiss-Prot:

TM14B_HUMAN :
  • Belongs to the TMEM14 family.
Family:
  • Belongs to the TMEM14 family.
genes like me logo Genes that share domains with TMEM14B: view

No data available for Gene Families for TMEM14B Gene

Function for TMEM14B Gene

genes like me logo Genes that share phenotypes with TMEM14B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM14B Gene

Localization for TMEM14B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM14B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM14B Gene COMPARTMENTS Subcellular localization image for TMEM14B gene
Compartment Confidence
extracellular 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM14B Gene

Pathways & Interactions for TMEM14B Gene

SuperPathways for TMEM14B Gene

No Data Available

Interacting Proteins for TMEM14B Gene

Gene Ontology (GO) - Biological Process for TMEM14B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM14B Gene

Drugs & Compounds for TMEM14B Gene

No Compound Related Data Available

Transcripts for TMEM14B Gene

Unigene Clusters for TMEM14B Gene

Transmembrane protein 14B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM14B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - - - -
SP6: - - -
SP7:
SP8: - - -

Relevant External Links for TMEM14B Gene

GeneLoc Exon Structure for
TMEM14B
ECgene alternative splicing isoforms for
TMEM14B

Expression for TMEM14B Gene

mRNA expression in normal human tissues for TMEM14B Gene

SOURCE GeneReport for Unigene cluster for TMEM14B Gene Hs.95600

genes like me logo Genes that share expression patterns with TMEM14B: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM14B Gene

Orthologs for TMEM14B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM14B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM14B 35
  • 99.71 (n)
  • 99.12 (a)
TMEM14B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM14C 36
  • 68 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 60 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 31 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tmem14c 36
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tmem14ca 36
  • 58 (a)
ManyToMany
tmem14cb 36
  • 46 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5532 36
  • 39 (a)
OneToMany
Species with no ortholog for TMEM14B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM14B Gene

ENSEMBL:
Gene Tree for TMEM14B (if available)
TreeFam:
Gene Tree for TMEM14B (if available)

Paralogs for TMEM14B Gene

Paralogs for TMEM14B Gene

genes like me logo Genes that share paralogs with TMEM14B: view

Variants for TMEM14B Gene

Sequence variations from dbSNP and Humsavar for TMEM14B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs494723 -- 10,745,994(+) GGGAC(C/T)TCTTA upstream-variant-2KB
rs565905 -- 10,758,583(+) AGTCT(A/G)GTGGA intron-variant
rs561325 -- 10,758,090(+) CCCCT(G/T)GATGG intron-variant
rs1233893 -- 10,752,650(+) caggg(G/T)ttttg intron-variant
rs1233894 -- 10,752,874(+) tgctt(A/T)gcttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM14B Gene

Variant ID Type Subtype PubMed ID
nsv462631 CNV Gain 19166990
nsv470800 CNV Gain 18288195
esv2663502 CNV Deletion 23128226
esv2731586 CNV Deletion 23290073
esv2677566 CNV Deletion 23128226

Variation tolerance for TMEM14B Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM14B Gene

HapMap Linkage Disequilibrium report
TMEM14B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM14B Gene

Disorders for TMEM14B Gene

Relevant External Links for TMEM14B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM14B

No disorders were found for TMEM14B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM14B Gene

Publications for TMEM14B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TMEM14B Gene

Sources for TMEM14B Gene

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