Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM14B Gene

Aliases for TMEM14B Gene

  • Transmembrane Protein 14B 2 3 5

External Ids for TMEM14B Gene

Previous GeneCards Identifiers for TMEM14B Gene

  • GC06P010810
  • GC06P010856
  • GC06P010624

Summaries for TMEM14B Gene

GeneCards Summary for TMEM14B Gene

TMEM14B (Transmembrane Protein 14B) is a Protein Coding gene. An important paralog of this gene is TMEM14C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM14B Gene

Genomics for TMEM14B Gene

Regulatory Elements for TMEM14B Gene

Enhancers for TMEM14B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F010517 1.4 FANTOM5 ENCODE 11.2 -226.5 -226471 7.1 HDGF PKNOX1 ARNT ARID4B DMAP1 FEZF1 ZNF2 ZNF766 CBX5 FOS GCNT2 TMEM14C PAK1IP1 C6orf52 TMEM14B RNA5SP203 SYCP2L LOC101928146 GC06M010576
GH06F010398 3.1 VISTA FANTOM5 Ensembl ENCODE 3.7 -337.9 -337865 22.9 CREB3L1 FEZF1 ZNF143 ZNF548 ZNF263 SP3 MEF2D ZNF610 GLIS1 NBN RNA5SP203 TMEM14C ERVFRD-1 TFAP2A PAK1IP1 TMEM14B C6orf52 TFAP2A-AS1
GH06F010440 1.4 FANTOM5 Ensembl ENCODE 2.3 -306.0 -306004 1.9 TBP MXI1 PKNOX1 TAF1 JUN MAX SIN3A CEBPG RAD21 FOSL1 TFAP2A TMEM14C TMEM14B PAK1IP1 GCNT2 MIR5689 MRPL48P1
GH06F010587 0.9 FANTOM5 ENCODE 2.4 -160.1 -160093 0.7 PKNOX1 NRF1 CEBPB MAFG ZEB2 ZNF316 PBX2 NFE2 EMSY MAFK GCNT2 TMEM14B RPL21P63 PIR63050
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM14B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM14B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001210804 141 2201 HDGF ARNT MLX CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for TMEM14B Gene

Chromosome:
6
Start:
10,747,759 bp from pter
End:
10,852,753 bp from pter
Size:
104,995 bases
Orientation:
Plus strand

Genomic View for TMEM14B Gene

Genes around TMEM14B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM14B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM14B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM14B Gene

Proteins for TMEM14B Gene

  • Protein details for TMEM14B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUH8-TM14B_HUMAN
    Recommended name:
    Transmembrane protein 14B
    Protein Accession:
    Q9NUH8
    Secondary Accessions:
    • Q5THN7
    • Q5THN8
    • Q96IX7
    • Q9BVN8

    Protein attributes for TMEM14B Gene

    Size:
    114 amino acids
    Molecular mass:
    12078 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM14B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM14B Gene

Post-translational modifications for TMEM14B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM14B Gene

Domains & Families for TMEM14B Gene

Protein Domains for TMEM14B Gene

Suggested Antigen Peptide Sequences for TMEM14B Gene

Graphical View of Domain Structure for InterPro Entry

Q9NUH8

UniProtKB/Swiss-Prot:

TM14B_HUMAN :
  • Belongs to the TMEM14 family.
Family:
  • Belongs to the TMEM14 family.
genes like me logo Genes that share domains with TMEM14B: view

No data available for Gene Families for TMEM14B Gene

Function for TMEM14B Gene

genes like me logo Genes that share phenotypes with TMEM14B: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM14B Gene

Localization for TMEM14B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM14B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM14B gene
Compartment Confidence
extracellular 2
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM14B: view

Pathways & Interactions for TMEM14B Gene

SuperPathways for TMEM14B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM14B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM14B Gene

Transcripts for TMEM14B Gene

Unigene Clusters for TMEM14B Gene

Transmembrane protein 14B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM14B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - - - -
SP6: - - -
SP7:
SP8: - - -

Relevant External Links for TMEM14B Gene

GeneLoc Exon Structure for
TMEM14B
ECgene alternative splicing isoforms for
TMEM14B

Expression for TMEM14B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM14B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM14B Gene:

TMEM14B

SOURCE GeneReport for Unigene cluster for TMEM14B Gene:

Hs.95600
genes like me logo Genes that share expression patterns with TMEM14B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMEM14B Gene

Orthologs for TMEM14B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM14B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM14B 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 71 (a)
ManyToMany
-- 35
  • 60 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Tmem14c 35
  • 71 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TMEM14C 35
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 62 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 62 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tmem14ca 35
  • 58 (a)
ManyToMany
tmem14cb 35
  • 46 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5532 35
  • 39 (a)
OneToMany
Species where no ortholog for TMEM14B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM14B Gene

ENSEMBL:
Gene Tree for TMEM14B (if available)
TreeFam:
Gene Tree for TMEM14B (if available)

Paralogs for TMEM14B Gene

Paralogs for TMEM14B Gene

genes like me logo Genes that share paralogs with TMEM14B: view

Variants for TMEM14B Gene

Sequence variations from dbSNP and Humsavar for TMEM14B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1046010 -- 10,756,544(+) GGACT(A/C/G)ATGAA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1046427 -- 10,751,146(+) CCGTC(C/T)CTGGC intron-variant, reference, synonymous-codon
rs111324359 -- 10,751,905(+) TTTCA(A/G)TACAT intron-variant
rs111358271 -- 10,748,411(+) CGATT(-/TGTGTG)TGTGT intron-variant
rs111683486 -- 10,747,611(+) CCGCC(A/T)ACGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM14B Gene

Variant ID Type Subtype PubMed ID
esv2663502 CNV deletion 23128226
esv2677566 CNV deletion 23128226
esv2731586 CNV deletion 23290073
esv3608082 CNV gain 21293372
esv3608084 CNV loss 21293372
nsv462631 CNV gain 19166990
nsv470800 CNV gain 18288195
nsv600979 CNV gain 21841781
nsv966670 CNV duplication 23825009

Variation tolerance for TMEM14B Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM14B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM14B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM14B Gene

Disorders for TMEM14B Gene

Relevant External Links for TMEM14B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM14B

No disorders were found for TMEM14B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM14B Gene

Publications for TMEM14B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 64
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for TMEM14B Gene

Sources for TMEM14B Gene

Content
Loading form....