TMEM14B Gene
protein-coding GIFtS: 43
GCID: GC06P010747
|
|
transmembrane protein 14B
| |
Aliases
for TMEM14B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 14B1 2 | | MGC12231 |
Export aliases for TMEM14B gene to outside databasesPrevious GC identifers: GC06P010810 GC06P010856 GC06P010624 |
Summaries
for TMEM14B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM14B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM14B gene promoter:
Bach1 Pax-6 Lmo2 POU2F1 POU2F1b POU2F1a Sox9 POU2F1c Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM14B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM14B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p25.1-p23 Ensembl cytogenetic band: 6p24.2 HGNC cytogenetic band: 6p25.1-p23TMEM14B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P010747: view genomic region
(about GC identifiers)
Start:
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10,747,973 bp from pter |
End:
|
10,930,656 bp from pter |
Size:
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182,684 bases |
Orientation:
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plus strand |
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Proteins
for TMEM14B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM14B_HUMAN, Q9NUH8 (See
protein sequence)Recommended Name: Transmembrane protein 14B Size: 114 amino acids; 12078 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q5THN8 Q96IX7 Q9BVN8Explore the universe of human proteins at neXtProt for TMEM14B: NX_Q9NUH8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NUH8
TMEM14B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001121183.1 NP_112231.3
ENSEMBL proteins: ENSP00000419375 ENSP00000368858 ENSP00000419208 ENSP00000417416 ENSP00000417095 ENSP00000417929 ENSP00000419156 ENSP00000418730 ENSP00000418334 ENSP00000368845 ENSP00000419806 ENSP00000420580 ENSP00000420658 ENSP00000420172 ENSP00000418927 ENSP00000419731
Human Recombinant Protein Products for TMEM14B:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TMEM14B for ontologies About GeneDecksing
TMEM14B Antibody Products:
Assay Products for TMEM14B: |
Protein
Domains /
Families
for TMEM14B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM14B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NUH8ProtoNet protein and cluster: Q9NUH8 1 Blocks protein family: IPB005349 Protein of unknown function UPF0136
UniProtKB/Swiss-Prot: TM14B_HUMAN, Q9NUH8Similarity: Belongs to the UPF0136 (TMEM14) family |
Function
for TMEM14B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
4 GenomeRNAi human phenotypes for TMEM14B:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM14B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM14B (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TMEM14B (NM_030969) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM14B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM14B |
|
Pathways & Interactions
for TMEM14B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM14B
5 Interacting proteins for TMEM14B (Q9NUH83) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TMEM14B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM14B
Search CenterWatch for drugs/clinical trials and news about TMEM14B / TM14B
|
Transcripts
for TMEM14B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM14B gene (2 alternative transcripts): NM_001127711.1 NM_030969.3 Unigene Cluster for TMEM14B: Transmembrane protein 14B Hs.95600 [show with all ESTs]Unigene Representative Sequence: AK31134018/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21): ENST00000472062 ENST00000379542(uc003mzk.4 uc010jor.3) ENST00000463448(uc010jos.1)
ENST00000473166 ENST00000460341 ENST00000491103 ENST00000480194 ENST00000480294
ENST00000473807 ENST00000475942 ENST00000461342 ENST00000492297 ENST00000379530
ENST00000463100 ENST00000473276 ENST00000467317 ENST00000481240 ENST00000478732
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM14B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM14B (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TMEM14B (NM_030969) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM14B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM14B |
Additional cDNA sequence: AK291883.1 AK294152.1 AK311340.1 BC001033.1 BC007080.1 BC013913.1 BC071660.1 21 DOTS entries: DT.87017216 DT.99960630 DT.121397398 DT.121397466 DT.95262805 DT.121397496 DT.100033338 DT.100796494 DT.102834849 DT.121397367 DT.121397404 DT.121397454 DT.121397539 DT.75104796 DT.95356477 DT.121397502 DT.40245627 DT.75164572 DT.87017218 DT.91838838 DT.92452626 24/663 AceView cDNA sequences (see all 663): BM887873 BQ935722 CA777519 CB130241 CR594179 AA120782 AW162019 BU947678 AA505915 AW439156 BE675483 AA654253 CA748653 AI950951 BU689496 BU169969 BE784090 BU786051 AA830816 BM666113 BM888344 BU197365 R07113 BX381354
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM14B (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | - | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | - | | - | | - | | | | | |
ECgene alternative splicing isoforms for TMEM14B
|
Expression
for TMEM14B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM14B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTTATTGA
About this image
See TMEM14B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM14B
SOURCE GeneReport for Unigene cluster: Hs.95600
SABiosciences Custom PCR Arrays for TMEM14B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM14B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TMEM14B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM14B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM14B |
Orthologs
for TMEM14B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM14B gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for TMEM14B (if available)
TreeFam Gene Tree for TMEM14B (if available) |
Paralogs
for TMEM14B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM14B gene
- TMEM14E2 TMEM14A2 TMEM14C2
18/76 SIMAP similar genes for TMEM14B using alignment to 11 protein entries: TM14B_HUMAN (see all proteins)
(see all similar genes):NRAMP1 HECW1 MEFV FAM3A RUFY1 C10orf137
RBP7 CERS5 NEK4 RBMS2 AEBP2 AURA2
DCTN5 ZNF212 TMEM14D AGBL3 ERBB2 FOPNL
TMEM14B for paralogs About GeneDecksing
|
Genomic Variants
for TMEM14B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM14B (10747973 - 10930656 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM14B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM14B |
|
Disorders
/ Diseases
for TMEM14B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TMEM14B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM14B gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM14B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TMEM14B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM14B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM14B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM14B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM14B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM14B gene:
Search GeneIP for patents involving TMEM14B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM14B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM14B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM14B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM14B | | | OriGene Protein Over-expression Lysate for TMEM14B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM14B | | OriGene 3'-UTR Clone for TMEM14B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM14B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM14B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TMEM14B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM14B | | OriGene Custom Protein Services for TMEM14B | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM14B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM14B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM14B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM14B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM14B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM14B |
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 |  |  |  | |
| | | | Search Tocris compounds for TMEM14B |
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 | | | TMEM14B Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | ThermoFisher Antibodies for TMEM14B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM14B |
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