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Aliases for TMEM14A Gene

Aliases for TMEM14A Gene

  • Transmembrane Protein 14A 2 3 5
  • C6orf73 3 4
  • PTD011 3

External Ids for TMEM14A Gene

Previous GeneCards Identifiers for TMEM14A Gene

  • GC06P052538
  • GC06P052582
  • GC06P052643
  • GC06P052535
  • GC06P052367

Summaries for TMEM14A Gene

GeneCards Summary for TMEM14A Gene

TMEM14A (Transmembrane Protein 14A) is a Protein Coding gene. Diseases associated with TMEM14A include Ovary Serous Adenocarcinoma and Ovarian Cystadenocarcinoma. An important paralog of this gene is TMEM14C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM14A Gene

Genomics for TMEM14A Gene

Regulatory Elements for TMEM14A Gene

Enhancers for TMEM14A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM14A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM14A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM14A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM14A Gene

Chromosome:
6
Start:
52,671,086 bp from pter
End:
52,686,588 bp from pter
Size:
15,503 bases
Orientation:
Plus strand

Genomic View for TMEM14A Gene

Genes around TMEM14A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM14A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM14A Gene

Proteins for TMEM14A Gene

  • Protein details for TMEM14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6G1-TM14A_HUMAN
    Recommended name:
    Transmembrane protein 14A
    Protein Accession:
    Q9Y6G1
    Secondary Accessions:
    • B2R552

    Protein attributes for TMEM14A Gene

    Size:
    99 amino acids
    Molecular mass:
    10712 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TMEM14A Gene

neXtProt entry for TMEM14A Gene

Proteomics data for TMEM14A Gene at MOPED

Post-translational modifications for TMEM14A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM14A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM14A Gene

Domains & Families for TMEM14A Gene

Protein Domains for TMEM14A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM14A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6G1

UniProtKB/Swiss-Prot:

TM14A_HUMAN :
  • Belongs to the TMEM14 family.
Family:
  • Belongs to the TMEM14 family.
genes like me logo Genes that share domains with TMEM14A: view

No data available for Gene Families for TMEM14A Gene

Function for TMEM14A Gene

Phenotypes for TMEM14A Gene

genes like me logo Genes that share phenotypes with TMEM14A: view

Animal Model Products

CRISPR Products

miRNA for TMEM14A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM14A Gene

Localization for TMEM14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM14A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM14A Gene COMPARTMENTS Subcellular localization image for TMEM14A gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TMEM14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM14A: view

Pathways & Interactions for TMEM14A Gene

SuperPathways for TMEM14A Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM14A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM14A Gene

Drugs & Compounds for TMEM14A Gene

No Compound Related Data Available

Transcripts for TMEM14A Gene

mRNA/cDNA for TMEM14A Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(160) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM14A Gene

Transmembrane protein 14A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM14A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - - -
SP5:
SP6: - -

Relevant External Links for TMEM14A Gene

GeneLoc Exon Structure for
TMEM14A
ECgene alternative splicing isoforms for
TMEM14A

Expression for TMEM14A Gene

mRNA expression in normal human tissues for TMEM14A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for TMEM14A Gene Hs.94896

genes like me logo Genes that share expression patterns with TMEM14A: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM14A Gene

Orthologs for TMEM14A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM14A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM14A 35
  • 93.1 (n)
  • 95.4 (a)
TMEM14A 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM14A 35
  • 91.19 (n)
  • 94.25 (a)
TMEM14A 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem14a 35
  • 89.66 (n)
  • 91.95 (a)
Tmem14a 16
Tmem14a 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM14A 35
  • 99.66 (n)
  • 100 (a)
TMEM14A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem14a 35
  • 89.27 (n)
  • 93.1 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM14A 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM14A 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM14A 35
  • 66.67 (n)
  • 63.22 (a)
TMEM14A 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM14A 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496530 35
  • 67.43 (n)
  • 65.52 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:163080 35
  • 57.47 (n)
  • 52.87 (a)
TMEM14A 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5532 36
  • 39 (a)
OneToMany
Species with no ortholog for TMEM14A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM14A Gene

ENSEMBL:
Gene Tree for TMEM14A (if available)
TreeFam:
Gene Tree for TMEM14A (if available)

Paralogs for TMEM14A Gene

Paralogs for TMEM14A Gene

(3) SIMAP similar genes for TMEM14A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEM14A: view

Variants for TMEM14A Gene

Sequence variations from dbSNP and Humsavar for TMEM14A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs11543266 - 52,681,851(+) TTGGA(C/T)GTTTG reference, missense
rs5028973 -- 52,684,158(+) TTGCA(A/G)GTTTA reference, missense
rs6458852 -- 52,670,317(+) gaggc(C/T)ggaga upstream-variant-2KB
rs6907304 -- 52,685,602(+) AAAAA(A/G)GAAGA intron-variant
rs6908551 -- 52,673,301(+) gcccc(A/G)cctgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM14A Gene

Variant ID Type Subtype PubMed ID
nsv830663 CNV Loss 17160897
nsv462945 CNV Loss 19166990
nsv470818 CNV Loss 18288195
esv273125 CNV Insertion 20981092
esv269679 CNV Insertion 20981092

Variation tolerance for TMEM14A Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.06% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM14A Gene

Disorders for TMEM14A Gene

MalaCards: The human disease database

(3) MalaCards diseases for TMEM14A Gene - From: DISEASES

Disorder Aliases PubMed IDs
ovary serous adenocarcinoma
  • malignant ovarian serous tumor
ovarian cystadenocarcinoma
  • cystadenocarcinoma of ovary
epilepsy, generalized, with febrile seizures plus, type 5
  • epilepsy, idiopathic generalized, 10
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM14A

Genetic Association Database (GAD)
TMEM14A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM14A
genes like me logo Genes that share disorders with TMEM14A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM14A Gene

Publications for TMEM14A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. (PMID: 23142642) Passantino R. … Guarneri P. (Biochim. Biophys. Acta 2013) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. TMEM14A inhibits N-(4-hydroxyphenyl)retinamide-induced apoptosis through the stabilization of mitochondrial membrane potential. (PMID: 21723035) Woo I.S. … Seo H.G. (Cancer Lett. 2011) 3

Products for TMEM14A Gene

Sources for TMEM14A Gene

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