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TMEM14A Gene

protein-coding   GIFtS: 46
GCID: GC06P052535

Transmembrane Protein 14A

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 14A1 2
C6orf732 3

External Ids:    HGNC: 210761   Entrez Gene: 289782   Ensembl: ENSG000000960927   UniProtKB: Q9Y6G13   

Export aliases for TMEM14A gene to outside databases

Previous GC identifers: GC06P052538 GC06P052582 GC06P052643 GC06P052367


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM14A Gene:
TMEM14A (transmembrane protein 14A) is a protein-coding gene. An important paralog of this gene is TMEM14B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM14A gene promoter:
         Oct-B1   POU2F2 (Oct-2.1)   oct-B2   oct-B3   POU2F2   POU2F2C   SRY   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM14A promoter sequence
   Search Chromatin IP Primers for TMEM14A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM14A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.2   Ensembl cytogenetic band:  6p12.2   HGNC cytogenetic band: 6p12.3

TMEM14A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM14A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P052535:  view genomic region     (about GC identifiers)

Start:
52,535,884 bp from pter      End:
52,551,386 bp from pter
Size:
15,503 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TM14A_HUMAN, Q9Y6G1 (See protein sequence)
Recommended Name: Transmembrane protein 14A  
Size: 99 amino acids; 10712 Da
2 PDB 3D structures from and Proteopedia for TMEM14A:
2LOO (3D)        2LOP (3D)    
Secondary accessions: B2R552

Explore the universe of human proteins at neXtProt for TMEM14A: NX_Q9Y6G1

Explore proteomics data for TMEM14A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMEM14A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054770.1  
    ENSEMBL proteins: 
     ENSP00000211314  

    TMEM14A Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TMEM14A

     
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    antibodies-online proteins for TMEM14A (2 products) 

     
    Search antibodies-online for peptides for TMEM14A

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    Cloud-Clone Corp. CLIAs for TMEM14A
    Search eBioscience for ELISAs for TMEM14A 
    antibodies-online kits for TMEM14A (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005349 UPF0136_TM

    Graphical View of Domain Structure for InterPro Entry Q9Y6G1

    ProtoNet protein and cluster: Q9Y6G1

    1 Blocks protein domain: IPB005349 Protein of unknown function UPF0136

    UniProtKB/Swiss-Prot: TM14A_HUMAN, Q9Y6G1
    Similarity: Belongs to the UPF0136 (TMEM14) family


    Find genes that share domains with TMEM14A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TMEM14A

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMEM14A:
    hsa-mir-181a-5p (MIRT025139), hsa-mir-373-3p (MIRT002540), hsa-mir-148b-3p (MIRT019430), hsa-mir-148a-3p (MIRT025971)

    Block miRNA regulation of human, mouse, rat TMEM14A using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate TMEM14A:
    hsa-miR-200c hsa-miR-429 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidTMEM14A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMEM14A

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    GenScript: all cDNA clones in your preferred vector: TMEM14A (NM_014051)
    Sino Biological Human cDNA Clone for TMEM14A
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM14A

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM14A_HUMAN, Q9Y6G1: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    endoplasmic reticulum1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMEM14A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM14A
    Interactions:

        Search GeneGlobe Interaction Network for TMEM14A

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for TMEM14A (Q9Y6G13 ENSP000002113144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    USP18Q9UMW83I2D: score=1 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    NUP35ENSP000002951194STRING: ENSP00000295119
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM14A (TM14A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM14A gene: 
    NM_014051.3  

    Unigene Cluster for TMEM14A:

    Transmembrane protein 14A
    Hs.94896  [show with all ESTs]
    Unigene Representative Sequence: BF690886
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000211314(uc003pax.3)
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate TMEM14A:
    hsa-miR-200c hsa-miR-429 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidTMEM14A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMEM14A
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM14A
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    GenScript: all cDNA clones in your preferred vector: TMEM14A (NM_014051)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM14A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM14A
    Primer
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    OriGene qPCR primer pairs and template standards for TMEM14A
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM14A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM14A
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM14A
      QuantiFast Probe-based Assays in human, mouse, rat TMEM14A

    Additional mRNA sequence: 

    AF239771.1 AK312063.1 BC015097.1 BC019328.1 

    10 DOTS entries:

    DT.91685505  DT.213523  DT.100660623  DT.92435606  DT.40118615  DT.100817795  DT.92435604  DT.95180552 
    DT.95316963  DT.97782406 

    Selected AceView cDNA sequences (see all 160):

    BI850372 AA029044 AI263509 AI358762 CA867953 AA811461 AA883614 BQ014279 
    AA379956 CA943679 AW273267 BM785286 BE296549 BU734097 BM806629 BU737656 
    AI928977 BC019328 CD370335 BX103663 CR618706 AI358016 CA448163 AF239771 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMEM14A (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c
    SP1:                                -                       -     -                           
    SP2:                                                        -     -                           
    SP3:                                -     -                 -     -                           
    SP4:                          -     -     -                 -     -                           
    SP5:                                                                                          


    ECgene alternative splicing isoforms for TMEM14A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM14A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCAAGTAA
    TMEM14A Expression
    About this image

    TMEM14A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM14A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.94896
        Custom PCR Arrays for TMEM14A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM14A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMEM14A gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem14a1 , 5 transmembrane protein 14A1, 5 89.66(n)1
    91.95(a)1
      1 (6.50 cM)5
    757121  NM_029398.21  NP_083674.21 
     212185755 
    chicken
    (Gallus gallus)
    Aves TMEM14A1 transmembrane protein 14A 66.67(n)
    63.22(a)
      421897  XM_419915.4  XP_419915.3 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM14A6
    transmembrane protein 14A
    64(a)
    1 ↔ 1
    1(151855291-151860151)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480349732   -- 74.7(n)    48034973 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1630801 zgc:163080 57.47(n)
    52.87(a)
      799515  NM_001082933.2  NP_001076402.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55326
    --
    39(a)
    1 → many
    2R(19640264-19640929)


    ENSEMBL Gene Tree for TMEM14A (if available)
    TreeFam Gene Tree for TMEM14A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM14A gene
    TMEM14B2  TMEM14C2  
    3 SIMAP similar genes for TMEM14A using alignment to 2 protein entries:     TM14A_HUMAN (see all proteins):
    TMEM14C    TMEM14B    TMEM14D

    Find genes that share paralogs with TMEM14A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM14A (see all 409)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs717997541,2
    C--52461241(+) ACAAC-/AAAAA 
            
    AAAAA
    1 -- int10--------
    rs73413271,2
    C,H--52534480(+) GGAGAG/CAAGGT 1 -- us2k1 trp34Minor allele frequency- C:0.00NS EA 420
    rs759720041,2
    C,F--52534496(+) GGCTGG/AGGTAA 1 -- us2k11Minor allele frequency- A:0.06NA 120
    rs1488857781,2
    C--52534497(+) GCTGGA/GGTAAG 1 -- us2k10--------
    rs1160126441,2
    F--52534605(+) CAACTC/GTTCTG 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1423203011,2
    --52534610(+) CTTCTA/GTGAAT 1 -- us2k10--------
    rs7673081,2
    C,F,H--52534645(-) AAGTTG/AGTCCT 1 -- us2k122Minor allele frequency- A:0.27NS EA NA WA 2526
    rs7673101,2
    H--52534673(-) TATAAC/TTACAT 1 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs1890666591,2
    --52534683(+) ATTACG/TTCCCT 1 -- us2k10--------
    rs121924451,2
    F--52534701(+) TTTTAC/TGCACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMEM14A (52535884 - 52551386 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TMEM14A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv269679CNV Insertion20981092
    esv273125CNV Insertion20981092
    nsv462945CNV Loss19166990
    nsv470818CNV Loss18288195
    nsv830663CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease from the University of Copenhagen DISEASES database for TMEM14A:
    Idiopathic generalized epilepsy

    Find genes that share disorders with TMEM14A           About GenesLikeMe

    Genetic Association Database (GAD): TMEM14A

    Export disorders for TMEM14A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM14A gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with TMEM14A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    3. Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. (PubMed id 23142642)1 Passantino R....Guarneri P. (Biochim. Biophys. Acta 2013)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Facile backbone structure determination of human membrane proteins by NMR spectroscopy. (PubMed id 22609626)2 Klammt C.... Choe S. (Nat. Methods 2012)
    6. TMEM14A inhibits N-(4-hydroxyphenyl)retinamide-induced apoptosis through the stabilization of mitochondrial membrane potential. (PubMed id 21723035)1 Woo I.S....Seo H.G. (Cancer Lett. 2011)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    9. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    10. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (Biochem. Biophys. Res. Commun. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 28978 HGNC: 21076 AceView: TMEM14A Ensembl:ENSG00000096092 euGenes: HUgn28978
    ECgene: TMEM14A H-InvDB: TMEM14A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM14A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM14A gene:
    Search GeneIP for patents involving TMEM14A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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