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Aliases for TMEM14A Gene

Aliases for TMEM14A Gene

  • Transmembrane Protein 14A 2 3
  • C6orf73 3 4
  • PTD011 3

External Ids for TMEM14A Gene

Previous GeneCards Identifiers for TMEM14A Gene

  • GC06P052538
  • GC06P052582
  • GC06P052643
  • GC06P052535
  • GC06P052367

Summaries for TMEM14A Gene

GeneCards Summary for TMEM14A Gene

TMEM14A (Transmembrane Protein 14A) is a Protein Coding gene. An important paralog of this gene is TMEM14C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM14A Gene

Genomics for TMEM14A Gene

Regulatory Elements for TMEM14A Gene

Genomic Location for TMEM14A Gene

Start:
52,671,086 bp from pter
End:
52,686,588 bp from pter
Size:
15,503 bases
Orientation:
Plus strand

Genomic View for TMEM14A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM14A Gene

Proteins for TMEM14A Gene

  • Protein details for TMEM14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6G1-TM14A_HUMAN
    Recommended name:
    Transmembrane protein 14A
    Protein Accession:
    Q9Y6G1
    Secondary Accessions:
    • B2R552

    Protein attributes for TMEM14A Gene

    Size:
    99 amino acids
    Molecular mass:
    10712 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TMEM14A Gene

neXtProt entry for TMEM14A Gene

Proteomics data for TMEM14A Gene at MOPED

Post-translational modifications for TMEM14A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM14A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM14A Gene

Domains for TMEM14A Gene

Protein Domains for TMEM14A Gene

Suggested Antigen Peptide Sequences for TMEM14A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6G1

UniProtKB/Swiss-Prot:

TM14A_HUMAN :
  • Q9Y6G1
Family:
  • Belongs to the TMEM14 family.
genes like me logo Genes that share domains with TMEM14A: view

No data available for Gene Families for TMEM14A Gene

Function for TMEM14A Gene

Gene Ontology (GO) - Molecular Function for TMEM14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM14A: view

Animal Model Products

CRISPR Products

miRNA for TMEM14A Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM14A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM14A Gene

Localization for TMEM14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM14A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM14A Gene COMPARTMENTS Subcellular localization image for TMEM14A gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TMEM14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM14A: view

Pathways for TMEM14A Gene

SuperPathways for TMEM14A Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM14A Gene

None

No data available for Pathways by source for TMEM14A Gene

Transcripts for TMEM14A Gene

mRNA/cDNA for TMEM14A Gene

(160) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM14A Gene

Transmembrane protein 14A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM14A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM14A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - - -
SP5:
SP6: - -

Relevant External Links for TMEM14A Gene

GeneLoc Exon Structure for
TMEM14A
ECgene alternative splicing isoforms for
TMEM14A

Expression for TMEM14A Gene

mRNA expression in normal human tissues for TMEM14A Gene

SOURCE GeneReport for Unigene cluster for TMEM14A Gene Hs.94896

genes like me logo Genes that share expressions with TMEM14A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for TMEM14A Gene

Orthologs for TMEM14A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM14A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM14A 35
  • 93.1 (n)
  • 95.4 (a)
TMEM14A 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM14A 35
  • 91.19 (n)
  • 94.25 (a)
TMEM14A 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem14a 35
  • 89.66 (n)
  • 91.95 (a)
Tmem14a 16
Tmem14a 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM14A 35
  • 99.66 (n)
  • 100 (a)
TMEM14A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem14a 35
  • 89.27 (n)
  • 93.1 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM14A 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM14A 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM14A 35
  • 66.67 (n)
  • 63.22 (a)
TMEM14A 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM14A 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496530 35
  • 67.43 (n)
  • 65.52 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:163080 35
  • 57.47 (n)
  • 52.87 (a)
TMEM14A 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5532 36
  • 39 (a)
OneToMany
Species with no ortholog for TMEM14A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM14A Gene

ENSEMBL:
Gene Tree for TMEM14A (if available)
TreeFam:
Gene Tree for TMEM14A (if available)

Paralogs for TMEM14A Gene

Paralogs for TMEM14A Gene

Selected SIMAP similar genes for TMEM14A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEM14A: view

Variants for TMEM14A Gene

Sequence variations from dbSNP and Humsavar for TMEM14A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs140746 -- 52,673,479(+) TCCTC(-/TGTT)TGTAA intron-variant
rs767308 -- 52,669,847(-) AAGTT(A/G)GTCCT upstream-variant-2KB
rs767309 -- 52,669,905(-) TTTGT(A/G)CATAA upstream-variant-2KB
rs767310 -- 52,669,875(-) TATAA(C/T)TACAT upstream-variant-2KB
rs767311 -- 52,669,904(-) TTGTG(C/T)ATAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM14A Gene

Variant ID Type Subtype PubMed ID
nsv830663 CNV Loss 17160897
nsv462945 CNV Loss 19166990
nsv470818 CNV Loss 18288195
esv273125 CNV Insertion 20981092
esv269679 CNV Insertion 20981092

Relevant External Links for TMEM14A Gene

HapMap Linkage Disequilibrium report
TMEM14A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM14A Gene

Disorders for TMEM14A Gene

(1) University of Copenhagen DISEASES for TMEM14A Gene

Relevant External Links for TMEM14A

Genetic Association Database (GAD)
TMEM14A
genes like me logo Genes that share disorders with TMEM14A: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for TMEM14A Gene

Publications for TMEM14A Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for TMEM14A Gene

Sources for TMEM14A Gene

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