TMEM14A Gene
protein-coding GIFtS: 46
GCID: GC06P052535
|
|
transmembrane protein 14A
| |
Aliases
for TMEM14A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 14A1 2 | | C6orf731 2 3 | | PTD0111 |
Export aliases for TMEM14A gene to outside databasesPrevious GC identifers: GC06P052538 GC06P052582 GC06P052643 GC06P052367 |
Summaries
for TMEM14A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM14A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM14A gene promoter:
Oct-B1 POU2F2 (Oct-2.1) oct-B2 oct-B3 POU2F2 POU2F2C SRY POU2F1 POU2F1a POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM14A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM14A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p12.2 Ensembl cytogenetic band: 6p12.2 HGNC cytogenetic band: 6p12.3TMEM14A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P052535: view genomic region
(about GC identifiers)
Start:
|
52,535,884 bp from pter |
End:
|
52,551,386 bp from pter |
Size:
|
15,503 bases |
Orientation:
|
plus strand |
|
Proteins
for TMEM14A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM14A_HUMAN, Q9Y6G1 (See
protein sequence)Recommended Name: Transmembrane protein 14A Size: 99 amino acids; 10712 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
2 PDB 3D structures from  and Proteopedia  for TMEM14A:2LOO (3D)
2LOP (3D)
Secondary accessions: B2R552Explore the universe of human proteins at neXtProt for TMEM14A: NX_Q9Y6G1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y6G1
TMEM14A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_054770.1
ENSEMBL proteins: ENSP00000211314
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM14A for ontologies About GeneDecksing
TMEM14A Antibody Products:
Assay Products for TMEM14A: |
Protein
Domains /
Families
for TMEM14A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM14A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y6G1ProtoNet protein and cluster: Q9Y6G1 1 Blocks protein family: IPB005349 Protein of unknown function UPF0136
UniProtKB/Swiss-Prot: TM14A_HUMAN, Q9Y6G1Similarity: Belongs to the UPF0136 (TMEM14) family |
Function
for TMEM14A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM14A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM14A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM14A (NM_014051) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM14A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM14A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM14A |
|
Pathways & Interactions
for TMEM14A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM14A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for TMEM14A (Q9Y6G13 ENSP000002113144) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TMEM14A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM14A
Search CenterWatch for drugs/clinical trials and news about TMEM14A / TM14A
|
Transcripts
for TMEM14A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM14A gene: NM_014051.3 Unigene Cluster for TMEM14A: Transmembrane protein 14A Hs.94896 [show with all ESTs]Unigene Representative Sequence: BF6908861 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000211314(uc003pax.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM14A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM14A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM14A (NM_014051) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM14A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM14A |
Additional cDNA sequence: AF239771.1 AK312063.1 BC015097.1 BC019328.1 10 DOTS entries: DT.91685505 DT.213523 DT.100660623 DT.92435606 DT.40118615 DT.100817795 DT.92435604 DT.95180552 DT.95316963 DT.97782406 24/160 AceView cDNA sequences (see all 160): CA867953 AA029044 CA943679 AI263509 AW273267 AI358016 CR618706 AA883614 AI358762 BM806629 AA379956 BQ014279 BU734097 CA448163 BU737656 BI850372 BX103663 AI928977 CD370335 BC019328 BE296549 BM785286 AA811461 AF239771
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM14A (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM14A
|
Expression
for TMEM14A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM14A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTCAAGTAA
About this image
See TMEM14A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM14A
SOURCE GeneReport for Unigene cluster: Hs.94896
SABiosciences Custom PCR Arrays for TMEM14A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM14A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM14A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM14A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM14A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM14A |
Orthologs
for TMEM14A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM14A gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for TMEM14A (if available)
TreeFam Gene Tree for TMEM14A (if available) |
Paralogs
for TMEM14A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM14A gene
- TMEM14E2 TMEM14B2 TMEM14C2
3 SIMAP similar genes for TMEM14A using alignment to 2 protein entries: TM14A_HUMAN (see all proteins):TMEM14C TMEM14B TMEM14D
TMEM14A for paralogs About GeneDecksing
|
Genomic Variants
for TMEM14A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM14A (52535884 - 52551386 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM14A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM14A |
|
Disorders
/ Diseases
for TMEM14A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM14A for disorders About GeneDecksing
4  diseases for TMEM14A: About MalaCardsjuvenile myoclonic epilepsy generalized epilepsy intrahepatic cholangiocarcinoma cholangiocarcinoma
1 disease from the University of Copenhagen DISEASES database for TMEM14A:Idiopathic generalized epilepsy Export disorders for TMEM14A gene to outside databases
|
Publications
for TMEM14A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM14A gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM14A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Facile backbone structure determination of human membrane proteins by NMR spectroscopy. (PubMed id 22609626)2 Klammt C.... Choe S. (2012)
- TMEM14A inhibits N-(4-hydroxyphenyl)retinamide-induce d apoptosis through the stabilization of mitochondrial membrane potential. (PubMed id 21723035)1 Woo I.S....Seo H.G. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for TMEM14A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM14A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM14A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM14A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM14A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM14A gene:
Search GeneIP for patents involving TMEM14A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM14A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM14A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM14A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM14A | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM14A | | OriGene 3'-UTR Clone for TMEM14A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM14A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM14A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM14A | | OriGene Custom Protein Services for TMEM14A | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM14A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM14A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM14A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM14A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM14A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM14A |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TMEM14A |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TMEM14A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM14A |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM14A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM14A |
|
|
|
|
