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Aliases for TMEM147 Gene

Aliases for TMEM147 Gene

  • Transmembrane Protein 147 2 3
  • Protein NIFIE 14 3 4
  • Seven Transmembrane Domain Protein 3
  • NIFIE14 3

External Ids for TMEM147 Gene

Summaries for TMEM147 Gene

GeneCards Summary for TMEM147 Gene

TMEM147 (Transmembrane Protein 147) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM147 Gene

Genomics for TMEM147 Gene

Genomic Location for TMEM147 Gene

Start:
35,545,595 bp from pter
End:
35,547,527 bp from pter
Size:
1,933 bases
Orientation:
Plus strand

Genomic View for TMEM147 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM147 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM147 Gene

Regulatory Elements for TMEM147 Gene

Proteins for TMEM147 Gene

  • Protein details for TMEM147 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVK8-TM147_HUMAN
    Recommended name:
    Transmembrane protein 147
    Protein Accession:
    Q9BVK8
    Secondary Accessions:
    • A8MWW0
    • O75790

    Protein attributes for TMEM147 Gene

    Size:
    224 amino acids
    Molecular mass:
    25261 Da
    Quaternary structure:
    • Forms a complex with NCLN and NOMO2, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, probably also interacts with NOMO1 and NOMO3.
    SequenceCaution:
    • Sequence=BG697070; Type=Frameshift; Positions=213; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM147 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM147 Gene

Proteomics data for TMEM147 Gene at MOPED

Post-translational modifications for TMEM147 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM147 Gene

No data available for DME Specific Peptides for TMEM147 Gene

Domains for TMEM147 Gene

Protein Domains for TMEM147 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with TMEM147: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM147 Gene

Function for TMEM147 Gene

Gene Ontology (GO) - Molecular Function for TMEM147 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM147: view

miRNA for TMEM147 Gene

miRTarBase miRNAs that target TMEM147

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM147 Gene

Localization for TMEM147 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM147 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM147 Gene COMPARTMENTS Subcellular localization image for TMEM147 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM147 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM147: view

Pathways for TMEM147 Gene

SuperPathways for TMEM147 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM147 Gene

None

No data available for Pathways by source for TMEM147 Gene

Transcripts for TMEM147 Gene

Unigene Clusters for TMEM147 Gene

Transmembrane protein 147:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM147 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: -
SP3: - -
SP4: - -
SP5: -
SP6: - - - -
SP7: -
SP8:

Relevant External Links for TMEM147 Gene

GeneLoc Exon Structure for
TMEM147
ECgene alternative splicing isoforms for
TMEM147

Expression for TMEM147 Gene

mRNA expression in normal human tissues for TMEM147 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM147 Gene

SOURCE GeneReport for Unigene cluster for TMEM147 Gene Hs.9234

genes like me logo Genes that share expressions with TMEM147: view

Orthologs for TMEM147 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM147 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM147 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM147 36
  • 92.11 (n)
  • 98.66 (a)
TMEM147 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM147 36
  • 91.52 (n)
  • 99.55 (a)
TMEM147 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem147 36
  • 90.92 (n)
  • 99.11 (a)
Tmem147 16
Tmem147 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM147 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem147 36
  • 90.62 (n)
  • 99.55 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM147 37
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem147 36
  • 71.49 (n)
  • 78.73 (a)
tmem147 37
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008757 36
  • 56.56 (n)
  • 50.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5861 36
  • 59.97 (n)
  • 50.47 (a)
CG5861 37
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK418.5 36
  • 47.51 (n)
  • 42.52 (a)
ZK418.5 37
  • 41 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G47640 36
  • 48.89 (n)
  • 40 (a)
rice
(Oryza sativa)
Liliopsida Os03g0766000 36
  • 52.21 (n)
  • 40.56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7965 37
  • 47 (a)
OneToOne
Species with no ortholog for TMEM147:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM147 Gene

ENSEMBL:
Gene Tree for TMEM147 (if available)
TreeFam:
Gene Tree for TMEM147 (if available)

Paralogs for TMEM147 Gene

No data available for Paralogs for TMEM147 Gene

Variants for TMEM147 Gene

Sequence variations from dbSNP and Humsavar for TMEM147 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
VAR_051429 -

Structural Variations from Database of Genomic Variants (DGV) for TMEM147 Gene

Variant ID Type Subtype PubMed ID
nsv911628 CNV Loss 21882294

Relevant External Links for TMEM147 Gene

HapMap Linkage Disequilibrium report
TMEM147

Disorders for TMEM147 Gene

(1) Novoseek inferred disease relationships for TMEM147 Gene

Disease -log(P) Hits PubMed IDs
cystinosis 69.9 1
genes like me logo Genes that share disorders with TMEM147: view

No data available for UniProtKB/Swiss-Prot for TMEM147 Gene

Publications for TMEM147 Gene

  1. Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. (PMID: 20538592) Dettmer U. … Haffner C. (J. Biol. Chem. 2010) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for TMEM147 Gene

  • antibodies-online peptides for TMEM147
  • antibodies-online antibodies for TMEM147
  • antibodies-online kits for TMEM147

Sources for TMEM147 Gene

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