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Aliases for TMEM147 Gene

Aliases for TMEM147 Gene

  • Transmembrane Protein 147 2 3 5
  • Protein NIFIE 14 3 4
  • Seven Transmembrane Domain Protein 3
  • NIFIE14 3

External Ids for TMEM147 Gene

Previous GeneCards Identifiers for TMEM147 Gene

  • GC19P040729
  • GC19P036037
  • GC19P032541
  • GC19P036038

Summaries for TMEM147 Gene

GeneCards Summary for TMEM147 Gene

TMEM147 (Transmembrane Protein 147) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM147 Gene

Genomics for TMEM147 Gene

Regulatory Elements for TMEM147 Gene

Promoters for TMEM147 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM147 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM147 Gene

Chromosome:
19
Start:
35,545,595 bp from pter
End:
35,547,527 bp from pter
Size:
1,933 bases
Orientation:
Plus strand

Genomic View for TMEM147 Gene

Genes around TMEM147 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM147 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM147 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM147 Gene

Proteins for TMEM147 Gene

  • Protein details for TMEM147 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVK8-TM147_HUMAN
    Recommended name:
    Transmembrane protein 147
    Protein Accession:
    Q9BVK8
    Secondary Accessions:
    • A8MWW0
    • O75790

    Protein attributes for TMEM147 Gene

    Size:
    224 amino acids
    Molecular mass:
    25261 Da
    Quaternary structure:
    • Forms a complex with NCLN and NOMO2, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, probably also interacts with NOMO1 and NOMO3.
    SequenceCaution:
    • Sequence=BG697070; Type=Frameshift; Positions=213; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM147 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM147 Gene

Proteomics data for TMEM147 Gene at MOPED

Post-translational modifications for TMEM147 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM147 Gene

No data available for DME Specific Peptides for TMEM147 Gene

Domains & Families for TMEM147 Gene

Protein Domains for TMEM147 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM147 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM147: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM147 Gene

Function for TMEM147 Gene

genes like me logo Genes that share phenotypes with TMEM147: view

Animal Model Products

CRISPR Products

miRNA for TMEM147 Gene

miRTarBase miRNAs that target TMEM147

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM147 Gene

Localization for TMEM147 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM147 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM147 Gene COMPARTMENTS Subcellular localization image for TMEM147 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM147 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM147: view

Pathways & Interactions for TMEM147 Gene

SuperPathways for TMEM147 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM147 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM147 Gene

Drugs & Compounds for TMEM147 Gene

No Compound Related Data Available

Transcripts for TMEM147 Gene

Unigene Clusters for TMEM147 Gene

Transmembrane protein 147:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM147 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: -
SP3: - -
SP4: - -
SP5: -
SP6: - - - -
SP7: -
SP8:

Relevant External Links for TMEM147 Gene

GeneLoc Exon Structure for
TMEM147
ECgene alternative splicing isoforms for
TMEM147

Expression for TMEM147 Gene

mRNA expression in normal human tissues for TMEM147 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM147 Gene

This gene is overexpressed in Fetal ovary (22.4), Ovary (13.3), Retina (12.1), and NK cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM147 Gene



SOURCE GeneReport for Unigene cluster for TMEM147 Gene Hs.9234

genes like me logo Genes that share expression patterns with TMEM147: view

Protein tissue co-expression partners for TMEM147 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM147 Gene

Orthologs for TMEM147 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM147 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM147 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM147 36
  • 99 (a)
OneToOne
TMEM147 35
  • 92.11 (n)
  • 98.66 (a)
dog
(Canis familiaris)
Mammalia TMEM147 35
  • 91.52 (n)
  • 99.55 (a)
TMEM147 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem147 16
Tmem147 36
  • 99 (a)
OneToOne
Tmem147 35
  • 90.92 (n)
  • 99.11 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM147 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem147 35
  • 90.62 (n)
  • 99.55 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM147 36
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem147 36
  • 78 (a)
OneToOne
tmem147 35
  • 71.49 (n)
  • 78.73 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008757 35
  • 56.56 (n)
  • 50.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5861 36
  • 47 (a)
OneToOne
CG5861 35
  • 59.97 (n)
  • 50.47 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK418.5 35
  • 47.51 (n)
  • 42.52 (a)
ZK418.5 36
  • 41 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G47640 35
  • 48.89 (n)
  • 40 (a)
rice
(Oryza sativa)
Liliopsida Os03g0766000 35
  • 52.21 (n)
  • 40.56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7965 36
  • 47 (a)
OneToOne
Species with no ortholog for TMEM147:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM147 Gene

ENSEMBL:
Gene Tree for TMEM147 (if available)
TreeFam:
Gene Tree for TMEM147 (if available)

Paralogs for TMEM147 Gene

No data available for Paralogs for TMEM147 Gene

Variants for TMEM147 Gene

Sequence variations from dbSNP and Humsavar for TMEM147 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_051429 -

Structural Variations from Database of Genomic Variants (DGV) for TMEM147 Gene

Variant ID Type Subtype PubMed ID
nsv911628 CNV Loss 21882294

Variation tolerance for TMEM147 Gene

Residual Variation Intolerance Score: 27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM147 Gene

HapMap Linkage Disequilibrium report
TMEM147

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM147 Gene

Disorders for TMEM147 Gene

Relevant External Links for TMEM147

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM147

No disorders were found for TMEM147 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM147 Gene

Publications for TMEM147 Gene

  1. Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. (PMID: 20538592) Dettmer U. … Haffner C. (J. Biol. Chem. 2010) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. (PMID: 23142642) Passantino R. … Guarneri P. (Biochim. Biophys. Acta 2013) 3
  4. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. (PMID: 23864651) Huang X. … Wheeler M.B. (Mol. Endocrinol. 2013) 3
  5. The membrane complex between transducin and dark-state rhodopsin exhibits large-amplitude interface dynamics on the sub-microsecond timescale: insights from all-atom MD simulations. (PMID: 20184892) Sgourakis N.G. … Garcia A.E. (J. Mol. Biol. 2010) 23

Products for TMEM147 Gene

Sources for TMEM147 Gene

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