Aliases for TMEM145 Gene
External Ids for TMEM145 Gene
- HGNC: 26912
- Entrez Gene: 284339
- Ensembl: ENSG00000167619
- UniProtKB: Q8NBT3
Previous GeneCards Identifiers for TMEM145 Gene
- GC19P047510
- GC19P042817
- GC19P039247
Summaries for TMEM145 Gene
GeneCards Summary for TMEM145 Gene
TMEM145 (Transmembrane Protein 145) is a Protein Coding gene.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM145 Gene
Genomics for TMEM145 Gene
Regulatory Elements for TMEM145 Gene
Enhancers for TMEM145 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around TMEM145 on UCSC Golden Path with GeneCards custom track
Promoters for TMEM145 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around TMEM145 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TMEM145 gene promoter:
Regulatory Element Products
Genomic Location for TMEM145 Gene
- Chromosome:
- 19
- Start:
- 42,313,325 bp from pter
- End:
- 42,325,064 bp from pter
- Size:
- 11,740 bases
- Orientation:
- Plus strand
Genomic View for TMEM145 Gene
Genes around TMEM145 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
TMEM145 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TMEM145 Gene
Proteins for TMEM145 Gene
-
Protein details for TMEM145 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NBT3-TM145_HUMAN
- Recommended name:
- Transmembrane protein 145
- Protein Accession:
- Q8NBT3
Protein attributes for TMEM145 Gene
- Size:
- 493 amino acids
- Molecular mass:
- 55534 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for TMEM145 Gene
Other Protein References for TMEM145 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TMEM145
- Origene Custom Protein Services for TMEM145
- Search GeneTex for Proteins for TMEM145
Assay Products
No data available for DME Specific Peptides for TMEM145 Gene
Domains & Families for TMEM145 Gene
Protein Domains for TMEM145 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TMEM145 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM145 Gene
Function for TMEM145 Gene
Phenotypes for TMEM145 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for TMEM145 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM145 gene
- Search ViGene Biosciences for TMEM145
CRISPR Products
-
OriGene CRISPR knockouts for TMEM145
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM145
- GenScript: Design CRISPR guide RNA sequences for TMEM145
miRNA for TMEM145 Gene
- miRTarBase miRNAs that target TMEM145
-
- hsa-mir-375 (MIRT019916)
- hsa-mir-665 (MIRT514141)
- hsa-mir-6716-5p (MIRT514142)
- hsa-mir-3622b-5p (MIRT514143)
- hsa-mir-4763-3p (MIRT514144)
- hsa-mir-1207-5p (MIRT514145)
- hsa-mir-7160-5p (MIRT514146)
- hsa-mir-6722-3p (MIRT514147)
- hsa-mir-1909-3p (MIRT514148)
- hsa-mir-6884-5p (MIRT514149)
- hsa-mir-485-5p (MIRT514150)
- hsa-mir-1827 (MIRT514151)
- hsa-mir-4649-3p (MIRT514152)
- hsa-mir-6783-5p (MIRT514153)
- hsa-mir-4478 (MIRT514154)
- hsa-mir-4419b (MIRT514155)
- hsa-mir-3929 (MIRT514156)
- hsa-mir-6893-5p (MIRT514157)
- hsa-mir-940 (MIRT514158)
- hsa-mir-6808-5p (MIRT514159)
- hsa-mir-5197-5p (MIRT514160)
- hsa-mir-7703 (MIRT661082)
- hsa-mir-6720-5p (MIRT661084)
- hsa-mir-6512-3p (MIRT661085)
- hsa-mir-542-3p (MIRT661086)
- hsa-mir-4252 (MIRT661087)
- hsa-mir-4793-3p (MIRT661088)
- hsa-mir-766-3p (MIRT661089)
- hsa-mir-1292-3p (MIRT661090)
- hsa-mir-6849-3p (MIRT661091)
- hsa-mir-1273g-3p (MIRT661092)
- hsa-mir-508-5p (MIRT661093)
miRNA Products
- Search ViGene Biosciences for TMEM145
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for TMEM145
- Browse OriGene Inhibitory RNA Products For TMEM145
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM145 gene
Clone Products
- OriGene clones in human for TMEM145
- OriGene ORF clones in human,mouse for TMEM145
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for TMEM145 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TMEM145 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM145 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM145 Gene
Localization for TMEM145 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TMEM145 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
No data available for Gene Ontology (GO) - Cellular Components for TMEM145 Gene
Pathways & Interactions for TMEM145 Gene
More details on SuperPathways for TMEM145
No Data Available
Interacting Proteins for TMEM145 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for TMEM145 Gene
Transcripts for TMEM145 Gene
mRNA/cDNA for TMEM145 Gene
- (4) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (3) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TMEM145 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TMEM145
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM145
- GenScript: Design CRISPR guide RNA sequences for TMEM145
miRNA Products
- Search ViGene Biosciences for TMEM145
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for TMEM145
- Browse OriGene Inhibitory RNA Products For TMEM145
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM145 gene
Clone Products
- OriGene clones in human for TMEM145
- OriGene ORF clones in human,mouse for TMEM145
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Flow Cytometry Products
Expression for TMEM145 Gene
mRNA differential expression in normal tissues according to GTEx for TMEM145 Gene
This gene is overexpressed in Brain - Cerebellum (x16.3) and Brain - Cerebellar Hemisphere (x14.0).
SOURCE GeneReport for Unigene cluster for TMEM145 Gene Hs.382075
Primer Products
-
OriGene qPCR primer pairs for TMEM145
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM145 Gene
Orthologs for TMEM145 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | TMEM145 35 |
|
||
| TMEM145 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | TMEM145 35 |
|
||
| TMEM145 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Tmem145 35 |
|
||
| Tmem145 16 |
|
||||
| Tmem145 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | TMEM145 35 |
|
||
| TMEM145 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Tmem145 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TMEM145 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TMEM145 36 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | TMEM145 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tmem145 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tmem145 35 |
|
||
| tmem145 36 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012225 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG9304 36 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | C15A7.2 35 |
|
||
| C15A7.2 36 |
|
OneToMany | |||
| T04F8.2 36 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToOne |
- Species with no ortholog for TMEM145:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TMEM145 Gene
(9) SIMAP similar genes for TMEM145 Gene using alignment to 3 proteins:
No data available for Paralogs for TMEM145 Gene
Variants for TMEM145 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs7254227 | - | 42,316,700(+) | TCCTG(A/C)TGATG | reference, missense | |
| rs13343719 | -- | 42,320,752(+) | cctcc(C/G)gagta | intron-variant | |
| rs13343761 | -- | 42,320,926(+) | gccgg(A/G)ccCAT | intron-variant | |
| rs1206009 | -- | 42,316,378(+) | GTCCT(A/G)AGGGA | intron-variant | |
| rs1209280 | -- | 42,315,835(+) | gacca(A/G)cctga | intron-variant |
Residual Variation Intolerance Score:
26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.62;
31.16% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM145 Gene
Disorders for TMEM145 Gene
Relevant External Links for TMEM145
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- TMEM145
No disorders were found for TMEM145 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM145 Gene
Publications for TMEM145 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
Products for TMEM145 Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TMEM145
- Origene Custom Protein Services for TMEM145
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for TMEM145
- Browse OriGene Inhibitory RNA Products For TMEM145
- OriGene qPCR primer pairs for TMEM145
- OriGene CRISPR knockouts for TMEM145
- OriGene clones in human for TMEM145
- OriGene ORF clones in human,mouse for TMEM145
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for TMEM145
- GenScript Custom Assay Services for TMEM145
- GenScript Custom overexpressing Cell Line Services for TMEM145
- GenScript: Design CRISPR guide RNA sequences for TMEM145
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TMEM145
- Invitrogen Antibodies for TMEM145
- ViGene Biosciences adenoviral particle packaged cDNA for TMEM145 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TMEM145 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TMEM145 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TMEM145 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TMEM145 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TMEM145 gene
- Search ViGene Biosciences for TMEM145
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Sources for TMEM145 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon