TMEM145 Gene
protein-coding GIFtS: 42
GCID: GC19P042817
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Transmembrane Protein 145
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Aliases
for TMEM145 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
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| Aliases |
|---|
| Transmembrane Protein 1451 2 |
Export aliases for TMEM145 gene to outside databasesPrevious GC identifers: GC19P047510 GC19P039247 |
Summaries
for TMEM145 gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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GeneCards Summary for TMEM145 Gene:
TMEM145 (transmembrane protein 145) is a protein-coding gene. Diseases associated with TMEM145 include malaria.
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Genomic Views
for TMEM145 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | RefSeq DNA sequence:- NC_000019.10 NT_011109.17 NC_018930.2
Regulatory elements:
 Regulatory transcription factor binding sites in the TMEM145 gene promoter:
Bach1 STAT1 NF-1 Elk-1 STAT1beta CUTL1 Nkx2-5 Gfi-1 STAT1alpha HSF2
Other transcription factors
Search Chromatin IP Primers for TMEM145
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM145 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2TMEM145 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P042817: view genomic region
(about GC identifiers)
Start:
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42,817,477 bp from pter |
End:
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42,829,214 bp from pter |
Size:
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11,738 bases |
Orientation:
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plus strand |
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Proteins
for TMEM145 gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
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UniProtKB/Swiss-Prot: TM145_HUMAN, Q8NBT3 (See
protein sequence)Recommended Name: Transmembrane protein 145 Size: 493 amino acids; 55534 DaExplore the universe of human proteins at neXtProt for TMEM145: NX_Q8NBT3
Explore proteomics data for TMEM145 at MOPED
Post-translational modifications:  Glycosylation2 at Asn35, Asn444 Modification sites at PhosphoSitePlus
See TMEM145 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB
REFSEQ proteins: NP_775904.2
ENSEMBL proteins: ENSP00000301204 ENSP00000470827 ENSP00000470602
TMEM145 Human Recombinant
Protein Products:TMEM145 Antibody
Products:TMEM145 Assay Products: |
Domains /
Families
for TMEM145 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | 1 InterPro protein domain:Graphical View of Domain Structure for InterPro Entry Q8NBT3 ProtoNet protein and cluster: Q8NBT3
TMEM145 for domains About GeneDecksing
|
Function
for TMEM145 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Animal Models:
Inhib. RNA
Products: |  | OriGene RNAi products in human, mouse, rat for TMEM145
| | | Predesigned siRNA for gene silencing in human, mouse, rat TMEM145 |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for TMEM145 | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM145  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM145 |
Localization
for TMEM145 gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot TM145_HUMAN, Q8NBT3: Membrane; Multi-pass membrane protein (Potential)Subcellular locations from COMPARTMENTS:
| Compartment | Confidence |
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| plasma membrane | 3 |
Gene Ontology (GO): 1 cellular component term: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016021 | integral component of membrane |
IEA | -- |
TMEM145 for ontologies About GeneDecksing
|
Pathways & Interactions
for TMEM145 gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM145
Interactions:
Search GeneGlobe Interaction Network for TMEM145
Gene Ontology (GO): 2 biological process terms: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor signaling pathway |
IEA | -- | | GO:0019236 | response to pheromone |
IEA | -- |
TMEM145 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM145 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
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 Browse compounds at ApexBio
 Browse Tocris compounds for TMEM145 (TM145)
|
Transcripts
for TMEM145 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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REFSEQ mRNAs for TMEM145 gene: NM_173633.2 Unigene Cluster for TMEM145: Transmembrane protein 145 Hs.382075 [show with all ESTs]Unigene Representative Sequence: NM_1736335 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000595775 ENST00000301204(uc002otk.1) ENST00000598766 ENST00000601020
ENST00000601644
Inhib. RNA
Products: | | OriGene RNAi products in human, mouse, rat for TMEM145
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat TMEM145 |
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for TMEM145
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM145 | | | QuantiTect SYBR Green Assays in human, mouse, rat TMEM145 | | | QuantiFast Probe-based Assays in human, mouse, rat TMEM145 |
Additional mRNA sequence: AK075286.1 2 DOTS entries: DT.100001064 DT.121472497 3 AceView cDNA sequences: AK075286 NM_173633 BG152493
GeneLoc Exon Structure
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Expression
for TMEM145 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMEM145 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACCCGCCCAT
About this image TMEM145 Protein expression data from MOPED1, PaxDb2 and
MaxQB3: About this image
SOURCE GeneReport for Unigene cluster: Hs.382075
Custom PCR Arrays for TMEM145
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for TMEM145
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM145 | | | QuantiTect SYBR Green Assays in human, mouse, rat TMEM145 | | | QuantiFast Probe-based Assays in human, mouse, rat TMEM145 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM145 |
Orthologs
for TMEM145 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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This gene was present in the common ancestor of animals.
Orthologs for TMEM145 gene from Selected species (see all 14) About this table
ENSEMBL Gene Tree for TMEM145 (if available)
TreeFam Gene Tree for TMEM145 (if available) |
Paralogs
for TMEM145 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | Paralogs for TMEM145 gene
9 SIMAP similar genes for TMEM145 using alignment to 3 protein entries: TM145_HUMAN (see all proteins):COPS7B TBC1D22A RANBP3 FP1523 C19orf82 ZRSR2
NDUFA7 PCBP2 HDGFRP2
TMEM145 for paralogs About GeneDecksing
|
Genomic Variants
for TMEM145 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM145 (42817477 - 42829214 bp)
Structural Variations
Database of Genomic Variants (DGV) 7 variations for TMEM145: About this table
| | Site Specific Mutation Identification with PCR Assays |
| | SeqTarget long-range PCR primers for resequencing TMEM145 |
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Disorders
/ Diseases
for TMEM145 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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1  disease for TMEM145:
About MalaCardsmalaria
TMEM145 for disorders About GeneDecksing
Export disorders for TMEM145 gene to outside databases
|
Publications
for TMEM145 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for TMEM145 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TMEM145) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
- Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (DNA Res. 2005)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
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External Searches for TMEM145 gene (in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing TMEM145 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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|
Other Databases showing TMEM145 gene
(According to HUGE)
About This Section
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Specialized Databases showing TMEM145 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for TMEM145 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
TryGeneCards Plus | Patent Information for TMEM145 gene:
Search GeneIP for patents involving TMEM145
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM145 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
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|  | Block miRNA regulation of human, mouse, rat TMEM145 using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing TMEM145 | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM145 | | Predesigned siRNA for gene silencing in human, mouse, rat TMEM145 | | | QuantiFast Probe-based Assays in human, mouse, rat TMEM145 | | QuantiTect SYBR Green Assays in human, mouse, rat TMEM145 | | | Custom PCR Arrays for TMEM145 | | Search Chromatin IP Primers for TMEM145 | | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM145 | | Search GeneGlobe Interaction Network for TMEM145 | | | Regulatory tfbs in TMEM145 promoter |
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 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM145 |
| |  |  |  |  | | | Search ThermoFisher Antibodies for TMEM145 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM145 |
| | | | LSBio Antibodies in human, mouse, rat for TMEM145 |
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