Aliases for TMEM145 Gene
External Ids for TMEM145 Gene
- HGNC: 26912
- Entrez Gene: 284339
- Ensembl: ENSG00000167619
- UniProtKB: Q8NBT3
Previous GeneCards Identifiers for TMEM145 Gene
- GC19P047510
- GC19P042817
- GC19P039247
Summaries for TMEM145 Gene
GeneCards Summary for TMEM145 Gene
TMEM145 (Transmembrane Protein 145) is a Protein Coding gene.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM145 Gene
Genomics for TMEM145 Gene
Regulatory Elements for TMEM145 Gene
Enhancers for TMEM145 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH19F042276 | 1.8 | FANTOM5 Ensembl ENCODE | 4.3 | -31.4 | -31412 | 11.1 | HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A YBX1 ZNF2 ZNF416 ZNF143 | ZNF526 ZNF574 CCDC97 CEACAMP1 CEACAMP10 ENSG00000278239 RPS19 DEDD2 MEGF8 CEACAM8 |
| GH19F041989 | 0.6 | FANTOM5 | 10.6 | -323.4 | -323405 | 0.3 | ZNF366 ZNF512 ZEB1 | ATP1A3 TMEM145 GRIK5 MEGF8 RABAC1 |
| GH19F042249 | 1.4 | FANTOM5 ENCODE | 2.5 | -60.0 | -60043 | 7.9 | HDGF WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF143 KLF13 ZNF263 | ZNF526 POU2F2 MEGF8 GRIK5 TMEM145 PAFAH1B3 PRR19 GSK3A ATP1A3 ENSG00000268643 |
| GH19F041997 | 1.2 | FANTOM5 ENCODE | 1.9 | -316.2 | -316199 | 0.8 | ZNF493 KLF17 SIN3A ZNF48 ZEB1 ZNF121 GLIS2 ZNF138 ZNF366 KLF7 | MEGF8 TMEM145 ATP1A3 RABAC1 |
| GH19F041996 | 0.9 | FANTOM5 ENCODE | 2.2 | -317.2 | -317174 | 0.3 | RFX1 POLR2A PATZ1 MAX BMI1 KDM1A REST PRDM1 | GRIK5 DMRTC2 LYPD4 LIPE TMEM145 ATP1A3 RABAC1 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around TMEM145 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TMEM145 gene promoter:
Regulatory Element Products
Genomic Location for TMEM145 Gene
- Chromosome:
- 19
- Start:
- 42,313,325 bp from pter
- End:
- 42,325,064 bp from pter
- Size:
- 11,740 bases
- Orientation:
- Plus strand
Genomic View for TMEM145 Gene
Genes around TMEM145 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
TMEM145 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TMEM145 Gene
Proteins for TMEM145 Gene
-
Protein details for TMEM145 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NBT3-TM145_HUMAN
- Recommended name:
- Transmembrane protein 145
- Protein Accession:
- Q8NBT3
Protein attributes for TMEM145 Gene
- Size:
- 493 amino acids
- Molecular mass:
- 55534 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for TMEM145 Gene
Other Protein References for TMEM145 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Invitrogen Antibodies for TMEM145
- GeneTex TMEM145 antibody for TMEM145
-
St John's Laboratory Antibodies for TMEM145
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TMEM145
- Origene Custom Protein Services for TMEM145
- Search GeneTex for Proteins for TMEM145
Assay Products
No data available for DME Specific Peptides for TMEM145 Gene
Domains & Families for TMEM145 Gene
Protein Domains for TMEM145 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TMEM145 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM145 Gene
Function for TMEM145 Gene
Phenotypes for TMEM145 Gene
- MGI mutant phenotypes for TMEM145:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TMEM145:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TMEM145
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TMEM145 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM145 gene
- Search ViGene Biosciences for TMEM145
CRISPR Products
-
OriGene CRISPR knockouts for TMEM145
- GenScript: Design CRISPR guide RNA sequences for TMEM145
miRNA for TMEM145 Gene
- miRTarBase miRNAs that target TMEM145
-
- hsa-mir-375 (MIRT019916)
- hsa-mir-665 (MIRT514141)
- hsa-mir-6716-5p (MIRT514142)
- hsa-mir-3622b-5p (MIRT514143)
- hsa-mir-4763-3p (MIRT514144)
- hsa-mir-1207-5p (MIRT514145)
- hsa-mir-7160-5p (MIRT514146)
- hsa-mir-6722-3p (MIRT514147)
- hsa-mir-1909-3p (MIRT514148)
- hsa-mir-6884-5p (MIRT514149)
- hsa-mir-485-5p (MIRT514150)
- hsa-mir-1827 (MIRT514151)
- hsa-mir-4649-3p (MIRT514152)
- hsa-mir-6783-5p (MIRT514153)
- hsa-mir-4478 (MIRT514154)
- hsa-mir-4419b (MIRT514155)
- hsa-mir-3929 (MIRT514156)
- hsa-mir-6893-5p (MIRT514157)
- hsa-mir-940 (MIRT514158)
- hsa-mir-6808-5p (MIRT514159)
- hsa-mir-5197-5p (MIRT514160)
- hsa-mir-7703 (MIRT661082)
- hsa-mir-6720-5p (MIRT661084)
- hsa-mir-6512-3p (MIRT661085)
- hsa-mir-542-3p (MIRT661086)
- hsa-mir-4252 (MIRT661087)
- hsa-mir-4793-3p (MIRT661088)
- hsa-mir-766-3p (MIRT661089)
- hsa-mir-1292-3p (MIRT661090)
- hsa-mir-6849-3p (MIRT661091)
- hsa-mir-1273g-3p (MIRT661092)
- hsa-mir-508-5p (MIRT661093)
miRNA Products
- Search ViGene Biosciences for TMEM145
Inhibitory RNA Products
- Origene shRNA, siRNA, mouse_rna, and RNAi products in human, mouse, rat for TMEM145
- Browse OriGene Inhibitory RNA Products For TMEM145
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM145 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for TMEM145
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TMEM145
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for TMEM145
-
ViGene Biosciences adenoviral particle packaged cDNA for TMEM145 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TMEM145 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM145 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM145 Gene
Localization for TMEM145 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TMEM145 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for TMEM145 Gene
No Data Available
Interacting Proteins for TMEM145 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | -- |
| GO:0019236 | response to pheromone | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for TMEM145 Gene
Transcripts for TMEM145 Gene
mRNA/cDNA for TMEM145 Gene
- (4) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (3) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TMEM145 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TMEM145
- GenScript: Design CRISPR guide RNA sequences for TMEM145
miRNA Products
- Search ViGene Biosciences for TMEM145
Inhibitory RNA Products
- Origene shRNA, siRNA, mouse_rna, and RNAi products in human, mouse, rat for TMEM145
- Browse OriGene Inhibitory RNA Products For TMEM145
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM145 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for TMEM145
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TMEM145
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for TMEM145 Gene
mRNA differential expression in normal tissues according to GTEx for TMEM145 Gene
This gene is overexpressed in Brain - Cerebellum (x16.3) and Brain - Cerebellar Hemisphere (x14.0).
NURSA nuclear receptor signaling pathways regulating expression of TMEM145 Gene:
TMEM145SOURCE GeneReport for Unigene cluster for TMEM145 Gene:
Hs.382075Primer Products
-
OriGene qPCR primer pairs for TMEM145
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMEM145 Gene
Orthologs for TMEM145 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TMEM145 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TMEM145 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TMEM145 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | TMEM145 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | TMEM145 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tmem145 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tmem145 34 16 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TMEM145 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tmem145 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tmem145 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012225 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG9304 35 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | C15A7.2 34 35 |
|
||
| T04F8.2 35 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for TMEM145 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TMEM145 Gene
(9) SIMAP similar genes for TMEM145 Gene using alignment to 3 proteins:
No data available for Paralogs for TMEM145 Gene
Variants for TMEM145 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs111303064 | -- | 42,323,628(+) | ACCAC(A/G)TGCGC | upstream-variant-2KB, reference, missense | |
| rs111353949 | -- | 42,319,758(+) | TCTTC(-/TTT)TTTTT | intron-variant | |
| rs111649036 | -- | 42,316,931(+) | CGCTC(A/G)CCCAT | reference, missense | |
| rs111859050 | -- | 42,318,002(+) | CTGTT(A/G)CCCAG | intron-variant | |
| rs111871714 | -- | 42,313,024(+) | AGTTT(C/G)GGGAC | upstream-variant-2KB |
Residual Variation Intolerance Score:
26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.62;
31.16% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TMEM145 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TMEM145
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM145 Gene
Disorders for TMEM145 Gene
Relevant External Links for TMEM145
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- TMEM145
No disorders were found for TMEM145 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM145 Gene
Publications for TMEM145 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 64
- The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
Products for TMEM145 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
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- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TMEM145
- Origene Custom Protein Services for TMEM145
- Origene shRNA, siRNA, mouse_rna, and RNAi products in human, mouse, rat for TMEM145
- Browse OriGene Inhibitory RNA Products For TMEM145
- OriGene qPCR primer pairs for TMEM145
- OriGene CRISPR knockouts for TMEM145
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA clones in your preferred vector
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- GenScript: Design CRISPR guide RNA sequences for TMEM145
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- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for TMEM145
- ViGene Biosciences adenoviral particle packaged cDNA for TMEM145 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TMEM145 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TMEM145 gene
- Search ViGene Biosciences for TMEM145
- Horizon Cell Lines for TMEM145
- Cyagen custom Knockout/knockin (KOKI) mouse models for TMEM145
- VectorBuilder custom plasmid, inducible vectors for TMEM145
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TMEM145
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for TMEM145 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab