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TMEM145 Gene

protein-coding GIFtS: 42
GCID: GC19P042817

Transmembrane Protein 145

See related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Transmembrane Protein 145¹ ²

External Ids:	HGNC: 26912¹	Entrez Gene: 284339²	Ensembl: ENSG00000167619⁷	UniProtKB: Q8NBT3³

Export aliases for TMEM145 gene to outside databases

Previous GC identifers: GC19P047510 GC19P039247

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM145 Gene:

TMEM145 (transmembrane protein 145) is a protein-coding gene. Diseases associated with TMEM145 include malaria.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000019.10 NT_011109.17 NC_018930.2

Regulatory elements:

Regulatory transcription factor binding sites in the TMEM145 gene promoter:
Bach1 STAT1 NF-1 Elk-1 STAT1beta CUTL1 Nkx2-5 Gfi-1 STAT1alpha HSF2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM145 promoter sequence

Search Chromatin IP Primers for TMEM145

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM145

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2

TMEM145 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM145 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P042817: view genomic region (about GC identifiers)

Start:	42,817,477 bp from pter	End:	42,829,214 bp from pter
Size:	11,738 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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UniProtKB/Swiss-Prot: TM145_HUMAN, Q8NBT3 (See protein sequence)

Recommended Name: Transmembrane protein 145

Size: 493 amino acids; 55534 Da

Explore the universe of human proteins at neXtProt for TMEM145: NX_Q8NBT3

Explore proteomics data for TMEM145 at MOPED

Post-translational modifications:

Glycosylation² at Asn35, Asn444

Modification sites at PhosphoSitePlus

See TMEM145 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_775904.2

ENSEMBL proteins:

ENSP00000301204 ENSP00000470827 ENSP00000470602

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:

IPR019336 Intimal_thickness-rel_rcpt

Graphical View of Domain Structure for InterPro Entry Q8NBT3

ProtoNet protein and cluster: Q8NBT3

TMEM145 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

TM145_HUMAN, Q8NBT3: Membrane; Multi-pass membrane protein (Potential)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	3

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral component of membrane	IEA	--

TMEM145 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

Search GeneGlobe Interaction Network for TMEM145

Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor signaling pathway	IEA	--
GO:0019236	response to pheromone	IEA	--

TMEM145 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TMEM145 gene:

NM_173633.2

Unigene Cluster for TMEM145:

Transmembrane protein 145

Hs.382075 [show with all ESTs]

Unigene Representative Sequence: NM_173633

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000595775 ENST00000301204(uc002otk.1) ENST00000598766 ENST00000601020

ENST00000601644

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Additional mRNA sequence: AK075286.1

2 DOTS entries:

DT.100001064 DT.121472497

3 AceView cDNA sequences:

AK075286 NM_173633 BG152493

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMEM145 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ACCCGCCCAT

About this image

TMEM145 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TMEM145 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.382075

Custom PCR Arrays for TMEM145

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TMEM145 gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tmem145^{1 , 5}	transmembrane protein 145^{1, 5}	90.45(n)¹ 97.95(a)¹		7 (13.74 cM)⁵ 330485¹ NM_183311.2¹ NP_899134.2¹ 25306106⁵
lizard (Anolis carolinensis)	Reptilia	TMEM145⁶	transmembrane protein 145	69(a)	1 ↔ 1	AAWZ02040267(1262-6371)
tropical clawed frog (Xenopus tropicalis)	Amphibia	tmem145¹	transmembrane protein 145	75.12(n) 85.92(a)		100497950 XM_002936403.2 XP_002936449.1
zebrafish (Danio rerio)	Actinopterygii	tmem145¹	transmembrane protein 145	68.76(n) 75.78(a)		557826 XM_680970.6 XP_686062.6
fruit fly (Drosophila melanogaster)	Insecta	CG9304⁶	--	16(a)	1 ↔ 1	2R(17860631-17863701)
worm (Caenorhabditis elegans)	Secernentea	C15A7.2¹	C15A7.2	45.78(n) 35.77(a)		182623 NM_077616.3 NP_510017.3

ENSEMBL Gene Tree for TMEM145 (if available)
TreeFam Gene Tree for TMEM145 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TMEM145 gene

9 SIMAP similar genes for TMEM145 using alignment to 3 protein entries: TM145_HUMAN (see all proteins):

COPS7B TBC1D22A RANBP3 FP1523 C19orf82 ZRSR2

NDUFA7 PCBP2 HDGFRP2

TMEM145 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185971795^1,2		--	42815739(+)	`GGCATG/TAGCCA`	1	--	us2k¹		0	--	--	--	--
rs116423948^1,2	F	--	42815746(+)	`GCCACC/TGTGCC`	1	--	us2k¹		1		WA	118
rs147344948^1,2		--	42815756(+)	`CCTGCA/GAACCC`	1	--	us2k¹		0	--	--	--	--
rs138951908^1,2		--	42815827(+)	`GAACAA/GCATAT`	1	--	us2k¹		0	--	--	--	--
rs190296369^1,2	C	--	42816089(+)	`CAAACC/TAGGCA`	1	--	us2k¹		0	--	--	--	--
rs112577218^1,2	C	--	42816100(+)	`TTTGCT/-TTTTT`	1	--	us2k¹		1		CSA	2
rs115704599^1,2	F	--	42816323(+)	`CCCCCG/ATTTTC`	1	--	us2k¹		1		WA	118
rs74951111^1,2	C,F	--	42816497(+)	`TCATAG/AGGCTG`	1	--	us2k¹		2		NA EA	240
rs183103243^1,2		--	42816561(+)	`GGGATC/TTGAAT`	1	--	us2k¹		0	--	--	--	--
rs149439835^1,2	C	--	42816687(+)	`ATGGTC/TAGGCA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TMEM145 (42817477 - 42829214 bp)

Structural Variations
Database of Genomic Variants (DGV) 7 variations for TMEM145: About this table

Variant ID	Type	Subtype	PubMed ID
esv2422471	CNV	Deletion	17116639
nsv520239	CNV	Loss	19592680
nsv911782	CNV	Loss	21882294
nsv833834	CNV	Loss	17160897
nsv911785	CNV	Loss	21882294
nsv522854	CNV	Gain	19592680
nsv526186	CNV	Gain	19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for TMEM145: About MalaCards

malaria

TMEM145 for disorders About GeneDecksing

Export disorders for TMEM145 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TMEM145 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TMEM145)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)¹ Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)¹ Otsuki T....Isogai T. (DNA Res. 2005)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (Nature 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 284339	HGNC: 26912	AceView: FLJ90805	Ensembl:ENSG00000167619	euGenes: HUgn284339
ECgene: TMEM145	H-InvDB: TMEM145

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TMEM145	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMEM145 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TMEM145 gene:
Search GeneIP for patents involving TMEM145

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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	SwitchGear Promoter luciferase reporter plasmids for TMEM145

Search ThermoFisher Antibodies for TMEM145

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LSBio Antibodies in human, mouse, rat for TMEM145

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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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Hot genes Disease genes TMEM145 gene at Home site.

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TMEM145 Gene

Transmembrane Protein 145

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for TMEM145 gene

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Export list of displayed genes

TMEM145 Gene

Transmembrane Protein 145

Aliasesfor TMEM145 gene

Summariesfor TMEM145 gene

Genomic Viewsfor TMEM145 gene

Proteinsfor TMEM145 gene

TMEM145 Human Recombinant Protein Products:

TMEM145 Antibody Products:

TMEM145 Assay Products:

Domains /Familiesfor TMEM145 gene

Functionfor TMEM145 gene

Localizationfor TMEM145 gene

Pathways & Interactionsfor TMEM145 gene

Drugs & Compoundsfor TMEM145 gene

Transcriptsfor TMEM145 gene

Expression for TMEM145 gene

Orthologsfor TMEM145 gene

Paralogsfor TMEM145 gene

Genomic Variantsfor TMEM145 gene

Disorders / Diseasesfor TMEM145 gene

Publicationsfor TMEM145 gene

External Searches for TMEM145 gene

Genome Databases showing TMEM145 gene

Other Databases showing TMEM145 gene

Specialized Databases showing TMEM145 gene

Intellectual Propertyfor TMEM145 gene

Productsfor TMEM145 gene

View Random Gene

Aliases
for TMEM145 gene

Summaries
for TMEM145 gene

Genomic Views
for TMEM145 gene

Proteins
for TMEM145 gene

Domains /
Families
for TMEM145 gene

Function
for TMEM145 gene

Localization
for TMEM145 gene

Pathways & Interactions
for TMEM145 gene

Drugs & Compounds
for TMEM145 gene

Transcripts
for TMEM145 gene

Expression
for TMEM145 gene

Orthologs
for TMEM145 gene

Paralogs
for TMEM145 gene

Genomic Variants
for TMEM145 gene

Disorders / Diseases
for TMEM145 gene

Publications
for TMEM145 gene

Intellectual Property
for TMEM145 gene

Products
for TMEM145 gene