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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM145 Gene

protein-coding   GIFtS: 39
GCID: GC19P042817

Transmembrane Protein 145

  Search for TMEM145
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 1451 2

External Ids:    HGNC: 269121   Entrez Gene: 2843392   Ensembl: ENSG000001676197   UniProtKB: Q8NBT33   

Export aliases for TMEM145 gene to outside databases

Previous GC identifers: GC19P047510 GC19P039247


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM145 Gene: 
TMEM145 (transmembrane protein 145) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM145 gene promoter:
         Bach1   STAT1   NF-1   Elk-1   STAT1beta   CUTL1   Nkx2-5   Gfi-1   STAT1alpha   HSF2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM145 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM145

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM145


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

TMEM145 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM145 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P042817:  view genomic region     (about GC identifiers)

Start:
42,817,477 bp from pter      End:
42,829,214 bp from pter
Size:
11,738 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM145_HUMAN, Q8NBT3 (See protein sequence)
Recommended Name: Transmembrane protein 145  
Size: 493 amino acids; 55534 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for TMEM145: NX_Q8NBT3

Explore proteomics data for TMEM145 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NBT3

  • TMEM145 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM145 Protein Expression
    REFSEQ proteins: NP_775904.2  
    ENSEMBL proteins: 
     ENSP00000301204   ENSP00000470827   ENSP00000470602  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    TMEM145 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019336 Intimal_thickness-rel_rcpt

    Graphical View of Domain Structure for InterPro Entry Q8NBT3

    ProtoNet protein and cluster: Q8NBT3


    TMEM145 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM145 
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    SwitchGear 3'UTR luciferase reporter plasmidTMEM145 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM145

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway IEA--
    GO:0019236response to pheromone IEA--

    TMEM145 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM145 (TM145)

    Search CenterWatch for drugs/clinical trials and news about TMEM145 / TM145

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM145 gene: 
    NM_173633.2  

    Unigene Cluster for TMEM145:

    Transmembrane protein 145
    Hs.382075  [show with all ESTs]
    Unigene Representative Sequence: NM_173633
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000595775 ENST00000301204(uc002otk.1) ENST00000598766 ENST00000601020
    ENST00000601644
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidTMEM145 3' UTR sequence
    Inhib. RNA
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    Sirion Biotech Customized lentivirus for stable overexpression of TMEM145 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM145
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM145

    Additional mRNA sequence: AK075286.1 

    2 DOTS entries:

    DT.100001064  DT.121472497 

    3 AceView cDNA sequences:

    NM_173633 BG152493 AK075286 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM145 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCGCCCAT
    TMEM145 Expression
    About this image


    See TMEM145 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM145

    SOURCE GeneReport for Unigene cluster: Hs.382075
        SABiosciences Custom PCR Arrays for TMEM145
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM145

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMEM145 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1451 , 5 transmembrane protein 1451, 5 90.29(n)1
    97(a)1
      7 (13.74 cM)5
    3304851  NM_183311.21  NP_899134.21 
     253061065 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1456
    Uncharacterized protein
    67(a)
    1 ↔ 1
    AAWZ02040267(1262-6371)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5578261 transmembrane protein 145-like 68.84(n)
    75.96(a)
      557826  XM_680970.5  XP_686062.5 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0122251 AGAP012225-PA 51.31(n)
    39.19(a)
      1280468  XM_320314.4  XP_320314.4 
    worm
    (Caenorhabditis elegans)
    Secernentea C15A7.21 Protein C15A7.2 44.81(n)
    34.18(a)
      182623  NM_077616.3  NP_510017.3 


    ENSEMBL Gene Tree for TMEM145 (if available)
    TreeFam Gene Tree for TMEM145 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMEM145 gene
    9 SIMAP similar genes for TMEM145 using alignment to 3 protein entries:     TM145_HUMAN (see all proteins):
    COPS7B    TBC1D22A    RANBP3    FP1523    LOC284385    ZRSR2
    NDUFA7    PCBP2    HDGFRP2

    TMEM145 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/239 SNPs in TMEM145 are shown (see all 239)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1859717951,2
    --42815739(+) GGCATG/TAGCCA 1 -- us2k10--------
    rs1164239481,2
    F--42815746(+) GCCACC/TGTGCC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1473449481,2
    --42815756(+) CCTGCA/GAACCC 1 -- us2k10--------
    rs1389519081,2
    --42815827(+) GAACAA/GCATAT 1 -- us2k10--------
    rs1902963691,2
    C--42816089(+) CAAACC/TAGGCA 1 -- us2k10--------
    rs1125772181,2
    C--42816100(+) TTTGCT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1157045991,2
    F--42816323(+) CCCCCG/ATTTTC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs749511111,2
    C,F--42816497(+) TCATAG/AGGCTG 1 -- us2k12Minor allele frequency- A:0.03NA EA 240
    rs1831032431,2
    --42816561(+) GGGATC/TTGAAT 1 -- us2k10--------
    rs1494398351,2
    C--42816687(+) ATGGTC/TAGGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMEM145 (42817477 - 42829214 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TMEM145:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422471CNV Deletion17116639
    nsv520239CNV Loss19592680
    nsv911782CNV Loss21882294
    nsv833834CNV Loss17160897
    nsv911785CNV Loss21882294
    nsv522854CNV Gain19592680
    nsv526186CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM145 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEM145)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284339 HGNC: 26912 AceView: FLJ90805 Ensembl:ENSG00000167619 euGenes: HUgn284339
    ECgene: TMEM145 H-InvDB: TMEM145

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM145 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM145 gene:
    Search GeneIP for patents involving TMEM145

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM145
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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