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TMEM145 Gene

protein-coding   GIFtS: 42
GCID: GC19P042817

Transmembrane Protein 145

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 1451 2

External Ids:    HGNC: 269121   Entrez Gene: 2843392   Ensembl: ENSG000001676197   UniProtKB: Q8NBT33   

Export aliases for TMEM145 gene to outside databases

Previous GC identifers: GC19P047510 GC19P039247


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM145 Gene:
TMEM145 (transmembrane protein 145) is a protein-coding gene. Diseases associated with TMEM145 include malaria.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM145 gene promoter:
         Bach1   STAT1   NF-1   Elk-1   STAT1beta   CUTL1   Nkx2-5   Gfi-1   STAT1alpha   HSF2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM145 promoter sequence
   Search Chromatin IP Primers for TMEM145

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM145


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

TMEM145 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM145 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P042817:  view genomic region     (about GC identifiers)

Start:
42,817,477 bp from pter      End:
42,829,214 bp from pter
Size:
11,738 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM145_HUMAN, Q8NBT3 (See protein sequence)
Recommended Name: Transmembrane protein 145  
Size: 493 amino acids; 55534 Da

Explore the universe of human proteins at neXtProt for TMEM145: NX_Q8NBT3

Explore proteomics data for TMEM145 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn35, Asn444
  • Modification sites at PhosphoSitePlus

  • See TMEM145 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775904.2  
    ENSEMBL proteins: 
     ENSP00000301204   ENSP00000470827   ENSP00000470602  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019336 Intimal_thickness-rel_rcpt

    Graphical View of Domain Structure for InterPro Entry Q8NBT3

    ProtoNet protein and cluster: Q8NBT3


    TMEM145 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM145
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    hsa-miR-577 hsa-miR-31 hsa-miR-182 hsa-miR-4254 hsa-miR-544 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidTMEM145 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM145_HUMAN, Q8NBT3: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    TMEM145 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM145
    Interactions:

        Search GeneGlobe Interaction Network for TMEM145

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway IEA--
    GO:0019236response to pheromone IEA--

    TMEM145 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM145 (TM145)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM145 gene: 
    NM_173633.2  

    Unigene Cluster for TMEM145:

    Transmembrane protein 145
    Hs.382075  [show with all ESTs]
    Unigene Representative Sequence: NM_173633
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000595775 ENST00000301204(uc002otk.1) ENST00000598766 ENST00000601020
    ENST00000601644
    miRNA
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    hsa-miR-577 hsa-miR-31 hsa-miR-182 hsa-miR-4254 hsa-miR-544 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidTMEM145 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat TMEM145

    Additional mRNA sequence: AK075286.1 

    2 DOTS entries:

    DT.100001064  DT.121472497 

    3 AceView cDNA sequences:

    AK075286 NM_173633 BG152493 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM145 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCGCCCAT
    TMEM145 Expression
    About this image

    TMEM145 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM145 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.382075
        Custom PCR Arrays for TMEM145
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM145

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMEM145 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1451 , 5 transmembrane protein 1451, 5 90.45(n)1
    97.95(a)1
      7 (13.74 cM)5
    3304851  NM_183311.21  NP_899134.21 
     253061065 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1456
    transmembrane protein 145
    69(a)
    1 ↔ 1
    AAWZ02040267(1262-6371)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmem1451 transmembrane protein 145 75.12(n)
    85.92(a)
      100497950  XM_002936403.2  XP_002936449.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmem1451 transmembrane protein 145 68.76(n)
    75.78(a)
      557826  XM_680970.6  XP_686062.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG93046
    --
    16(a)
    1 ↔ 1
    2R(17860631-17863701)
    worm
    (Caenorhabditis elegans)
    Secernentea C15A7.21 C15A7.2 45.78(n)
    35.77(a)
      182623  NM_077616.3  NP_510017.3 


    ENSEMBL Gene Tree for TMEM145 (if available)
    TreeFam Gene Tree for TMEM145 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM145 gene
    9 SIMAP similar genes for TMEM145 using alignment to 3 protein entries:     TM145_HUMAN (see all proteins):
    COPS7B    TBC1D22A    RANBP3    FP1523    C19orf82    ZRSR2
    NDUFA7    PCBP2    HDGFRP2

    TMEM145 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM145 (see all 239)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1859717951,2
    --42815739(+) GGCATG/TAGCCA 1 -- us2k10--------
    rs1164239481,2
    F--42815746(+) GCCACC/TGTGCC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1473449481,2
    --42815756(+) CCTGCA/GAACCC 1 -- us2k10--------
    rs1389519081,2
    --42815827(+) GAACAA/GCATAT 1 -- us2k10--------
    rs1902963691,2
    C--42816089(+) CAAACC/TAGGCA 1 -- us2k10--------
    rs1125772181,2
    C--42816100(+) TTTGCT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1157045991,2
    F--42816323(+) CCCCCG/ATTTTC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs749511111,2
    C,F--42816497(+) TCATAG/AGGCTG 1 -- us2k12Minor allele frequency- A:0.03NA EA 240
    rs1831032431,2
    --42816561(+) GGGATC/TTGAAT 1 -- us2k10--------
    rs1494398351,2
    C--42816687(+) ATGGTC/TAGGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMEM145 (42817477 - 42829214 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TMEM145:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422471CNV Deletion17116639
    nsv520239CNV Loss19592680
    nsv911782CNV Loss21882294
    nsv833834CNV Loss17160897
    nsv911785CNV Loss21882294
    nsv522854CNV Gain19592680
    nsv526186CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for TMEM145:    
    About MalaCards
    malaria


    TMEM145 for disorders           About GeneDecksing


    Export disorders for TMEM145 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM145 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMEM145)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (DNA Res. 2005)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284339 HGNC: 26912 AceView: FLJ90805 Ensembl:ENSG00000167619 euGenes: HUgn284339
    ECgene: TMEM145 H-InvDB: TMEM145

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM145 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM145 gene:
    Search GeneIP for patents involving TMEM145

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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