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Aliases for TMEM145 Gene

Aliases for TMEM145 Gene

  • Transmembrane Protein 145 2 3 5

External Ids for TMEM145 Gene

Previous GeneCards Identifiers for TMEM145 Gene

  • GC19P047510
  • GC19P042817
  • GC19P039247

Summaries for TMEM145 Gene

GeneCards Summary for TMEM145 Gene

TMEM145 (Transmembrane Protein 145) is a Protein Coding gene.

Additional gene information for TMEM145 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM145 Gene

Genomics for TMEM145 Gene

Regulatory Elements for TMEM145 Gene

Enhancers for TMEM145 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H042267 1.9 FANTOM5 ENCODE dbSUPER 10.1 -42.4 -42438 6 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 YBX1 ZBTB7B YY1 ZNF526 ZNF574 CCDC97 DEDD2 MEGF8 CEACAM3 PRR19 PAFAH1B3 GSK3A TMEM145
GH19H041882 1.4 ENCODE dbSUPER 9.9 -426.7 -426667 9 MLX FEZF1 DMAP1 YBX1 YY1 ZNF143 ZNF548 SP3 SSRP1 ZNF610 ZNF526 HNRNPUL1 CCDC97 ZNF574 RABAC1 CYP2G1P ENSG00000271299 CEACAMP1 CYP2G2P MEGF8
GH19H041957 1.4 ENCODE dbSUPER 9.9 -354.7 -354691 2 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF302 ZNF207 ZNF526 HNRNPUL1 CCDC97 ZNF574 RABAC1 RPS19 CEACAMP1 CYP2G2P ENSG00000271299 MEGF8
GH19H041348 1.4 ENCODE dbSUPER 9.9 -961.7 -961712 6 HDGF PKNOX1 ZFP64 ARID4B SIN3A YBX1 DMAP1 ZNF143 ZNF207 SP3 ZNF574 ZNF526 SNRPA HNRNPUL1 CCDC97 ENSG00000269843 COQ8B ITPKC CIC CYP2G1P
GH19H041499 1.3 Ensembl ENCODE 9.9 -812.5 -812462 2 SIN3A FEZF1 ZNF2 ELK1 ZNF302 FOS KLF7 ATF7 SP3 YY2 NUMBL CYP2G1P SNRPA HNRNPUL1 PCAT19 ZNF526 CCDC97 MEGF8 ENSG00000269843 ZNF574
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM145 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM145 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109793 175 601 SIN3A ZNF2 ZNF121 ZNF766 GLIS2 ATF7 NCOA1 MIER2 REST GLIS1

Genomic Location for TMEM145 Gene

Chromosome:
19
Start:
42,313,325 bp from pter
End:
42,325,064 bp from pter
Size:
11,740 bases
Orientation:
Plus strand

Genomic View for TMEM145 Gene

Genes around TMEM145 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM145 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM145 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM145 Gene

Proteins for TMEM145 Gene

  • Protein details for TMEM145 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBT3-TM145_HUMAN
    Recommended name:
    Transmembrane protein 145
    Protein Accession:
    Q8NBT3

    Protein attributes for TMEM145 Gene

    Size:
    493 amino acids
    Molecular mass:
    55534 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM145 Gene

Post-translational modifications for TMEM145 Gene

  • Glycosylation at posLast=3535 and posLast=444444
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM145 Gene

No data available for DME Specific Peptides for TMEM145 Gene

Domains & Families for TMEM145 Gene

Gene Families for TMEM145 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM145 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM145 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM145: view

No data available for UniProtKB/Swiss-Prot for TMEM145 Gene

Function for TMEM145 Gene

Phenotypes From GWAS Catalog for TMEM145 Gene

genes like me logo Genes that share phenotypes with TMEM145: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM145
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM145 Gene

Localization for TMEM145 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM145 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM145 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM145 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM145: view

Pathways & Interactions for TMEM145 Gene

SuperPathways for TMEM145 Gene

No Data Available

Interacting Proteins for TMEM145 Gene

Gene Ontology (GO) - Biological Process for TMEM145 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0019236 response to pheromone IEA --
genes like me logo Genes that share ontologies with TMEM145: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM145 Gene

Drugs & Compounds for TMEM145 Gene

No Compound Related Data Available

Transcripts for TMEM145 Gene

mRNA/cDNA for TMEM145 Gene

(4) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM145 Gene

Transmembrane protein 145:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM145
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM145 Gene

No ASD Table

Relevant External Links for TMEM145 Gene

GeneLoc Exon Structure for
TMEM145
ECgene alternative splicing isoforms for
TMEM145

Expression for TMEM145 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM145 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM145 Gene

This gene is overexpressed in Brain - Cerebellum (x16.3) and Brain - Cerebellar Hemisphere (x14.0).

NURSA nuclear receptor signaling pathways regulating expression of TMEM145 Gene:

TMEM145

SOURCE GeneReport for Unigene cluster for TMEM145 Gene:

Hs.382075

Evidence on tissue expression from TISSUES for TMEM145 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with TMEM145: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM145 Gene

Orthologs for TMEM145 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM145 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM145 33 34
  • 99.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM145 34
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM145 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM145 33 34
  • 92.79 (n)
dog
(Canis familiaris)
Mammalia TMEM145 33 34
  • 92.19 (n)
rat
(Rattus norvegicus)
Mammalia Tmem145 33
  • 90.91 (n)
mouse
(Mus musculus)
Mammalia Tmem145 33 16 34
  • 90.45 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM145 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem145 33
  • 75.12 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem145 33 34
  • 68.76 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012225 33
  • 51.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9304 34
  • 16 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C15A7.2 33 34
  • 45.78 (n)
T04F8.2 34
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToOne
Species where no ortholog for TMEM145 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM145 Gene

ENSEMBL:
Gene Tree for TMEM145 (if available)
TreeFam:
Gene Tree for TMEM145 (if available)

Paralogs for TMEM145 Gene

(9) SIMAP similar genes for TMEM145 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMEM145: view

No data available for Paralogs for TMEM145 Gene

Variants for TMEM145 Gene

Sequence variations from dbSNP and Humsavar for TMEM145 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000167014 -- 42,311,744(+) TAGGC(C/T)ATGCT upstream-variant-2KB
rs1000198515 -- 42,311,431(+) TCCCG(A/G)GGAGC upstream-variant-2KB
rs1000419722 -- 42,317,527(+) TTTAT(A/T)CTCTT intron-variant
rs1000730640 -- 42,313,129(+) AGGAC(A/G)CAGGA upstream-variant-2KB
rs1001525024 -- 42,321,124(+) GCCCA(A/G)ATTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM145 Gene

Variant ID Type Subtype PubMed ID
esv2422471 CNV deletion 17116639
nsv1160627 CNV deletion 26073780
nsv520239 CNV loss 19592680
nsv522854 CNV gain 19592680
nsv526186 CNV gain 19592680
nsv833834 CNV loss 17160897

Variation tolerance for TMEM145 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM145 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM145

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM145 Gene

Disorders for TMEM145 Gene

Relevant External Links for TMEM145

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM145

No disorders were found for TMEM145 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM145 Gene

Publications for TMEM145 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 60
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 60

Products for TMEM145 Gene

Sources for TMEM145 Gene

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