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Aliases for TMEM145 Gene

Aliases for TMEM145 Gene

  • Transmembrane Protein 145 2 3 5

External Ids for TMEM145 Gene

Previous GeneCards Identifiers for TMEM145 Gene

  • GC19P047510
  • GC19P042817
  • GC19P039247

Summaries for TMEM145 Gene

GeneCards Summary for TMEM145 Gene

TMEM145 (Transmembrane Protein 145) is a Protein Coding gene.

Additional gene information for TMEM145 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM145 Gene

Genomics for TMEM145 Gene

GeneHancer (GH) Regulatory Elements for TMEM145 Gene

Promoters and enhancers for TMEM145 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I042313 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.1 128 0.8 SIN3A ZNF2 ZNF121 ZNF766 GLIS2 ATF7 NCOA1 MIER2 REST GLIS1 TMEM145 MEGF8 GC19M042311
GH19I042267 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -42.4 -42437 6.9 MLX FEZF1 YBX1 YY1 SLC30A9 E2F8 ZNF143 ZNF548 SP3 NFYC CIC PIR59110 ZNF526 ZNF574 CCDC97 DEDD2 MEGF8 CEACAM3 PAFAH1B3 PRR19
GH19I041882 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.9 -426.7 -426666 9.2 MLX FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 ARHGEF1 ZNF526 HNRNPUL1 CCDC97 ZNF574 RPS19 RABAC1 CYP2G1P MEGF8 AXL
GH19I041957 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.9 -354.7 -354690 2.9 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B RABAC1 ZNF526 HNRNPUL1 CCDC97 ZNF574 RPS19 MEGF8 CD79A ATP1A3 ERF
GH19I041348 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.9 -961.7 -961712 6.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A YBX1 DMAP1 IRF4 ZNF213 ZNF207 TMEM91 ENSG00000255730 TGFB1 ZNF526 SNRPA ZNF574 HNRNPUL1 ENSG00000269843 CCDC97 COQ8B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM145 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM145 gene promoter:

Genomic Locations for TMEM145 Gene

Genomic Locations for TMEM145 Gene
chr19:42,313,325-42,325,064
(GRCh38/hg38)
Size:
11,740 bases
Orientation:
Plus strand
chr19:42,817,477-42,829,214
(GRCh37/hg19)

Genomic View for TMEM145 Gene

Genes around TMEM145 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM145 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM145 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM145 Gene

Proteins for TMEM145 Gene

  • Protein details for TMEM145 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBT3-TM145_HUMAN
    Recommended name:
    Transmembrane protein 145
    Protein Accession:
    Q8NBT3

    Protein attributes for TMEM145 Gene

    Size:
    493 amino acids
    Molecular mass:
    55534 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM145 Gene

Post-translational modifications for TMEM145 Gene

  • Glycosylation at posLast=3535 and posLast=444444

Other Protein References for TMEM145 Gene

No data available for DME Specific Peptides for TMEM145 Gene

Domains & Families for TMEM145 Gene

Gene Families for TMEM145 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM145 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM145 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM145: view

No data available for UniProtKB/Swiss-Prot for TMEM145 Gene

Function for TMEM145 Gene

Phenotypes From GWAS Catalog for TMEM145 Gene

genes like me logo Genes that share phenotypes with TMEM145: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM145 Gene

Localization for TMEM145 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM145 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM145 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM145 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM145: view

Pathways & Interactions for TMEM145 Gene

SuperPathways for TMEM145 Gene

No Data Available

Interacting Proteins for TMEM145 Gene

Gene Ontology (GO) - Biological Process for TMEM145 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0019236 response to pheromone IEA --
genes like me logo Genes that share ontologies with TMEM145: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM145 Gene

Drugs & Compounds for TMEM145 Gene

No Compound Related Data Available

Transcripts for TMEM145 Gene

mRNA/cDNA for TMEM145 Gene

(4) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM145 Gene

Transmembrane protein 145:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM145 Gene

No ASD Table

Relevant External Links for TMEM145 Gene

GeneLoc Exon Structure for
TMEM145
ECgene alternative splicing isoforms for
TMEM145

Expression for TMEM145 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM145 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM145 Gene

This gene is overexpressed in Brain - Cerebellum (x16.3) and Brain - Cerebellar Hemisphere (x14.0).

NURSA nuclear receptor signaling pathways regulating expression of TMEM145 Gene:

TMEM145

SOURCE GeneReport for Unigene cluster for TMEM145 Gene:

Hs.382075

Evidence on tissue expression from TISSUES for TMEM145 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with TMEM145: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM145 Gene

Orthologs for TMEM145 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM145 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM145 33 34
  • 99.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM145 34
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM145 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM145 33 34
  • 92.79 (n)
dog
(Canis familiaris)
Mammalia TMEM145 33 34
  • 92.19 (n)
rat
(Rattus norvegicus)
Mammalia Tmem145 33
  • 90.91 (n)
mouse
(Mus musculus)
Mammalia Tmem145 33 16 34
  • 90.45 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM145 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem145 33
  • 75.12 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem145 33 34
  • 68.76 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012225 33
  • 51.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9304 34
  • 16 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C15A7.2 33 34
  • 45.78 (n)
T04F8.2 34
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToOne
Species where no ortholog for TMEM145 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM145 Gene

ENSEMBL:
Gene Tree for TMEM145 (if available)
TreeFam:
Gene Tree for TMEM145 (if available)

Paralogs for TMEM145 Gene

(9) SIMAP similar genes for TMEM145 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMEM145: view

No data available for Paralogs for TMEM145 Gene

Variants for TMEM145 Gene

Sequence variations from dbSNP and Humsavar for TMEM145 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000167014 -- 42,311,744(+) C/T upstream_transcript_variant
rs1000198515 -- 42,311,431(+) A/G upstream_transcript_variant
rs1000419722 -- 42,317,527(+) T/A intron_variant
rs1000730640 -- 42,313,129(+) A/G upstream_transcript_variant
rs1001525024 -- 42,321,124(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM145 Gene

Variant ID Type Subtype PubMed ID
esv2422471 CNV deletion 17116639
nsv1160627 CNV deletion 26073780
nsv520239 CNV loss 19592680
nsv522854 CNV gain 19592680
nsv526186 CNV gain 19592680
nsv833834 CNV loss 17160897

Variation tolerance for TMEM145 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM145 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM145

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM145 Gene

Disorders for TMEM145 Gene

Additional Disease Information for TMEM145

No disorders were found for TMEM145 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM145 Gene

Publications for TMEM145 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 58
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for TMEM145 Gene

Sources for TMEM145 Gene

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