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Aliases for TMEM145 Gene

Aliases for TMEM145 Gene

  • Transmembrane Protein 145 2 3 5

External Ids for TMEM145 Gene

Previous GeneCards Identifiers for TMEM145 Gene

  • GC19P047510
  • GC19P042817
  • GC19P039247

Summaries for TMEM145 Gene

GeneCards Summary for TMEM145 Gene

TMEM145 (Transmembrane Protein 145) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM145 Gene

Genomics for TMEM145 Gene

Regulatory Elements for TMEM145 Gene

Promoters for TMEM145 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM145 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM145 Gene

Chromosome:
19
Start:
42,313,325 bp from pter
End:
42,325,064 bp from pter
Size:
11,740 bases
Orientation:
Plus strand

Genomic View for TMEM145 Gene

Genes around TMEM145 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM145 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM145 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM145 Gene

Proteins for TMEM145 Gene

  • Protein details for TMEM145 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBT3-TM145_HUMAN
    Recommended name:
    Transmembrane protein 145
    Protein Accession:
    Q8NBT3

    Protein attributes for TMEM145 Gene

    Size:
    493 amino acids
    Molecular mass:
    55534 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM145 Gene

Proteomics data for TMEM145 Gene at MOPED

Post-translational modifications for TMEM145 Gene

  • Glycosylation at Asn 35 and Asn 444
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM145 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM145 Gene

Domains & Families for TMEM145 Gene

Protein Domains for TMEM145 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM145 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM145: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM145 Gene

Function for TMEM145 Gene

genes like me logo Genes that share phenotypes with TMEM145: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM145 Gene

Localization for TMEM145 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM145 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM145 Gene COMPARTMENTS Subcellular localization image for TMEM145 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for TMEM145 Gene

Pathways & Interactions for TMEM145 Gene

SuperPathways for TMEM145 Gene

No Data Available

Interacting Proteins for TMEM145 Gene

Gene Ontology (GO) - Biological Process for TMEM145 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with TMEM145: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM145 Gene

Drugs & Compounds for TMEM145 Gene

No Compound Related Data Available

Transcripts for TMEM145 Gene

mRNA/cDNA for TMEM145 Gene

(4) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM145 Gene

Transmembrane protein 145:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM145 Gene

No ASD Table

Relevant External Links for TMEM145 Gene

GeneLoc Exon Structure for
TMEM145
ECgene alternative splicing isoforms for
TMEM145

Expression for TMEM145 Gene

mRNA expression in normal human tissues for TMEM145 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM145 Gene

This gene is overexpressed in Brain - Cerebellum (x16.3) and Brain - Cerebellar Hemisphere (x14.0).

SOURCE GeneReport for Unigene cluster for TMEM145 Gene Hs.382075

genes like me logo Genes that share expression patterns with TMEM145: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM145 Gene

Orthologs for TMEM145 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM145 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM145 35
  • 92.79 (n)
  • 98.18 (a)
TMEM145 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM145 35
  • 92.19 (n)
  • 97 (a)
TMEM145 36
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem145 35
  • 90.45 (n)
  • 97.95 (a)
Tmem145 16
Tmem145 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM145 35
  • 99.46 (n)
  • 99.8 (a)
TMEM145 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem145 35
  • 90.91 (n)
  • 97.73 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM145 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM145 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM145 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem145 35
  • 75.12 (n)
  • 85.92 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem145 35
  • 68.76 (n)
  • 75.78 (a)
tmem145 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012225 35
  • 51.33 (n)
  • 38.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9304 36
  • 16 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C15A7.2 35
  • 45.78 (n)
  • 35.77 (a)
C15A7.2 36
  • 29 (a)
OneToMany
T04F8.2 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for TMEM145:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM145 Gene

ENSEMBL:
Gene Tree for TMEM145 (if available)
TreeFam:
Gene Tree for TMEM145 (if available)

Paralogs for TMEM145 Gene

(9) SIMAP similar genes for TMEM145 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMEM145: view

No data available for Paralogs for TMEM145 Gene

Variants for TMEM145 Gene

Sequence variations from dbSNP and Humsavar for TMEM145 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7254227 - 42,316,700(+) TCCTG(A/C)TGATG reference, missense
rs1206009 -- 42,316,378(+) GTCCT(A/G)AGGGA intron-variant
rs1209280 -- 42,315,835(+) gacca(A/G)cctga intron-variant
rs1211265 -- 42,316,169(+) gaggg(C/T)ctggg intron-variant
rs1685566 -- 42,312,744(+) gctca(C/T)gcctg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM145 Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV Gain 19592680
nsv520239 CNV Loss 19592680
nsv911782 CNV Loss 21882294
nsv526186 CNV Gain 19592680
esv2422471 CNV Deletion 17116639
nsv833834 CNV Loss 17160897
nsv911785 CNV Loss 21882294

Variation tolerance for TMEM145 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM145 Gene

HapMap Linkage Disequilibrium report
TMEM145

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM145 Gene

Disorders for TMEM145 Gene

Relevant External Links for TMEM145

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM145

No disorders were found for TMEM145 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM145 Gene

Publications for TMEM145 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3

Products for TMEM145 Gene

Sources for TMEM145 Gene

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