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Aliases for TMEM144 Gene

Aliases for TMEM144 Gene

  • Transmembrane Protein 144 2 3 5

External Ids for TMEM144 Gene

Previous GeneCards Identifiers for TMEM144 Gene

  • GC04P159351
  • GC04P159131
  • GC04P154882

Summaries for TMEM144 Gene

GeneCards Summary for TMEM144 Gene

TMEM144 (Transmembrane Protein 144) is a Protein Coding gene. GO annotations related to this gene include carbohydrate transmembrane transporter activity.

Additional gene information for TMEM144 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM144 Gene

Genomics for TMEM144 Gene

Regulatory Elements for TMEM144 Gene

Enhancers for TMEM144 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H158168 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -29.7 -29735 6 ELF3 TBP ATF1 ARID4B SIN3A DMAP1 THRB RAD21 ZNF143 RCOR1 FAM198B-AS1 TMEM144 FAM198B
GH04H158158 1.5 FANTOM5 Ensembl ENCODE dbSUPER 8.3 -40.7 -40737 4 JUN DPF2 ATF2 ZNF217 CTBP1 JUND GATA3 POLR2A CREB1 ATF7 FAM198B-AS1 TMEM144 GC04P158124
GH04H158155 0.8 ENCODE 14.3 -45.1 -45066 2 FOXA2 SAP130 RARA CTBP1 GATA3 HOMEZ SOX5 FOXA3 HMG20A PPARG FAM198B-AS1 TMEM144 GC04P158124
GH04H158163 1.3 FANTOM5 Ensembl ENCODE dbSUPER 8.3 -37.1 -37133 2 CTCF JUND POLR2A KDM1A FAM198B-AS1 TMEM144 GC04P158124
GH04H158208 1.6 FANTOM5 ENCODE dbSUPER 5.4 +8.9 8856 3 HDGF PKNOX1 ATF1 ARNT ARID4B DMAP1 YY1 GLIS2 GATA2 FOS C4orf46 TMEM144 GC04P158212
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM144 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM144 Gene

Chromosome:
4
Start:
158,201,604 bp from pter
End:
158,255,411 bp from pter
Size:
53,808 bases
Orientation:
Plus strand

Genomic View for TMEM144 Gene

Genes around TMEM144 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM144 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM144 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM144 Gene

Proteins for TMEM144 Gene

  • Protein details for TMEM144 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5S9-TM144_HUMAN
    Recommended name:
    Transmembrane protein 144
    Protein Accession:
    Q7Z5S9
    Secondary Accessions:
    • D3DP24
    • Q49A05
    • Q9NUT3

    Protein attributes for TMEM144 Gene

    Size:
    345 amino acids
    Molecular mass:
    37653 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM144 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM144 Gene

Post-translational modifications for TMEM144 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM144 Gene

Domains & Families for TMEM144 Gene

Gene Families for TMEM144 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM144 Gene

Suggested Antigen Peptide Sequences for TMEM144 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z5S9

UniProtKB/Swiss-Prot:

TM144_HUMAN :
  • Belongs to the TMEM144 family.
Family:
  • Belongs to the TMEM144 family.
genes like me logo Genes that share domains with TMEM144: view

Function for TMEM144 Gene

Phenotypes From GWAS Catalog for TMEM144 Gene

Gene Ontology (GO) - Molecular Function for TMEM144 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015144 carbohydrate transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with TMEM144: view
genes like me logo Genes that share phenotypes with TMEM144: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM144
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM144 Gene

Localization for TMEM144 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM144 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM144 gene
Compartment Confidence
plasma membrane 3
mitochondrion 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM144 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM144: view

Pathways & Interactions for TMEM144 Gene

SuperPathways for TMEM144 Gene

No Data Available

Interacting Proteins for TMEM144 Gene

Selected Interacting proteins: Q7Z5S9-TM144_HUMAN for TMEM144 Gene via IID

Symbol External ID(s) Details
MOBP

Gene Ontology (GO) - Biological Process for TMEM144 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034219 carbohydrate transmembrane transport IEA --
genes like me logo Genes that share ontologies with TMEM144: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM144 Gene

Drugs & Compounds for TMEM144 Gene

No Compound Related Data Available

Transcripts for TMEM144 Gene

Unigene Clusters for TMEM144 Gene

Transmembrane protein 144:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM144
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM144 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: -
SP6: - - - - -
SP7: - - - -
SP8: - - -
SP9: - - - - - -
SP10:
SP11: - - - -
SP12: - - - -
SP13: - -

ExUns: 14b ^ 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for TMEM144 Gene

GeneLoc Exon Structure for
TMEM144
ECgene alternative splicing isoforms for
TMEM144

Expression for TMEM144 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM144 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM144 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x12.0), Brain - Substantia nigra (x6.7), and Brain - Hippocampus (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of TMEM144 Gene:

TMEM144

SOURCE GeneReport for Unigene cluster for TMEM144 Gene:

Hs.176227

Evidence on tissue expression from TISSUES for TMEM144 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with TMEM144: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM144 Gene

Orthologs for TMEM144 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM144 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM144 33 34
  • 99.23 (n)
dog
(Canis familiaris)
Mammalia TMEM144 33 34
  • 91.3 (n)
cow
(Bos Taurus)
Mammalia TMEM144 33 34
  • 89.37 (n)
rat
(Rattus norvegicus)
Mammalia Tmem144 33
  • 83.57 (n)
mouse
(Mus musculus)
Mammalia Tmem144 33 16 34
  • 83.19 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM144 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM144 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM144 33 34
  • 73.47 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM144 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem144 33
  • 69.59 (n)
Str.16658 33
zebrafish
(Danio rerio)
Actinopterygii tmem144a 33 34
  • 64.32 (n)
tmem144b 34
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R144.6 33 34
  • 51.81 (n)
W02D3.4 34
  • 39 (a)
OneToMany
T19A6.4 34
  • 34 (a)
OneToMany
F49C12.6 34
  • 33 (a)
OneToMany
W06A7.4 34
  • 32 (a)
OneToMany
K07F5.12 34
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4465 34
  • 41 (a)
OneToOne
Species where no ortholog for TMEM144 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM144 Gene

ENSEMBL:
Gene Tree for TMEM144 (if available)
TreeFam:
Gene Tree for TMEM144 (if available)

Paralogs for TMEM144 Gene

No data available for Paralogs for TMEM144 Gene

Variants for TMEM144 Gene

Sequence variations from dbSNP and Humsavar for TMEM144 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000020619 -- 158,219,953(+) TAAGG(A/G)TGAAA intron-variant
rs1000046253 -- 158,249,614(+) TTATT(A/C)TTCTG intron-variant
rs1000056559 -- 158,220,447(+) AGTCT(A/C)TCAGG intron-variant
rs1000075169 -- 158,214,518(+) TGATG(C/G)AGAAG intron-variant
rs1000114632 -- 158,204,496(+) CTAAA(G/T)TCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM144 Gene

Variant ID Type Subtype PubMed ID
nsv1021067 CNV gain 25217958

Variation tolerance for TMEM144 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM144 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM144

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM144 Gene

Disorders for TMEM144 Gene

Relevant External Links for TMEM144

Genetic Association Database (GAD)
TMEM144
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM144

No disorders were found for TMEM144 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM144 Gene

Publications for TMEM144 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 60
  4. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PMID: 17903298) Meigs JB … Dupuis J (BMC medical genetics 2007) 45 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for TMEM144 Gene

Sources for TMEM144 Gene

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