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Aliases for TMEM143 Gene

Aliases for TMEM143 Gene

  • Transmembrane Protein 143 2 3

External Ids for TMEM143 Gene

Previous GeneCards Identifiers for TMEM143 Gene

  • GC19M053528
  • GC19M048835
  • GC19M045217

Summaries for TMEM143 Gene

GeneCards Summary for TMEM143 Gene

TMEM143 (Transmembrane Protein 143) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM143 Gene

Genomics for TMEM143 Gene

Regulatory Elements for TMEM143 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM143 Gene

Start:
48,332,356 bp from pter
End:
48,364,237 bp from pter
Size:
31,882 bases
Orientation:
Minus strand

Genomic View for TMEM143 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM143 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM143 Gene

Proteins for TMEM143 Gene

  • Protein details for TMEM143 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AN5-TM143_HUMAN
    Recommended name:
    Transmembrane protein 143
    Protein Accession:
    Q96AN5
    Secondary Accessions:
    • A8K656
    • Q6UXY4
    • Q9NV49

    Protein attributes for TMEM143 Gene

    Size:
    459 amino acids
    Molecular mass:
    51715 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM143 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM143 Gene

Proteomics data for TMEM143 Gene at MOPED

Post-translational modifications for TMEM143 Gene

  • Ubiquitination at Lys405
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM143 Gene

Domains for TMEM143 Gene

Protein Domains for TMEM143 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM143 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM143: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM143 Gene

Function for TMEM143 Gene

Gene Ontology (GO) - Molecular Function for TMEM143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM143: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM143 Gene

Localization for TMEM143 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM143 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM143 Gene COMPARTMENTS Subcellular localization image for TMEM143 gene
Compartment Confidence
mitochondrion 4
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM143: view

Pathways for TMEM143 Gene

SuperPathways for TMEM143 Gene

No Data Available

Interacting Proteins for TMEM143 Gene

Gene Ontology (GO) - Biological Process for TMEM143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM143: view

No data available for Pathways by source for TMEM143 Gene

Transcripts for TMEM143 Gene

Unigene Clusters for TMEM143 Gene

Transmembrane protein 143:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM143

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TMEM143

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM143 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9
SP1: - - -
SP2: - - - - - - - -
SP3: - -
SP4: - - - -
SP5: -
SP6: - - -
SP7: - - - - - -
SP8: -
SP9:

Relevant External Links for TMEM143 Gene

GeneLoc Exon Structure for
TMEM143
ECgene alternative splicing isoforms for
TMEM143

Expression for TMEM143 Gene

mRNA expression in normal human tissues for TMEM143 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM143 Gene

This gene is overexpressed in Muscle - Skeletal (6.9) and Heart - Left Ventricle (6.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM143 Gene

SOURCE GeneReport for Unigene cluster for TMEM143 Gene Hs.351335

genes like me logo Genes that share expressions with TMEM143: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM143 Gene

Orthologs for TMEM143 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM143 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM143 35
  • 99.71 (n)
  • 99.78 (a)
TMEM143 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM143 35
  • 85.41 (n)
  • 84.58 (a)
TMEM143 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM143 35
  • 87.75 (n)
  • 87.31 (a)
TMEM143 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem143 35
  • 83.85 (n)
  • 84.8 (a)
Tmem143 16
Tmem143 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM143 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM143 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem143 35
  • 84.21 (n)
  • 84.8 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM143 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem143 35
  • 61.45 (n)
  • 59.52 (a)
Species with no ortholog for TMEM143:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM143 Gene

ENSEMBL:
Gene Tree for TMEM143 (if available)
TreeFam:
Gene Tree for TMEM143 (if available)

Paralogs for TMEM143 Gene

No data available for Paralogs for TMEM143 Gene

Variants for TMEM143 Gene

Sequence variations from dbSNP and Humsavar for TMEM143 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs275576 -- 48,332,337(+) CAGTG(C/T)GTTAA downstream-variant-500B
rs275577 -- 48,339,869(+) gattt(C/T)aggca intron-variant
rs275578 -- 48,344,262(+) TTAAT(G/T)TGTCT intron-variant
rs275579 -- 48,344,541(+) gcctc(A/G)gcctc intron-variant
rs275580 -- 48,344,583(+) gaacc(C/T)ggccT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM143 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
esv34181 CNV Loss 18971310
nsv469623 CNV Complex 16826518
nsv833854 CNV Loss 17160897
esv2718671 CNV Deletion 23290073
esv2718672 CNV Deletion 23290073
nsv137963 CNV Loss 16902084
esv2718674 CNV Deletion 23290073
dgv5e22 CNV Deletion 17803354
esv2674971 CNV Deletion 23128226

Relevant External Links for TMEM143 Gene

HapMap Linkage Disequilibrium report
TMEM143

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM143 Gene

Disorders for TMEM143 Gene

Relevant External Links for TMEM143

Genetic Association Database (GAD)
TMEM143
Human Genome Epidemiology (HuGE) Navigator
TMEM143
genes like me logo Genes that share disorders with TMEM143: view

No data available for UniProtKB/Swiss-Prot for TMEM143 Gene

Publications for TMEM143 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TMEM143 Gene

Sources for TMEM143 Gene

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