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Aliases for TMEM143 Gene

Aliases for TMEM143 Gene

  • Transmembrane Protein 143 2 3 5

External Ids for TMEM143 Gene

Previous GeneCards Identifiers for TMEM143 Gene

  • GC19M053528
  • GC19M048835
  • GC19M045217

Summaries for TMEM143 Gene

GeneCards Summary for TMEM143 Gene

TMEM143 (Transmembrane Protein 143) is a Protein Coding gene.

Additional gene information for TMEM143 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM143 Gene

Genomics for TMEM143 Gene

Regulatory Elements for TMEM143 Gene

Enhancers for TMEM143 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H048328 1.7 FANTOM5 ENCODE dbSUPER 24.4 +32.6 32572 5 HDGF PKNOX1 ARNT SIN3A FEZF1 YBX1 ZNF2 YY1 ZNF766 ZNF207 TMEM143 BICRA GRWD1 CA11 ZSWIM9 SYNGR4 NOP53-AS1 EMP3 RUVBL2 RASIP1
GH19H048253 1.7 FANTOM5 ENCODE dbSUPER 11.2 +106.8 106786 7 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 NOP53-AS1 KDELR1 BICRA CARD8-AS1 GRWD1 SNRNP70 SNORD23 NOP53 RPL18 PLA2G4C
GH19H048424 1.4 FANTOM5 Ensembl ENCODE 11.6 -60.8 -60841 1 NFRKB BATF ELK1 ZNF143 FOS ATF7 RUNX3 IKZF2 SMARCC1 ZBTB2 GRWD1 KCNJ14 CYTH2 SYNGR4 TMEM143 KDELR1
GH19H048319 1.4 ENCODE dbSUPER 11.6 +40.3 40296 8 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 YBX1 YY1 ZNF766 ZNF143 KDELR1 SNORD23 NOP53 RPL18 BICRA GRWD1 NOP53-AS1 TMEM143 CCDC114 SNRNP70
GH19H048418 1.2 Ensembl ENCODE 12 -54.8 -54788 1 HDGF PKNOX1 ARNT ARID4B ETS1 ZNF766 GATA2 ZNF207 ZNF143 ATF7 GRIN2D TMEM143 SYNGR4 BAX KDELR1 GRWD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM143 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM143 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110693 437 1601 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 ZNF766 ZNF143 FOS SP3

Genomic Location for TMEM143 Gene

Chromosome:
19
Start:
48,332,356 bp from pter
End:
48,364,237 bp from pter
Size:
31,882 bases
Orientation:
Minus strand

Genomic View for TMEM143 Gene

Genes around TMEM143 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM143 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM143 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM143 Gene

Proteins for TMEM143 Gene

  • Protein details for TMEM143 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AN5-TM143_HUMAN
    Recommended name:
    Transmembrane protein 143
    Protein Accession:
    Q96AN5
    Secondary Accessions:
    • A8K656
    • Q6UXY4
    • Q9NV49

    Protein attributes for TMEM143 Gene

    Size:
    459 amino acids
    Molecular mass:
    51715 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM143 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM143 Gene

Post-translational modifications for TMEM143 Gene

  • Ubiquitination at Lys405
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM143 Gene

Domains & Families for TMEM143 Gene

Gene Families for TMEM143 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM143 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM143 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM143: view

No data available for UniProtKB/Swiss-Prot for TMEM143 Gene

Function for TMEM143 Gene

Phenotypes From GWAS Catalog for TMEM143 Gene

Gene Ontology (GO) - Molecular Function for TMEM143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM143: view

Phenotypes for TMEM143 Gene

GenomeRNAi human phenotypes for TMEM143:
genes like me logo Genes that share phenotypes with TMEM143: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM143
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM143 Gene

Localization for TMEM143 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM143 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM143 gene
Compartment Confidence
mitochondrion 5
plasma membrane 2
nucleus 2
extracellular 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM143: view

Pathways & Interactions for TMEM143 Gene

SuperPathways for TMEM143 Gene

No Data Available

Interacting Proteins for TMEM143 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000293261%0d%0a9606.ENSP00000301305%0d%0a
Selected Interacting proteins: ENSP00000293261 Q96AN5-TM143_HUMAN for TMEM143 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM143: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM143 Gene

Drugs & Compounds for TMEM143 Gene

No Compound Related Data Available

Transcripts for TMEM143 Gene

Unigene Clusters for TMEM143 Gene

Transmembrane protein 143:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM143
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM143 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9
SP1: - - -
SP2: - - - - - - - -
SP3: - -
SP4: - - - -
SP5: -
SP6: - - -
SP7: - - - - - -
SP8: -
SP9:

Relevant External Links for TMEM143 Gene

GeneLoc Exon Structure for
TMEM143
ECgene alternative splicing isoforms for
TMEM143

Expression for TMEM143 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM143 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM143 Gene

This gene is overexpressed in Muscle - Skeletal (x6.9) and Heart - Left Ventricle (x6.0).

Protein differential expression in normal tissues from HIPED for TMEM143 Gene

This gene is overexpressed in Heart (45.7) and Plasma (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM143 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM143 Gene:

TMEM143

SOURCE GeneReport for Unigene cluster for TMEM143 Gene:

Hs.351335

Evidence on tissue expression from TISSUES for TMEM143 Gene

  • Intestine(4.2)
  • Nervous system(3.9)
  • Muscle(2.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with TMEM143: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM143 Gene

Orthologs for TMEM143 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM143 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM143 33 34
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia TMEM143 33 34
  • 87.75 (n)
cow
(Bos Taurus)
Mammalia TMEM143 33 34
  • 85.41 (n)
rat
(Rattus norvegicus)
Mammalia Tmem143 33
  • 84.21 (n)
mouse
(Mus musculus)
Mammalia Tmem143 33 16 34
  • 83.85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM143 34
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM143 34
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM143 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem143 33
  • 61.45 (n)
Species where no ortholog for TMEM143 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM143 Gene

ENSEMBL:
Gene Tree for TMEM143 (if available)
TreeFam:
Gene Tree for TMEM143 (if available)

Paralogs for TMEM143 Gene

No data available for Paralogs for TMEM143 Gene

Variants for TMEM143 Gene

Sequence variations from dbSNP and Humsavar for TMEM143 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000014629 -- 48,339,136(+) GGCTG(A/G)AAGGG intron-variant
rs1000033332 -- 48,364,869(+) CAGGC(C/T)CTTCA intron-variant, upstream-variant-2KB
rs1000188953 -- 48,350,547(+) AGAGC(A/G)CACGA intron-variant
rs1000288117 -- 48,357,550(+) ACAGG(G/T)TTTCA intron-variant
rs1000465163 -- 48,338,333(+) AGCTG(-/C)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM143 Gene

Variant ID Type Subtype PubMed ID
dgv5e22 CNV deletion 17803354
esv2674971 CNV deletion 23128226
esv2718671 CNV deletion 23290073
esv2718672 CNV deletion 23290073
esv2718674 CNV deletion 23290073
esv3407988 CNV insertion 20981092
esv34181 CNV loss 18971310
esv3556504 CNV deletion 23714750
esv3644585 CNV loss 21293372
esv3893229 CNV loss 25118596
nsv1138715 CNV deletion 24896259
nsv137963 CNV deletion 16902084
nsv469623 CNV loss 16826518
nsv833854 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for TMEM143 Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM143 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM143

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM143 Gene

Disorders for TMEM143 Gene

Relevant External Links for TMEM143

Genetic Association Database (GAD)
TMEM143
Human Genome Epidemiology (HuGE) Navigator
TMEM143
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM143

No disorders were found for TMEM143 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM143 Gene

Publications for TMEM143 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 60
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for TMEM143 Gene

Sources for TMEM143 Gene

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