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Aliases for TMEM141 Gene

Aliases for TMEM141 Gene

  • Transmembrane Protein 141 2 3 5

External Ids for TMEM141 Gene

Previous GeneCards Identifiers for TMEM141 Gene

  • GC09P138805
  • GC09P139685
  • GC09P109144

Summaries for TMEM141 Gene

GeneCards Summary for TMEM141 Gene

TMEM141 (Transmembrane Protein 141) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM141 Gene

Genomics for TMEM141 Gene

Regulatory Elements for TMEM141 Gene

Enhancers for TMEM141 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G136787 1.7 Ensembl ENCODE dbSUPER 11.3 +3.4 3389 14.2 MLX AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D LCN8 ABCA2 NALT1 LCN10 TMEM141 LCN12 PRR31 C8G FBXW5 DPH7
GH09G136881 1.6 Ensembl ENCODE dbSUPER 11.8 +91.3 91338 2.7 HDGF PKNOX1 FOXA2 MLX AGO1 ARID4B SIN3A DMAP1 YY1 SLC30A9 PHPT1 MAMDC4 C9orf172 TMEM141 LCN12 PRR31 FBXW5 C8G RABL6 C9orf139
GH09G136900 1.4 Ensembl ENCODE dbSUPER 11.7 +110.9 110850 4.0 ELF3 HDGF TBP PKNOX1 FOXA2 SIN3A RAD21 ZBTB40 YY1 EGR1 TRAF2 TMEM141 PHPT1 LCN12 C9orf142 SAPCD2 MIR4479 PIR43412
GH09G136884 1.3 ENCODE dbSUPER 11.8 +95.0 94950 3.1 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B ZNF207 ZNF143 FOS PHPT1 SNHG7 MAMDC4 C9orf172 FBXW5 C8G LCN12 TMEM141 PRR31 RABL6
GH09G136898 0.8 ENCODE dbSUPER 11.7 +107.8 107792 1.8 CTCF BACH1 ZNF600 MLLT1 NR3C1 TMEM141 C9orf142 LCNL1 MIR4479 PIR43412
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM141 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM141 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000243088 75 1201 HDGF PKNOX1 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for TMEM141 Gene

Chromosome:
9
Start:
136,791,325 bp from pter
End:
136,793,317 bp from pter
Size:
1,993 bases
Orientation:
Plus strand

Genomic View for TMEM141 Gene

Genes around TMEM141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM141 Gene

Proteins for TMEM141 Gene

  • Protein details for TMEM141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96I45-TM141_HUMAN
    Recommended name:
    Transmembrane protein 141
    Protein Accession:
    Q96I45
    Secondary Accessions:
    • A6NIZ7
    • Q5T5R5

    Protein attributes for TMEM141 Gene

    Size:
    108 amino acids
    Molecular mass:
    11875 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI12680.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TMEM141 Gene

neXtProt entry for TMEM141 Gene

Post-translational modifications for TMEM141 Gene

No Post-translational modifications

Other Protein References for TMEM141 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM141 Gene

Domains & Families for TMEM141 Gene

Protein Domains for TMEM141 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM141 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96I45

UniProtKB/Swiss-Prot:

TM141_HUMAN :
  • Belongs to the TMEM141 family.
Family:
  • Belongs to the TMEM141 family.
genes like me logo Genes that share domains with TMEM141: view

No data available for Gene Families for TMEM141 Gene

Function for TMEM141 Gene

genes like me logo Genes that share phenotypes with TMEM141: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM141 Gene

Localization for TMEM141 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM141 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM141 gene
Compartment Confidence
cytoskeleton 3
mitochondrion 3
extracellular 2
plasma membrane 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TMEM141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005930 axoneme IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM141: view

Pathways & Interactions for TMEM141 Gene

SuperPathways for TMEM141 Gene

No Data Available

Interacting Proteins for TMEM141 Gene

Selected Interacting proteins: Q96I45-TM141_HUMAN for TMEM141 Gene via IID

Gene Ontology (GO) - Biological Process for TMEM141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003341 cilium movement IBA --
GO:0036158 outer dynein arm assembly IBA --
genes like me logo Genes that share ontologies with TMEM141: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM141 Gene

Drugs & Compounds for TMEM141 Gene

No Compound Related Data Available

Transcripts for TMEM141 Gene

mRNA/cDNA for TMEM141 Gene

Unigene Clusters for TMEM141 Gene

Transmembrane protein 141:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM141 Gene

No ASD Table

Relevant External Links for TMEM141 Gene

GeneLoc Exon Structure for
TMEM141
ECgene alternative splicing isoforms for
TMEM141

Expression for TMEM141 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM141 Gene

Protein differential expression in normal tissues from HIPED for TMEM141 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.9), Heart (13.1), and Placenta (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM141 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM141 Gene:

TMEM141

SOURCE GeneReport for Unigene cluster for TMEM141 Gene:

Hs.356744

Evidence on tissue expression from TISSUES for TMEM141 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM141: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM141 Gene

Orthologs for TMEM141 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM141 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM141 34 35
  • 98.46 (n)
mouse
(Mus musculus)
Mammalia Tmem141 34 16 35
  • 85.4 (n)
cow
(Bos Taurus)
Mammalia TMEM141 34 35
  • 84.57 (n)
rat
(Rattus norvegicus)
Mammalia Tmem141 34
  • 84.26 (n)
dog
(Canis familiaris)
Mammalia TMEM141 34 35
  • 82.72 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM141 35
  • 35 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM141 34 35
  • 68.27 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem141 34
  • 69.02 (n)
Str.15697 34
zebrafish
(Danio rerio)
Actinopterygii tmem141 34 35
  • 60 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG42488 35
  • 23 (a)
OneToOne
Species where no ortholog for TMEM141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM141 Gene

ENSEMBL:
Gene Tree for TMEM141 (if available)
TreeFam:
Gene Tree for TMEM141 (if available)

Paralogs for TMEM141 Gene

Pseudogenes.org Pseudogenes for TMEM141 Gene

genes like me logo Genes that share paralogs with TMEM141: view

No data available for Paralogs for TMEM141 Gene

Variants for TMEM141 Gene

Sequence variations from dbSNP and Humsavar for TMEM141 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000046607 -- 136,793,779(+) AGCAC(C/T)GAAGA downstream-variant-500B
rs1000057128 -- 136,789,807(+) TTATA(A/G)AGTAG upstream-variant-2KB
rs1000071872 -- 136,791,040(+) GCCTG(C/T)GCAGG upstream-variant-2KB
rs1000141204 -- 136,793,442(+) TAGGC(A/C)ACGTG downstream-variant-500B
rs1000248751 -- 136,792,918(+) ACCCT(C/T)CCCAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM141 Gene

Variant ID Type Subtype PubMed ID
esv2422220 CNV deletion 17116639
esv2739392 CNV deletion 23290073
esv2759720 CNV loss 17122850
esv3891732 CNV loss 25118596
nsv466681 CNV loss 19166990
nsv469918 CNV loss 18288195
nsv523639 CNV loss 19592680
nsv615982 CNV loss 21841781
nsv818738 CNV gain 17921354

Variation tolerance for TMEM141 Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM141 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM141

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM141 Gene

Disorders for TMEM141 Gene

Relevant External Links for TMEM141

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM141

No disorders were found for TMEM141 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM141 Gene

Publications for TMEM141 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  4. Facile backbone structure determination of human membrane proteins by NMR spectroscopy. (PMID: 22609626) Klammt C. … Choe S. (Nat. Methods 2012) 4 64
  5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64

Products for TMEM141 Gene

Sources for TMEM141 Gene

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