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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM141 Gene

protein-coding   GIFtS: 40
GCID: GC09P139685

Transmembrane Protein 141

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 1411 2
RP11-216L13.72

External Ids:    HGNC: 282111   Entrez Gene: 850142   Ensembl: ENSG000002441877   UniProtKB: Q96I453   

Export aliases for TMEM141 gene to outside databases

Previous GC identifers: GC09P138805 GC09P109144


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM141 Gene: 
TMEM141 (transmembrane protein 141) is a protein-coding gene. Diseases associated with TMEM141 include intrahepatic cholangiocarcinoma, and cholangiocarcinoma.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_024000.16  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM141 gene promoter:
         GCNF   C/EBPalpha   E47   c-Rel   GCNF-1   IRF-7A   Cart-1   LyF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM141 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM141

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM141


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

TMEM141 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM141 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P139685:  view genomic region     (about GC identifiers)

Start:
139,685,777 bp from pter      End:
139,695,010 bp from pter
Size:
9,234 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM141_HUMAN, Q96I45 (See protein sequence)
Recommended Name: Transmembrane protein 141  
Size: 108 amino acids; 11875 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=CAI12680.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for TMEM141:
2LOR (3D)    
Secondary accessions: A6NIZ7 Q5T5R5

Explore the universe of human proteins at neXtProt for TMEM141: NX_Q96I45

Explore proteomics data for TMEM141 at MOPED 

TMEM141 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TMEM141 Protein Expression

REFSEQ proteins: NP_116317.1  
ENSEMBL proteins: 
 ENSP00000290079  

Human Recombinant Protein Products for TMEM141: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

TMEM141 for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for TMEM141


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR026788 Tmem141

Graphical View of Domain Structure for InterPro Entry Q96I45

ProtoNet protein and cluster: Q96I45

UniProtKB/Swiss-Prot: TM141_HUMAN, Q96I45
Similarity: Belongs to the TMEM141 family


TMEM141 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 GenomeRNAi human phenotype for TMEM141:
 Increased HPV18 LCR reporter a 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM141 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM141

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM141 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM141 

miRNA
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Inhib. RNA
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Sirion Biotech Customized adenovirus for overexpression of TMEM141

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OriGene ORF clones in mouse, rat for TMEM141
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GenScript: all cDNA clones in your preferred vector: TMEM141 (NM_032928)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM141
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                     Customized lentivirus expression plasmids for stable overexpression of TMEM141 

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM141


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM141

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for TMEM141 (Q96I453 ENSP000002900794) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SAT1P216733I2D: score=1 
--ENSP000003887794STRING: ENSP00000388779
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM141 (TM141)

Search CenterWatch for drugs/clinical trials and news about TMEM141 / TM141

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM141 gene: 
NM_032928.3  

Unigene Cluster for TMEM141:

Transmembrane protein 141
Hs.356744  [show with all ESTs]
Unigene Representative Sequence: BM910333
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000290079(uc011meg.1 uc004cje.4) ENST00000465017 ENST00000483187
ENST00000479737 ENST00000456614 ENST00000484854 ENST00000489739
miRNA
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Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for TMEM141
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM141
Clone
Products:
     
OriGene clones in human, mouse for TMEM141 (see all 7)
OriGene ORF clones in mouse, rat for TMEM141
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TMEM141 (NM_032928)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM141
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM141
Sirion Biotech Customized lentivirus for stable overexpression of TMEM141 
                     Customized lentivirus expression plasmids for stable overexpression of TMEM141 
Primer
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OriGene qPCR primer pairs and template standards for TMEM141
OriGene qSTAR qPCR primer pairs in human, mouse for TMEM141
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM141
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM141

Additional mRNA sequence: BC007834.2 

10 DOTS entries:

DT.315700  DT.92427466  DT.100776913  DT.97859138  DT.95277070  DT.91813993  DT.92427464  DT.95277068 
DT.91832982  DT.40245730 

24/671 AceView cDNA sequences (see all 671):

BU156593 CK725110 BU634537 BU552576 AI028649 AW297187 BC021095 BE793937 
BM726483 AI919375 AW235265 BU166582 CB268150 AI027576 AI677984 BM981414 
AI573120 BE205840 AW027697 AI684649 BU625418 BQ425491 NM_024718 BQ233310 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM141 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTCTGCACTG
TMEM141 Expression
About this image


See TMEM141 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM141

SOURCE GeneReport for Unigene cluster: Hs.356744
    SABiosciences Custom PCR Arrays for TMEM141
Primer
Products:
OriGene qPCR primer pairs and template standards for TMEM141
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM141
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM141
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM141

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TMEM141 gene from 5/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmem1411 , 5 transmembrane protein 1411, 5 85.4(n)1
80.95(a)1
  2 (17.57 cM)5
518751  NM_001040130.31  NP_001035219.21 
 256200675 
chicken
(Gallus gallus)
Aves TMEM1411 transmembrane protein 141 68.93(n)
59.22(a)
  417294  XM_415567.3  XP_415567.3 
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.156972 Transcribed sequence with weak similarity to protein more 77.16(n)    BX742935.1 
zebrafish
(Danio rerio)
Actinopterygii tmem1411 transmembrane protein 141 60.26(n)
60.58(a)
  767658  NM_001076598.1  NP_001070066.1 
fruit fly
(Drosophila melanogaster)
Insecta CG424886
--
23(a)
1 ↔ 1
3R(21308888-21309254)


ENSEMBL Gene Tree for TMEM141 (if available)
TreeFam Gene Tree for TMEM141 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TMEM141 gene

TMEM141 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for TMEM141
PGOHUM00000251022


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/149 SNPs in TMEM141 are shown (see all 149)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs24923061,2
C,F--139683979(-) tcatcG/Accatt 1 -- us2k13Minor allele frequency- A:0.50NA 6
rs24981941,2
C--139683997(+) caagcG/Atactg 1 -- us2k12Minor allele frequency- A:0.25NA 4
rs1150259791,2
C,F--139684135(+) AGCAGA/GATAAT 1 -- us2k11Minor allele frequency- G:0.05WA 118
rs1892434841,2
--139684276(+) CCACAC/TTTTGA 1 -- us2k10--------
rs3696164471,2
C--139684338(+) TCAGC-/T/TT  
        
TTTTT
1 -- us2k10--------
rs24981951,2
C,F,A--139684421(+) CCTCCA/GCCTCC 1 -- us2k14Minor allele frequency- G:0.38NA WA 8
rs1812768871,2
--139684523(+) AGAGAC/TGGGGT 1 -- us2k10--------
rs1498134741,2
C--139684577(+) ATCCAC/TCTGCC 1 -- us2k10--------
rs101234241,2
C,F--139684622(+) GCCACC/TGCACC 1 -- us2k16Minor allele frequency- T:0.13NA EA 248
rs586230471,2
C,F--139684719(+) CAACAC/TGTATA 1 -- us2k11Minor allele frequency- T:0.50WA 2

HapMap Linkage Disequilibrium report for TMEM141 (139685777 - 139695010 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/18 variations for TMEM141 (see all 18):    About this table     
Variant IDTypeSubtypePubMed ID
esv2739392CNV Deletion23290073
esv2422220CNV Deletion17116639
dgv8414n71CNV Loss21882294
dgv8416n71CNV Loss21882294
nsv894386CNV Loss21882294
nsv466681CNV Loss19166990
dgv8418n71CNV Loss21882294
dgv8415n71CNV Loss21882294
dgv8417n71CNV Loss21882294
nsv469918CNV Loss18288195

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for TMEM141:    About MalaCards
intrahepatic cholangiocarcinoma    cholangiocarcinoma


TMEM141 for disorders           About GeneDecksing


Export disorders for TMEM141 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TMEM141 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM141)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
  3. Facile backbone structure determination of human membrane proteins by NMR spectroscopy. (PubMed id 22609626)2 Klammt C.... Choe S. (2012)
  4. A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. (PubMed id 20305087)1 Mak A.B....Moffat J. (2010)
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  6. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 85014 HGNC: 28211 AceView: C9orf86andKIAA1984andMGC14141 Ensembl:ENSG00000244187 euGenes: HUgn85014
ECgene: TMEM141 H-InvDB: TMEM141

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TMEM141 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TMEM141 gene:
Search GeneIP for patents involving TMEM141

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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