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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMEM140 Gene

protein-coding GIFtS: 37
GCID: GC07P134832

transmembrane protein 140

Search for TMEM140
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transmembrane Protein 140¹ ²
FLJ11000¹

External Ids:	HGNC: 21870¹	Entrez Gene: 55281²	Ensembl: ENSG00000146859⁷	UniProtKB: Q9NV12³

Export aliases for TMEM140 gene to outside databases

Previous GC identifers: GC07P134483 GC07P129135

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TMEM140 gene promoter:
SREBP-1c GATA-1 PPAR-gamma1 IRF-2 FOXO4 FOXJ2 (long isoform) IRF-7A PPAR-gamma2 FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM140 promoter sequence

Search SABiosciences Chromatin IP Primers for TMEM140

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM140

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q33 Ensembl cytogenetic band: 7q33 HGNC cytogenetic band: 7q33

TMEM140 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM140 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P134832: view genomic region (about GC identifiers)

Start:	134,832,766 bp from pter	End:	134,850,967 bp from pter
Size:	18,202 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 134,177,123-134,195,325

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TM140_HUMAN, Q9NV12 (See protein sequence)

Recommended Name: Transmembrane protein 140

Size: 185 amino acids; 20419 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: A4D1P9 Q8WUC3

Explore the universe of human proteins at neXtProt for TMEM140: NX_Q9NV12

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NV12

TMEM140 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060765.3

ENSEMBL proteins:

ENSP00000275767

Human Recombinant Protein Products for TMEM140:

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	Uscn Proteins for TMEM140

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

TMEM140 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9NV12

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TMEM140

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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM140:
		hsa-miR-644 hsa-miR-182 hsa-miR-4302 hsa-miR-3119 hsa-miR-3653 hsa-miR-744*
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMEM140

1 Interacting protein for TMEM140 (Q9NV12³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CREB3	O43889³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM140
Search CenterWatch for drugs/clinical trials and news about TMEM140 / TM140

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM140 gene:

NM_018295.3

Unigene Cluster for TMEM140:

Transmembrane protein 140

Hs.741457 [show with all ESTs]

Unigene Representative Sequence: NM_018295

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000275767(uc003vsi.3) ENST00000466307

miRNA Products:		OriGene 3'-UTR Clone: TMEM140 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM140
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM140:
		hsa-miR-644 hsa-miR-182 hsa-miR-4302 hsa-miR-3119 hsa-miR-3653 hsa-miR-744*
		SwitchGear 3'UTR luciferase reporter plasmid: TMEM140 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM140 (see all 7) OriGene shRNA RFP: TMEM140 OriGene siRNA: TMEM140
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM140
		Sirion Biotech Custom design and validation of potent shRNA sequences against TMEM140

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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM140
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM140

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Additional cDNA sequence:

AK001862.1 AK128762.1 AK225055.1 AK301268.1 BC020942.1

15 DOTS entries:

DT.95208627 DT.446506 DT.107104 DT.97810909 DT.100821173 DT.97802988 DT.100821160 DT.121060787

DT.100799308 DT.40266335 DT.95158234 DT.40259704 DT.91829356 DT.100821163 DT.95158232

24/285 AceView cDNA sequences (see all 285):

BQ226755 CB132170 BM727136 AW515167 BC024018 AA906037 BQ440169 BU539869

AI827176 BQ949282 BC000168 BU621670 BE785683 BM789844 BC010361 AI187313

BM727569 BQ437301 BQ026608 AA954030 CR596076 BP342152 AW167607 BM126906

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM140 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

TMEM140 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TMEM140 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM140

SOURCE GeneReport for Unigene cluster: Hs.741457

SABiosciences Custom PCR Arrays for TMEM140

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM140 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM140

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM140

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TMEM140 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tmem140^{1 , 5}	transmembrane protein 140^{1, 5}	76.97(n)¹ 63.48(a)¹		6 (15.18 cM)⁵ 68487¹ NM_197986.2¹ NP_932103.1¹ 34863146⁵
chicken (Gallus gallus)	Aves	TMEM140¹	transmembrane protein 140	52.16(n) 43.53(a)		417940 XM_416181.3 XP_416181.2
lizard (Anolis carolinensis)	Reptilia	TMEM140⁶	--	39(a)	1 ↔ 1	5(27929166-27929714)

ENSEMBL Gene Tree for TMEM140 (if available)
TreeFam Gene Tree for TMEM140 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75952361^1,2	C	--	134175995(+)	`CTAGGT/CACATG`	2	--	int¹ us2k¹		2	NA	122
rs73153782^1,2	C,F	--	134176258(+)	`GCAAAG/CTAGGT`	2	--	int¹ us2k¹		1	NA	120
rs6945839^1,2	A,H	--	134176613(+)	`CCCCAA/GTGCTT`	2	--	int¹ us2k¹		4	NS EA	418
rs60713805^1,2	C	--	134177042(+)	`TGTAGG/ATAAAG`	2	--	int¹ us2k¹		2	WA	120
rs111230612^1,2		--	134177656(+)	`AGAAAC/TGATGC`	2	--	us2k¹ int¹		2	CSA WA	120
rs78948930^1,2	F	--	134177942(+)	`TCATGC/GCCCAG`	2	--	us2k¹ int¹		1	NA	120
rs73153787^1,2	C	--	134179249(+)	`ATTTAT/CTTGGG`	2	--	us2k¹ int¹		1	NA	120
rs73725240^1,2	C	--	134179573(+)	`GGCACT/CGATTC`	1	--	int¹		2	WA	120
rs73725242^1,2	C	--	134180522(+)	`TCCACC/AAGAAA`	1	--	int¹		2	WA	120
rs77775910^1,2	C,F	--	134180569(+)	`CCTGCG/ACCCTT`	1	--	int¹		1	EA	120

HapMap Linkage Disequilibrium report for TMEM140 (134832766 - 134850967 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM140: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM140

DNA2.0 Custom Variant and Variant Library Synthesis for TMEM140

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMEM140 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM140)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The DNA sequence of human chromosome 7. (PubMed id 12853948)² Hillier L.W.... Wilson R.K. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)¹ Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55281	HGNC: 21870	AceView: MGC5242	Ensembl:ENSG00000146859	euGenes: HUgn55281
ECgene: TMEM140	H-InvDB: TMEM140

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TMEM140	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMEM140 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TMEM140 gene:
Search GeneIP for patents involving TMEM140

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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TMEM140 Gene

transmembrane protein 140

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TMEM140 Gene

transmembrane protein 140

Aliasesfor TMEM140 gene

Summariesfor TMEM140 gene

Genomic Viewsfor TMEM140 gene

Proteinsfor TMEM140 gene

Protein Domains /Familiesfor TMEM140 gene

Functionfor TMEM140 gene

Pathways & Interactionsfor TMEM140 gene

Drugs & Compoundsfor TMEM140 gene

Transcriptsfor TMEM140 gene

Expression for TMEM140 gene

Orthologsfor TMEM140 gene

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Disorders / Diseasesfor TMEM140 gene

Publicationsfor TMEM140 gene

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Genome Databases showing TMEM140 gene

Other Databases showing TMEM140 gene

Specialized Databases showing TMEM140 gene

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Productsfor TMEM140 gene

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Aliases
for TMEM140 gene

Summaries
for TMEM140 gene

Genomic Views
for TMEM140 gene

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for TMEM140 gene

Protein Domains /
Families
for TMEM140 gene

Function
for TMEM140 gene

Pathways & Interactions
for TMEM140 gene

Drugs & Compounds
for TMEM140 gene

Transcripts
for TMEM140 gene

Expression
for TMEM140 gene

Orthologs
for TMEM140 gene

Paralogs
for TMEM140 gene

Genomic Variants
for TMEM140 gene

Disorders / Diseases
for TMEM140 gene

Publications
for TMEM140 gene

Intellectual Property
for TMEM140 gene

Products
for TMEM140 gene