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Aliases for TMEM140 Gene

Aliases for TMEM140 Gene

  • Transmembrane Protein 140 2 3

External Ids for TMEM140 Gene

Previous GeneCards Identifiers for TMEM140 Gene

  • GC07P134483
  • GC07P134832
  • GC07P129135

Summaries for TMEM140 Gene

GeneCards Summary for TMEM140 Gene

TMEM140 (Transmembrane Protein 140) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM140 Gene

Genomics for TMEM140 Gene

Regulatory Elements for TMEM140 Gene

Genomic Location for TMEM140 Gene

Chromosome:
7
Start:
135,148,014 bp from pter
End:
135,166,215 bp from pter
Size:
18,202 bases
Orientation:
Plus strand

Genomic View for TMEM140 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM140 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM140 Gene

Proteins for TMEM140 Gene

  • Protein details for TMEM140 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV12-TM140_HUMAN
    Recommended name:
    Transmembrane protein 140
    Protein Accession:
    Q9NV12
    Secondary Accessions:
    • A4D1P9
    • Q8WUC3

    Protein attributes for TMEM140 Gene

    Size:
    185 amino acids
    Molecular mass:
    20419 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM140 Gene

Proteomics data for TMEM140 Gene at MOPED

Post-translational modifications for TMEM140 Gene

  • Glycosylation at Asn 38
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM140 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM140 Gene

Domains & Families for TMEM140 Gene

Protein Domains for TMEM140 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM140 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM140: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM140 Gene

Function for TMEM140 Gene

Gene Ontology (GO) - Molecular Function for TMEM140 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM140: view
genes like me logo Genes that share phenotypes with TMEM140: view

Animal Model Products

CRISPR Products

miRNA for TMEM140 Gene

miRTarBase miRNAs that target TMEM140

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM140

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM140 Gene

Localization for TMEM140 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM140 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM140 Gene COMPARTMENTS Subcellular localization image for TMEM140 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TMEM140 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM140: view

Pathways & Interactions for TMEM140 Gene

SuperPathways for TMEM140 Gene

No Data Available

Interacting Proteins for TMEM140 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000275767%0d%0a9606.ENSP00000316130%0d%0a
Selected Interacting proteins: Q9NV12-TM140_HUMAN ENSP00000275767 for TMEM140 Gene via I2D UniProtKB STRING

Gene Ontology (GO) - Biological Process for TMEM140 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM140 Gene

Drugs & Compounds for TMEM140 Gene

No Compound Related Data Available

Transcripts for TMEM140 Gene

mRNA/cDNA for TMEM140 Gene

Unigene Clusters for TMEM140 Gene

Transmembrane protein 140:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM140

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM140 Gene

No ASD Table

Relevant External Links for TMEM140 Gene

GeneLoc Exon Structure for
TMEM140
ECgene alternative splicing isoforms for
TMEM140

Expression for TMEM140 Gene

mRNA expression in normal human tissues for TMEM140 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM140 Gene

This gene is overexpressed in Whole Blood (x20.1).

SOURCE GeneReport for Unigene cluster for TMEM140 Gene Hs.521213

genes like me logo Genes that share expression patterns with TMEM140: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM140 Gene

Orthologs for TMEM140 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM140 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM140 35
  • 80.71 (n)
  • 74.84 (a)
TMEM140 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM140 35
  • 82.43 (n)
  • 73.37 (a)
TMEM140 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem140 35
  • 76.97 (n)
  • 64.04 (a)
Tmem140 16
Tmem140 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM140 35
  • 98.56 (n)
  • 96.76 (a)
TMEM140 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem140 35
  • 79.4 (n)
  • 67.98 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM140 36
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM140 35
  • 52.44 (n)
  • 46 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM140 36
  • 39 (a)
OneToOne
Species with no ortholog for TMEM140:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM140 Gene

ENSEMBL:
Gene Tree for TMEM140 (if available)
TreeFam:
Gene Tree for TMEM140 (if available)

Paralogs for TMEM140 Gene

No data available for Paralogs for TMEM140 Gene

Variants for TMEM140 Gene

Sequence variations from dbSNP and Humsavar for TMEM140 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
VAR_030262 -
VAR_030263 -
VAR_030264 -
VAR_030265 -
VAR_035670 A colorectal cancer sample

Structural Variations from Database of Genomic Variants (DGV) for TMEM140 Gene

Variant ID Type Subtype PubMed ID
nsv527174 CNV Loss 19592680
nsv889225 CNV Loss 21882294
esv2665250 CNV Deletion 23128226
nsv527014 CNV Gain 19592680

Variation tolerance for TMEM140 Gene

Residual Variation Intolerance Score: 79.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.81; 67.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM140 Gene

HapMap Linkage Disequilibrium report
TMEM140

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM140 Gene

Disorders for TMEM140 Gene

Relevant External Links for TMEM140

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM140
genes like me logo Genes that share disorders with TMEM140: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM140 Gene

Publications for TMEM140 Gene

  1. HSV-1 nucleocapsid egress mediated by UL31 in association with UL34 is impeded by cellular transmembrane protein 140. (PMID: 25036476) Guan Y. … Li Q. (Virology 2014) 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 67
  4. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 67
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67

Products for TMEM140 Gene

Sources for TMEM140 Gene

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