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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM140 Gene

protein-coding   GIFtS: 38
GCID: GC07P134832

Transmembrane Protein 140

  Search for TMEM140
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 1401 2

External Ids:    HGNC: 218701   Entrez Gene: 552812   Ensembl: ENSG000001468597   UniProtKB: Q9NV123   

Export aliases for TMEM140 gene to outside databases

Previous GC identifers: GC07P134483 GC07P129135


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM140 Gene: 
TMEM140 (transmembrane protein 140) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM140 gene promoter:
         SREBP-1c   GATA-1   PPAR-gamma1   IRF-2   FOXO4   FOXJ2 (long isoform)   IRF-7A   PPAR-gamma2   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM140 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM140

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM140


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q33   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q33

TMEM140 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM140 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P134832:  view genomic region     (about GC identifiers)

Start:
134,832,766 bp from pter      End:
134,850,967 bp from pter
Size:
18,202 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 134,177,123-134,195,325     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM140_HUMAN, Q9NV12 (See protein sequence)
Recommended Name: Transmembrane protein 140  
Size: 185 amino acids; 20419 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A4D1P9 Q8WUC3

Explore the universe of human proteins at neXtProt for TMEM140: NX_Q9NV12

Explore proteomics data for TMEM140 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NV12

  • TMEM140 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM140 Protein Expression
    REFSEQ proteins: NP_060765.4  
    ENSEMBL proteins: 
     ENSP00000275767  

    Human Recombinant Protein Products for TMEM140: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    TMEM140 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9NV12


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM140 
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    SwitchGear 3'UTR luciferase reporter plasmidTMEM140 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM140

    1 Interacting protein for TMEM140 (Q9NV123) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM140 (TM140)

    Search CenterWatch for drugs/clinical trials and news about TMEM140 / TM140

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM140 gene: 
    NM_018295.4  

    Unigene Cluster for TMEM140:

    Transmembrane protein 140
    Hs.521213  [show with all ESTs]
    Unigene Representative Sequence: NM_018295
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000275767(uc003vsi.3) ENST00000466307
    miRNA
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    hsa-miR-644 hsa-miR-182 hsa-miR-4302 hsa-miR-3119 hsa-miR-3653 hsa-miR-744*
    SwitchGear 3'UTR luciferase reporter plasmidTMEM140 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TMEM140
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM140
    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM140
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM140
    Sirion Biotech Customized lentivirus for stable overexpression of TMEM140 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM140
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM140

    Additional mRNA sequence: 

    AK001862.1 AK128762.1 AK225055.1 AK301268.1 BC020942.1 

    17 DOTS entries:

    DT.95208627  DT.446506  DT.107104  DT.97810909  DT.100821173  DT.97802988  DT.121060787  DT.100799308 
    DT.100821160  DT.40266335  DT.95158234  DT.100821163  DT.40259704  DT.91829356  DT.95158232  DT.97854645 
    DT.121060841 

    24/285 AceView cDNA sequences (see all 285):

    CA389716 AI241581 AA872499 BQ221195 CK906339 NM_024033 AA037625 BE730720 
    AA809505 AK056910 AA876151 BQ071086 BE619122 BQ423284 AK130795 BQ000683 
    BX098568 BM704142 BQ430486 BM126635 AI354477 CK906338 AI655857 AA969038 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM140 expression in normal human tissues (normalized intensities)      TMEM140 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TMEM140 Expression
    About this image


    TMEM140 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Mesenchymal Stem Cells
             Human Mesenchymal Stem Cells (hMSC)-2   
     
     Blood (Hematopoietic System)
             leukocytes   
     
     Breast (Uncategorized)
             Human Mammary Fibroblasts (HMF)   
     
     Adipose (Muscoskeletal System)
             Human Mesenchymal Stem Cell-adipose (HMSC-ad)   
     
     Skeletal Muscle (Muscoskeletal System)
             quadriceps   

    See TMEM140 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM140

    SOURCE GeneReport for Unigene cluster: Hs.521213
        SABiosciences Custom PCR Arrays for TMEM140
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM140
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM140

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM140 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1401 , 5 transmembrane protein 1401, 5 76.97(n)1
    63.48(a)1
      6 (15.18 cM)5
    684871  NM_197986.21  NP_932103.11 
     348631465 
    chicken
    (Gallus gallus)
    Aves TMEM1401 transmembrane protein 140 52.16(n)
    43.53(a)
      417940  XM_416181.3  XP_416181.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1406
    Uncharacterized protein
    38(a)
    1 ↔ 1
    5(27929166-27929714)


    ENSEMBL Gene Tree for TMEM140 (if available)
    TreeFam Gene Tree for TMEM140 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/357 SNPs in TMEM140 are shown (see all 357)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356704
    A colorectal cancer sample4--see VAR_0356702 A E mis40--------
    VAR_0302654
    ----see VAR_0302652 F L mis40--------
    rs737252401,2
    C,F--134179573(+) GGCACT/CGATTC 1 -- int12Minor allele frequency- C:0.11WA 120
    rs1819789901,2
    --134179706(+) TGGTGC/TGGGAA 1 -- int10--------
    rs77954971,2
    C,F,A,H--134179707(+) GGTGCA/GGGAAA 1 -- int115Minor allele frequency- G:0.49NS EA NA WA CSA 784
    rs1384950961,2
    --134179801(+) CACAAA/GCTGGA 1 -- int10--------
    rs1413384801,2
    --134179830(+) AGAAAC/GCAAAT 1 -- int10--------
    rs1450936541,2
    --134179849(+) CTGGAC/TGTGGT 1 -- int10--------
    rs1389725361,2
    --134179940(+) ACCCTG/TGGTGA 1 -- int10--------
    rs1419994441,2
    --134180003(+) ACATTC/TTCTCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for TMEM140 (134832766 - 134850967 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TMEM140:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2665250CNV Deletion23128226
    nsv889225CNV Loss21882294
    nsv527174CNV Loss19592680
    nsv527014CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM140 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEM140)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    5. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
    10. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55281 HGNC: 21870 AceView: MGC5242 Ensembl:ENSG00000146859 euGenes: HUgn55281
    ECgene: TMEM140 H-InvDB: TMEM140

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM140 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM140 gene:
    Search GeneIP for patents involving TMEM140

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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