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TMEM140 Gene

protein-coding   GIFtS: 42
GCID: GC07P134832

Transmembrane Protein 140

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 1401 2

External Ids:    HGNC: 218701   Entrez Gene: 552812   Ensembl: ENSG000001468597   UniProtKB: Q9NV123   

Export aliases for TMEM140 gene to outside databases

Previous GC identifers: GC07P134483 GC07P129135


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM140 Gene:
TMEM140 (transmembrane protein 140) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM140 gene promoter:
         SREBP-1c   GATA-1   PPAR-gamma1   IRF-2   FOXO4   FOXJ2 (long isoform)   IRF-7A   PPAR-gamma2   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM140 promoter sequence
   Search Chromatin IP Primers for TMEM140

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM140


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q33   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q33

TMEM140 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM140 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P134832:  view genomic region     (about GC identifiers)

Start:
134,832,766 bp from pter      End:
134,850,967 bp from pter
Size:
18,202 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 134,177,123-134,195,325     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TM140_HUMAN, Q9NV12 (See protein sequence)
Recommended Name: Transmembrane protein 140  
Size: 185 amino acids; 20419 Da
Secondary accessions: A4D1P9 Q8WUC3

Explore the universe of human proteins at neXtProt for TMEM140: NX_Q9NV12

Post-translational modifications: 

  • Glycosylation2 at Asn38
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_060765.4  
    ENSEMBL proteins: 
     ENSP00000275767  

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    Search eBioscience for ELISAs for TMEM140 
    antibodies-online kits for TMEM140 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028038 TM140

    Graphical View of Domain Structure for InterPro Entry Q9NV12

    ProtoNet protein and cluster: Q9NV12


    Find genes that share domains with TMEM140           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TMEM140

    miRNA
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    miRTarBase miRNAs that target TMEM140:
    hsa-mir-335-5p (MIRT018245)

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    hsa-miR-644 hsa-miR-182 hsa-miR-4302 hsa-miR-3119 hsa-miR-3653 hsa-miR-744*
    SwitchGear 3'UTR luciferase reporter plasmidTMEM140 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM140


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM140_HUMAN, Q9NV12: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMEM140           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM140
    Interactions:

        Search GeneGlobe Interaction Network for TMEM140

    1 Interacting protein for TMEM140 (Q9NV123) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM140 (TM140)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM140 gene: 
    NM_018295.4  

    Unigene Cluster for TMEM140:

    Transmembrane protein 140
    Hs.521213  [show with all ESTs]
    Unigene Representative Sequence: NM_018295
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000275767(uc003vsi.3) ENST00000466307
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate TMEM140:
    hsa-miR-644 hsa-miR-182 hsa-miR-4302 hsa-miR-3119 hsa-miR-3653 hsa-miR-744*
    SwitchGear 3'UTR luciferase reporter plasmidTMEM140 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMEM140
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM140
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM140
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM140
      QuantiFast Probe-based Assays in human, mouse, rat TMEM140

    Additional mRNA sequence: 

    AK001862.1 AK128762.1 AK225055.1 AK301268.1 BC020942.1 

    17 DOTS entries:

    DT.95208627  DT.446506  DT.107104  DT.97810909  DT.100821173  DT.97802988  DT.121060787  DT.100799308 
    DT.100821160  DT.40266335  DT.95158234  DT.100821163  DT.40259704  DT.91829356  DT.95158232  DT.97854645 
    DT.121060841 

    Selected AceView cDNA sequences (see all 285):

    NM_024033 AA876151 BQ071086 BE730720 AA809505 CA389716 BE619122 CK906339 
    BQ423284 AK056910 BQ221195 AA872499 AA037625 BQ216753 AI241581 AK130795 
    BQ000683 BX098568 BM704142 BQ430486 BM126635 AI354477 CK906338 AI655857 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM140 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TMEM140 Expression
    About this image


    TMEM140 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    TMEM140 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.521213
        Custom PCR Arrays for TMEM140
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TMEM140
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM140

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM140 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1401 , 5 transmembrane protein 1401, 5 76.97(n)1
    64.04(a)1
      6 (15.18 cM)5
    684871  NM_197986.21  NP_932103.11 
     348631465 
    chicken
    (Gallus gallus)
    Aves TMEM1401 transmembrane protein 140 52.44(n)
    46(a)
      417940  XM_003640367.2  XP_003640415.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1406
    transmembrane protein 140
    39(a)
    1 ↔ 1
    5(27929166-27929714)


    ENSEMBL Gene Tree for TMEM140 (if available)
    TreeFam Gene Tree for TMEM140 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM140 (see all 357)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356704
    A colorectal cancer sample4--see VAR_0356702 A E mis40--------
    rs737252401,2
    C,F--134179573(+) GGCACT/CGATTC 1 -- int12Minor allele frequency- C:0.11WA 120
    rs1819789901,2
    --134179706(+) TGGTGC/TGGGAA 1 -- int10--------
    rs77954971,2
    C,F,A,H--134179707(+) GGTGCA/GGGAAA 1 -- int115Minor allele frequency- G:0.49NS EA NA WA CSA 784
    rs1384950961,2
    --134179801(+) CACAAA/GCTGGA 1 -- int10--------
    rs1413384801,2
    --134179830(+) AGAAAC/GCAAAT 1 -- int10--------
    rs1450936541,2
    --134179849(+) CTGGAC/TGTGGT 1 -- int10--------
    rs1389725361,2
    --134179940(+) ACCCTG/TGGTGA 1 -- int10--------
    rs1419994441,2
    --134180003(+) ACATTC/TTCTCA 1 -- int10--------
    rs1437122241,2
    --134180046(+) TTGTAA/GTCTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TMEM140 (134832766 - 134850967 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TMEM140:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665250CNV Deletion23128226
    nsv889225CNV Loss21882294
    nsv527174CNV Loss19592680
    nsv527014CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM140 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMEM140)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    5. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    10. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55281 HGNC: 21870 AceView: MGC5242 Ensembl:ENSG00000146859 euGenes: HUgn55281
    ECgene: TMEM140 H-InvDB: TMEM140

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM140 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM140 gene:
    Search GeneIP for patents involving TMEM140

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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