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Aliases for TMEM139 Gene

Aliases for TMEM139 Gene

  • Transmembrane Protein 139 2 3

External Ids for TMEM139 Gene

Summaries for TMEM139 Gene

GeneCards Summary for TMEM139 Gene

TMEM139 (Transmembrane Protein 139) is a Protein Coding gene. Diseases associated with TMEM139 include intrahepatic cholangiocarcinoma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM139 Gene

Genomics for TMEM139 Gene

Genomic Location for TMEM139 Gene

Start:
143,279,957 bp from pter
End:
143,288,049 bp from pter
Size:
8,093 bases
Orientation:
Plus strand

Genomic View for TMEM139 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM139 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM139 Gene

Regulatory Elements for TMEM139 Gene

Proteins for TMEM139 Gene

  • Protein details for TMEM139 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV31-TM139_HUMAN
    Recommended name:
    Transmembrane protein 139
    Protein Accession:
    Q8IV31
    Secondary Accessions:
    • B2RCL5
    • D3DXD4
    • Q6ZME2
    • Q8NC22
    • Q96AU8

    Protein attributes for TMEM139 Gene

    Size:
    216 amino acids
    Molecular mass:
    23729 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH16719.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMEM139 Gene

Proteomics data for TMEM139 Gene at MOPED

Post-translational modifications for TMEM139 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM139 Gene

Domains for TMEM139 Gene

Protein Domains for TMEM139 Gene

ProtoNet:
genes like me logo Genes that share domains with TMEM139: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM139 Gene

Function for TMEM139 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM139 Gene

Localization for TMEM139 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM139 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM139 Gene COMPARTMENTS Subcellular localization image for TMEM139 gene
Compartment Confidence
extracellular 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TMEM139 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM139: view

Pathways for TMEM139 Gene

SuperPathways for TMEM139 Gene

No Data Available

Interacting Proteins for TMEM139 Gene

Selected Interacting proteins: Q8IV31-TM139_HUMAN for TMEM139 Gene via MINT I2D

Symbol External ID(s) Details
SMURF2

Gene Ontology (GO) - Biological Process for TMEM139 Gene

None

No data available for Pathways by source for TMEM139 Gene

Transcripts for TMEM139 Gene

Unigene Clusters for TMEM139 Gene

Transmembrane protein 139:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM139 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: -
SP2: - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - -

Relevant External Links for TMEM139 Gene

GeneLoc Exon Structure for
TMEM139
ECgene alternative splicing isoforms for
TMEM139

Expression for TMEM139 Gene

mRNA expression in normal human tissues for TMEM139 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM139 Gene

This gene is overexpressed in Kidney - Cortex (10.0) and Brain - Spinal cord (cervical c-1) (4.4).

SOURCE GeneReport for Unigene cluster for TMEM139 Gene Hs.731832

genes like me logo Genes that share expressions with TMEM139: view

Orthologs for TMEM139 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM139 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM139 36
  • 99.38 (n)
  • 98.61 (a)
TMEM139 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM139 36
  • 81.89 (n)
  • 68.27 (a)
TMEM139 37
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM139 36
  • 82.61 (n)
  • 75.85 (a)
TMEM139 37
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem139 36
  • 72.96 (n)
  • 58.02 (a)
Tmem139 16
Tmem139 37
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM139 37
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM139 37
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem139 36
  • 74.53 (n)
  • 59.91 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM139 37
  • 31 (a)
OneToOne
Species with no ortholog for TMEM139:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM139 Gene

ENSEMBL:
Gene Tree for TMEM139 (if available)
TreeFam:
Gene Tree for TMEM139 (if available)

Paralogs for TMEM139 Gene

No data available for Paralogs for TMEM139 Gene

Variants for TMEM139 Gene

Sequence variations from dbSNP and Humsavar for TMEM139 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1005926 -- 143,283,174(-) ACTGT(C/T)CACAT upstream-variant-2KB
rs7806162 -- 143,284,712(+) AACTC(A/C)GGTCC upstream-variant-2KB
rs28404932 -- 143,284,648(+) GAAGG(C/T)AAACT upstream-variant-2KB
rs28478073 -- 143,283,199(+) TAAAC(A/G)TTTTA upstream-variant-2KB
rs59344050 -- 143,285,372(+) GTGCG(C/T)CTGTG utr-variant-5-prime, intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM139 Gene

Variant ID Type Subtype PubMed ID
nsv831169 CNV Loss 17160897

Relevant External Links for TMEM139 Gene

HapMap Linkage Disequilibrium report
TMEM139
Human Gene Mutation Database (HGMD)
TMEM139

Disorders for TMEM139 Gene

Relevant External Links for TMEM139

Genetic Association Database (GAD)
TMEM139
Human Genome Epidemiology (HuGE) Navigator
TMEM139
genes like me logo Genes that share disorders with TMEM139: view

No data available for UniProtKB/Swiss-Prot for TMEM139 Gene

Publications for TMEM139 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  4. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 49
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for TMEM139 Gene

  • antibodies-online peptides for TMEM139
  • antibodies-online antibodies for TMEM139
  • antibodies-online kits for TMEM139

Sources for TMEM139 Gene

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