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Aliases for TMEM139 Gene

Aliases for TMEM139 Gene

  • Transmembrane Protein 139 2 3 5

External Ids for TMEM139 Gene

Previous GeneCards Identifiers for TMEM139 Gene

  • GC07P142687
  • GC07P142977
  • GC07P137319
  • GC07P143306
  • GC07P143312

Summaries for TMEM139 Gene

GeneCards Summary for TMEM139 Gene

TMEM139 (Transmembrane Protein 139) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM139 Gene

  • May be involved in cellular trafficking of proteins such as SLC4A1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM139 Gene

Genomics for TMEM139 Gene

Regulatory Elements for TMEM139 Gene

Enhancers for TMEM139 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM139 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM139 Gene

143,279,957 bp from pter
143,288,049 bp from pter
8,093 bases
Plus strand

Genomic View for TMEM139 Gene

Genes around TMEM139 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM139 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM139 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM139 Gene

Proteins for TMEM139 Gene

  • Protein details for TMEM139 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 139
    Protein Accession:
    Secondary Accessions:
    • B2RCL5
    • D3DXD4
    • Q6ZME2
    • Q8NC22
    • Q96AU8

    Protein attributes for TMEM139 Gene

    216 amino acids
    Molecular mass:
    23729 Da
    Quaternary structure:
    • Interacts with isoform 2 of SLC4A1 (PubMed:26049106).
    • Sequence=AAH16719.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TMEM139 Gene

Proteomics data for TMEM139 Gene at MOPED

Post-translational modifications for TMEM139 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM139 Gene

Domains & Families for TMEM139 Gene

Protein Domains for TMEM139 Gene


Suggested Antigen Peptide Sequences for TMEM139 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM139: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM139 Gene

Function for TMEM139 Gene

Molecular function for TMEM139 Gene

UniProtKB/Swiss-Prot Function:
May be involved in cellular trafficking of proteins such as SLC4A1.

Phenotypes for TMEM139 Gene

GenomeRNAi human phenotypes for TMEM139:
genes like me logo Genes that share phenotypes with TMEM139: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM139

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM139 Gene

Localization for TMEM139 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM139 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM139 Gene COMPARTMENTS Subcellular localization image for TMEM139 gene
Compartment Confidence
extracellular 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for TMEM139 Gene

Pathways & Interactions for TMEM139 Gene

SuperPathways for TMEM139 Gene

No Data Available

Interacting Proteins for TMEM139 Gene

Selected Interacting proteins: Q8IV31-TM139_HUMAN for TMEM139 Gene via MINT I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMEM139 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM139 Gene

Drugs & Compounds for TMEM139 Gene

No Compound Related Data Available

Transcripts for TMEM139 Gene

Unigene Clusters for TMEM139 Gene

Transmembrane protein 139:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM139 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: -
SP2: - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - -

Relevant External Links for TMEM139 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM139 Gene

mRNA expression in normal human tissues for TMEM139 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM139 Gene

This gene is overexpressed in Kidney - Cortex (x10.0) and Brain - Spinal cord (cervical c-1) (x4.4).

SOURCE GeneReport for Unigene cluster for TMEM139 Gene Hs.731832

genes like me logo Genes that share expression patterns with TMEM139: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM139 Gene

Orthologs for TMEM139 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM139 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM139 35
  • 81.89 (n)
  • 68.27 (a)
TMEM139 36
  • 67 (a)
(Canis familiaris)
Mammalia TMEM139 35
  • 82.61 (n)
  • 75.85 (a)
TMEM139 36
  • 74 (a)
(Mus musculus)
Mammalia Tmem139 35
  • 72.96 (n)
  • 58.02 (a)
Tmem139 16
Tmem139 36
  • 57 (a)
(Pan troglodytes)
Mammalia TMEM139 35
  • 99.38 (n)
  • 98.61 (a)
TMEM139 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmem139 35
  • 74.53 (n)
  • 59.91 (a)
(Monodelphis domestica)
Mammalia TMEM139 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM139 36
  • 42 (a)
(Anolis carolinensis)
Reptilia TMEM139 36
  • 31 (a)
Species with no ortholog for TMEM139:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM139 Gene

Gene Tree for TMEM139 (if available)
Gene Tree for TMEM139 (if available)

Paralogs for TMEM139 Gene

No data available for Paralogs for TMEM139 Gene

Variants for TMEM139 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM139 Gene

Variant ID Type Subtype PubMed ID
nsv831169 CNV Loss 17160897

Variation tolerance for TMEM139 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM139 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TMEM139 Gene

Disorders for TMEM139 Gene

Relevant External Links for TMEM139

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM139 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM139 Gene

Publications for TMEM139 Gene

  1. Transmembrane protein 139 (TMEM139) interacts with human kidney isoform of anion exchanger 1 (kAE1). (PMID: 26049106) Nuiplot N.O. … Akkarapatumwong V. (Biochem. Biophys. Res. Commun. 2015) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3

Products for TMEM139 Gene

Sources for TMEM139 Gene