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Aliases for TMEM139 Gene

Aliases for TMEM139 Gene

  • Transmembrane Protein 139 2 3 5

External Ids for TMEM139 Gene

Previous GeneCards Identifiers for TMEM139 Gene

  • GC07P142687
  • GC07P142977
  • GC07P137319
  • GC07P143306
  • GC07P143312
  • GC07P143324
  • GC07P143355
  • GC07P143419

Summaries for TMEM139 Gene

GeneCards Summary for TMEM139 Gene

TMEM139 (Transmembrane Protein 139) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM139 Gene

  • May be involved in cellular trafficking of proteins such as SLC4A1.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM139 Gene

Genomics for TMEM139 Gene

Regulatory Elements for TMEM139 Gene

Enhancers for TMEM139 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G143258 1.5 FANTOM5 Ensembl ENCODE 13.4 -20.7 -20689 2.2 FOXA2 YY1 TCF12 ZNF766 GATA2 CBX5 FOS SP3 CAVIN1 JUNB TMEM139 LOC105375545 CASP2 RN7SL535P EPHA1-AS1 EPHA1 FAM131B HINT1P1 CLCN1 ZYX
GH07G143248 1.2 Ensembl ENCODE 11.7 -30.0 -29954 2.6 ELF3 CBX3 MLX ARID4B RAD21 RARA YY1 MIXL1 THAP11 NR2F2 TMEM139 LOC105375545 CASP2 RN7SL535P FAM131B EPHB6 GSTK1
GH07G143345 1.2 Ensembl ENCODE 11.1 +65.7 65669 1.0 FOXA2 ATF1 GLI4 ZNF2 ZNF48 YY1 GLIS2 KLF7 KDM4B REST CLCN1 HINT1P1 ZYX LOC100507507 CASP2 RN7SL535P LOC105375545 TMEM139 EPHA1-AS1 EPHA1
GH07G143244 1 FANTOM5 Ensembl ENCODE 11.7 -34.7 -34662 1.3 MCM7 PRDM6 ZNF266 FOS FAM131B TMEM139 LOC105375545 CASP2 RN7SL535P ZYX LOC100507507 OR9A2 TAS2R39 TRPV6
GH07G143256 0.9 ENCODE 12.8 -22.9 -22862 1.5 HDAC1 HDGF PKNOX1 CBX3 ATF1 ZNF2 ZBTB40 CHAMP1 TCF12 ZNF766 TMEM139 RN7SL535P CASP2 LOC105375545 HINT1P1 CLCN1 EPHA1-AS1 EPHA1 LOC100507507 ZYX
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM139 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM139 Gene

Chromosome:
7
Start:
143,279,957 bp from pter
End:
143,288,049 bp from pter
Size:
8,093 bases
Orientation:
Plus strand

Genomic View for TMEM139 Gene

Genes around TMEM139 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM139 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM139 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM139 Gene

Proteins for TMEM139 Gene

  • Protein details for TMEM139 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV31-TM139_HUMAN
    Recommended name:
    Transmembrane protein 139
    Protein Accession:
    Q8IV31
    Secondary Accessions:
    • B2RCL5
    • D3DXD4
    • Q6ZME2
    • Q8NC22
    • Q96AU8

    Protein attributes for TMEM139 Gene

    Size:
    216 amino acids
    Molecular mass:
    23729 Da
    Quaternary structure:
    • Interacts with isoform 2 of SLC4A1 (PubMed:26049106).
    SequenceCaution:
    • Sequence=AAH16719.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TMEM139 Gene

Post-translational modifications for TMEM139 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM139 Gene

Domains & Families for TMEM139 Gene

Protein Domains for TMEM139 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM139 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM139: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM139 Gene

Function for TMEM139 Gene

Molecular function for TMEM139 Gene

UniProtKB/Swiss-Prot Function:
May be involved in cellular trafficking of proteins such as SLC4A1.

Gene Ontology (GO) - Molecular Function for TMEM139 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26049106
genes like me logo Genes that share ontologies with TMEM139: view

Phenotypes for TMEM139 Gene

GenomeRNAi human phenotypes for TMEM139:
genes like me logo Genes that share phenotypes with TMEM139: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM139

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM139 Gene

Localization for TMEM139 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM139 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM139 gene
Compartment Confidence
plasma membrane 2
extracellular 2

Gene Ontology (GO) - Cellular Components for TMEM139 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM139: view

Pathways & Interactions for TMEM139 Gene

SuperPathways for TMEM139 Gene

No Data Available

Interacting Proteins for TMEM139 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000352284%0d%0a9606.ENSP00000368884%0d%0a9606.ENSP00000300747%0d%0a
Selected Interacting proteins: Q8IV31-TM139_HUMAN ENSP00000352284 for TMEM139 Gene via IID MINT STRING

Gene Ontology (GO) - Biological Process for TMEM139 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM139 Gene

Drugs & Compounds for TMEM139 Gene

No Compound Related Data Available

Transcripts for TMEM139 Gene

Unigene Clusters for TMEM139 Gene

Transmembrane protein 139:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM139 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: -
SP2: - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - -

Relevant External Links for TMEM139 Gene

GeneLoc Exon Structure for
TMEM139
ECgene alternative splicing isoforms for
TMEM139

Expression for TMEM139 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM139 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM139 Gene

This gene is overexpressed in Kidney - Cortex (x10.0) and Brain - Spinal cord (cervical c-1) (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of TMEM139 Gene:

TMEM139

SOURCE GeneReport for Unigene cluster for TMEM139 Gene:

Hs.731832

Evidence on tissue expression from TISSUES for TMEM139 Gene

  • Intestine(4.2)
  • Lung(4.2)
  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with TMEM139: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM139 Gene

Orthologs for TMEM139 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM139 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM139 34 35
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia TMEM139 34 35
  • 82.61 (n)
cow
(Bos Taurus)
Mammalia TMEM139 34 35
  • 81.89 (n)
rat
(Rattus norvegicus)
Mammalia Tmem139 34
  • 74.53 (n)
mouse
(Mus musculus)
Mammalia Tmem139 34 16 35
  • 72.96 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM139 35
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM139 35
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM139 35
  • 31 (a)
OneToOne
Species where no ortholog for TMEM139 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM139 Gene

ENSEMBL:
Gene Tree for TMEM139 (if available)
TreeFam:
Gene Tree for TMEM139 (if available)

Paralogs for TMEM139 Gene

No data available for Paralogs for TMEM139 Gene

Variants for TMEM139 Gene

Sequence variations from dbSNP and Humsavar for TMEM139 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000525435 -- 143,285,162(+) TCCCC(G/T)GCCCA intron-variant, nc-transcript-variant, utr-variant-5-prime
rs1000593564 -- 143,283,825(+) CAGTG(A/C)CCACA intron-variant, upstream-variant-2KB
rs1000856564 -- 143,287,015(+) ATTTG(A/C)GTCTT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000956468 -- 143,285,533(+) TAGGA(A/G)CAATA intron-variant
rs1001391691 -- 143,284,404(+) ATCTT(-/GAA)GACTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM139 Gene

Variant ID Type Subtype PubMed ID
nsv831169 CNV loss 17160897

Variation tolerance for TMEM139 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM139 Gene

Human Gene Mutation Database (HGMD)
TMEM139
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM139

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM139 Gene

Disorders for TMEM139 Gene

Relevant External Links for TMEM139

Genetic Association Database (GAD)
TMEM139
Human Genome Epidemiology (HuGE) Navigator
TMEM139
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM139

No disorders were found for TMEM139 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM139 Gene

Publications for TMEM139 Gene

  1. Transmembrane protein 139 (TMEM139) interacts with human kidney isoform of anion exchanger 1 (kAE1). (PMID: 26049106) Nuiplot N.O. … Akkarapatumwong V. (Biochem. Biophys. Res. Commun. 2015) 3 4 64
  2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 64
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for TMEM139 Gene

Sources for TMEM139 Gene

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