TMEM139 Gene
protein-coding GIFtS: 41
GCID: GC07P142977
|
|
transmembrane protein 139
| |
Aliases
for TMEM139 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 1391 2 | | FLJ905861 |
Export aliases for TMEM139 gene to outside databasesPrevious GC identifers: GC07P142687 GC07P137319 |
Summaries
for TMEM139 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM139 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM139 gene promoter:
SRF TBP AML1a SRF (504 AA) Meis-1b E47 TFIID Meis-1a ZIC2/Zic2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM139
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM139 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q34 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q34TMEM139 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P142977: view genomic region
(about GC identifiers)
Start:
|
142,977,050 bp from pter |
End:
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142,985,141 bp from pter |
Size:
|
8,092 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 142,384,179-142,387,257 |
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Proteins
for TMEM139 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM139_HUMAN, Q8IV31 (See
protein sequence)Recommended Name: Transmembrane protein 139 precursor Size: 216 amino acids; 23729 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AAH16719.1; Type=Erroneous initiation;
Secondary accessions: B2RCL5 D3DXD4 Q6ZME2 Q8NC22 Q96AU8Explore the universe of human proteins at neXtProt for TMEM139: NX_Q8IV31
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IV31
TMEM139 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (6 alternative transcripts):
NP_001229702.1 NP_001229703.1 NP_001229704.1 NP_001229705.1 NP_001229706.1 NP_699176.1
ENSEMBL proteins: ENSP00000386879 ENSP00000352284 ENSP00000386335 ENSP00000387044 ENSP00000386564
Human Recombinant Protein Products for TMEM139:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM139 for ontologies About GeneDecksing
TMEM139 Antibody Products:
Assay Products for TMEM139: |
Protein
Domains /
Families
for TMEM139 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8IV31 |
Function
for TMEM139 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 MGI phenotypic allele  for Tmem139 (no phenotypes)
TMEM139 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Tmem139tm1Lex for TMEM139
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM139 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM139 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM139 (NM_153345) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM139 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM139 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM139 |
|
Pathways & Interactions
for TMEM139 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM139
1 Interacting protein for TMEM139 (Q8IV312, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TMEM139 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM139
Search CenterWatch for drugs/clinical trials and news about TMEM139 / TM139
|
Transcripts
for TMEM139 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM139 gene (6 alternative transcripts): NM_001242773.1 NM_001242774.1 NM_001242775.1 NM_001242776.1 NM_001242777.1 NM_153345.2 Unigene Cluster for TMEM139: Transmembrane protein 139 Hs.731832 [show with all ESTs]Unigene Representative Sequence: BC0355179 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000409102 ENST00000487419 ENST00000359333(uc022aoc.1 uc010lov.3 uc003wck.4 uc003wcn.3 uc022aod.1 uc003wcm.3)
ENST00000480421 ENST00000409244 ENST00000409541 ENST00000410004(uc003wcl.3)
ENST00000482420 ENST00000471161
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM139 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM139 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM139 (NM_153345) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM139 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM139 |
Additional cDNA sequence: AB074268.1 AK027352.1 AK075067.1 AK172816.1 AK315170.1 AY358781.1 BC016719.1 BC035517.1 BC035888.1 BC048333.2 NR_040003.1 8 DOTS entries: DT.413995 DT.100735045 DT.101972273 DT.409499 DT.121119596 DT.121119465 DT.101966469 DT.40242195 24/92 AceView cDNA sequences (see all 92): BC035517 CB142336 BC048333 BC035888 AK075067 AI984393 BG402914 AI346094 BF739805 BE018738 CB241413 AA872608 AW138330 AW058583 CB156055 BI772441 CD674062 AK027352 AL549843 AI832147 BM995528 BM676746 CA439205 NM_153345
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM139 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP3: | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM139
|
Expression
for TMEM139 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM139 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCCTCCCC
About this image
See TMEM139 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM139
SOURCE GeneReport for Unigene cluster: Hs.731832
SABiosciences Custom PCR Arrays for TMEM139
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM139
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM139 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM139 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM139 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM139 |
Orthologs
for TMEM139 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TMEM139 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for TMEM139 (if available)
TreeFam Gene Tree for TMEM139 (if available) |
Paralogs
for TMEM139 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM139 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM139 (142977050 - 142985141 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM139: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM139 |
|
Disorders
/ Diseases
for TMEM139 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM139 for disorders About GeneDecksing
3  diseases for TMEM139: About MalaCardsintrahepatic cholangiocarcinoma cholangiocarcinoma parkinson's disease
Human Genome Epidemiology (HuGE) Navigator: TMEM139 (1 document)
Export disorders for TMEM139 gene to outside databases
|
Publications
for TMEM139 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM139 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with TMEM139) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1 Hosgood H.D....Lan Q. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Identification of genes related to Parkinson's disease using expressed sequence tags. (PubMed id 17213182)1 Kim J.M....Kim N.S. (2006)
- Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
|
External Searches for TMEM139 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM139 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM139 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM139 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM139 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM139 gene:
Search GeneIP for patents involving TMEM139
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM139 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM139 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM139 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM139 | | | OriGene Protein Over-expression Lysate for TMEM139 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM139 | | OriGene 3'-UTR Clone for TMEM139 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM139 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM139 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM139 | | OriGene Custom Protein Services for TMEM139 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM139 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM139 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM139 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM139 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM139 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM139 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TMEM139 |
| |  |  |  |  | | | | |
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 |
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 | | | TMEM139 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM139 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TMEM139 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM139 |
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