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TMEM138 Gene

protein-coding   GIFtS: 46
GCID: GC11P061129

Transmembrane Protein 138

  See TMEM138-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 1381 2
JBTS165

External Ids:    HGNC: 269441   Entrez Gene: 515242   Ensembl: ENSG000001494837   OMIM: 6144595   UniProtKB: Q9NPI03   

Export aliases for TMEM138 gene to outside databases

Previous GC identifers: GC11P060887 GC11P057458


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMEM138 Gene:
This gene encodes a multi-pass transmembrane protein. Reduced expression of this gene in mouse fibroblasts causes
short cilia and failure of ciliogenesis. Expression of this gene is tightly coordinated with expression of the
neighboring gene TMEM216. Mutations in this gene are associated with the autosomal recessive neurodevelopmental
disorder Joubert Syndrome. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Mar
2012)

GeneCards Summary for TMEM138 Gene:
TMEM138 (transmembrane protein 138) is a protein-coding gene. Diseases associated with TMEM138 include joubert syndrome 16, and tmem138-related joubert syndrome.

UniProtKB/Swiss-Prot: TM138_HUMAN, Q9NPI0
Function: Required for ciliogenesis

Gene Wiki entry for TMEM138 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM138 gene promoter:
         NF-1   NF-kappaB   YY1   CREB   deltaCREB   NF-kappaB2   STAT3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM138 promoter sequence
   Search Chromatin IP Primers for TMEM138

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM138


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.2

TMEM138 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM138 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P061129:  view genomic region     (about GC identifiers)

Start:
61,129,473 bp from pter      End:
61,136,981 bp from pter
Size:
7,509 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM138_HUMAN, Q9NPI0 (See protein sequence)
Recommended Name: Transmembrane protein 138  
Size: 162 amino acids; 19262 Da
Miscellaneous: TMEM138 and TMEM216 genes are adjacent and are aligned in a head-to-tail configuration. They share
some cis regulatory region and display coordinated expression. Genes were joined by chromoaomal rearrangement at
the amphiboan to reptile evolutionary transition around 340 million years ago (PubMed:22282472)
Sequence caution: Sequence=CAI46174.1; Type=Frameshift; Positions=101;
Secondary accessions: A6NGA7 B4E044 Q5JPE1
Alternative splicing: 3 isoforms:  Q9NPI0-1   Q9NPI0-2   Q9NPI0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM138: NX_Q9NPI0

Explore proteomics data for TMEM138 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn6

  • See TMEM138 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057548.1  
    ENSEMBL proteins: 
     ENSP00000278826   ENSP00000445792   ENSP00000371206  

    TMEM138 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TMEM138

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR024133 TM_138

    Graphical View of Domain Structure for InterPro Entry Q9NPI0

    ProtoNet protein and cluster: Q9NPI0

    UniProtKB/Swiss-Prot: TM138_HUMAN, Q9NPI0
    Similarity: Belongs to the TMEM138 family


    Find genes that share domains with TMEM138           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TM138_HUMAN, Q9NPI0
    Function: Required for ciliogenesis

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM138
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM138
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM138

    miRNA
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    miRTarBase miRNAs that target TMEM138:
    hsa-mir-340-5p (MIRT019560)

    Block miRNA regulation of human, mouse, rat TMEM138 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TMEM138:
    hsa-miR-3163 hsa-miR-1252 hsa-miR-4302 hsa-miR-340 hsa-miR-1248
    SwitchGear 3'UTR luciferase reporter plasmidTMEM138 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMEM138
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM138

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    Clone
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    OriGene ORF clones in mouse, rat for TMEM138
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMEM138 (NM_016464)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM138
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM138
    Addgene plasmids for TMEM138 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM138


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM138_HUMAN, Q9NPI0: Vacuole membrane; Multi-pass membrane protein. Cell projection, cilium. Note=Localizes to
    vesicles en route to the base of cilium
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    vacuole5
    plasma membrane3
    cytoskeleton1
    extracellular1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005774vacuolar membrane IEA--
    GO:0005929cilium IDA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMEM138           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM138
    Interactions:

        Search GeneGlobe Interaction Network for TMEM138

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042384cilium assembly IMP--

    Find genes that share ontologies with TMEM138           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM138 (TM138)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM138 gene: 
    NM_016464.4  

    Unigene Cluster for TMEM138:

    Transmembrane protein 138
    Hs.406530  [show with all ESTs]
    Unigene Representative Sequence: AL832879
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278826(uc021qke.1 uc001nrl.2) ENST00000534963 ENST00000543594
    ENST00000542946 ENST00000540194 ENST00000507563(uc010rli.2) ENST00000423772
    ENST00000451389 ENST00000545420 ENST00000381787 ENST00000539776 ENST00000543833

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMEM138 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TMEM138:
    hsa-miR-3163 hsa-miR-1252 hsa-miR-4302 hsa-miR-340 hsa-miR-1248
    SwitchGear 3'UTR luciferase reporter plasmidTMEM138 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMEM138
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM138
    Clone
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    OriGene clones in human, mouse for TMEM138 (see all 7)
    OriGene ORF clones in mouse, rat for TMEM138
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMEM138 (NM_016464)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM138
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM138
    Addgene plasmids for TMEM138 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMEM138
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM138
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM138
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM138
      QuantiFast Probe-based Assays in human, mouse, rat TMEM138

    Additional mRNA sequence: 

    AF151030.1 AF151032.1 AK027724.1 AK307371.1 AL832879.1 BC005201.1 NR_028473.1 

    24 DOTS entries:

    DT.97860343  DT.418132  DT.100879116  DT.97820214  DT.100879131  DT.100879111  DT.100879120  DT.100879128 
    DT.40280039  DT.102839521  DT.91767868  DT.95126757  DT.100867732  DT.100879122  DT.100879126  DT.120694348 
    DT.120694414  DT.100715194  DT.120694328  DT.120694312  DT.120694425  DT.453250  DT.95126755  DT.120694196 

    Selected AceView cDNA sequences (see all 305):

    C20821 AA953562 CR596588 BQ421457 AI567294 CA487416 AI076123 BQ007931 
    AA253341 AA410332 N39763 BG109406 BI063556 BM661711 AA453693 CR602992 
    BM663427 AA808331 BM999850 CA313117 CD671257 AI804016 AA447763 AI080662 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMEM138 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d
    SP1:                                -     -           -     -           -     -                                       
    SP2:                                -     -           -     -           -     -                                       
    SP3:                                -     -           -     -           -     -                                       
    SP4:                                -     -           -     -           -     -                                       
    SP5:                                -     -           -     -           -                                             


    ECgene alternative splicing isoforms for TMEM138

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM138 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAAACAGC
    TMEM138 Expression
    About this image

    TMEM138 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM138 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406530
        Custom PCR Arrays for TMEM138
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    QuantiFast Probe-based Assays in human, mouse, rat TMEM138
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM138

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMEM138 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1381 , 5 transmembrane protein 1381, 5 89.71(n)1
    91.98(a)1
      19 (6.60 cM)5
    729821  NM_028411.31  NP_082687.11 
     105708855 
    chicken
    (Gallus gallus)
    Aves TMEM1381 transmembrane protein 138 79.09(n)
    83.23(a)
      426323  NM_001277895.1  NP_001264824.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1386
    transmembrane protein 138
    83(a)
    1 ↔ 1
    GL343235.1(838946-844877)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.323862 Xenopus laevis transcribed sequence with weak similarity more 76.48(n)    BJ615922.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmem1381 transmembrane protein 138 67.49(n)
    67.9(a)
      100332440  XM_002666770.2  XP_002666816.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG139991 CG13999 46.08(n)
    30.15(a)
      33826  NM_135128.3  NP_608972.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F10B5.96
    Protein F10B5.9 (F10B5.9) mRNA, complete cds
    27(a)
    1 ↔ 1
    II(8157362-8158045) WBGene00008643


    ENSEMBL Gene Tree for TMEM138 (if available)
    TreeFam Gene Tree for TMEM138 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM138 (see all 180)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0670604
    Joubert syndrome 16 (JBTS16)4--see VAR_0670602 A T mis40--------
    VAR_0670614
    Joubert syndrome 16 (JBTS16)4--see VAR_0670612 A V mis40--------
    VAR_0670624
    Joubert syndrome 16 (JBTS16)4--see VAR_0670622 Y C mis40--------
    VAR_0670594
    Joubert syndrome 16 (JBTS16)4--see VAR_0670592 H R mis40--------
    rs1506339441,2
    --61047803(+) AGAGAC/TAGACT 2 -- us2k10--------
    rs1388390731,2
    C--61047908(+) GGCATC/GCACCT 2 -- us2k10--------
    rs1919672241,2
    --61048043(+) ACAAAA/CCAAAA 2 -- us2k10--------
    rs1842301671,2
    --61048198(+) TCCAGA/GTAGTA 2 -- us2k10--------
    rs1493476431,2
    --61048247(+) CTATGA/TCATCA 2 -- us2k10--------
    rs1877343651,2
    --61048321(+) AGTAAC/TATTTA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMEM138 (61129473 - 61136981 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMEM138: --
    Human Gene Mutation Database (HGMD): TMEM138
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TMEM138
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM138

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614459   
    OMIM disorders: 614465  
    UniProtKB/Swiss-Prot: TM138_HUMAN, Q9NPI0
  • Joubert syndrome 16 (JBTS16) [MIM:614465]: An autosomal recessive disorder characterized by oculomotor
    apraxia, variable coloboma, and rare kidney involvement. Neuroradiologically, it is characterized by an
    abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth
    sign). Additional variable features include retinal dystrophy and polydactyly. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 5 diseases for TMEM138:    
    About MalaCards
    joubert syndrome 16    tmem138-related joubert syndrome    joubert syndrome and related disorders    joubert syndrome 2
    joubert syndrome


    Find genes that share disorders with TMEM138           About GenesLikeMe


    Export disorders for TMEM138 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM138 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMEM138)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evolutionarily assembled cis-regulatory module at a human ciliopathy locus. (PubMed id 22282472)1, 2 Lee J.H.... Gleeson J.G. (Science 2012)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Joubert Syndrome and Related Disorders (PubMed id 20301500)1 Pagon R.A....Stephens K. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51524 HGNC: 26944 AceView: HSPC196 Ensembl:ENSG00000149483 euGenes: HUgn51524
    ECgene: TMEM138 H-InvDB: TMEM138

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TMEM138 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TMEM138 gene:
    Search GeneIP for patents involving TMEM138

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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