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Aliases for TMEM136 Gene

Aliases for TMEM136 Gene

  • Transmembrane Protein 136 2 3 5

External Ids for TMEM136 Gene

Previous GeneCards Identifiers for TMEM136 Gene

  • GC11P119702
  • GC11P120195
  • GC11P116136

Summaries for TMEM136 Gene

GeneCards Summary for TMEM136 Gene

TMEM136 (Transmembrane Protein 136) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM136 Gene

Genomics for TMEM136 Gene

Regulatory Elements for TMEM136 Gene

Enhancers for TMEM136 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G120347 1.3 ENCODE dbSUPER 54.6 +22.7 22728 1.1 PKNOX1 ARID4B FEZF1 ZNF2 YY1 ZNF302 SP5 MXD4 REST ZNF662 TMEM136 TBCEL TECTA THY1 ARHGEF12 PIR31602
GH11G120328 1.7 Ensembl ENCODE dbSUPER 25.3 +10.9 10893 14.1 CREB3L1 MLX AGO1 ZFP64 YBX1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 TMEM136 THY1 ARHGEF12
GH11G120390 1 Ensembl ENCODE 23.5 +67.0 67030 2.6 ELF3 SOX13 TBP DRAP1 SAP130 ZNF644 YY1 TEAD3 NCOR1 MAFK TMEM136 ARHGEF12 GC11P120421 ENSG00000274303
GH11G120344 1.5 Ensembl ENCODE dbSUPER 15.3 +20.0 20046 1.3 PKNOX1 SIN3A YY1 TCF12 ZNF766 ELK1 GATA2 FOS JUNB TBX21 TMEM136 ARHGEF12 PIR31602
GH11G120324 1.3 ENCODE dbSUPER 17.1 +1.6 1555 3.9 PKNOX1 FOXA2 ARNT CREB3L1 ZFP64 SIN3A ARID4B FEZF1 ZNF2 FOS TMEM136 ARHGEF12
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM136 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM136 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045894 970 1201 ATF1 ARNT SIN3A ZNF2 ZNF48 TCF12 GLIS2 ZNF263 SP3 PPARG

Genomic Location for TMEM136 Gene

Chromosome:
11
Start:
120,324,630 bp from pter
End:
120,333,688 bp from pter
Size:
9,059 bases
Orientation:
Plus strand

Genomic View for TMEM136 Gene

Genes around TMEM136 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM136 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM136 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM136 Gene

Proteins for TMEM136 Gene

  • Protein details for TMEM136 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRR5-TM136_HUMAN
    Recommended name:
    Transmembrane protein 136
    Protein Accession:
    Q6ZRR5
    Secondary Accessions:
    • B4DGQ4
    • B4E230
    • Q8IZ79

    Protein attributes for TMEM136 Gene

    Size:
    245 amino acids
    Molecular mass:
    27859 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM136 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM136 Gene

Post-translational modifications for TMEM136 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM136 Gene

Domains & Families for TMEM136 Gene

Gene Families for TMEM136 Gene

Protein Domains for TMEM136 Gene

Suggested Antigen Peptide Sequences for TMEM136 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZRR5

UniProtKB/Swiss-Prot:

TM136_HUMAN :
  • Belongs to the TMEM136 family.
Family:
  • Belongs to the TMEM136 family.
genes like me logo Genes that share domains with TMEM136: view

Function for TMEM136 Gene

Phenotypes for TMEM136 Gene

genes like me logo Genes that share phenotypes with TMEM136: view

Animal Models for TMEM136 Gene

MGI Knock Outs for TMEM136:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM136 Gene

Localization for TMEM136 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM136 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM136 gene
Compartment Confidence
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TMEM136 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM136: view

Pathways & Interactions for TMEM136 Gene

SuperPathways for TMEM136 Gene

No Data Available

Interacting Proteins for TMEM136 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000312672%0d%0a9606.ENSP00000264748%0d%0a
Selected Interacting proteins: ENSP00000312672 for TMEM136 Gene via STRING

Symbol External ID(s) Details
FGFRL1

Gene Ontology (GO) - Biological Process for TMEM136 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM136 Gene

Drugs & Compounds for TMEM136 Gene

No Compound Related Data Available

Transcripts for TMEM136 Gene

Unigene Clusters for TMEM136 Gene

Transmembrane protein 136:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM136 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b
SP1: - - -
SP2: -
SP3: - - -
SP4:
SP5: - - - -
SP6: - -

Relevant External Links for TMEM136 Gene

GeneLoc Exon Structure for
TMEM136
ECgene alternative splicing isoforms for
TMEM136

Expression for TMEM136 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM136 Gene

Protein differential expression in normal tissues from HIPED for TMEM136 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM136 Gene



Protein tissue co-expression partners for TMEM136 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM136 Gene:

TMEM136

SOURCE GeneReport for Unigene cluster for TMEM136 Gene:

Hs.643516

Evidence on tissue expression from TISSUES for TMEM136 Gene

  • Nervous system(4.6)
  • Pancreas(4)
genes like me logo Genes that share expression patterns with TMEM136: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM136 Gene

Orthologs for TMEM136 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM136 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM136 34 35
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia TMEM136 34 35
  • 90.92 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM136 35
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM136 34 35
  • 89.52 (n)
mouse
(Mus musculus)
Mammalia Tmem136 34 16 35
  • 88.84 (n)
rat
(Rattus norvegicus)
Mammalia Tmem136 34
  • 88.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM136 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM136 35
  • 72 (a)
OneToOne
LOC100857845 34
  • 70.88 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM136 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489109 34
  • 68.43 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100537789 34
  • 64.79 (n)
TMEM136 (3 of 3) 35
  • 58 (a)
OneToMany
tmem136b 35
  • 57 (a)
OneToMany
tmem136a 35
  • 56 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToOne
Species where no ortholog for TMEM136 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM136 Gene

ENSEMBL:
Gene Tree for TMEM136 (if available)
TreeFam:
Gene Tree for TMEM136 (if available)

Paralogs for TMEM136 Gene

No data available for Paralogs for TMEM136 Gene

Variants for TMEM136 Gene

Sequence variations from dbSNP and Humsavar for TMEM136 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000265530 -- 120,325,318(+) CGGGC(C/T)GGGAG utr-variant-5-prime
rs1000670121 -- 120,326,095(+) AGTTT(A/G)TCTCA intron-variant, utr-variant-5-prime
rs1000866460 -- 120,325,759(+) AAATG(A/C)CCTTC intron-variant, utr-variant-5-prime
rs1001335590 -- 120,323,437(+) AGATT(C/T)AGATA upstream-variant-2KB
rs1001532648 -- 120,329,724(+) TGTTC(A/C)TTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM136 Gene

Variant ID Type Subtype PubMed ID
esv1582263 CNV insertion 17803354
esv2457390 CNV insertion 19546169
esv2533688 CNV deletion 19546169
esv2549681 CNV deletion 19546169
nsv1129158 CNV insertion 24896259
nsv1134181 CNV deletion 24896259

Variation tolerance for TMEM136 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM136 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM136

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM136 Gene

Disorders for TMEM136 Gene

Relevant External Links for TMEM136

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM136

No disorders were found for TMEM136 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM136 Gene

Publications for TMEM136 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for TMEM136 Gene

Sources for TMEM136 Gene

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