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Aliases for TMEM136 Gene

Aliases for TMEM136 Gene

  • Transmembrane Protein 136 2 3

External Ids for TMEM136 Gene

Previous GeneCards Identifiers for TMEM136 Gene

  • GC11P119702
  • GC11P120195
  • GC11P116136

Summaries for TMEM136 Gene

GeneCards Summary for TMEM136 Gene

TMEM136 (Transmembrane Protein 136) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM136 Gene

Genomics for TMEM136 Gene

Regulatory Elements for TMEM136 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM136 Gene

120,324,630 bp from pter
120,333,688 bp from pter
9,059 bases
Plus strand

Genomic View for TMEM136 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM136 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM136 Gene

Proteins for TMEM136 Gene

  • Protein details for TMEM136 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 136
    Protein Accession:
    Secondary Accessions:
    • B4DGQ4
    • B4E230
    • Q8IZ79

    Protein attributes for TMEM136 Gene

    245 amino acids
    Molecular mass:
    27859 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM136 Gene


neXtProt entry for TMEM136 Gene

Proteomics data for TMEM136 Gene at MOPED

Post-translational modifications for TMEM136 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM136 Gene

Domains & Families for TMEM136 Gene

Protein Domains for TMEM136 Gene

Suggested Antigen Peptide Sequences for TMEM136 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
  • Belongs to the TMEM136 family.
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
  • Belongs to the TMEM136 family.
genes like me logo Genes that share domains with TMEM136: view

No data available for Gene Families for TMEM136 Gene

Function for TMEM136 Gene

Phenotypes for TMEM136 Gene

GenomeRNAi human phenotypes for TMEM136:
genes like me logo Genes that share phenotypes with TMEM136: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM136

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM136 Gene

Localization for TMEM136 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM136 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM136 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM136: view

No data available for Subcellular locations from COMPARTMENTS for TMEM136 Gene

Pathways & Interactions for TMEM136 Gene

SuperPathways for TMEM136 Gene

No Data Available

Interacting Proteins for TMEM136 Gene

Gene Ontology (GO) - Biological Process for TMEM136 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM136 Gene

Drugs & Compounds for TMEM136 Gene

No Compound Related Data Available

Transcripts for TMEM136 Gene

Unigene Clusters for TMEM136 Gene

Transmembrane protein 136:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM136

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM136 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b
SP1: - - -
SP2: -
SP3: - - -
SP5: - - - -
SP6: - -

Relevant External Links for TMEM136 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM136 Gene

mRNA expression in normal human tissues for TMEM136 Gene

Protein differential expression in normal tissues from HIPED for TMEM136 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM136 Gene

SOURCE GeneReport for Unigene cluster for TMEM136 Gene Hs.643516

genes like me logo Genes that share expression patterns with TMEM136: view

Protein tissue co-expression partners for TMEM136 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM136 Gene

Orthologs for TMEM136 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM136 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM136 35
  • 89.52 (n)
  • 92.24 (a)
TMEM136 36
  • 92 (a)
(Canis familiaris)
Mammalia TMEM136 35
  • 90.92 (n)
  • 95.53 (a)
TMEM136 36
  • 95 (a)
(Mus musculus)
Mammalia Tmem136 35
  • 88.84 (n)
  • 92.65 (a)
Tmem136 16
Tmem136 36
  • 93 (a)
(Pan troglodytes)
Mammalia TMEM136 35
  • 99.5 (n)
  • 99.63 (a)
TMEM136 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tmem136 35
  • 88.03 (n)
  • 91.43 (a)
(Monodelphis domestica)
Mammalia TMEM136 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM136 36
  • 84 (a)
(Gallus gallus)
Aves LOC100857845 35
  • 70.88 (n)
  • 72.24 (a)
TMEM136 36
  • 72 (a)
(Anolis carolinensis)
Reptilia TMEM136 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489109 35
  • 68.43 (n)
  • 71.14 (a)
(Danio rerio)
Actinopterygii LOC100537789 35
  • 64.79 (n)
  • 61.47 (a)
TMEM136 (3 of 3) 36
  • 58 (a)
tmem136a 36
  • 56 (a)
tmem136b 36
  • 57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
Species with no ortholog for TMEM136:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM136 Gene

Gene Tree for TMEM136 (if available)
Gene Tree for TMEM136 (if available)

Paralogs for TMEM136 Gene

No data available for Paralogs for TMEM136 Gene

Variants for TMEM136 Gene

Sequence variations from dbSNP and Humsavar for TMEM136 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1058187 -- 120,333,195(+) AAAAA(A/G)AAAAA utr-variant-3-prime
rs1893261 -- 120,327,384(+) ACCCA(A/G)TGCTG synonymous-codon, reference, intron-variant
rs4408322 -- 120,329,673(+) ATAAT(G/T)GGATT intron-variant
rs4606487 -- 120,328,869(+) TATGT(A/T)TATGT intron-variant
rs7111221 -- 120,327,925(+) CCCCC(A/G)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM136 Gene

Variant ID Type Subtype PubMed ID
esv2457390 CNV Insertion 19546169
esv2549681 CNV Deletion 19546169
esv1582263 CNV Insertion 17803354
esv2533688 CNV Deletion 19546169

Variation tolerance for TMEM136 Gene

Residual Variation Intolerance Score: 72.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM136 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM136 Gene

Disorders for TMEM136 Gene

Relevant External Links for TMEM136

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMEM136: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM136 Gene

Publications for TMEM136 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 67
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for TMEM136 Gene

Sources for TMEM136 Gene

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