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Aliases for TMEM136 Gene

Aliases for TMEM136 Gene

  • Transmembrane Protein 136 2 3

External Ids for TMEM136 Gene

Summaries for TMEM136 Gene

GeneCards Summary for TMEM136 Gene

TMEM136 (Transmembrane Protein 136) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM136 Gene

Genomics for TMEM136 Gene

Genomic Location for TMEM136 Gene

Start:
120,325,129 bp from pter
End:
120,333,682 bp from pter
Size:
8,554 bases
Orientation:
Plus strand

Genomic View for TMEM136 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM136 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM136 Gene

Regulatory Elements for TMEM136 Gene

Proteins for TMEM136 Gene

  • Protein details for TMEM136 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRR5-TM136_HUMAN
    Recommended name:
    Transmembrane protein 136
    Protein Accession:
    Q6ZRR5
    Secondary Accessions:
    • B4DGQ4
    • B4E230
    • Q8IZ79

    Protein attributes for TMEM136 Gene

    Size:
    245 amino acids
    Molecular mass:
    27859 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM136 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM136 Gene

Proteomics data for TMEM136 Gene at MOPED

Post-translational modifications for TMEM136 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM136 Gene

Domains for TMEM136 Gene

Protein Domains for TMEM136 Gene

UniProtKB/Swiss-Prot:

TM136_HUMAN
Domain:
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.:
    • Q6ZRR5
Family:
  • Belongs to the TMEM136 family.:
    • Q6ZRR5
genes like me logo Genes that share domains with TMEM136: view

No data available for Gene Families for TMEM136 Gene

Function for TMEM136 Gene

miRNA for TMEM136 Gene

miRTarBase miRNAs that target TMEM136

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM136 Gene

Localization for TMEM136 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM136 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM136 Gene COMPARTMENTS Subcellular localization image for TMEM136 gene
Compartment Confidence
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TMEM136 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM136: view

Pathways for TMEM136 Gene

SuperPathways for TMEM136 Gene

No Data Available

Interacting Proteins for TMEM136 Gene

Gene Ontology (GO) - Biological Process for TMEM136 Gene

None

No data available for Pathways by source for TMEM136 Gene

Transcripts for TMEM136 Gene

Unigene Clusters for TMEM136 Gene

Transmembrane protein 136:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM136 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b
SP1: - - -
SP2: -
SP3: - - -
SP4:
SP5: - - - -
SP6: - -

Relevant External Links for TMEM136 Gene

GeneLoc Exon Structure for
TMEM136
ECgene alternative splicing isoforms for
TMEM136

Expression for TMEM136 Gene

mRNA expression in normal human tissues for TMEM136 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM136 Gene

SOURCE GeneReport for Unigene cluster for TMEM136 Gene Hs.643516

genes like me logo Genes that share expressions with TMEM136: view

Orthologs for TMEM136 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM136 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM136 36
  • 99.5 (n)
  • 99.63 (a)
TMEM136 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM136 36
  • 89.52 (n)
  • 92.24 (a)
TMEM136 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM136 36
  • 90.92 (n)
  • 95.53 (a)
TMEM136 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem136 36
  • 88.84 (n)
  • 92.65 (a)
Tmem136 16
Tmem136 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM136 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM136 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem136 36
  • 88.03 (n)
  • 91.43 (a)
chicken
(Gallus gallus)
Aves LOC100857845 36
  • 70.88 (n)
  • 72.24 (a)
TMEM136 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM136 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489109 36
  • 68.43 (n)
  • 71.14 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100537789 36
  • 64.79 (n)
  • 61.47 (a)
TMEM136 (3 of 3) 37
  • 58 (a)
OneToMany
tmem136a 37
  • 56 (a)
OneToMany
tmem136b 37
  • 57 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 41 (a)
OneToOne
Species with no ortholog for TMEM136:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM136 Gene

ENSEMBL:
Gene Tree for TMEM136 (if available)
TreeFam:
Gene Tree for TMEM136 (if available)

Paralogs for TMEM136 Gene

No data available for Paralogs for TMEM136 Gene

Variants for TMEM136 Gene

Sequence variations from dbSNP and Humsavar for TMEM136 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1058187 -- 120,333,195(+) AAAAA(A/G)AAAAA utr-variant-3-prime
rs1893261 -- 120,327,384(+) ACCCA(A/G)TGCTG synonymous-codon, reference, intron-variant
rs4408322 -- 120,329,673(+) ATAAT(G/T)GGATT intron-variant
rs4606487 -- 120,328,869(+) TATGT(A/T)TATGT intron-variant
rs7111221 -- 120,327,925(+) CCCCC(A/G)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM136 Gene

Variant ID Type Subtype PubMed ID
esv2457390 CNV Insertion 19546169
esv2549681 CNV Deletion 19546169
esv1582263 CNV Insertion 17803354
esv2533688 CNV Deletion 19546169

Relevant External Links for TMEM136 Gene

HapMap Linkage Disequilibrium report
TMEM136

Disorders for TMEM136 Gene

No disorders were found for TMEM136 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM136 Gene

Publications for TMEM136 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for TMEM136 Gene

Sources for TMEM136 Gene

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