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Aliases for TMEM135 Gene

Aliases for TMEM135 Gene

  • Transmembrane Protein 135 2 3 5
  • Peroxisomal Membrane Protein 52 3 4
  • PMP52 3 4

External Ids for TMEM135 Gene

Previous GeneCards Identifiers for TMEM135 Gene

  • GC11P086427
  • GC11P086749
  • GC11P083035

Summaries for TMEM135 Gene

GeneCards Summary for TMEM135 Gene

TMEM135 (Transmembrane Protein 135) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM135 Gene

  • Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization.

Additional gene information for TMEM135 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM135 Gene

Genomics for TMEM135 Gene

Regulatory Elements for TMEM135 Gene

Enhancers for TMEM135 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H086937 1.5 Ensembl ENCODE dbSUPER 5.3 -97.3 -97260 5.5 HDGF FOXA2 ATF1 MLX ARNT ARID4B BRCA1 YY1 ZNF766 GATA2 CCDC81 LOC100506368 ENSG00000255471 TMEM135 FZD4
GH11H087037 1.1 ENCODE 5.8 +0.1 87 3.1 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 ZNF766 DEK SP3 TMEM135 XIAPP2
GH11H087030 1.1 Ensembl ENCODE 4.9 -7.0 -7044 0.4 HDAC1 ATF1 ZBTB40 GATA2 ETV6 ATF7 RUNX3 CREM THAP11 HCFC1 TMEM135 LOC105369422 HNRNPCP8
GH11H087028 0.9 ENCODE 5 -8.8 -8756 1.4 ELF3 FOXA2 ARID4B DMAP1 RARA CREM MIXL1 THAP11 SP5 CEBPB TMEM135 ME3 HNRNPCP8 LOC105369422
GH11H087081 0.6 ENCODE 5.2 +43.8 43796 0.8 SOX13 TARDBP NBN RBBP5 ATF7 YBX1 MLLT1 EED TMEM135 XIAPP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM135 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM135 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000043089 556 2001 HDGF FOXA2 MLX ARID4B SIN3A YY1 ZNF766 DEK SP3 SP5

Genomic Locations for TMEM135 Gene

Genomic Locations for TMEM135 Gene
290,991 bases
Plus strand

Genomic View for TMEM135 Gene

Genes around TMEM135 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM135 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM135 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM135 Gene

Proteins for TMEM135 Gene

  • Protein details for TMEM135 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 135
    Protein Accession:
    Secondary Accessions:
    • Q6AW91
    • Q8ND01
    • Q9H6M3

    Protein attributes for TMEM135 Gene

    458 amino acids
    Molecular mass:
    52291 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15233.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM135 Gene


neXtProt entry for TMEM135 Gene

Post-translational modifications for TMEM135 Gene

  • Ubiquitination at Lys433
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM135 Gene

Domains & Families for TMEM135 Gene

Gene Families for TMEM135 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM135 Gene

Suggested Antigen Peptide Sequences for TMEM135 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM135 family.
  • Belongs to the TMEM135 family.
genes like me logo Genes that share domains with TMEM135: view

Function for TMEM135 Gene

Molecular function for TMEM135 Gene

UniProtKB/Swiss-Prot Function:
Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization.

Phenotypes From GWAS Catalog for TMEM135 Gene

genes like me logo Genes that share phenotypes with TMEM135: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM135 Gene

Localization for TMEM135 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM135 Gene

Mitochondrion membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM135 gene
Compartment Confidence
peroxisome 5
mitochondrion 4
nucleus 2
cytosol 2
plasma membrane 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IBA,ISS --
GO:0005778 peroxisomal membrane IEA --
GO:0005811 lipid particle IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM135: view

Pathways & Interactions for TMEM135 Gene

SuperPathways for TMEM135 Gene

No Data Available

Interacting Proteins for TMEM135 Gene

Selected Interacting proteins: Q86UB9-TM135_HUMAN for TMEM135 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMEM135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007031 peroxisome organization IEA,ISS --
GO:0009409 response to cold IEA --
GO:0032094 response to food IEA --
GO:0090140 regulation of mitochondrial fission IEA --
genes like me logo Genes that share ontologies with TMEM135: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM135 Gene

Drugs & Compounds for TMEM135 Gene

No Compound Related Data Available

Transcripts for TMEM135 Gene

Unigene Clusters for TMEM135 Gene

Transmembrane protein 135:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM135 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP2: -

Relevant External Links for TMEM135 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM135 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM135 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM135 Gene

This gene is overexpressed in Liver (42.8) and Testis (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM135 Gene

Protein tissue co-expression partners for TMEM135 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM135 Gene:


SOURCE GeneReport for Unigene cluster for TMEM135 Gene:


Evidence on tissue expression from TISSUES for TMEM135 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with TMEM135: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM135 Gene

Orthologs for TMEM135 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM135 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM135 33 34
  • 99.78 (n)
(Canis familiaris)
Mammalia TMEM135 33 34
  • 93.74 (n)
(Bos Taurus)
Mammalia TMEM135 33 34
  • 93.38 (n)
(Monodelphis domestica)
Mammalia TMEM135 34
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM135 34
  • 92 (a)
(Mus musculus)
Mammalia Tmem135 33 16 34
  • 86.97 (n)
(Rattus norvegicus)
Mammalia Tmem135 33
  • 86.61 (n)
(Gallus gallus)
Aves TMEM135 33 34
  • 80.06 (n)
(Anolis carolinensis)
Reptilia TMEM135 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem135 33
  • 75.7 (n)
(Danio rerio)
Actinopterygii tmem135 33 34
  • 69.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11737 33 34
  • 43.93 (n)
CG31259 34
  • 30 (a)
CG31454 34
  • 29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007085 33
  • 42.56 (n)
(Caenorhabditis elegans)
Secernentea tmem-135 33 34
  • 46.17 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3886 34
  • 35 (a)
Species where no ortholog for TMEM135 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM135 Gene

Gene Tree for TMEM135 (if available)
Gene Tree for TMEM135 (if available)

Paralogs for TMEM135 Gene

No data available for Paralogs for TMEM135 Gene

Variants for TMEM135 Gene

Sequence variations from dbSNP and Humsavar for TMEM135 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000000640 -- 87,258,756(+) GTGCC(A/C)AAGTT intron-variant
rs1000008910 -- 87,270,652(+) TCCTC(A/T)GAAAC intron-variant
rs1000029158 -- 87,325,501(+) CTCTC(G/T)CCCTC nc-transcript-variant, utr-variant-3-prime
rs1000043494 -- 87,127,912(+) ACAAT(A/C)ATGTA intron-variant
rs1000048233 -- 87,172,308(+) TATGA(A/G)ACAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM135 Gene

Variant ID Type Subtype PubMed ID
nsv555708 CNV loss 21841781
nsv555707 CNV loss 21841781
nsv555706 CNV loss 21841781
nsv528940 CNV loss 19592680
nsv525787 CNV loss 19592680
nsv521810 CNV loss 19592680
nsv518332 CNV loss 19592680
nsv478956 CNV novel sequence insertion 20440878
nsv468776 CNV loss 19166990
nsv420 CNV deletion 18451855
nsv1149922 CNV duplication 26484159
nsv1138059 CNV deletion 24896259
nsv1116678 CNV tandem duplication 24896259
nsv1113417 CNV deletion 24896259
nsv1042017 CNV gain 25217958
esv999908 CNV deletion 20482838
esv3627122 CNV loss 21293372
esv3627119 CNV loss 21293372
esv3627117 CNV gain 21293372
esv3627116 CNV loss 21293372
esv3627115 CNV loss 21293372
esv3627114 CNV gain 21293372
esv3627113 CNV loss 21293372
esv3627099 CNV gain 21293372
esv3153107 CNV deletion 24192839
esv2762929 CNV loss 21179565
esv2744865 CNV deletion 23290073
esv2744864 CNV deletion 23290073
esv2744862 CNV deletion 23290073
esv2744861 CNV deletion 23290073
esv2744860 CNV deletion 23290073
esv2744859 CNV deletion 23290073
esv2656806 CNV deletion 23128226
esv2631282 CNV deletion 19546169
esv2429813 CNV deletion 19546169
esv21627 CNV loss 19812545
esv1070532 CNV deletion 17803354
dgv2057n54 CNV loss 21841781
dgv2056n54 CNV loss 21841781

Variation tolerance for TMEM135 Gene

Residual Variation Intolerance Score: 59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM135 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM135 Gene

Disorders for TMEM135 Gene

Relevant External Links for TMEM135

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM135 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM135 Gene

Publications for TMEM135 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. (PMID: 24430505) Moayyeri A … Kaptoge SK (Human molecular genetics 2014) 3 60
  5. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PMID: 19010793) Baranzini SE … Oksenberg JR (Human molecular genetics 2009) 45 60

Products for TMEM135 Gene

Sources for TMEM135 Gene

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