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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM135 Gene

protein-coding   GIFtS: 50
GCID: GC11P086749

transmembrane protein 135
 Explore 3 diseases affiliated with
TMEM135 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TMEM135    

Aliases
for TMEM135 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transmembrane Protein 1351 2
Peroxisomal Membrane Protein 522 3
PMP522 3
FLJ221041

External Ids:    HGNC: 261671   Entrez Gene: 650842   Ensembl: ENSG000001665757   UniProtKB: Q86UB93   
ORGUL members:         
NONCODE:n409073    

Export aliases for TMEM135 gene to outside databases

Previous GC identifers: GC11P086427 GC11P083035


Summaries
for TMEM135 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TM135_HUMAN, Q86UB9
Function: May be involved in peroxisome organization




Genomic Views
for TMEM135 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM135 gene promoter:
         E2F-4   E2F-3a   E2F-5   GATA-3   E2F-2   LCR-F1   GATA-2   GATA-1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM135 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM135

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM135


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.2   Ensembl cytogenetic band:  11q14.2   HGNC cytogenetic band: 11q14.2

TMEM135 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM135 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P086749:  view genomic region     (about GC identifiers)

Start:
 86,748,886 bp from pter      End:
 87,039,876 bp from pter
Size:
 290,991 bases      Orientation:
 plus strand

Proteins
for TMEM135 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TM135_HUMAN, Q86UB9 (See protein sequence)
Recommended Name: Transmembrane protein 135  
Size: 458 amino acids; 52291 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential). Peroxisome (By similarity)
Sequence caution: Sequence=BAB15233.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6AW91 Q8ND01 Q9H6M3
Alternative splicing: 2 isoforms:  Q86UB9-1   Q86UB9-2   

Explore the universe of human proteins at neXtProt for TMEM135: NX_Q86UB9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86UB9

    • TMEM135 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001162195.1  NP_075069.3  

    ENSEMBL proteins: 
     ENSP00000345513   ENSP00000433674   ENSP00000436179   ENSP00000433927   ENSP00000306344  
     ENSP00000347973   ENSP00000439525  

    Human Recombinant Protein Products: 
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    OriGene Custom Protein Services for TMEM135 
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    Novus Biologicals TMEM135 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TMEM135

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005777peroxisome ISS--
    GO:0016021integral to membrane IEA--


    TMEM135 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TMEM135

    Protein Domains /
    Families
    for TMEM135 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TMEM135 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026749 Tmem135

    Graphical View of Domain Structure for InterPro Entry Q86UB9

    ProtoNet protein and cluster: Q86UB9


    Function
    for TMEM135 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TM135_HUMAN, Q86UB9
    Function: May be involved in peroxisome organization

    miRNA
    Products:            		 OriGene 3'-UTR Clone: TMEM135
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM135
    8/149 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM135 (see all 149):
    hsa-miR-124* hsa-miR-579 hsa-miR-640 hsa-miR-106a hsa-miR-1245 hsa-miR-3622b-3p hsa-miR-149 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmid: TMEM135 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM135 (see all 7)
    OriGene shRNA RFP: TMEM135
    OriGene siRNA: TMEM135
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM135

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TMEM135

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM135 (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM135 (NM_022918)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM135
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM135 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TMEM135
    Search LifeMap BioReagents cell lines for TMEM135

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM135

    2 GenomeRNAi human phenotypes for TMEM135:
     Decreased viability of wild-ty  Synthetic lethal with Ras 


    Pathways & Interactions
    for TMEM135 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM135

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for TMEM135 (Q86UB93 ENSP000003063444) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC23Q9UJX23I2D: score=5 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007031peroxisome organization ISS--


    TMEM135 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TMEM135 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM135
    Search CenterWatch for drugs/clinical trials and news about TMEM135 / TM135 

    Transcripts
    for TMEM135 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TMEM135 gene (2 alternative transcripts): 
    NM_001168724.1  NM_022918.3  

    Unigene Cluster for TMEM135:

    Transmembrane protein 135
    Hs.188591  [show with all ESTs]
    Unigene Representative Sequence: NM_022918
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340353(uc001pch.3 uc010rtt.2 uc001pci.3) ENST00000529023
    ENST00000526733 ENST00000532959 ENST00000525018 ENST00000305494 ENST00000531800
    ENST00000531643 ENST00000528861 ENST00000355734(uc001pcg.2) ENST00000535167


    miRNA
    Products:             		 OriGene 3'-UTR Clone: TMEM135
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM135
    8/149 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM135 (see all 149):
    hsa-miR-124* hsa-miR-579 hsa-miR-640 hsa-miR-106a hsa-miR-1245 hsa-miR-3622b-3p hsa-miR-149 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmid: TMEM135 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM135 (see all 7)
    OriGene shRNA RFP: TMEM135
    OriGene siRNA: TMEM135
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM135
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM135 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM135 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM135 (NM_022918)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM135
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM135 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM135
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM135
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM135
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM135

    Additional cDNA sequence: 

    AK000684.1 AK024853.1 AK025757.1 AK225364.1 AK291804.1 AK296774.1 AK302473.1 AL834493.1 
    BC012553.1 BC030952.1 BC051462.1 BX648678.1 NR_033149.1 

    14 DOTS entries:

    DT.100775823  DT.416181  DT.91761618  DT.91937820  DT.92427443  DT.100020742  DT.100720658  DT.101978030 
    DT.422922  DT.120756562  DT.120756596  DT.95367525  DT.91916212  DT.91996576 

    24/131 AceView cDNA sequences (see all 131):

    BG619333 AL834493 BU630984 BM819781 AI655359 BI087663 CA843394 BM456444 
    AA977408 Z44556 CA392495 AA403251 AI655365 BX642198 BX648678 AI086325 
    CB306573 BM729349 CB242106 CK903658 AW243907 AW673339 AI985182 CA392496 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM135    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                                                                                                      
    SP2:                                -                                                                     


    ECgene alternative splicing isoforms for TMEM135

    Expression
    for TMEM135 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM135 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGCAGAATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TMEM135 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TMEM135 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM135

    SOURCE GeneReport for Unigene cluster: Hs.188591
        SABiosciences Custom PCR Arrays for TMEM135
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM135

    Orthologs
    for TMEM135 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TMEM135 gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tmem1351 , 5 transmembrane protein 1351, 5 86.97(n)1
    91.92(a)1    		   7 (49.32 cM)5
    727591  NM_028343.41  NP_082619.31 
     891397235 
    chicken
    (Gallus gallus)    		 Aves TMEM1351 transmembrane protein 135 80.06(n)
    83.19(a)    		   419015  XM_003640593.1  XP_003640641.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TMEM1356
    		 --
    		 85(a)
    		 1 ↔ 1
    		 3(199793364-199818148)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BX843655.12   -- 81.58(n)    BX843655.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii 570624852   -- 74.26(n)    57062485 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG117376
    CG312596
    (see all 3)    		 --
    		 31(a)
    30(a)
    (see all 3)    		 many → 1
    many → 1
    (see all 3)    		 3R(4343586-4347100)
    3R(4349668-4351844)
    worm
    (Caenorhabditis elegans)    		 Secernentea tmem-1351 Protein TMEM-135 45.85(n)
    32.54(a)    		   180740  NM_076399.5  NP_508800.2 


    ENSEMBL Gene Tree for TMEM135 (if available)
    TreeFam Gene Tree for TMEM135 (if available) 

    Paralogs
    for TMEM135 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for TMEM135 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5924 NCBI SNPs in TMEM135 are shown (see all 5924)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs793770151,2
    		C,F,--86746906(+) NNNNGC/TATCTG 3 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1441555281,2
    		C,--86746971(+) AGGTT-/GTCTCC 3 -- us2k10--------
    rs562018671,2
    		C--86747023(+) GTGCCC/TGGATA 3 -- us2k10--------
    rs1467276801,2
    		--86747143(+) TCCCAC/TTAATT 3 -- us2k10--------
    rs1112768191,2
    		--86747158(+) AAGATG/TGTATT 3 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs49439701,2
    		C,--86747332(+) TTGAGA/CTAGAG 3 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1873614291,2
    		--86747426(+) TCAGTC/TCCTGA 3 -- us2k10--------
    rs803178361,2
    		C--86747485(-) ACTACC/G/TAAATA 3 -- us2k11NA 2
    rs747116331,2
    		C--86747518(-) AGACCG/AGCCTG 3 -- us2k12Minor allele frequency- A:0.00NA 4
    rs754654141,2
    		C--86747525(-) GAGTTC/TGAGAC 3 -- us2k11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for TMEM135 (86748886 - 86998886 bp, first 250kb of TMEM135)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for TMEM135
         4 CNVs: 66020 101285 101284 85902
    Human Gene Mutation Database (HGMD): TMEM135

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM135
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM135

    Disorders / Diseases
    for TMEM135 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TMEM135 for disorders           About GeneDecksing

    3 diseases for TMEM135:    About MalaCards
    hypohidrotic ectodermal dysplasia    ectodermal dysplasia    pituitary tumor

    Human Genome Epidemiology (HuGE) Navigator: TMEM135 (1 document)

    Export disorders for TMEM135 gene to outside databases

    Publications
    for TMEM135 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM135 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with TMEM135)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    3. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells. (PubMed id 9915854)1 Pei L. (1999)

    External Searches for TMEM135 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing TMEM135 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 65084 HGNC: 26167 AceView: FLJ22104 Ensembl:ENSG00000166575 euGenes: HUgn65084
    ECgene: TMEM135 H-InvDB: TMEM135

    Other Databases showing TMEM135 gene

    (According to HUGE)
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    Specialized Databases showing TMEM135 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM135 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TMEM135 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TMEM135 gene:
    Search GeneIP for patents involving TMEM135

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