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Aliases for TMEM135 Gene

Aliases for TMEM135 Gene

  • Transmembrane Protein 135 2 3
  • Peroxisomal Membrane Protein 52 3 4
  • PMP52 3 4

External Ids for TMEM135 Gene

Previous GeneCards Identifiers for TMEM135 Gene

  • GC11P086427
  • GC11P086749
  • GC11P083035

Summaries for TMEM135 Gene

GeneCards Summary for TMEM135 Gene

TMEM135 (Transmembrane Protein 135) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM135 Gene

  • May be involved in peroxisome organization

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM135 Gene

Genomics for TMEM135 Gene

Regulatory Elements for TMEM135 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM135 Gene

87,037,844 bp from pter
87,328,834 bp from pter
290,991 bases
Plus strand

Genomic View for TMEM135 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for TMEM135 Gene

Proteins for TMEM135 Gene

  • Protein details for TMEM135 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 135
    Protein Accession:
    Secondary Accessions:
    • Q6AW91
    • Q8ND01
    • Q9H6M3

    Protein attributes for TMEM135 Gene

    458 amino acids
    Molecular mass:
    52291 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15233.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM135 Gene


neXtProt entry for TMEM135 Gene

Proteomics data for TMEM135 Gene at MOPED

Post-translational modifications for TMEM135 Gene

  • Ubiquitination at Lys 433
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM135 Gene

Antibody Products

No data available for DME Specific Peptides for TMEM135 Gene

Domains & Families for TMEM135 Gene

Protein Domains for TMEM135 Gene


Suggested Antigen Peptide Sequences for TMEM135 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM135: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM135 Gene

Function for TMEM135 Gene

Molecular function for TMEM135 Gene

UniProtKB/Swiss-Prot Function:
May be involved in peroxisome organization
genes like me logo Genes that share phenotypes with TMEM135: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM135

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM135 Gene

Localization for TMEM135 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM135 Gene

Membrane; Multi-pass membrane protein. Peroxisome.

Subcellular locations from

Jensen Localization Image for TMEM135 Gene COMPARTMENTS Subcellular localization image for TMEM135 gene
Compartment Confidence
peroxisome 4

Gene Ontology (GO) - Cellular Components for TMEM135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM135: view

Pathways & Interactions for TMEM135 Gene

SuperPathways for TMEM135 Gene

No Data Available

Interacting Proteins for TMEM135 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q86UB9-TM135_HUMAN ENSP00000306344 for TMEM135 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for TMEM135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007031 peroxisome organization ISS --
genes like me logo Genes that share ontologies with TMEM135: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM135 Gene

Drugs & Compounds for TMEM135 Gene

No Compound Related Data Available

Transcripts for TMEM135 Gene

Unigene Clusters for TMEM135 Gene

Transmembrane protein 135:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM135

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM135 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP2: -

Relevant External Links for TMEM135 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM135 Gene

mRNA expression in normal human tissues for TMEM135 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM135 Gene

This gene is overexpressed in Liver (42.8) and Testis (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM135 Gene

SOURCE GeneReport for Unigene cluster for TMEM135 Gene Hs.188591

genes like me logo Genes that share expression patterns with TMEM135: view

Protein tissue co-expression partners for TMEM135 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM135 Gene

Orthologs for TMEM135 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM135 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM135 35
  • 93.38 (n)
  • 94.32 (a)
TMEM135 36
  • 94 (a)
(Canis familiaris)
Mammalia TMEM135 35
  • 93.74 (n)
  • 95.85 (a)
TMEM135 36
  • 96 (a)
(Mus musculus)
Mammalia Tmem135 35
  • 86.97 (n)
  • 91.92 (a)
Tmem135 16
Tmem135 36
  • 92 (a)
(Pan troglodytes)
Mammalia TMEM135 35
  • 99.78 (n)
  • 99.56 (a)
TMEM135 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tmem135 35
  • 86.61 (n)
  • 91.48 (a)
(Monodelphis domestica)
Mammalia TMEM135 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM135 36
  • 92 (a)
(Gallus gallus)
Aves TMEM135 35
  • 80.06 (n)
  • 83.19 (a)
TMEM135 36
  • 83 (a)
(Anolis carolinensis)
Reptilia TMEM135 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem135 35
  • 75.7 (n)
  • 79.74 (a)
(Danio rerio)
Actinopterygii tmem135 35
  • 69.07 (n)
  • 75.71 (a)
tmem135 36
  • 75 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007085 35
  • 42.56 (n)
  • 32.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11737 35
  • 43.93 (n)
  • 33.64 (a)
CG11737 36
  • 31 (a)
CG31259 36
  • 30 (a)
CG31454 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea tmem-135 35
  • 46.17 (n)
  • 32.54 (a)
tmem-135 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3886 36
  • 35 (a)
Species with no ortholog for TMEM135:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM135 Gene

Gene Tree for TMEM135 (if available)
Gene Tree for TMEM135 (if available)

Paralogs for TMEM135 Gene

genes like me logo Genes that share paralogs with TMEM135: view

No data available for Paralogs for TMEM135 Gene

Variants for TMEM135 Gene

Sequence variations from dbSNP and Humsavar for TMEM135 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2560 -- 87,258,422(-) ACAAA(A/C)TGCAT intron-variant
rs2561 -- 87,258,348(-) AGCTT(C/T)AGCCA intron-variant
rs61552 -- 87,209,136(-) ttata(C/T)agttg intron-variant
rs167301 -- 87,283,194(-) ACCAC(A/G)CCTGG intron-variant
rs169971 -- 87,231,897(+) ttagt(C/G)aacct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM135 Gene

Variant ID Type Subtype PubMed ID
esv2656806 CNV Deletion 23128226
esv21627 CNV Loss 19812545
nsv898058 CNV Loss 21882294
nsv898059 CNV Loss 21882294
nsv468776 CNV Loss 19166990
esv2744859 CNV Deletion 23290073
nsv898060 CNV Loss 21882294
nsv420 CNV Loss 18451855
dgv1248n71 CNV Loss 21882294
nsv898062 CNV Loss 21882294
nsv898064 CNV Loss 21882294
nsv518332 CNV Loss 19592680
nsv525787 CNV Loss 19592680
nsv528940 CNV Loss 19592680
dgv1249n71 CNV Loss 21882294
nsv898067 CNV Loss 21882294
nsv898068 CNV Loss 21882294
dgv1250n71 CNV Loss 21882294
esv2744860 CNV Deletion 23290073
dgv1251n71 CNV Loss 21882294
nsv898074 CNV Loss 21882294
esv2744861 CNV Deletion 23290073
esv2631282 CNV Deletion 19546169
esv2744862 CNV Deletion 23290073
esv2744864 CNV Deletion 23290073
esv999908 CNV Deletion 20482838
esv1070532 CNV Deletion 17803354
esv2744865 CNV Deletion 23290073
esv2429813 CNV Deletion 19546169
nsv521810 CNV Loss 19592680

Variation tolerance for TMEM135 Gene

Residual Variation Intolerance Score: 59.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM135 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM135 Gene

Disorders for TMEM135 Gene

Relevant External Links for TMEM135

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMEM135: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM135 Gene

Publications for TMEM135 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein. (PMID: 8696334) Kere J. … Schlessinger D. (Nat. Genet. 1996) 23 67
  3. Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. (PMID: 24430505) Moayyeri A. … Kaptoge S.K. (Hum. Mol. Genet. 2014) 67
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  5. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PMID: 19010793) Baranzini S.E. … Oksenberg J.R. (Hum. Mol. Genet. 2009) 67

Products for TMEM135 Gene

Sources for TMEM135 Gene

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