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TMEM135 Gene

protein-coding   GIFtS: 53
GCID: GC11P086749

Transmembrane Protein 135

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 1351 2
Peroxisomal Membrane Protein 522 3
PMP522 3

External Ids:    HGNC: 261671   Entrez Gene: 650842   Ensembl: ENSG000001665757   UniProtKB: Q86UB93   

Export aliases for TMEM135 gene to outside databases

Previous GC identifers: GC11P086427 GC11P083035


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM135 Gene:
TMEM135 (transmembrane protein 135) is a protein-coding gene.

UniProtKB/Swiss-Prot: TM135_HUMAN, Q86UB9
Function: May be involved in peroxisome organization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM135 gene promoter:
         E2F-4   E2F-3a   E2F-5   GATA-3   E2F-2   LCR-F1   GATA-2   GATA-1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM135 promoter sequence
   Search Chromatin IP Primers for TMEM135

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM135


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.2   Ensembl cytogenetic band:  11q14.2   HGNC cytogenetic band: 11q14.2

TMEM135 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM135 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P086749:  view genomic region     (about GC identifiers)

Start:
86,748,886 bp from pter      End:
87,039,876 bp from pter
Size:
290,991 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TM135_HUMAN, Q86UB9 (See protein sequence)
Recommended Name: Transmembrane protein 135  
Size: 458 amino acids; 52291 Da
Sequence caution: Sequence=BAB15233.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6AW91 Q8ND01 Q9H6M3
Alternative splicing: 2 isoforms:  Q86UB9-1   Q86UB9-2   

Explore the universe of human proteins at neXtProt for TMEM135: NX_Q86UB9

Explore proteomics data for TMEM135 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys433
  • Modification sites at PhosphoSitePlus

  • See TMEM135 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001162195.1  NP_075069.3  

    ENSEMBL proteins: 
     ENSP00000345513   ENSP00000433674   ENSP00000436179   ENSP00000433927   ENSP00000306344  
     ENSP00000347973   ENSP00000439525  

    TMEM135 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TMEM135

     
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    antibodies-online peptides for TMEM135

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    antibodies-online antibodies for TMEM135 (5 products) 

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    Search eBioscience for ELISAs for TMEM135 
    antibodies-online kits for TMEM135 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026749 Tmem135

    Graphical View of Domain Structure for InterPro Entry Q86UB9

    ProtoNet protein and cluster: Q86UB9


    Find genes that share domains with TMEM135           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TM135_HUMAN, Q86UB9
    Function: May be involved in peroxisome organization

    Phenotypes:
         2 GenomeRNAi human phenotypes for TMEM135:

     Decreased viability of wild-ty  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TMEM135

    miRNA
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    miRTarBase miRNAs that target TMEM135:
    hsa-let-7d-5p (MIRT032182), hsa-mir-196a-5p (MIRT026055), hsa-mir-335-5p (MIRT018717)

    Block miRNA regulation of human, mouse, rat TMEM135 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM135 (see all 149):
    hsa-miR-124* hsa-miR-579 hsa-miR-640 hsa-miR-106a hsa-miR-1245 hsa-miR-3622b-3p hsa-miR-149 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidTMEM135 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMEM135

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM135 (NM_022918)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM135


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM135_HUMAN, Q86UB9: Membrane; Multi-pass membrane protein (Potential). Peroxisome (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome4
    cytosol2
    nucleus2
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005777peroxisome ISS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMEM135           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM135
    Interactions:

        Search GeneGlobe Interaction Network for TMEM135

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TMEM135 (Q86UB93 ENSP000003063444) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC23Q9UJX23, ENSP000003783504I2D: score=5 STRING: ENSP00000378350
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007031peroxisome organization ISS--

    Find genes that share ontologies with TMEM135           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM135 (TM135)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM135 gene (2 alternative transcripts): 
    NM_001168724.1  NM_022918.3  

    Unigene Cluster for TMEM135:

    Transmembrane protein 135
    Hs.188591  [show with all ESTs]
    Unigene Representative Sequence: NM_022918
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340353(uc001pch.3 uc010rtt.2 uc001pci.3) ENST00000529023
    ENST00000526733 ENST00000532959 ENST00000525018 ENST00000305494 ENST00000531800
    ENST00000531643 ENST00000528861 ENST00000355734(uc001pcg.2) ENST00000535167

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMEM135 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM135 (see all 149):
    hsa-miR-124* hsa-miR-579 hsa-miR-640 hsa-miR-106a hsa-miR-1245 hsa-miR-3622b-3p hsa-miR-149 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidTMEM135 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TMEM135
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM135
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM135 (NM_022918)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM135
    Primer
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    OriGene qPCR primer pairs and template standards for TMEM135
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM135
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM135
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM135
      QuantiFast Probe-based Assays in human, mouse, rat TMEM135

    Additional mRNA sequence: 

    AK000684.1 AK024853.1 AK025757.1 AK225364.1 AK291804.1 AK296774.1 AK302473.1 AL834493.1 
    BC012553.1 BC030952.1 BC051462.1 BX648678.1 NR_033149.1 

    14 DOTS entries:

    DT.100775823  DT.416181  DT.91761618  DT.91937820  DT.92427443  DT.100020742  DT.100720658  DT.101978030 
    DT.422922  DT.120756562  DT.120756596  DT.95367525  DT.91916212  DT.91996576 

    Selected AceView cDNA sequences (see all 131):

    BM729349 CB242106 CK903658 AW243907 AW673339 BI087663 AI655359 BM819781 
    CA843394 AA977408 AA403251 CA392495 Z44556 BX642198 AI655365 BM456444 
    CB306573 AI086325 AA635051 BG619333 BX648678 AL834493 BU630984 AI985182 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM135    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                                                                                                      
    SP2:                                -                                                                     


    ECgene alternative splicing isoforms for TMEM135

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM135 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCAGAATA
    TMEM135 Expression
    About this image

    TMEM135 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM135 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.188591
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM135

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMEM135 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1351 , 5 transmembrane protein 1351, 5 86.97(n)1
    91.92(a)1
      7 (49.32 cM)5
    727591  NM_028343.41  NP_082619.31 
     891397235 
    chicken
    (Gallus gallus)
    Aves TMEM1351 transmembrane protein 135 80.06(n)
    83.19(a)
      419015  XM_003640593.2  XP_003640641.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1356
    transmembrane protein 135
    85(a)
    1 ↔ 1
    3(199788879-199977403)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX843655.12   -- 81.58(n)    BX843655.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570624852   -- 74.26(n)    57062485 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG117371 CG11737 43.93(n)
    33.64(a)
      41009  NM_001275442.1  NP_001262371.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tmem-1351 tmem-135 46.17(n)
    32.54(a)
      180740  NM_076399.6  NP_508800.2 


    ENSEMBL Gene Tree for TMEM135 (if available)
    TreeFam Gene Tree for TMEM135 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM135 gene
    Selected SIMAP similar genes for TMEM135 using alignment to 7 protein entries:     TM135_HUMAN (see all proteins) (see all similar genes):
    ZNF547    FAM3A    NRAMP1    ZCCHC10    CTSS    ZNF670
    CCT3    C14orf178    FAM138C    KIAA1651    CRCP    LINC00596
    TSEN2    ZNF564    ZNF737    ZNF738    AGBL3    APOD

    Find genes that share paralogs with TMEM135           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM135 (see all 6883)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs354182331,2
    C--83126344(+) ACTAT-/AC/CA 
            
    AGTAT
    3 -- int10--------
    rs793770151,2
    C,F--86746906(+) ATCTGC/TATCTG 3 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1441555281,2
    C--86746971(+) AGGTT-/GTCTCC 3 -- us2k10--------
    rs562018671,2
    C--86747023(+) GTGCCC/TGGATA 3 -- us2k10--------
    rs1467276801,2
    --86747143(+) TCCCAC/TTAATT 3 -- us2k10--------
    rs1112768191,2
    F--86747158(+) AAGATG/TGTATT 3 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs49439701,2
    C--86747332(+) ttgagA/Ctagag 3 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1873614291,2
    --86747426(+) TCAGTC/TCCTGA 3 -- us2k10--------
    rs780021151,2
    C--86747677(+) GAAATC/TACAGG 3 -- us2k14Minor allele frequency- T:0.04NA WA EA 360
    rs750346691,2
    C,F--86747707(+) CTGTCA/GCAAAG 3 -- us2k11Minor allele frequency- G:0.06WA 118

    HapMap Linkage Disequilibrium report for TMEM135 (86748886 - 86998886 bp, first 250kb of TMEM135)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TMEM135 (see all 30):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744861CNV Deletion23290073
    esv2744860CNV Deletion23290073
    esv2744864CNV Deletion23290073
    esv2656806CNV Deletion23128226
    esv2631282CNV Deletion19546169
    esv2429813CNV Deletion19546169
    esv999908CNV Deletion20482838
    esv1070532CNV Deletion17803354
    esv2744862CNV Deletion23290073
    esv2744859CNV Deletion23290073

    Human Gene Mutation Database (HGMD): TMEM135
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM135
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM135

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with TMEM135           About GenesLikeMe

    Genetic Association Database (GAD): TMEM135
    Human Genome Epidemiology (HuGE) Navigator: TMEM135 (1 document)

    Export disorders for TMEM135 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM135 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with TMEM135)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    7. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PubMed id 19010793)4 Baranzini S.E....Oksenberg J.R. (Hum. Mol. Genet. 2009)
    8. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PubMed id 17903295)4 Lunetta K.L....Murabito J.M. (BMC Med. Genet. 2007)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 65084 HGNC: 26167 AceView: FLJ22104 Ensembl:ENSG00000166575 euGenes: HUgn65084
    ECgene: TMEM135 H-InvDB: TMEM135

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TMEM135 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM135 gene:
    Search GeneIP for patents involving TMEM135

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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