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Aliases for TMEM134 Gene

Aliases for TMEM134 Gene

  • Transmembrane Protein 134 2 3

External Ids for TMEM134 Gene

Previous GeneCards Identifiers for TMEM134 Gene

  • GC11M066989
  • GC11M067231
  • GC11M063561

Summaries for TMEM134 Gene

GeneCards Summary for TMEM134 Gene

TMEM134 (Transmembrane Protein 134) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM134 Gene

Genomics for TMEM134 Gene

Regulatory Elements for TMEM134 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM134 Gene

Start:
67,461,710 bp from pter
End:
67,469,277 bp from pter
Size:
7,568 bases
Orientation:
Minus strand

Genomic View for TMEM134 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM134 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM134 Gene

Proteins for TMEM134 Gene

  • Protein details for TMEM134 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6X4-TM134_HUMAN
    Recommended name:
    Transmembrane protein 134
    Protein Accession:
    Q9H6X4
    Secondary Accessions:
    • Q08AK4
    • Q6PJN3

    Protein attributes for TMEM134 Gene

    Size:
    195 amino acids
    Molecular mass:
    21586 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM134 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM134 Gene

Proteomics data for TMEM134 Gene at MOPED

Post-translational modifications for TMEM134 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TMEM134

No data available for DME Specific Peptides for TMEM134 Gene

Domains for TMEM134 Gene

Protein Domains for TMEM134 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM134 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H6X4

UniProtKB/Swiss-Prot:

TM134_HUMAN :
  • Belongs to the TMEM134/TMEM230 family.
Family:
  • Belongs to the TMEM134/TMEM230 family.
genes like me logo Genes that share domains with TMEM134: view

No data available for Gene Families for TMEM134 Gene

Function for TMEM134 Gene

Phenotypes for TMEM134 Gene

genes like me logo Genes that share phenotypes with TMEM134: view

Animal Model Products

CRISPR Products

miRNA for TMEM134 Gene

miRTarBase miRNAs that target TMEM134

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM134

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM134 Gene

Localization for TMEM134 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM134 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM134 Gene COMPARTMENTS Subcellular localization image for TMEM134 gene
Compartment Confidence
plasma membrane 3
cytosol 1

Gene Ontology (GO) - Cellular Components for TMEM134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM134: view

Pathways for TMEM134 Gene

SuperPathways for TMEM134 Gene

No Data Available

Interacting Proteins for TMEM134 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000312615%0d%0a9606.ENSP00000328182%0d%0a9606.ENSP00000378426%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000312615 for TMEM134 Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM134 Gene

None

No data available for Pathways by source for TMEM134 Gene

Transcripts for TMEM134 Gene

Unigene Clusters for TMEM134 Gene

Transmembrane protein 134:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM134

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM134 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - -
SP11: - - - -
SP12: - - - - - - - - -
SP13: - - -
SP14: - -
SP15: - - - - - - - - - - - - -
SP16: - - - -
SP17: - - -
SP18: - -
SP19:
SP20: -

ExUns: 8c · 8d · 8e · 8f · 8g · 8h · 8i
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for TMEM134 Gene

GeneLoc Exon Structure for
TMEM134
ECgene alternative splicing isoforms for
TMEM134

Expression for TMEM134 Gene

mRNA expression in normal human tissues for TMEM134 Gene

Protein differential expression in normal tissues for TMEM134 Gene

This gene is overexpressed in Testis (38.1) and Blymphocyte (23.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM134 Gene

SOURCE GeneReport for Unigene cluster for TMEM134 Gene Hs.288761

genes like me logo Genes that share expressions with TMEM134: view

Expression partners for TMEM134 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM134 Gene

Orthologs for TMEM134 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM134 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM134 35
  • 92.41 (n)
  • 93.33 (a)
TMEM134 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM134 35
  • 93.73 (n)
  • 92.47 (a)
TMEM134 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem134 35
  • 90.94 (n)
  • 93.33 (a)
Tmem134 16
chimpanzee
(Pan troglodytes)
Mammalia TMEM134 35
  • 100 (n)
  • 100 (a)
TMEM134 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem134 35
  • 89.23 (n)
  • 92.31 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM134 36
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem134 35
  • 56.74 (n)
  • 57.45 (a)
zgc64040 35
tmem134 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12025 36
  • 31 (a)
OneToOne
Species with no ortholog for TMEM134:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM134 Gene

ENSEMBL:
Gene Tree for TMEM134 (if available)
TreeFam:
Gene Tree for TMEM134 (if available)

Paralogs for TMEM134 Gene

(1) SIMAP similar genes for TMEM134 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM134: view

No data available for Paralogs for TMEM134 Gene

Variants for TMEM134 Gene

Sequence variations from dbSNP and Humsavar for TMEM134 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs57538070 -- 67,463,948(+) GAGGG(A/G)GCTGG downstream-variant-500B
rs57159660 -- 67,464,337(+) AGGAG(-/GAG)AGCAA downstream-variant-500B
rs56405884 -- 67,467,635(+) GACGG(A/G)GTTGC intron-variant
rs34210249 -- 67,470,597(+) TATAG(-/G)ATACA upstream-variant-2KB
rs34176110 -- 67,465,272(+) CTGGG(-/G)AAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM134 Gene

Variant ID Type Subtype PubMed ID
nsv897797 CNV Loss 21882294
nsv897801 CNV Loss 21882294
dgv1193n71 CNV Loss 21882294
dgv1194n71 CNV Loss 21882294
nsv521723 CNV Loss 19592680
nsv468604 CNV Loss 19166990
nsv527056 CNV Loss 19592680
esv2422195 CNV Duplication 17116639

Relevant External Links for TMEM134 Gene

HapMap Linkage Disequilibrium report
TMEM134

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM134 Gene

Disorders for TMEM134 Gene

Relevant External Links for TMEM134

Genetic Association Database (GAD)
TMEM134

No disorders were found for TMEM134 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TMEM134 Gene

Publications for TMEM134 Gene

  1. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 3
  2. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for TMEM134 Gene

Sources for TMEM134 Gene

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