TMEM134 Gene
protein-coding GIFtS: 43
GCID: GC11M067231
|
|
transmembrane protein 134
| |
Aliases
for TMEM134 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 1341 2 | | FLJ217491 |
Export aliases for TMEM134 gene to outside databasesPrevious GC identifers: GC11M066989 GC11M063561 |
Summaries
for TMEM134 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM134 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM134 gene promoter:
Pax-5 NF-E2 p45 PPAR-alpha PPAR-gamma1 c-Myb PPAR-gamma2 Pax-4a NF-E2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM134
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM134 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.2 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13.2TMEM134 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M067231: view genomic region
(about GC identifiers)
Start:
|
67,231,819 bp from pter |
End:
|
67,236,743 bp from pter |
Size:
|
4,925 bases |
Orientation:
|
minus strand |
|
Proteins
for TMEM134 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM134_HUMAN, Q9H6X4 (See
protein sequence)Recommended Name: Transmembrane protein 134 Size: 195 amino acids; 21586 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q08AK4 Q6PJN3Alternative splicing: 3 isoforms: Q9H6X4-1 Q9H6X4-2 Q9H6X4-3 Explore the universe of human proteins at neXtProt for TMEM134: NX_Q9H6X4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H6X4
TMEM134 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001072118.1 NP_001072119.1 NP_079400.1
ENSEMBL proteins: ENSP00000438439 ENSP00000377455 ENSP00000312615 ENSP00000440630 ENSP00000441975 ENSP00000395482 ENSP00000439609
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM134 for ontologies About GeneDecksing
TMEM134 Antibody Products:
Assay Products for TMEM134: |
Protein
Domains /
Families
for TMEM134 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM134 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H6X4ProtoNet protein and cluster: Q9H6X4 UniProtKB/Swiss-Prot: TM134_HUMAN, Q9H6X4Similarity: Belongs to the TMEM134/TMEM230 family |
Function
for TMEM134 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM134 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM134 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): TMEM134 (NM_001078651) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM134 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM134 |
2 GenomeRNAi human phenotypes for TMEM134:
|
Pathways & Interactions
for TMEM134 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM134
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TMEM134 (ENSP000003126154) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TMEM134 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM134
Search CenterWatch for drugs/clinical trials and news about TMEM134 / TM134
|
Transcripts
for TMEM134 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM134 gene (3 alternative transcripts): NM_001078650.2 NM_001078651.2 NM_025124.3 Unigene Cluster for TMEM134: Transmembrane protein 134 Hs.288761 [show with all ESTs]Unigene Representative Sequence: AY00714317 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000545682(uc001olp.1 uc001olq.1 uc001olr.1 uc001ols.1)
ENST00000543661 ENST00000535813 ENST00000393877 ENST00000308022 ENST00000535175
ENST00000541059 ENST00000536020 ENST00000537601 ENST00000501408(uc010rpt.1 uc009yrx.2 uc010rpu.1 uc001olu.3)
ENST00000535585 ENST00000540133 ENST00000452789 ENST00000541598 ENST00000544903
ENST00000536773 ENST00000538561
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM134 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM134 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): TMEM134 (NM_001078651) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM134 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM134 |
Additional cDNA sequence: AK025402.1 AK296988.1 AK303342.1 AK310743.1 AY007143.1 BC051854.1 BC125134.1 NR_073409.1 NR_073410.1 NR_073411.1 NR_073412.1 NR_073413.1 17 DOTS entries: DT.100028282 DT.101983406 DT.120726904 DT.75103568 DT.86848198 DT.97845053 DT.91749337 DT.120726912 DT.95114139 DT.97822331 DT.120726896 DT.100000704 DT.120726897 DT.120726915 DT.91749345 DT.95114099 DT.99992006 24/207 AceView cDNA sequences (see all 207): BU735216 BM680961 CR601766 AI377213 BM696697 BM980023 BQ227843 CK825054 BC051854 AI144114 BE645876 AV746713 BI963053 AI216651 BG488634 BM725947 BM701657 AW967881 AI281030 BX280869 BF512094 CA435777 CD675984 BI964088
GeneLoc Exon Structure
5/20 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM134 (see all 20) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | |
| ExUns: | 8c | · | 8d | · | 8e | · | 8f | · | 8g | · | 8h | · | 8i |
|---|
|
| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM134
|
Expression
for TMEM134 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM134 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGGCCTGGC
About this image
See TMEM134 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM134
SOURCE GeneReport for Unigene cluster: Hs.288761
SABiosciences Custom PCR Arrays for TMEM134
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM134
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM134 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM134 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM134 |
Orthologs
for TMEM134 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM134 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for TMEM134 (if available)
TreeFam Gene Tree for TMEM134 (if available) |
Paralogs
for TMEM134 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM134 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM134 (67231819 - 67236743 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMEM134
1 CNV: 5275 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM134 |
|
Disorders
/ Diseases
for TMEM134 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TMEM134 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM134 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM134) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of transmembrane protein 134 as a novel LMP1-binding protein by using bimolecular fluorescence complementation and an e nhanced retroviral mutagen. (PubMed id 22855487)1 Talaty P....Everly D.N. (2012)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (1996)
|
External Searches for TMEM134 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM134 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM134 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM134 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM134 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM134 gene:
Search GeneIP for patents involving TMEM134
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM134 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM134 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM134 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM134 | | | OriGene Protein Over-expression Lysate for TMEM134 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM134 | | OriGene 3'-UTR Clone for TMEM134 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM134 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM134 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TMEM134 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM134 | | OriGene Custom Protein Services for TMEM134 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM134 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM134 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM134 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM134 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM134 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM134 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TMEM134 |
| |  |  |  |  | | | | |
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 | | | TMEM134 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for TMEM134 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM134 |
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