Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM133 Gene

Aliases for TMEM133 Gene

  • Transmembrane Protein 133 2 3 5
  • AD031 3

External Ids for TMEM133 Gene

Previous GeneCards Identifiers for TMEM133 Gene

  • GC11P100371
  • GC11P100862
  • GC11P096799

Summaries for TMEM133 Gene

Entrez Gene Summary for TMEM133 Gene

  • There is evidence that this intronless gene is transcribed but the protein is predicted. The gene function is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMEM133 Gene

TMEM133 (Transmembrane Protein 133) is a Protein Coding gene.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM133 Gene

Genomics for TMEM133 Gene

Regulatory Elements for TMEM133 Gene

Enhancers for TMEM133 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G100738 1 Ensembl ENCODE 20.1 -251.6 -251563 4.0 SRF MTA2 RAD21 TBX21 NR2F2 POLR2A SMARCA4 IKZF1 BCL6B HNF4A TMEM133 ARHGAP42 LOC100128386 RN7SKP115
GH11G100684 0.7 ENCODE 18.1 -306.9 -306933 1.7 SOX13 FOXA2 TBL1XR1 ARID3A ZNF600 FOS CREM MTA2 NR2F1 BHLHE40 TMEM133 LOC100128386 ARHGAP42 LOC440063
GH11G100718 1.1 Ensembl ENCODE 11.4 -272.3 -272257 1.6 FEZF1 RAD21 RFX5 YY1 GATA2 RCOR1 FOS NR2F2 MAFF SMARCA4 TMEM133 ARHGAP42 LOC100128386 RN7SKP115
GH11G100686 0.9 ENCODE 11.5 -304.4 -304425 2.8 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ETS1 ZNF143 FOS ZNF263 SP3 TMEM133 LOC100128386 ARHGAP42 LOC440063
GH11G100638 0.8 Ensembl ENCODE 11.7 -352.7 -352702 1.6 FOXA2 HLF BCL6B BCL6 NR2F2 TRIM28 TMEM133 RN7SL222P GC11M100607
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM133 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM133 Gene

100,991,989 bp from pter
100,993,941 bp from pter
1,953 bases
Plus strand

Genomic View for TMEM133 Gene

Genes around TMEM133 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM133 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM133 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM133 Gene

Proteins for TMEM133 Gene

  • Protein details for TMEM133 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 133
    Protein Accession:

    Protein attributes for TMEM133 Gene

    129 amino acids
    Molecular mass:
    14539 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM133 Gene

Post-translational modifications for TMEM133 Gene

No Post-translational modifications

Other Protein References for TMEM133 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM133 Gene

Domains & Families for TMEM133 Gene

Protein Domains for TMEM133 Gene


Suggested Antigen Peptide Sequences for TMEM133 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM133: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM133 Gene

Function for TMEM133 Gene

genes like me logo Genes that share phenotypes with TMEM133: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM133 Gene

Localization for TMEM133 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM133 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM133 gene
Compartment Confidence
extracellular 3
cytosol 2
plasma membrane 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM133: view

Pathways & Interactions for TMEM133 Gene

SuperPathways for TMEM133 Gene

No Data Available

Interacting Proteins for TMEM133 Gene

Gene Ontology (GO) - Biological Process for TMEM133 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM133 Gene

Drugs & Compounds for TMEM133 Gene

No Compound Related Data Available

Transcripts for TMEM133 Gene

mRNA/cDNA for TMEM133 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(78) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM133 Gene

Transmembrane protein 133:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM133 Gene

No ASD Table

Relevant External Links for TMEM133 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM133 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM133 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TMEM133 Gene:


SOURCE GeneReport for Unigene cluster for TMEM133 Gene:


Evidence on tissue expression from TISSUES for TMEM133 Gene

  • Adrenal gland(4.1)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with TMEM133: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM133 Gene

Orthologs for TMEM133 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TMEM133 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM133 34 35
  • 98.97 (n)
Species where no ortholog for TMEM133 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM133 Gene

Gene Tree for TMEM133 (if available)
Gene Tree for TMEM133 (if available)

Paralogs for TMEM133 Gene

No data available for Paralogs for TMEM133 Gene

Variants for TMEM133 Gene

Sequence variations from dbSNP and Humsavar for TMEM133 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1001172149 -- 100,990,558(+) TAAAC(A/G)TTTGA upstream-variant-2KB, utr-variant-3-prime
rs1001340800 -- 100,993,127(+) TCCTC(A/G)GTAGG utr-variant-3-prime
rs1002363733 -- 100,991,948(+) ATTCG(A/G)TGATA upstream-variant-2KB, utr-variant-3-prime
rs1003257955 -- 100,993,225(+) ATTTT(A/G)CCTTG utr-variant-3-prime
rs1003574532 -- 100,993,818(+) ACACA(C/T)ACATA utr-variant-3-prime

Variation tolerance for TMEM133 Gene

Residual Variation Intolerance Score: 71.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM133 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM133 Gene

Disorders for TMEM133 Gene

Relevant External Links for TMEM133

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM133 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM133 Gene

Publications for TMEM133 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain L.V. … van Duijn C.M. (Nat. Genet. 2011) 3 64
  4. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. (PMID: 21909115) . … Johnson T. (Nature 2011) 3 64

Products for TMEM133 Gene

Sources for TMEM133 Gene

Loading form....