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Aliases for TMEM133 Gene

Aliases for TMEM133 Gene

  • Transmembrane Protein 133 2 3 5
  • AD031 3

External Ids for TMEM133 Gene

Previous GeneCards Identifiers for TMEM133 Gene

  • GC11P100371
  • GC11P100862
  • GC11P096799

Summaries for TMEM133 Gene

Entrez Gene Summary for TMEM133 Gene

  • There is evidence that this intronless gene is transcribed but the protein is predicted. The gene function is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMEM133 Gene

TMEM133 (Transmembrane Protein 133) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM133 Gene

Genomics for TMEM133 Gene

Regulatory Elements for TMEM133 Gene

Enhancers for TMEM133 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F100738 1.2 Ensembl ENCODE 20.1 -251.5 -251466 4.2 SRF MTA2 TBX21 NR2F2 SMARCA4 POLR2A IKZF1 BCL6 PRDM1 TRIM28 TMEM133 ARHGAP42 LOC100128386 RN7SKP115
GH11F100684 0.8 Ensembl ENCODE 18.1 -305.4 -305413 4.8 TBP PKNOX1 TBL1XR1 ARID4B SIN3A DMAP1 ZNF48 ZBTB40 RAD21 RARA TMEM133 LOC100128386 ARHGAP42 LOC440063
GH11F100970 0.4 ENCODE 12.2 -21.0 -20965 0.2 PKNOX1 TAL1 FEZF1 ZNF316 GATA3 NFE2 MAFK NFE2L2 MAFG DPF2 TMEM133 LOC105369457
GH11F100725 1.1 FANTOM5 Ensembl ENCODE 12 -264.8 -264799 2.4 REST NR2F2 TMEM133 LOC100128386 ARHGAP42 RN7SKP115
GH11F100638 0.9 Ensembl ENCODE 11.7 -352.7 -352702 1.6 HLF BCL6 TRIM28 TMEM133 RN7SL222P GC11M100607
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM133 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM133 Gene

Chromosome:
11
Start:
100,991,989 bp from pter
End:
100,993,941 bp from pter
Size:
1,953 bases
Orientation:
Plus strand

Genomic View for TMEM133 Gene

Genes around TMEM133 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM133 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM133 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM133 Gene

Proteins for TMEM133 Gene

  • Protein details for TMEM133 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2Q1-TM133_HUMAN
    Recommended name:
    Transmembrane protein 133
    Protein Accession:
    Q9H2Q1

    Protein attributes for TMEM133 Gene

    Size:
    129 amino acids
    Molecular mass:
    14539 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM133 Gene

Post-translational modifications for TMEM133 Gene

No Post-translational modifications

Other Protein References for TMEM133 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM133 Gene

Domains & Families for TMEM133 Gene

Protein Domains for TMEM133 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM133 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM133: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM133 Gene

Function for TMEM133 Gene

genes like me logo Genes that share phenotypes with TMEM133: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM133 Gene

Localization for TMEM133 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM133 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM133 Gene COMPARTMENTS Subcellular localization image for TMEM133 gene
Compartment Confidence
extracellular 3
cytosol 2
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMEM133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM133: view

Pathways & Interactions for TMEM133 Gene

SuperPathways for TMEM133 Gene

No Data Available

Interacting Proteins for TMEM133 Gene

Gene Ontology (GO) - Biological Process for TMEM133 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM133 Gene

Transcripts for TMEM133 Gene

mRNA/cDNA for TMEM133 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(78) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM133 Gene

Transmembrane protein 133:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM133 Gene

No ASD Table

Relevant External Links for TMEM133 Gene

GeneLoc Exon Structure for
TMEM133
ECgene alternative splicing isoforms for
TMEM133

Expression for TMEM133 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM133 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TMEM133 Gene:

TMEM133

SOURCE GeneReport for Unigene cluster for TMEM133 Gene:

Hs.44004
genes like me logo Genes that share expression patterns with TMEM133: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMEM133 Gene

Orthologs for TMEM133 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TMEM133 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM133 34 35
  • 98.97 (n)
Species where no ortholog for TMEM133 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM133 Gene

ENSEMBL:
Gene Tree for TMEM133 (if available)
TreeFam:
Gene Tree for TMEM133 (if available)

Paralogs for TMEM133 Gene

No data available for Paralogs for TMEM133 Gene

Variants for TMEM133 Gene

Sequence variations from dbSNP and Humsavar for TMEM133 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1047624 -- 100,993,002(+) AAAAA(C/G)CAGAG utr-variant-3-prime
rs112211961 -- 100,990,196(+) TGGTT(A/G)CCTGC upstream-variant-2KB, utr-variant-3-prime
rs113121016 -- 100,992,220(+) ACTTA(A/T)ACTTT utr-variant-3-prime, utr-variant-5-prime
rs114921248 -- 100,992,563(+) TGTAA(C/T)ATCGA reference, synonymous-codon, utr-variant-3-prime
rs116452980 -- 100,993,867(+) AAATT(G/T)CCACA utr-variant-3-prime

Variation tolerance for TMEM133 Gene

Residual Variation Intolerance Score: 71.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM133 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM133

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM133 Gene

Disorders for TMEM133 Gene

Relevant External Links for TMEM133

Genetic Association Database (GAD)
TMEM133
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM133

No disorders were found for TMEM133 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM133 Gene

Publications for TMEM133 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain L.V. … van Duijn C.M. (Nat. Genet. 2011) 3 64
  4. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. (PMID: 21909115) . … Johnson T. (Nature 2011) 3 64

Products for TMEM133 Gene

Sources for TMEM133 Gene

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