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TMEM133 Gene

protein-coding   GIFtS: 37
GCID: GC11P100862

Transmembrane Protein 133

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 1331 2

External Ids:    HGNC: 240331   Entrez Gene: 839352   Ensembl: ENSG000001706477   UniProtKB: Q9H2Q13   

Export aliases for TMEM133 gene to outside databases

Previous GC identifers: GC11P100371 GC11P096799


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMEM133 Gene:
There is evidence that this intronless gene is transcribed but the protein is predicted. The gene function is
unknown. (provided by RefSeq, Jul 2008)

GeneCards Summary for TMEM133 Gene:
TMEM133 (transmembrane protein 133) is a protein-coding gene. Diseases associated with TMEM133 include food allergy.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM133 gene promoter:
         AML1a   Pax-2   Pax-2a   LCR-F1   POU2F1   Pax-2b   POU2F1a   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM133 promoter sequence
   Search Chromatin IP Primers for TMEM133

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM133


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.1   Ensembl cytogenetic band:  11q22.1   HGNC cytogenetic band: 11q22.1

TMEM133 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM133 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P100862:  view genomic region     (about GC identifiers)

Start:
100,862,811 bp from pter      End:
100,864,666 bp from pter
Size:
1,856 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TM133_HUMAN, Q9H2Q1 (See protein sequence)
Recommended Name: Transmembrane protein 133  
Size: 129 amino acids; 14539 Da

Explore the universe of human proteins at neXtProt for TMEM133: NX_Q9H2Q1

Explore proteomics data for TMEM133 at MOPED


See TMEM133 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_114410.1  
ENSEMBL proteins: 
 ENSP00000303999  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q9H2Q1


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     2 GenomeRNAi human phenotypes for TMEM133:
 Increased homologous recombina  Synthetic lethal with c-Myc af 

Animal Models:
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hsa-miR-548j hsa-miR-548k hsa-miR-106a hsa-miR-519a hsa-miR-548l hsa-miR-93 hsa-miR-3613-3p hsa-miR-548a-5p
SwitchGear 3'UTR luciferase reporter plasmidTMEM133 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TM133_HUMAN, Q9H2Q1: Membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
cytosol2
mitochondrion1
nucleus1
plasma membrane1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

TMEM133 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM133
Interactions:

    Search GeneGlobe Interaction Network for TMEM133

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TMEM133 (TM133)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TMEM133 gene: 
NM_032021.2  

Unigene Cluster for TMEM133:

Transmembrane protein 133
Hs.44004  [show with all ESTs]
Unigene Representative Sequence: AF247167
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000303130(uc001pgf.3)
miRNA
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SwitchGear 3'UTR luciferase reporter plasmidTMEM133 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat TMEM133
Clone
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  QuantiFast Probe-based Assays in human, mouse, rat TMEM133

Additional mRNA sequence: 

AF247167.1 AK314174.1 BC058024.1 BC093843.1 BC112050.1 

1 DOTS entry:

DT.311552 

Selected AceView cDNA sequences (see all 78):

BM804259 AI417838 AL701071 AW340014 BM014001 BM564678 CR620896 AA417982 
NM_032021 AA278669 N30408 BX116126 CF552909 CB044016 BM894179 BM726747 
BF513771 CK824101 AA406599 AA282736 BQ187761 AI352084 AI239749 BG545256 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMEM133 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTATTCCTA
TMEM133 Expression
About this image


TMEM133 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Brain (Nervous System)
         Oligodendrocyte Precursor Cells Forebrain White Matter
TMEM133 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TMEM133 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.44004
    Custom PCR Arrays for TMEM133
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM133

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for TMEM133 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM1331 transmembrane protein 133 98.97(n)
96.9(a)
  100615815  XM_003313269.2  XP_003313317.1 


ENSEMBL Gene Tree for TMEM133 (if available)
TreeFam Gene Tree for TMEM133 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TMEM133 (see all 77)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs133774861,2
C--100862300(+) CCTCAG/ATACAA 1 -- us2k14Minor allele frequency- A:0.09NA WA 124
rs1439317381,2
C--100862335(+) CTCTCC/TTGTTT 1 -- us2k10--------
rs1863370451,2
--100862452(+) TTCACA/GAAGTA 1 -- us2k10--------
rs1472396501,2
--100862583(+) TTTTCA/GGAGAT 1 -- us2k10--------
rs4998611,2
C,F,A,H--100862593(+) TAGTGG/AAGGAA 1 -- us2k1 trp322Minor allele frequency- A:0.08NS EA NA WA CSA 1842
rs1389608911,2
C--100862596(+) GAAGG-/AAAAAA 1 -- us2k10--------
rs792250981,2
F--100862653(+) TAAAGA/TTACAT 1 -- us2k11Minor allele frequency- T:0.03NA 120
rs1487223301,2
--100862721(+) AAAATC/TCACTA 1 -- us2k10--------
rs1828757101,2
--100862850(+) GAAGAG/TTCCCT 1 -- ut510--------
rs1424439641,2
--100862885(+) AAATT-/GTAGTGAT 1 -- cds10--------

HapMap Linkage Disequilibrium report for TMEM133 (100862811 - 100864666 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TMEM133: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TMEM133
DNA2.0 Custom Variant and Variant Library Synthesis for TMEM133

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for TMEM133:    
About MalaCards
food allergy


TMEM133 for disorders           About GeneDecksing

Genetic Association Database (GAD): TMEM133

Export disorders for TMEM133 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TMEM133 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TMEM133)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  3. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1 Wain L.V....van Duijn C.M. (Nat. Genet. 2011)
  4. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. (PubMed id 21909115)1  ....Johnson T. (Nature 2011)
  5. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 83935 HGNC: 24033 AceView: AD031 Ensembl:ENSG00000170647 euGenes: HUgn83935
ECgene: TMEM133 H-InvDB: TMEM133

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TMEM133 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TMEM133 gene:
Search GeneIP for patents involving TMEM133

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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