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Aliases for TMEM132E Gene

Aliases for TMEM132E Gene

  • Transmembrane Protein 132E 2 3
  • DFNB99 3

External Ids for TMEM132E Gene

Previous GeneCards Identifiers for TMEM132E Gene

  • GC17P029932
  • GC17P032907
  • GC17P029094

Summaries for TMEM132E Gene

GeneCards Summary for TMEM132E Gene

TMEM132E (Transmembrane Protein 132E) is a Protein Coding gene. An important paralog of this gene is TMEM132A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM132E Gene

Genomics for TMEM132E Gene

Regulatory Elements for TMEM132E Gene

Genomic Location for TMEM132E Gene

Start:
34,580,749 bp from pter
End:
34,639,318 bp from pter
Size:
58,570 bases
Orientation:
Plus strand

Genomic View for TMEM132E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM132E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM132E Gene

Proteins for TMEM132E Gene

  • Protein details for TMEM132E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IEE7-T132E_HUMAN
    Recommended name:
    Transmembrane protein 132E
    Protein Accession:
    Q6IEE7
    Secondary Accessions:
    • Q8WUF4
    • Q8WVA5

    Protein attributes for TMEM132E Gene

    Size:
    984 amino acids
    Molecular mass:
    107094 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM132E Gene

Proteomics data for TMEM132E Gene at MOPED

Post-translational modifications for TMEM132E Gene

  • Glycosylation at Asn91, Asn228, and Asn309
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM132E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM132E Gene

Domains for TMEM132E Gene

Protein Domains for TMEM132E Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM132E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IEE7

UniProtKB/Swiss-Prot:

T132E_HUMAN :
  • Q6IEE7
Family:
  • Belongs to the TMEM132 family.
genes like me logo Genes that share domains with TMEM132E: view

No data available for Gene Families for TMEM132E Gene

Function for TMEM132E Gene

Phenotypes for TMEM132E Gene

GenomeRNAi human phenotypes for TMEM132E:
genes like me logo Genes that share phenotypes with TMEM132E: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM132E Gene

Localization for TMEM132E Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM132E Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM132E Gene COMPARTMENTS Subcellular localization image for TMEM132E gene
Compartment Confidence
endoplasmic reticulum 2
plasma membrane 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM132E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM132E: view

Pathways for TMEM132E Gene

SuperPathways for TMEM132E Gene

No Data Available

Interacting Proteins for TMEM132E Gene

Selected Interacting proteins: Q6IEE7-T132E_HUMAN for TMEM132E Gene via I2D

Symbol External ID(s) Details
TARBP2

Gene Ontology (GO) - Biological Process for TMEM132E Gene

None

No data available for Pathways by source for TMEM132E Gene

Transcripts for TMEM132E Gene

mRNA/cDNA for TMEM132E Gene

(12) Selected AceView cDNA sequences:
(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM132E Gene

Transmembrane protein 132E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM132E Gene

No ASD Table

Relevant External Links for TMEM132E Gene

GeneLoc Exon Structure for
TMEM132E
ECgene alternative splicing isoforms for
TMEM132E

Expression for TMEM132E Gene

mRNA expression in normal human tissues for TMEM132E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM132E Gene

This gene is overexpressed in Brain - Cerebellum (10.1) and Brain - Cerebellar Hemisphere (8.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM132E Gene

SOURCE GeneReport for Unigene cluster for TMEM132E Gene Hs.310482

genes like me logo Genes that share expressions with TMEM132E: view

No data available for mRNA Expression by UniProt/SwissProt for TMEM132E Gene

Orthologs for TMEM132E Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM132E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM132E 35
  • 99.31 (n)
  • 99.35 (a)
TMEM132E 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM132E 35
  • 91.44 (n)
  • 95.95 (a)
TMEM132E 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM132E 35
  • 90.01 (n)
  • 93.48 (a)
TMEM132E 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem132e 35
  • 86.42 (n)
  • 93.38 (a)
Tmem132e 16
Tmem132e 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM132E 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM132E 36
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem132e 35
  • 86.61 (n)
  • 93.29 (a)
chicken
(Gallus gallus)
Aves TMEM132E 35
  • 76.28 (n)
  • 77.69 (a)
TMEM132E 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM132E 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491853 35
  • 65.26 (n)
  • 69.27 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2901 35
zebrafish
(Danio rerio)
Actinopterygii tmem132e 35
  • 63.57 (n)
  • 61.3 (a)
TMEM132E 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004670 35
  • 40.83 (n)
  • 33.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14446 35
  • 44.97 (n)
  • 32.79 (a)
CG14446 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.10 36
  • 17 (a)
OneToMany
Species with no ortholog for TMEM132E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM132E Gene

ENSEMBL:
Gene Tree for TMEM132E (if available)
TreeFam:
Gene Tree for TMEM132E (if available)

Paralogs for TMEM132E Gene

Paralogs for TMEM132E Gene

Selected SIMAP similar genes for TMEM132E Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TMEM132E Gene

genes like me logo Genes that share paralogs with TMEM132E: view

Variants for TMEM132E Gene

Sequence variations from dbSNP and Humsavar for TMEM132E Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs730814 -- 34,636,818(-) TGCCT(A/G)ACCTT intron-variant
rs730815 -- 34,636,802(-) TACCC(C/G)CATCA intron-variant
rs736301 -- 34,610,894(-) catcc(A/G)tattt intron-variant
rs740637 -- 34,587,421(+) AGGCA(A/C)ATTTC intron-variant
rs758403 -- 34,629,267(-) CTTGT(C/T)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM132E Gene

Variant ID Type Subtype PubMed ID
nsv519297 CNV Gain 19592680
esv33292 CNV Gain 17666407
esv2715864 CNV Deletion 23290073
esv2715865 CNV Deletion 23290073
nsv833423 CNV Loss 17160897

Relevant External Links for TMEM132E Gene

HapMap Linkage Disequilibrium report
TMEM132E
Human Gene Mutation Database (HGMD)
TMEM132E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM132E Gene

Disorders for TMEM132E Gene

UniProtKB/Swiss-Prot

T132E_HUMAN
  • Note=TMEM132E is located in a region involved in a heterozygous deletion of approximately 4.7 Mb; this deletion, involving the NF1 gene and contiguous genes lying in its flanking regions, is observed in a patient 17q11.2 microdeletion syndrome, a syndrome characterized by variable facial dysmorphism, mental retardation, developmental delay, and an excessive number of neurofibromas. {ECO:0000269 PubMed:14569139}.

Relevant External Links for TMEM132E

Genetic Association Database (GAD)
TMEM132E
genes like me logo Genes that share disorders with TMEM132E: view

Publications for TMEM132E Gene

  1. Heterogeneity of breakpoints in non-LCR-mediated large constitutional deletions of the 17q11.2 NF1 tumour suppressor region. (PMID: 14569139) Kehrer-Sawatzki H. … Jenne D.E. (J. Med. Genet. 2003) 3 4
  2. Whole-exome sequencing identifies a variant in TMEM132E causing autosomal-recessive nonsyndromic hearing loss DFNB99. (PMID: 25331638) Li J. … Liu Q. (Hum. Mutat. 2015) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM132E Gene

Sources for TMEM132E Gene

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