TMEM132E Gene
protein-coding GIFtS: 39
GCID: GC17P032907
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transmembrane protein 132E
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Aliases
for TMEM132E gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 132E1 2 |
Export aliases for TMEM132E gene to outside databasesPrevious GC identifers: GC17P029932 GC17P029094 |
Summaries
for TMEM132E gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM132E gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM132E gene promoter:
Pax-5 CUTL1 AP-2gamma E47 YY1 c-Ets-1 S8 HSF2 Hand1 ZIC2/Zic2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM132E
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM132E |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q12TMEM132E Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P032907: view genomic region
(about GC identifiers)
Start:
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32,907,768 bp from pter |
End:
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32,966,337 bp from pter |
Size:
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58,570 bases |
Orientation:
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plus strand |
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Proteins
for TMEM132E gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T132E_HUMAN, Q6IEE7 (See
protein sequence)Recommended Name: Transmembrane protein 132E precursor Size: 984 amino acids; 107094 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: Q8WUF4 Q8WVA5Explore the universe of human proteins at neXtProt for TMEM132E: NX_Q6IEE7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6IEE7
TMEM132E Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_997196.1
ENSEMBL proteins: ENSP00000316532
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM132E for ontologies About GeneDecksing
TMEM132E Antibody Products:
Assay Products for TMEM132E: |
Protein
Domains /
Families
for TMEM132E gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM132E for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6IEE7ProtoNet protein and cluster: Q6IEE7 UniProtKB/Swiss-Prot: T132E_HUMAN, Q6IEE7Similarity: Belongs to the TMEM132 family |
Function
for TMEM132E gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM132E (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM132E
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM132E (NM_207313) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM132E | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM132E |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM132E |
1 GenomeRNAi human phenotype for TMEM132E:
|
Pathways & Interactions
for TMEM132E gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM132E
1 Interacting protein for TMEM132E (Q6IEE73) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TMEM132E gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM132E
Search CenterWatch for drugs/clinical trials and news about TMEM132E / T132E
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Transcripts
for TMEM132E gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM132E gene: NM_207313.1 Unigene Cluster for TMEM132E: Transmembrane protein 132E Hs.310482 [show with all ESTs]Unigene Representative Sequence: NM_2073132 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000321639(uc002hif.3) ENST00000577271
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM132E (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM132E
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM132E (NM_207313) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM132E | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM132E |
Additional cDNA sequence: BC018318.1 BC020591.1 1 DOTS entry: DT.102629 12 AceView cDNA sequences: AI678145 AA777050 NM_207313 BN000149 BC020591 BF346126 BQ068843 BC018318 BX281016 BG912538 N34927 BQ339724
GeneLoc Exon Structure
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Expression
for TMEM132E gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM132E expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACAGAGAGT
About this image
See TMEM132E Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM132E
SOURCE GeneReport for Unigene cluster: Hs.310482
SABiosciences Custom PCR Arrays for TMEM132E
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM132E
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM132E | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM132E | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM132E | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM132E |
Orthologs
for TMEM132E gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM132E gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for TMEM132E (if available)
TreeFam Gene Tree for TMEM132E (if available) |
Paralogs
for TMEM132E gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM132E gene
- TMEM132D2 TMEM132A2 TMEM132C2 TMEM132B2
3 SIMAP similar genes for TMEM132E using alignment to 1 protein entry: T132E_HUMAN:TMEM132C TMEM132D TMEM132B
TMEM132E for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TMEM132E
PGOHUM00000239608
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Genomic Variants
for TMEM132E gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM132E (32907768 - 32966337 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMEM132E
1 CNV: 7152 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM132E |
|
Disorders
/ Diseases
for TMEM132E gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TMEM132E for disorders About MalaCards
TMEM132E for disorders About GeneDecksing
UniProtKB/Swiss-Prot: T132E_HUMAN, Q6IEE7
Note=TMEM132E is located in a region involved in a heterozygous deletion of approximately 4.7 Mb; thisdeletion, involving the NF1 gene and contiguous genes lying in its flanking regions, is observed in a patient 17q11.2microdeletion syndrome, a syndrome characterized by variable facial dysmorphism, mental retardation, developmentaldelay, and an excessive number of neurofibromas
Export disorders for TMEM132E gene to outside databases
|
Publications
for TMEM132E gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM132E gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM132E) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Heterogeneity of breakpoints in non-LCR-mediated large constitutional deletions of the 17q11.2 NF1 tumour suppressor region. (PubMed id 14569139)1, 2 Kehrer-Sawatzki H.... Jenne D.E. (2003)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TMEM132E gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TMEM132E gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM132E gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM132E gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM132E | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TMEM132E gene:
Search GeneIP for patents involving TMEM132E
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM132E gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM132E | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM132E | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM132E | | | OriGene Protein Over-expression Lysate for TMEM132E | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM132E | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM132E | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM132E | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM132E | | OriGene Custom Protein Services for TMEM132E | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM132E | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM132E | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM132E | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM132E | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM132E | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM132E |
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 | | | TMEM132E Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM132E |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM132E |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM132E |
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