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Aliases for TMEM132D Gene

Aliases for TMEM132D Gene

  • Transmembrane Protein 132D 2 3 5
  • Mature Oligodendrocytes Transmembrane Protein 3 4
  • Mature OL Transmembrane Protein 3 4
  • MOLT 3 4
  • Protein Phosphatase 1, Regulatory Subunit 153 3
  • Regulatory Subunit 153 2
  • Protein Phosphatase 1 2
  • EC 63
  • EC 63
  • PPP1R153 3
  • KIAA1944 4
  • HBE120 4

External Ids for TMEM132D Gene

Previous GeneCards Identifiers for TMEM132D Gene

  • GC12M128122
  • GC12M129556
  • GC12M126540

Summaries for TMEM132D Gene

GeneCards Summary for TMEM132D Gene

TMEM132D (Transmembrane Protein 132D) is a Protein Coding gene. Diseases associated with TMEM132D include Pthirus Pubis Infestation and Lice Infestation. An important paralog of this gene is TMEM132A.

UniProtKB/Swiss-Prot for TMEM132D Gene

  • May serve as a cell-surface marker for oligodendrocyte differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM132D Gene

Genomics for TMEM132D Gene

Regulatory Elements for TMEM132D Gene

Enhancers for TMEM132D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM132D on UCSC Golden Path with GeneCards custom track

Promoters for TMEM132D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM132D on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM132D Gene

129,071,725 bp from pter
129,903,730 bp from pter
832,006 bases
Minus strand

Genomic View for TMEM132D Gene

Genes around TMEM132D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM132D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM132D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM132D Gene

Proteins for TMEM132D Gene

  • Protein details for TMEM132D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 132D
    Protein Accession:
    Secondary Accessions:
    • Q14C96
    • Q76M59
    • Q8N1W9
    • Q8N3Q5
    • Q8TF57

    Protein attributes for TMEM132D Gene

    1099 amino acids
    Molecular mass:
    122309 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB85530.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM132D Gene


neXtProt entry for TMEM132D Gene

Proteomics data for TMEM132D Gene at MOPED

Selected DME Specific Peptides for TMEM132D Gene

Post-translational modifications for TMEM132D Gene

  • Glycosylation at Asn 505
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM132D Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TMEM132D Gene

Gene Families for TMEM132D Gene

Protein Domains for TMEM132D Gene

Suggested Antigen Peptide Sequences for TMEM132D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM132 family.
  • Belongs to the TMEM132 family.
genes like me logo Genes that share domains with TMEM132D: view

Function for TMEM132D Gene

Molecular function for TMEM132D Gene

UniProtKB/Swiss-Prot Function:
May serve as a cell-surface marker for oligodendrocyte differentiation.

Enzyme Numbers (IUBMB) for TMEM132D Gene

genes like me logo Genes that share phenotypes with TMEM132D: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM132D Gene

Localization for TMEM132D Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM132D Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM132D Gene COMPARTMENTS Subcellular localization image for TMEM132D gene
Compartment Confidence
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM132D Gene

Pathways & Interactions for TMEM132D Gene

SuperPathways for TMEM132D Gene

No Data Available

Interacting Proteins for TMEM132D Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000408581 Q14C87-T132D_HUMAN for TMEM132D Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for TMEM132D Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM132D Gene

Drugs & Compounds for TMEM132D Gene

No Compound Related Data Available

Transcripts for TMEM132D Gene

mRNA/cDNA for TMEM132D Gene

Unigene Clusters for TMEM132D Gene

Transmembrane protein 132D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM132D Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - - - -

Relevant External Links for TMEM132D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM132D Gene

mRNA expression in normal human tissues for TMEM132D Gene

mRNA differential expression in normal tissues according to GTEx for TMEM132D Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x10.1), Brain - Cortex (x8.5), and Brain - Anterior cingulate cortex (BA24) (x8.1).

Protein differential expression in normal tissues from HIPED for TMEM132D Gene

This gene is overexpressed in Pancreas (42.9) and Urinary Bladder (17.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM132D Gene

SOURCE GeneReport for Unigene cluster for TMEM132D Gene Hs.507268

mRNA Expression by UniProt/SwissProt for TMEM132D Gene

Tissue specificity: Expressed in mature oligodendrocytes. Detected in the brain, lung, pancreas and testis.
genes like me logo Genes that share expression patterns with TMEM132D: view

Primer Products

No data available for Protein tissue co-expression partners for TMEM132D Gene

Orthologs for TMEM132D Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM132D Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM132D 35
  • 83.83 (n)
  • 84.87 (a)
TMEM132D 36
  • 85 (a)
(Canis familiaris)
Mammalia TMEM132D 35
  • 82.77 (n)
  • 83.21 (a)
TMEM132D 36
  • 83 (a)
(Mus musculus)
Mammalia Tmem132d 35
  • 81.86 (n)
  • 83.23 (a)
Tmem132d 16
Tmem132d 36
  • 83 (a)
(Pan troglodytes)
Mammalia TMEM132D 35
  • 98.88 (n)
  • 98.45 (a)
TMEM132D 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmem132d 35
  • 81.83 (n)
  • 83.41 (a)
(Monodelphis domestica)
Mammalia TMEM132D 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
-- 36
  • 81 (a)
(Gallus gallus)
Aves TMEM132D 35
  • 75.96 (n)
  • 80.78 (a)
TMEM132D 36
  • 80 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 76 (a)
-- 36
  • 69 (a)
(Danio rerio)
Actinopterygii si:dkey-112m2.1 35
  • 59.83 (n)
  • 53.57 (a)
CT027623.1 36
  • 47 (a)
CT583723.1 36
  • 41 (a)
FP102168.1 36
  • 29 (a)
si:dkey-112m2.1 36
  • 52 (a)
si:dkey-1d7.3 36
  • 34 (a)
si:dkey-215k6.1 36
  • 52 (a)
si:dkeyp-14d3.1 36
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14446 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea Y71H2AM.10 36
  • 20 (a)
Species with no ortholog for TMEM132D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM132D Gene

Gene Tree for TMEM132D (if available)
Gene Tree for TMEM132D (if available)

Paralogs for TMEM132D Gene

Paralogs for TMEM132D Gene

(4) SIMAP similar genes for TMEM132D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM132D: view

Variants for TMEM132D Gene

Sequence variations from dbSNP and Humsavar for TMEM132D Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs555131 - 129,074,541(+) GTCTG(A/C)AAGTG reference, missense
VAR_053887 -
VAR_053888 -
rs1922657 -- 129,293,863(+) GGCCC(A/G)GTTCC intron-variant
rs1947327 -- 129,807,851(+) GCAAT(C/T)TGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM132D Gene

Variant ID Type Subtype PubMed ID
nsv899621 CNV Gain 21882294
nsv899622 CNV Gain 21882294
nsv899624 CNV Gain 21882294
nsv899625 CNV Gain 21882294
nsv930 CNV Loss 18451855
nsv899626 CNV Loss 21882294
nsv821223 CNV Deletion 20802225
nsv512296 CNV Loss 21212237
esv2026523 CNV Deletion 18987734
esv28886 CNV Gain+Loss 19812545
esv5156 CNV Deletion 18987735
dgv228e201 CNV Deletion 23290073
dgv229e201 CNV Deletion 23290073
esv2746686 CNV Deletion 23290073
esv1447000 CNV Insertion 17803354
nsv517810 CNV Loss 19592680
esv2643994 CNV Deletion 19546169
esv1937281 CNV Deletion 18987734
nsv832550 CNV Loss 17160897
esv2673323 CNV Deletion 23128226
nsv899627 CNV Loss 21882294
nsv899628 CNV Loss 21882294
esv990167 CNV Loss 20482838
esv1035997 CNV Insertion 17803354
esv2674846 CNV Deletion 23128226
nsv899629 CNV Loss 21882294
esv2746688 CNV Deletion 23290073
esv275507 CNV Loss 21479260
esv275449 CNV Gain+Loss 21479260
nsv528720 CNV Loss 19592680
esv2667037 CNV Deletion 23128226
esv29089 CNV Loss 19812545
esv2746689 CNV Deletion 23290073
esv1272347 CNV Insertion 17803354
esv2746690 CNV Deletion 23290073
esv2746691 CNV Deletion 23290073
esv2466603 CNV Deletion 19546169
esv2080358 CNV Deletion 18987734
esv4067 CNV Deletion 18987735
esv2746692 CNV Deletion 23290073
esv9297 CNV Loss 19470904
esv2617454 CNV Deletion 19546169
esv2387529 CNV Deletion 18987734
esv2746693 CNV Deletion 23290073
nsv53551 CNV Loss 16902084
esv1537948 CNV Deletion 17803354
esv28408 CNV Gain+Loss 19812545
nsv826544 CNV Gain 20364138
esv2746694 CNV Deletion 23290073
esv2108752 CNV Deletion 18987734
dgv328e199 CNV Deletion 23128226
esv2746695 CNV Deletion 23290073
nsv512297 CNV Loss 21212237
esv2472744 CNV Deletion 19546169
nsv820410 CNV Deletion 20802225
esv2746698 CNV Deletion 23290073
esv2658113 CNV Deletion 23128226
esv1094163 CNV Deletion 17803354
esv2146269 CNV Deletion 18987734
esv2746699 CNV Deletion 23290073
esv2352393 CNV Deletion 18987734
esv2746700 CNV Deletion 23290073
esv2746701 CNV Deletion 23290073
esv2678068 CNV Deletion 23128226
nsv52627 CNV Insertion 16902084
esv1407768 CNV Insertion 17803354
esv2320601 CNV Deletion 18987734
esv2661380 CNV Deletion 23128226
nsv507683 CNV Insertion 20534489
nsv518434 CNV Loss 19592680
esv2746702 CNV Deletion 23290073
esv2746703 CNV Deletion 23290073
dgv1505n71 CNV Loss 21882294
esv9576 CNV Gain 19470904
essv11539 CNV CNV 17122850
dgv533e1 CNV Complex 17122850
nsv9011 CNV Loss 18304495
esv2746704 CNV Deletion 23290073
esv2746705 CNV Deletion 23290073
nsv53089 CNV Loss 16902084
nsv931 CNV Insertion 18451855
esv2666167 CNV Deletion 23128226
esv34208 CNV Gain 17911159
nsv818937 CNV Gain 17921354
nsv933 CNV Insertion 18451855
nsv436144 CNV Deletion 17901297
nsv9012 CNV Loss 18304495
esv2666701 CNV Deletion 23128226
esv26145 CNV Loss 19812545
esv2421700 CNV Deletion 20811451
nsv442297 CNV CNV 18776908
nsv517682 CNV Loss 19592680
esv2653252 CNV Deletion 19546169
esv2208288 CNV Deletion 18987734
esv3662 CNV Deletion 18987735
esv2670908 CNV Deletion 23128226
esv7244 CNV Loss 19470904
esv2746706 CNV Deletion 23290073
nsv53131 CNV Loss 16902084
nsv9013 CNV Loss 18304495
esv24214 CNV Loss 19812545
esv2746707 CNV Deletion 23290073
esv2746709 CNV Deletion 23290073
esv2538595 CNV Deletion 19546169
esv2746710 CNV Deletion 23290073
esv2145629 CNV Deletion 18987734
esv3125 CNV Deletion 18987735
esv2746711 CNV Deletion 23290073
esv2746712 CNV Deletion 23290073
nsv934 CNV Insertion 18451855
nsv9015 CNV Loss 18304495
nsv832551 CNV Loss 17160897
esv1161203 CNV Insertion 17803354
nsv53735 CNV Insertion 16902084
esv2676606 CNV Deletion 23128226
esv2746713 CNV Deletion 23290073
esv2331492 CNV Deletion 18987734
esv2746714 CNV Deletion 23290073
esv996554 CNV Deletion 20482838
esv2746715 CNV Deletion 23290073
esv1397992 CNV Deletion 17803354
esv2746716 CNV Deletion 23290073
esv2746717 CNV Deletion 23290073
nsv9016 CNV Loss 18304495
esv27708 CNV Loss 19812545
esv2658219 CNV Deletion 23128226
esv2746718 CNV Deletion 23290073
nsv826545 CNV Loss 20364138
nsv935 CNV Loss 18451855
nsv9017 CNV Loss 18304495
esv28732 CNV Loss 19812545
esv991412 CNV Loss 20482838
esv1008687 CNV Deletion 20482838
nsv820908 CNV Deletion 20802225
esv1675208 CNV Deletion 17803354
esv992696 CNV Deletion 20482838
esv2673704 CNV Deletion 23128226
esv2746720 CNV Deletion 23290073
esv2746721 CNV Deletion 23290073

Variation tolerance for TMEM132D Gene

Residual Variation Intolerance Score: 4.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.44; 71.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM132D Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM132D Gene

Disorders for TMEM132D Gene

MalaCards: The human disease database

(3) MalaCards diseases for TMEM132D Gene - From: DISEASES

Disorder Aliases PubMed IDs
pthirus pubis infestation
  • crabs
lice infestation
  • infestation by pediculus
parasitic ectoparasitic infectious disease
  • ectoparasitism
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM132D

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMEM132D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM132D Gene

Publications for TMEM132D Gene

  1. Molecular cloning of a novel transmembrane protein MOLT expressed by mature oligodendrocytes. (PMID: 12966072) Nomoto H. … Ninomiya Y. (J. Biochem. 2003) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3
  3. Higher anxiety and larger amygdala volumes in carriers of a TMEM132D risk variant for panic disorder. (PMID: 24495968) Haaker J. … Kalisch R. (Transl Psychiatry 2014) 3
  4. Genome-wide and gene-based association studies of anxiety disorders in European and African American samples. (PMID: 25390645) Otowa T. … Hettema J.M. (PLoS ONE 2014) 3
  5. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3

Products for TMEM132D Gene

Sources for TMEM132D Gene