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Aliases for TMEM132D Gene

Aliases for TMEM132D Gene

  • Transmembrane Protein 132D 2 3
  • MOLT 3 4 6
  • Mature Oligodendrocytes Transmembrane Protein 3 4
  • Mature OL Transmembrane Protein 3 4
  • KIAA1944 4 6
  • Protein Phosphatase 1, Regulatory Subunit 153 3
  • Regulatory Subunit 153 2
  • Protein Phosphatase 1 2
  • EC 3.6.3.14 63
  • EC 1.17.7.1 63
  • PPP1R153 3
  • HBE120 4

External Ids for TMEM132D Gene

Previous GeneCards Identifiers for TMEM132D Gene

  • GC12M128122
  • GC12M129556
  • GC12M126540

Summaries for TMEM132D Gene

GeneCards Summary for TMEM132D Gene

TMEM132D (Transmembrane Protein 132D) is a Protein Coding gene. An important paralog of this gene is TMEM132A.

UniProtKB/Swiss-Prot for TMEM132D Gene

  • May serve as a cell-surface marker for oligodendrocyte differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM132D Gene

Genomics for TMEM132D Gene

Regulatory Elements for TMEM132D Gene

Genomic Location for TMEM132D Gene

Start:
129,071,725 bp from pter
End:
129,903,667 bp from pter
Size:
831,943 bases
Orientation:
Minus strand

Genomic View for TMEM132D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM132D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM132D Gene

Proteins for TMEM132D Gene

  • Protein details for TMEM132D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14C87-T132D_HUMAN
    Recommended name:
    Transmembrane protein 132D
    Protein Accession:
    Q14C87
    Secondary Accessions:
    • Q14C96
    • Q76M59
    • Q8N1W9
    • Q8N3Q5
    • Q8TF57

    Protein attributes for TMEM132D Gene

    Size:
    1099 amino acids
    Molecular mass:
    122309 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85530.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM132D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM132D Gene

Proteomics data for TMEM132D Gene at MOPED

Selected DME Specific Peptides for TMEM132D Gene

Post-translational modifications for TMEM132D Gene

  • Glycosylation at Asn505
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM132D Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for TMEM132D Gene

Protein Domains for TMEM132D Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM132D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14C87

UniProtKB/Swiss-Prot:

T132D_HUMAN :
  • Q14C87
Family:
  • Belongs to the TMEM132 family.
genes like me logo Genes that share domains with TMEM132D: view

No data available for Gene Families for TMEM132D Gene

Function for TMEM132D Gene

Molecular function for TMEM132D Gene

UniProtKB/Swiss-Prot Function: May serve as a cell-surface marker for oligodendrocyte differentiation.

Enzyme Numbers (IUBMB) for TMEM132D Gene

Gene Ontology (GO) - Molecular Function for TMEM132D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19389623
genes like me logo Genes that share ontologies with TMEM132D: view

Phenotypes for TMEM132D Gene

GenomeRNAi human phenotypes for TMEM132D:
genes like me logo Genes that share phenotypes with TMEM132D: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM132D Gene

Localization for TMEM132D Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM132D Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM132D Gene COMPARTMENTS Subcellular localization image for TMEM132D gene
Compartment Confidence
extracellular 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM132D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane NAS 12966072
genes like me logo Genes that share ontologies with TMEM132D: view

Pathways for TMEM132D Gene

SuperPathways for TMEM132D Gene

No Data Available

Interacting Proteins for TMEM132D Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000408581%0d%0a9606.ENSP00000326031%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000408581 Q14C87-T132D_HUMAN for TMEM132D Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for TMEM132D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with TMEM132D: view

No data available for Pathways by source for TMEM132D Gene

Transcripts for TMEM132D Gene

mRNA/cDNA for TMEM132D Gene

Unigene Clusters for TMEM132D Gene

Transmembrane protein 132D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM132D Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - - - -
SP2:
SP3:
SP4:

Relevant External Links for TMEM132D Gene

GeneLoc Exon Structure for
TMEM132D
ECgene alternative splicing isoforms for
TMEM132D

Expression for TMEM132D Gene

mRNA expression in normal human tissues for TMEM132D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM132D Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (10.1), Brain - Cortex (8.5), and Brain - Anterior cingulate cortex (BA24) (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM132D Gene

SOURCE GeneReport for Unigene cluster for TMEM132D Gene Hs.507268

mRNA Expression by UniProt/SwissProt for TMEM132D Gene

Q14C87-T132D_HUMAN
Tissue specificity: Expressed in mature oligodendrocytes. Detected in the brain, lung, pancreas and testis.
genes like me logo Genes that share expressions with TMEM132D: view

Orthologs for TMEM132D Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM132D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM132D 35
  • 98.88 (n)
  • 98.45 (a)
TMEM132D 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM132D 35
  • 83.83 (n)
  • 84.87 (a)
TMEM132D 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM132D 35
  • 82.77 (n)
  • 83.21 (a)
TMEM132D 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem132d 35
  • 81.86 (n)
  • 83.23 (a)
Tmem132d 16
Tmem132d 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM132D 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem132d 35
  • 81.83 (n)
  • 83.41 (a)
chicken
(Gallus gallus)
Aves TMEM132D 35
  • 75.96 (n)
  • 80.78 (a)
TMEM132D 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 76 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CT027623.1 36
  • 47 (a)
ManyToMany
CT583723.1 36
  • 41 (a)
ManyToMany
FP102168.1 36
  • 29 (a)
ManyToMany
si:dkey-112m2.1 35
  • 59.83 (n)
  • 53.57 (a)
si:dkey-112m2.1 36
  • 52 (a)
ManyToMany
si:dkey-1d7.3 36
  • 34 (a)
ManyToMany
si:dkey-215k6.1 36
  • 52 (a)
ManyToMany
si:dkeyp-14d3.1 36
  • 51 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14446 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.10 36
  • 20 (a)
OneToMany
Species with no ortholog for TMEM132D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM132D Gene

ENSEMBL:
Gene Tree for TMEM132D (if available)
TreeFam:
Gene Tree for TMEM132D (if available)

Paralogs for TMEM132D Gene

Paralogs for TMEM132D Gene

Selected SIMAP similar genes for TMEM132D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM132D: view

Variants for TMEM132D Gene

Sequence variations from dbSNP and Humsavar for TMEM132D Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs17772 -- 129,890,903(+) CAAAT(A/G)GATCC intron-variant
rs89690 -- 129,821,496(-) CCCTG(A/C)AATTA intron-variant
rs89691 -- 129,821,632(-) TTGCC(C/T)CTGCC intron-variant
rs89692 -- 129,821,647(-) TTTTG(A/G)TTGGC intron-variant
rs149773 -- 129,637,745(+) agcct(C/T)aggaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM132D Gene

Variant ID Type Subtype PubMed ID
nsv899621 CNV Gain 21882294
nsv899622 CNV Gain 21882294
nsv899624 CNV Gain 21882294
nsv899625 CNV Gain 21882294
nsv930 CNV Loss 18451855
nsv899626 CNV Loss 21882294
nsv821223 CNV Deletion 20802225
nsv512296 CNV Loss 21212237
esv2026523 CNV Deletion 18987734
esv28886 CNV Gain+Loss 19812545
esv5156 CNV Deletion 18987735
dgv228e201 CNV Deletion 23290073
dgv229e201 CNV Deletion 23290073
esv2746686 CNV Deletion 23290073
esv1447000 CNV Insertion 17803354
nsv517810 CNV Loss 19592680
esv2643994 CNV Deletion 19546169
esv1937281 CNV Deletion 18987734
nsv832550 CNV Loss 17160897
esv2673323 CNV Deletion 23128226
nsv899627 CNV Loss 21882294
nsv899628 CNV Loss 21882294
esv990167 CNV Loss 20482838
esv1035997 CNV Insertion 17803354
esv2674846 CNV Deletion 23128226
nsv899629 CNV Loss 21882294
esv2746688 CNV Deletion 23290073
esv275507 CNV Loss 21479260
esv275449 CNV Gain+Loss 21479260
nsv528720 CNV Loss 19592680
esv2667037 CNV Deletion 23128226
esv29089 CNV Loss 19812545
esv2746689 CNV Deletion 23290073
esv1272347 CNV Insertion 17803354
esv2746690 CNV Deletion 23290073
esv2746691 CNV Deletion 23290073
esv2466603 CNV Deletion 19546169
esv2080358 CNV Deletion 18987734
esv4067 CNV Deletion 18987735
esv2746692 CNV Deletion 23290073
esv9297 CNV Loss 19470904
esv2617454 CNV Deletion 19546169
esv2387529 CNV Deletion 18987734
esv2746693 CNV Deletion 23290073
nsv53551 CNV Loss 16902084
esv1537948 CNV Deletion 17803354
esv28408 CNV Gain+Loss 19812545
nsv826544 CNV Gain 20364138
esv2746694 CNV Deletion 23290073
esv2108752 CNV Deletion 18987734
dgv328e199 CNV Deletion 23128226
esv2746695 CNV Deletion 23290073
nsv512297 CNV Loss 21212237
esv2472744 CNV Deletion 19546169
nsv820410 CNV Deletion 20802225
esv2746698 CNV Deletion 23290073
esv2658113 CNV Deletion 23128226
esv1094163 CNV Deletion 17803354
esv2146269 CNV Deletion 18987734
esv2746699 CNV Deletion 23290073
esv2352393 CNV Deletion 18987734
esv2746700 CNV Deletion 23290073
esv2746701 CNV Deletion 23290073
esv2678068 CNV Deletion 23128226
nsv52627 CNV Insertion 16902084
esv1407768 CNV Insertion 17803354
esv2320601 CNV Deletion 18987734
esv2661380 CNV Deletion 23128226
nsv507683 CNV Insertion 20534489
nsv518434 CNV Loss 19592680
esv2746702 CNV Deletion 23290073
esv2746703 CNV Deletion 23290073
dgv1505n71 CNV Loss 21882294
esv9576 CNV Gain 19470904
essv11539 CNV CNV 17122850
dgv533e1 CNV Complex 17122850
nsv9011 CNV Loss 18304495
esv2746704 CNV Deletion 23290073
esv2746705 CNV Deletion 23290073
nsv53089 CNV Loss 16902084
nsv931 CNV Insertion 18451855
esv2666167 CNV Deletion 23128226
esv34208 CNV Gain 17911159
nsv818937 CNV Gain 17921354
nsv933 CNV Insertion 18451855
nsv436144 CNV Deletion 17901297
nsv9012 CNV Loss 18304495
esv2666701 CNV Deletion 23128226
esv26145 CNV Loss 19812545
esv2421700 CNV Deletion 20811451
nsv442297 CNV CNV 18776908
nsv517682 CNV Loss 19592680
esv2653252 CNV Deletion 19546169
esv2208288 CNV Deletion 18987734
esv3662 CNV Deletion 18987735
esv2670908 CNV Deletion 23128226
esv7244 CNV Loss 19470904
esv2746706 CNV Deletion 23290073
nsv53131 CNV Loss 16902084
nsv9013 CNV Loss 18304495
esv24214 CNV Loss 19812545
esv2746707 CNV Deletion 23290073
esv2746709 CNV Deletion 23290073
esv2538595 CNV Deletion 19546169
esv2746710 CNV Deletion 23290073
esv2145629 CNV Deletion 18987734
esv3125 CNV Deletion 18987735
esv2746711 CNV Deletion 23290073
esv2746712 CNV Deletion 23290073
nsv934 CNV Insertion 18451855
nsv9015 CNV Loss 18304495
nsv832551 CNV Loss 17160897
esv1161203 CNV Insertion 17803354
nsv53735 CNV Insertion 16902084
esv2676606 CNV Deletion 23128226
esv2746713 CNV Deletion 23290073
esv2331492 CNV Deletion 18987734
esv2746714 CNV Deletion 23290073
esv996554 CNV Deletion 20482838
esv2746715 CNV Deletion 23290073
esv1397992 CNV Deletion 17803354
esv2746716 CNV Deletion 23290073
esv2746717 CNV Deletion 23290073
nsv9016 CNV Loss 18304495
esv27708 CNV Loss 19812545
esv2658219 CNV Deletion 23128226
esv2746718 CNV Deletion 23290073
nsv826545 CNV Loss 20364138
nsv935 CNV Loss 18451855
nsv9017 CNV Loss 18304495
esv28732 CNV Loss 19812545
esv991412 CNV Loss 20482838
esv1008687 CNV Deletion 20482838
nsv820908 CNV Deletion 20802225
esv1675208 CNV Deletion 17803354
esv992696 CNV Deletion 20482838
esv2673704 CNV Deletion 23128226
esv2746720 CNV Deletion 23290073
esv2746721 CNV Deletion 23290073

Relevant External Links for TMEM132D Gene

HapMap Linkage Disequilibrium report
TMEM132D
Human Gene Mutation Database (HGMD)
TMEM132D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM132D Gene

Disorders for TMEM132D Gene

(1) University of Copenhagen DISEASES for TMEM132D Gene

Relevant External Links for TMEM132D

Genetic Association Database (GAD)
TMEM132D
Human Genome Epidemiology (HuGE) Navigator
TMEM132D
genes like me logo Genes that share disorders with TMEM132D: view

No data available for UniProtKB/Swiss-Prot for TMEM132D Gene

Publications for TMEM132D Gene

  1. Molecular cloning of a novel transmembrane protein MOLT expressed by mature oligodendrocytes. (PMID: 12966072) Nomoto H. … Ninomiya Y. (J. Biochem. 2003) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for TMEM132D Gene

Sources for TMEM132D Gene

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