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Aliases for TMEM132C Gene

Aliases for TMEM132C Gene

  • Transmembrane Protein 132C 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 152 2 3
  • PPP1R152 3

External Ids for TMEM132C Gene

Previous GeneCards Identifiers for TMEM132C Gene

  • GC12P127318
  • GC12P127556
  • GC12P128899
  • GC12P125993
  • GC12P128751

Summaries for TMEM132C Gene

GeneCards Summary for TMEM132C Gene

TMEM132C (Transmembrane Protein 132C) is a Protein Coding gene. An important paralog of this gene is TMEM132D.

Additional gene information for TMEM132C Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM132C Gene

Genomics for TMEM132C Gene

GeneHancer (GH) Regulatory Elements for TMEM132C Gene

Promoters and enhancers for TMEM132C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I128267 Promoter 0.6 EPDnew 550.8 +0.0 5 0.1 EZH2 TMEM132C ENSG00000279180
GH12I128604 Enhancer 0.5 FANTOM5 2.8 +337.2 337246 0.1 MCM7 ARHGAP35 GMEB1 ZBTB2 DACH1 TMEM132C GC12M128595 GC12P128747
GH12I128337 Enhancer 0.4 ENCODE 0.2 +70.4 70417 1 MAX MNT MIR3612 ENSG00000257025 TMEM132C
GH12I128387 Enhancer 0.8 FANTOM5 ENCODE 0.1 +121.4 121420 2 CTCF ZNF143 SMC3 REST ZNF24 RAD21 ENSG00000257025 GC12M128380 MIR3612 TMEM132C
GH12I128449 Enhancer 0.7 ENCODE 0.1 +182.2 182218 0 SIX4 NCOA3 PKNOX1 NFIB NEUROD1 CTBP1 GATA3 POLR2A RCOR1 FOS ENSG00000256630 GC12M128595 TMEM132C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM132C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM132C gene promoter:

Genomic Locations for TMEM132C Gene

Genomic Locations for TMEM132C Gene
440,513 bases
Plus strand

Genomic View for TMEM132C Gene

Genes around TMEM132C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM132C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM132C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM132C Gene

Proteins for TMEM132C Gene

  • Protein details for TMEM132C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 132C
    Protein Accession:
    Secondary Accessions:
    • Q69YX8

    Protein attributes for TMEM132C Gene

    1108 amino acids
    Molecular mass:
    121787 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM132C Gene

Post-translational modifications for TMEM132C Gene

  • Glycosylation at posLast=316316 and isoforms=373

Other Protein References for TMEM132C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM132C Gene

Domains & Families for TMEM132C Gene

Gene Families for TMEM132C Gene

Protein Domains for TMEM132C Gene

Suggested Antigen Peptide Sequences for TMEM132C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM132 family.
  • Belongs to the TMEM132 family.
genes like me logo Genes that share domains with TMEM132C: view

Function for TMEM132C Gene

Phenotypes From GWAS Catalog for TMEM132C Gene

Gene Ontology (GO) - Molecular Function for TMEM132C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM132C: view

Phenotypes for TMEM132C Gene

GenomeRNAi human phenotypes for TMEM132C:
genes like me logo Genes that share phenotypes with TMEM132C: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM132C Gene

Localization for TMEM132C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM132C Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM132C gene
Compartment Confidence
cytosol 4
cytoskeleton 2
nucleus 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM132C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with TMEM132C: view

Pathways & Interactions for TMEM132C Gene

SuperPathways for TMEM132C Gene

No Data Available

Interacting Proteins for TMEM132C Gene

Selected Interacting proteins: Q8N3T6-T132C_HUMAN for TMEM132C Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMEM132C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM132C: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM132C Gene

Drugs & Compounds for TMEM132C Gene

No Compound Related Data Available

Transcripts for TMEM132C Gene

mRNA/cDNA for TMEM132C Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM132C Gene

Transmembrane protein 132C:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM132C Gene

No ASD Table

Relevant External Links for TMEM132C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM132C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM132C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM132C Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.9) and Adipose - Subcutaneous (x4.6).

Protein differential expression in normal tissues from HIPED for TMEM132C Gene

This gene is overexpressed in Lung (40.2) and Platelet (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM132C Gene

Protein tissue co-expression partners for TMEM132C Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM132C Gene:


SOURCE GeneReport for Unigene cluster for TMEM132C Gene:


Evidence on tissue expression from TISSUES for TMEM132C Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TMEM132C: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM132C Gene

Orthologs for TMEM132C Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM132C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM132C 33 34
  • 98.8 (n)
(Bos Taurus)
Mammalia TMEM132C 33 34
  • 84.39 (n)
(Canis familiaris)
Mammalia TMEM132C 33 34
  • 82.85 (n)
(Mus musculus)
Mammalia Tmem132c 33 16 34
  • 80.09 (n)
(Rattus norvegicus)
Mammalia Tmem132c 33
  • 79.84 (n)
(Monodelphis domestica)
Mammalia TMEM132C 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 78 (a)
-- 34
  • 72 (a)
(Gallus gallus)
Aves TMEM132C 33 34
  • 73.04 (n)
(Anolis carolinensis)
Reptilia TMEM132C 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem132c 33
  • 65.64 (n)
(Danio rerio)
Actinopterygii LOC556622 33
  • 56.92 (n)
si:dkey-215k6.1 34
  • 54 (a)
si:dkey-112m2.1 34
  • 51 (a)
si:dkeyp-14d3.1 34
  • 49 (a)
CT027623.1 34
  • 48 (a)
CT583723.1 34
  • 38 (a)
si:dkey-1d7.3 34
  • 34 (a)
FP102168.1 34
  • 31 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14446 34
  • 21 (a)
(Caenorhabditis elegans)
Secernentea Y71H2AM.10 34
  • 20 (a)
Species where no ortholog for TMEM132C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM132C Gene

Gene Tree for TMEM132C (if available)
Gene Tree for TMEM132C (if available)

Paralogs for TMEM132C Gene

Paralogs for TMEM132C Gene

(4) SIMAP similar genes for TMEM132C Gene using alignment to 3 proteins: Pseudogenes for TMEM132C Gene

genes like me logo Genes that share paralogs with TMEM132C: view

Variants for TMEM132C Gene

Sequence variations from dbSNP and Humsavar for TMEM132C Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000000618 -- 128,662,269(+) A/G intron_variant
rs1000006108 -- 128,397,766(+) A/G intron_variant
rs1000006890 -- 128,360,854(+) G/A intron_variant
rs1000015878 -- 128,291,298(+) C/G intron_variant
rs1000017653 -- 128,503,719(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM132C Gene

Variant ID Type Subtype PubMed ID
dgv1573n100 CNV gain 25217958
dgv207e201 CNV deletion 23290073
dgv208e201 CNV deletion 23290073
dgv2955n54 CNV loss 21841781
dgv77n111 CNV deletion 26073780
dgv939e59 CNV duplication 20981092
esv1452324 CNV deletion 17803354
esv1613955 CNV insertion 17803354
esv2064315 CNV deletion 18987734
esv22474 CNV loss 19812545
esv2366910 CNV deletion 18987734
esv2430199 CNV insertion 19546169
esv24895 CNV loss 19812545
esv2660111 CNV deletion 23128226
esv2666857 CNV deletion 23128226
esv2667521 CNV deletion 23128226
esv2670752 CNV deletion 23128226
esv2671695 CNV deletion 23128226
esv2675939 CNV deletion 23128226
esv2677056 CNV deletion 23128226
esv2746638 CNV deletion 23290073
esv2746639 CNV deletion 23290073
esv2746640 CNV deletion 23290073
esv2746643 CNV deletion 23290073
esv2746645 CNV deletion 23290073
esv2746646 CNV deletion 23290073
esv2746647 CNV deletion 23290073
esv2746648 CNV deletion 23290073
esv2746649 CNV deletion 23290073
esv2746650 CNV deletion 23290073
esv2746651 CNV deletion 23290073
esv2746653 CNV deletion 23290073
esv2746654 CNV deletion 23290073
esv2746655 CNV deletion 23290073
esv2746656 CNV deletion 23290073
esv2746658 CNV deletion 23290073
esv2746660 CNV deletion 23290073
esv2746661 CNV deletion 23290073
esv2746662 CNV deletion 23290073
esv2746664 CNV deletion 23290073
esv2759920 CNV loss 17122850
esv2760254 CNV loss 21179565
esv28350 CNV loss 19812545
esv3309369 CNV mobile element insertion 20981092
esv3331464 CNV insertion 20981092
esv33712 CNV gain 17666407
esv3405457 CNV insertion 20981092
esv3549986 CNV deletion 23714750
esv3549987 CNV deletion 23714750
esv3549989 CNV deletion 23714750
esv3580528 CNV loss 25503493
esv3581993 CNV gain 25503493
esv3631133 CNV gain 21293372
esv3631137 CNV loss 21293372
esv3631139 CNV loss 21293372
esv3631140 CNV loss 21293372
esv3631141 CNV loss 21293372
esv3631142 CNV gain 21293372
esv3631143 CNV gain 21293372
esv3892275 CNV loss 25118596
esv4473 CNV loss 18987735
esv9303 CNV loss 19470904
nsv1046660 CNV loss 25217958
nsv1047578 CNV loss 25217958
nsv1051433 CNV gain 25217958
nsv1070144 CNV deletion 25765185
nsv1070564 CNV deletion 25765185
nsv1113537 CNV deletion 24896259
nsv1118509 CNV duplication 24896259
nsv1124806 CNV deletion 24896259
nsv1125563 CNV tandem duplication 24896259
nsv1138185 CNV deletion 24896259
nsv1141221 CNV duplication 24896259
nsv1142820 CNV tandem duplication 24896259
nsv1145642 CNV deletion 24896259
nsv1150834 CNV insertion 26484159
nsv1151971 CNV deletion 26484159
nsv1160070 CNV duplication 26073780
nsv1160071 CNV duplication 26073780
nsv1160072 CNV duplication 26073780
nsv1160075 CNV duplication 26073780
nsv437775 CNV loss 16327808
nsv438241 CNV loss 16468122
nsv470325 CNV gain 18288195
nsv475359 CNV novel sequence insertion 20440878
nsv510325 OTHER sequence alteration 20534489
nsv513377 CNV insertion 21212237
nsv518258 CNV loss 19592680
nsv520287 CNV loss 19592680
nsv52720 CNV insertion 16902084
nsv527302 CNV loss 19592680
nsv52909 CNV deletion 16902084
nsv560643 CNV gain 21841781
nsv832547 CNV gain 17160897
nsv9008 CNV gain 18304495

Variation tolerance for TMEM132C Gene

Gene Damage Index Score: 11.24; 92.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM132C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM132C Gene

Disorders for TMEM132C Gene

Additional Disease Information for TMEM132C

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM132C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM132C Gene

Publications for TMEM132C Gene

  1. A genome-wide association study of attempted suicide. (PMID: 21423239) Willour VL … Potash JB (Molecular psychiatry 2012) 3 44 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Genome-wide association study in Han Chinese identifies three novel loci for human height. (PMID: 23456168) Hao Y … Gu D (Human genetics 2013) 3 58
  4. A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. (PMID: 24025145) Chung S … Nakamura Y (Breast cancer research : BCR 2013) 3 58
  5. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PMID: 21083371) Chinn LW … O'Brien SJ (The Journal of infectious diseases 2010) 44 58

Products for TMEM132C Gene

Sources for TMEM132C Gene

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