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Aliases for TMEM132C Gene

Aliases for TMEM132C Gene

  • Transmembrane Protein 132C 2 3
  • Protein Phosphatase 1, Regulatory Subunit 152 3
  • Regulatory Subunit 152 2
  • Protein Phosphatase 1 2
  • PPP1R152 3

External Ids for TMEM132C Gene

Summaries for TMEM132C Gene

GeneCards Summary for TMEM132C Gene

TMEM132C (Transmembrane Protein 132C) is a Protein Coding gene. An important paralog of this gene is TMEM132A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM132C Gene

Genomics for TMEM132C Gene

Genomic Location for TMEM132C Gene

Start:
128,267,403 bp from pter
End:
128,707,915 bp from pter
Size:
440,513 bases
Orientation:
Plus strand

Genomic View for TMEM132C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM132C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM132C Gene

Regulatory Elements for TMEM132C Gene

Proteins for TMEM132C Gene

  • Protein details for TMEM132C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3T6-T132C_HUMAN
    Recommended name:
    Transmembrane protein 132C
    Protein Accession:
    Q8N3T6
    Secondary Accessions:
    • Q69YX8

    Protein attributes for TMEM132C Gene

    Size:
    1108 amino acids
    Molecular mass:
    121787 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM132C Gene

Proteomics data for TMEM132C Gene at MOPED

Post-translational modifications for TMEM132C Gene

  • Glycosylation at Asn316 and Asn373

Other Protein References for TMEM132C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM132C Gene

Domains for TMEM132C Gene

Protein Domains for TMEM132C Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

T132C_HUMAN
Family:
  • Belongs to the TMEM132 family.:
    • Q8N3T6
genes like me logo Genes that share domains with TMEM132C: view

No data available for Gene Families for TMEM132C Gene

Function for TMEM132C Gene

Gene Ontology (GO) - Molecular Function for TMEM132C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM132C: view

Phenotypes for TMEM132C Gene

GenomeRNAi human phenotypes for TMEM132C:
genes like me logo Genes that share phenotypes with TMEM132C: view

miRNA for TMEM132C Gene

miRTarBase miRNAs that target TMEM132C

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM132C Gene

Localization for TMEM132C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM132C Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM132C Gene COMPARTMENTS Subcellular localization image for TMEM132C gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMEM132C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM132C: view

Pathways for TMEM132C Gene

SuperPathways for TMEM132C Gene

No Data Available

Interacting Proteins for TMEM132C Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000410852%0d%0a9606.ENSP00000326031%0d%0a
Selected Interacting proteins: ENSP00000410852 for TMEM132C Gene via STRING

Symbol External ID(s) Details
PPP1CA

Gene Ontology (GO) - Biological Process for TMEM132C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM132C: view

No data available for Pathways by source for TMEM132C Gene

Transcripts for TMEM132C Gene

mRNA/cDNA for TMEM132C Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM132C Gene

Transmembrane protein 132C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM132C Gene

No ASD Table

Relevant External Links for TMEM132C Gene

GeneLoc Exon Structure for
TMEM132C
ECgene alternative splicing isoforms for
TMEM132C

Expression for TMEM132C Gene

mRNA expression in normal human tissues for TMEM132C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM132C Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (4.9) and Adipose - Subcutaneous (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM132C Gene

SOURCE GeneReport for Unigene cluster for TMEM132C Gene Hs.49599

genes like me logo Genes that share expressions with TMEM132C: view

Orthologs for TMEM132C Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM132C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM132C 36
  • 98.8 (n)
  • 98.83 (a)
TMEM132C 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM132C 36
  • 84.39 (n)
  • 84.17 (a)
TMEM132C 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM132C 36
  • 82.85 (n)
  • 80.99 (a)
TMEM132C 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem132c 36
  • 80.09 (n)
  • 79.09 (a)
Tmem132c 16
Tmem132c 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM132C 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 78 (a)
OneToMany
-- 37
  • 72 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem132c 36
  • 79.84 (n)
  • 78.38 (a)
chicken
(Gallus gallus)
Aves TMEM132C 36
  • 73.04 (n)
  • 75.95 (a)
TMEM132C 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM132C 37
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem132c 36
  • 65.64 (n)
  • 67.66 (a)
zebrafish
(Danio rerio)
Actinopterygii CT027623.1 37
  • 48 (a)
ManyToMany
CT583723.1 37
  • 38 (a)
ManyToMany
FP102168.1 37
  • 31 (a)
ManyToMany
LOC556622 36
  • 56.92 (n)
  • 50.34 (a)
si:dkey-112m2.1 37
  • 51 (a)
ManyToMany
si:dkey-1d7.3 37
  • 34 (a)
ManyToMany
si:dkey-215k6.1 37
  • 54 (a)
ManyToMany
si:dkeyp-14d3.1 37
  • 49 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14446 37
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.10 37
  • 20 (a)
OneToMany
Species with no ortholog for TMEM132C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM132C Gene

ENSEMBL:
Gene Tree for TMEM132C (if available)
TreeFam:
Gene Tree for TMEM132C (if available)

Paralogs for TMEM132C Gene

Paralogs for TMEM132C Gene

Selected SIMAP similar genes for TMEM132C Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for TMEM132C Gene

genes like me logo Genes that share paralogs with TMEM132C: view

Variants for TMEM132C Gene

Sequence variations from dbSNP and Humsavar for TMEM132C Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs718397 -- 128,525,930(+) AATCC(C/T)GGATG intron-variant
rs867881 -- 128,339,173(-) GTGGG(A/G)GCTGA intron-variant
rs867965 -- 128,622,586(-) TCATG(C/T)ACGTC intron-variant
rs867966 -- 128,622,936(-) GCAAA(C/T)ATTTT intron-variant
rs871479 -- 128,613,141(-) ACCAT(C/T)CAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM132C Gene

Variant ID Type Subtype PubMed ID
nsv510325 CNV Loss 20534489
esv2746638 CNV Deletion 23290073
esv2064315 CNV Deletion 18987734
esv2667521 CNV Deletion 23128226
esv1613955 CNV Insertion 17803354
esv2746639 CNV Deletion 23290073
esv2746640 CNV Deletion 23290073
dgv226e201 CNV Deletion 23290073
esv2746643 CNV Deletion 23290073
nsv437775 CNV Loss 16327808
esv24895 CNV Loss 19812545
nsv9008 CNV Gain 18304495
nsv438241 CNV Loss 16468122
esv33712 CNV Gain 17666407
esv2675939 CNV Deletion 23128226
esv22474 CNV Loss 19812545
esv2660111 CNV Deletion 23128226
nsv832547 CNV Gain 17160897
esv2746645 CNV Deletion 23290073
esv2746646 CNV Deletion 23290073
esv2746647 CNV Deletion 23290073
nsv52720 CNV Insertion 16902084
esv2746648 CNV Deletion 23290073
esv2746649 CNV Deletion 23290073
esv2746650 CNV Deletion 23290073
nsv899616 CNV Gain 21882294
esv4473 CNV Deletion 18987735
esv2666857 CNV Deletion 23128226
esv2746651 CNV Deletion 23290073
nsv527302 CNV Loss 19592680
esv2746653 CNV Deletion 23290073
nsv518258 CNV Loss 19592680
esv2430199 CNV Insertion 19546169
esv2746654 CNV Deletion 23290073
nsv513377 CNV Insertion 21212237
esv2670752 CNV Deletion 23128226
esv2366910 CNV Deletion 18987734
dgv532e1 CNV Complex 17122850
esv28350 CNV Loss 19812545
esv2677056 CNV Deletion 23128226
esv2671695 CNV Deletion 23128226
esv2746655 CNV Deletion 23290073
nsv52909 CNV Loss 16902084
esv2746656 CNV Deletion 23290073
dgv227e201 CNV Deletion 23290073
esv2746658 CNV Deletion 23290073
esv2746660 CNV Deletion 23290073
esv273642 CNV Insertion 20981092
nsv470325 CNV Gain 18288195
nsv520287 CNV Loss 19592680
nsv899617 CNV Loss 21882294
esv2746661 CNV Deletion 23290073
esv2746662 CNV Deletion 23290073
esv1452324 CNV Deletion 17803354
esv2746664 CNV Deletion 23290073

Relevant External Links for TMEM132C Gene

HapMap Linkage Disequilibrium report
TMEM132C

Disorders for TMEM132C Gene

Relevant External Links for TMEM132C

Genetic Association Database (GAD)
TMEM132C
Human Genome Epidemiology (HuGE) Navigator
TMEM132C
genes like me logo Genes that share disorders with TMEM132C: view

No data available for UniProtKB/Swiss-Prot for TMEM132C Gene

Publications for TMEM132C Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  2. A genome-wide association study of attempted suicide. (PMID: 21423239) Willour V.L. … Potash J.B. (Mol. Psychiatry 2012) 3 49
  3. Genome-wide association study in Han Chinese identifies three novel loci for human height. (PMID: 23456168) Hao Y. … Gu D. (Hum. Genet. 2013) 3
  4. A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. (PMID: 24025145) Chung S. … Nakamura Y. (Breast Cancer Res. 2013) 3
  5. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PMID: 17903295) Lunetta K.L. … Murabito J.M. (BMC Med. Genet. 2007) 49

Products for TMEM132C Gene

Sources for TMEM132C Gene

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