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Aliases for TMEM132B Gene

Aliases for TMEM132B Gene

  • Transmembrane Protein 132B 2 3 5
  • KIAA1786 4
  • KIAA1906 4

External Ids for TMEM132B Gene

Previous GeneCards Identifiers for TMEM132B Gene

  • GC12P124377
  • GC12P125811
  • GC12P122777
  • GC12P125671

Summaries for TMEM132B Gene

GeneCards Summary for TMEM132B Gene

TMEM132B (Transmembrane Protein 132B) is a Protein Coding gene. An important paralog of this gene is TMEM132C.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM132B Gene

Genomics for TMEM132B Gene

Regulatory Elements for TMEM132B Gene

Enhancers for TMEM132B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G125097 0.5 FANTOM5 dbSUPER 34.7 -89.1 -89145 0.4 TMEM132B AACS LOC100131779 LOC105370052 PIR33215
GH12G125330 1 Ensembl ENCODE 10.3 +144.4 144429 0.8 CTCF RB1 ZMYM3 ZNF48 RAD21 ZNF121 ZFHX2 GLIS2 POLR2A EGR1 TMEM132B ENSG00000279462 GC12P125434
GH12G124679 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.4 -502.6 -502592 10.1 PKNOX1 FOXA2 ARID4B SIN3A YY1 ZNF766 ZNF207 ZNF548 FOS NFYC ATP6V0A2 NCOR2 TMEM132B DNAH10 UBC PIR31698 GC12M124443
GH12G125328 0.5 ENCODE 19.2 +142.7 142731 1.5 JUND SMARCA4 POLR2A CTBP2 CHD7 TMEM132B ENSG00000279462 GC12P125434
GH12G125092 1.5 FANTOM5 ENCODE dbSUPER 5.8 -92.9 -92852 3.6 FOXA2 ZFP64 ARID4B DMAP1 YY1 SP5 MXD4 MIER2 PPARG KAT8 AACS TMEM132B LOC105370052 PIR33215
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM132B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM132B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000059034 -174 801 INSM2 KLF17 NFXL1 GLIS2 ZNF416 EGR2 ZNF263 SP3 SP5 GLIS1

Genomic Location for TMEM132B Gene

Chromosome:
12
Start:
125,186,774 bp from pter
End:
125,662,377 bp from pter
Size:
475,604 bases
Orientation:
Plus strand

Genomic View for TMEM132B Gene

Genes around TMEM132B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM132B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM132B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM132B Gene

Proteins for TMEM132B Gene

  • Protein details for TMEM132B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14DG7-T132B_HUMAN
    Recommended name:
    Transmembrane protein 132B
    Protein Accession:
    Q14DG7
    Secondary Accessions:
    • A2RRG8
    • Q8NA73
    • Q96JN9
    • Q96PY1

    Protein attributes for TMEM132B Gene

    Size:
    1078 amino acids
    Molecular mass:
    119477 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM132B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM132B Gene

Post-translational modifications for TMEM132B Gene

  • Glycosylation at posLast=343343, isoforms=2366, and Asn381
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM132B Gene

No data available for DME Specific Peptides for TMEM132B Gene

Domains & Families for TMEM132B Gene

Protein Domains for TMEM132B Gene

Suggested Antigen Peptide Sequences for TMEM132B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14DG7

UniProtKB/Swiss-Prot:

T132B_HUMAN :
  • Belongs to the TMEM132 family.
Family:
  • Belongs to the TMEM132 family.
genes like me logo Genes that share domains with TMEM132B: view

No data available for Gene Families for TMEM132B Gene

Function for TMEM132B Gene

Gene Ontology (GO) - Molecular Function for TMEM132B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM132B: view
genes like me logo Genes that share phenotypes with TMEM132B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM132B Gene

Localization for TMEM132B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM132B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM132B gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM132B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with TMEM132B: view

Pathways & Interactions for TMEM132B Gene

SuperPathways for TMEM132B Gene

No Data Available

Interacting Proteins for TMEM132B Gene

Gene Ontology (GO) - Biological Process for TMEM132B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM132B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM132B Gene

Transcripts for TMEM132B Gene

Unigene Clusters for TMEM132B Gene

Transmembrane protein 132B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM132B Gene

No ASD Table

Relevant External Links for TMEM132B Gene

GeneLoc Exon Structure for
TMEM132B
ECgene alternative splicing isoforms for
TMEM132B

Expression for TMEM132B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM132B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM132B Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.0), Brain - Anterior cingulate cortex (BA24) (x5.5), Brain - Cortex (x5.5), and Brain - Nucleus accumbens (basal ganglia) (x4.6).

Protein differential expression in normal tissues from HIPED for TMEM132B Gene

This gene is overexpressed in Plasma (57.3) and Pancreatic juice (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM132B Gene



Protein tissue co-expression partners for TMEM132B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM132B Gene:

TMEM132B

SOURCE GeneReport for Unigene cluster for TMEM132B Gene:

Hs.524838

Evidence on tissue expression from TISSUES for TMEM132B Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with TMEM132B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM132B Gene

Orthologs for TMEM132B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM132B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM132B 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia TMEM132B 34 35
  • 87.08 (n)
cow
(Bos Taurus)
Mammalia TMEM132B 34 35
  • 86.71 (n)
rat
(Rattus norvegicus)
Mammalia Tmem132b 34
  • 83.37 (n)
mouse
(Mus musculus)
Mammalia Tmem132b 34 16 35
  • 82.99 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM132B 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM132B 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM132B 34 35
  • 72.36 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM132B 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem132b 34
  • 66.41 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-215k6.1 35
  • 51 (a)
ManyToMany
si:dkey-112m2.1 35
  • 46 (a)
ManyToMany
si:dkeyp-14d3.1 35
  • 45 (a)
ManyToMany
CT027623.1 35
  • 41 (a)
ManyToMany
CT583723.1 35
  • 34 (a)
ManyToMany
si:dkey-1d7.3 35
  • 32 (a)
ManyToMany
FP102168.1 35
  • 26 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14446 35
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.10 35
  • 19 (a)
OneToMany
Species where no ortholog for TMEM132B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM132B Gene

ENSEMBL:
Gene Tree for TMEM132B (if available)
TreeFam:
Gene Tree for TMEM132B (if available)

Paralogs for TMEM132B Gene

Paralogs for TMEM132B Gene

(4) SIMAP similar genes for TMEM132B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TMEM132B Gene

genes like me logo Genes that share paralogs with TMEM132B: view

Variants for TMEM132B Gene

Sequence variations from dbSNP and Humsavar for TMEM132B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000002107 -- 125,241,287(+) TATTT(C/T)GAGAT intron-variant
rs1000006889 -- 125,617,872(+) CTGAT(G/T)CTTTC intron-variant
rs1000009734 -- 125,490,256(+) TTATC(C/G)TCATT intron-variant
rs1000019837 -- 125,247,978(+) GGGGA(C/G/T)ACATC intron-variant
rs1000020647 -- 125,414,654(+) CCAGC(A/G)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM132B Gene

Variant ID Type Subtype PubMed ID
dgv204e201 CNV deletion 23290073
dgv205e201 CNV deletion 23290073
dgv892n106 CNV deletion 24896259
dgv929e59 CNV duplication 20981092
esv1336277 CNV insertion 17803354
esv2402185 CNV deletion 18987734
esv24345 CNV loss 19812545
esv2676387 CNV deletion 23128226
esv2676988 CNV deletion 23128226
esv2746571 CNV deletion 23290073
esv2746577 CNV deletion 23290073
esv2746578 CNV deletion 23290073
esv2746579 CNV deletion 23290073
esv2746580 CNV deletion 23290073
esv2746581 CNV deletion 23290073
esv274917 CNV loss 21479260
esv3310557 CNV novel sequence insertion 20981092
esv3351714 CNV duplication 20981092
esv3451232 CNV duplication 20981092
esv3580514 CNV loss 25503493
esv3631039 CNV gain 21293372
esv3631043 CNV loss 21293372
esv4399 CNV loss 18987735
esv7647 CNV loss 19470904
esv991637 CNV deletion 20482838
nsv1036206 CNV gain 25217958
nsv1051020 CNV gain 25217958
nsv1070141 CNV deletion 25765185
nsv1122782 CNV deletion 24896259
nsv1135798 CNV deletion 24896259
nsv471987 CNV novel sequence insertion 20440878
nsv473690 CNV novel sequence insertion 20440878
nsv518416 CNV loss 19592680
nsv832540 CNV gain 17160897
nsv832541 CNV gain 17160897
nsv918 CNV insertion 18451855
nsv919 CNV insertion 18451855
nsv976658 CNV duplication 23825009

Variation tolerance for TMEM132B Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.12; 93.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM132B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM132B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM132B Gene

Disorders for TMEM132B Gene

Relevant External Links for TMEM132B

Genetic Association Database (GAD)
TMEM132B
Human Genome Epidemiology (HuGE) Navigator
TMEM132B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM132B

No disorders were found for TMEM132B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM132B Gene

Publications for TMEM132B Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4 64
  5. Lessons learned from whole exome sequencing in multiplex families affected by a complex genetic disorder, intracranial aneurysm. (PMID: 25803036) Farlow J.L. … Foroud T. (PLoS ONE 2015) 3 64

Products for TMEM132B Gene

Sources for TMEM132B Gene

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