Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM132B Gene

Aliases for TMEM132B Gene

  • Transmembrane Protein 132B 2 3 5
  • KIAA1786 4
  • KIAA1906 4

External Ids for TMEM132B Gene

Previous GeneCards Identifiers for TMEM132B Gene

  • GC12P124377
  • GC12P125811
  • GC12P122777
  • GC12P125671

Summaries for TMEM132B Gene

GeneCards Summary for TMEM132B Gene

TMEM132B (Transmembrane Protein 132B) is a Protein Coding gene. An important paralog of this gene is TMEM132D.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM132B Gene

Genomics for TMEM132B Gene

Regulatory Elements for TMEM132B Gene

Promoters for TMEM132B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM132B on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM132B Gene

Chromosome:
12
Start:
125,186,774 bp from pter
End:
125,662,377 bp from pter
Size:
475,604 bases
Orientation:
Plus strand

Genomic View for TMEM132B Gene

Genes around TMEM132B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM132B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM132B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM132B Gene

Proteins for TMEM132B Gene

  • Protein details for TMEM132B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14DG7-T132B_HUMAN
    Recommended name:
    Transmembrane protein 132B
    Protein Accession:
    Q14DG7
    Secondary Accessions:
    • A2RRG8
    • Q8NA73
    • Q96JN9
    • Q96PY1

    Protein attributes for TMEM132B Gene

    Size:
    1078 amino acids
    Molecular mass:
    119477 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM132B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM132B Gene

Proteomics data for TMEM132B Gene at MOPED

Post-translational modifications for TMEM132B Gene

  • Glycosylation at Asn 343, Asn 366, and Asn 381
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM132B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM132B Gene

Domains & Families for TMEM132B Gene

Protein Domains for TMEM132B Gene

Suggested Antigen Peptide Sequences for TMEM132B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14DG7

UniProtKB/Swiss-Prot:

T132B_HUMAN :
  • Belongs to the TMEM132 family.
Family:
  • Belongs to the TMEM132 family.
genes like me logo Genes that share domains with TMEM132B: view

No data available for Gene Families for TMEM132B Gene

Function for TMEM132B Gene

genes like me logo Genes that share phenotypes with TMEM132B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM132B Gene

Localization for TMEM132B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM132B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM132B Gene COMPARTMENTS Subcellular localization image for TMEM132B gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM132B Gene

Pathways & Interactions for TMEM132B Gene

SuperPathways for TMEM132B Gene

No Data Available

Interacting Proteins for TMEM132B Gene

Gene Ontology (GO) - Biological Process for TMEM132B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM132B Gene

Drugs & Compounds for TMEM132B Gene

No Compound Related Data Available

Transcripts for TMEM132B Gene

Unigene Clusters for TMEM132B Gene

Transmembrane protein 132B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM132B Gene

No ASD Table

Relevant External Links for TMEM132B Gene

GeneLoc Exon Structure for
TMEM132B
ECgene alternative splicing isoforms for
TMEM132B

Expression for TMEM132B Gene

mRNA expression in normal human tissues for TMEM132B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM132B Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.0), Brain - Anterior cingulate cortex (BA24) (x5.5), Brain - Cortex (x5.5), and Brain - Nucleus accumbens (basal ganglia) (x4.6).

Protein differential expression in normal tissues from HIPED for TMEM132B Gene

This gene is overexpressed in Plasma (57.3) and Pancreatic juice (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM132B Gene



SOURCE GeneReport for Unigene cluster for TMEM132B Gene Hs.524838

genes like me logo Genes that share expression patterns with TMEM132B: view

Protein tissue co-expression partners for TMEM132B Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM132B Gene

Orthologs for TMEM132B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM132B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM132B 36
  • 99 (a)
OneToOne
TMEM132B 35
  • 99.55 (n)
  • 99.66 (a)
cow
(Bos Taurus)
Mammalia TMEM132B 35
  • 86.71 (n)
  • 87.94 (a)
TMEM132B 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM132B 35
  • 87.08 (n)
  • 88.58 (a)
TMEM132B 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem132b 16
Tmem132b 36
  • 85 (a)
OneToOne
Tmem132b 35
  • 82.99 (n)
  • 86.91 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM132B 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM132B 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem132b 35
  • 83.37 (n)
  • 87.57 (a)
chicken
(Gallus gallus)
Aves TMEM132B 35
  • 72.36 (n)
  • 73.15 (a)
TMEM132B 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM132B 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem132b 35
  • 66.41 (n)
  • 63.83 (a)
zebrafish
(Danio rerio)
Actinopterygii CT027623.1 36
  • 41 (a)
ManyToMany
CT583723.1 36
  • 34 (a)
ManyToMany
FP102168.1 36
  • 26 (a)
ManyToMany
si:dkey-112m2.1 36
  • 46 (a)
ManyToMany
si:dkey-1d7.3 36
  • 32 (a)
ManyToMany
si:dkey-215k6.1 36
  • 51 (a)
ManyToMany
si:dkeyp-14d3.1 36
  • 45 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14446 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.10 36
  • 19 (a)
OneToMany
Species with no ortholog for TMEM132B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM132B Gene

ENSEMBL:
Gene Tree for TMEM132B (if available)
TreeFam:
Gene Tree for TMEM132B (if available)

Paralogs for TMEM132B Gene

Paralogs for TMEM132B Gene

(4) SIMAP similar genes for TMEM132B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TMEM132B Gene

genes like me logo Genes that share paralogs with TMEM132B: view

Variants for TMEM132B Gene

Sequence variations from dbSNP and Humsavar for TMEM132B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_031786 -
rs364441 -- 125,319,615(+) TCAGG(C/G)CTGCG intron-variant
rs366660 -- 125,427,265(-) ataaa(C/T)gttgC intron-variant
rs368306 -- 125,416,368(-) AGGCC(A/G)CATGT intron-variant
rs724346 -- 125,416,857(-) TGCAG(A/G)GAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM132B Gene

Variant ID Type Subtype PubMed ID
nsv832540 CNV Gain 17160897
nsv918 CNV Insertion 18451855
esv2746571 CNV Deletion 23290073
dgv223e201 CNV Deletion 23290073
dgv224e201 CNV Deletion 23290073
esv7647 CNV Loss 19470904
esv2676988 CNV Deletion 23128226
esv24345 CNV Loss 19812545
nsv832541 CNV Gain 17160897
esv2746577 CNV Deletion 23290073
esv4399 CNV Deletion 18987735
esv2746578 CNV Deletion 23290073
esv2676387 CNV Deletion 23128226
nsv518416 CNV Loss 19592680
esv274917 CNV Loss 21479260
nsv899597 CNV Gain 21882294
esv2746579 CNV Deletion 23290073
esv2402185 CNV Deletion 18987734
esv2746580 CNV Deletion 23290073
esv2746581 CNV Deletion 23290073
esv991637 CNV Deletion 20482838
esv1336277 CNV Insertion 17803354
nsv919 CNV Insertion 18451855

Variation tolerance for TMEM132B Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.12; 93.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM132B Gene

HapMap Linkage Disequilibrium report
TMEM132B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM132B Gene

Disorders for TMEM132B Gene

Relevant External Links for TMEM132B

Genetic Association Database (GAD)
TMEM132B
Human Genome Epidemiology (HuGE) Navigator
TMEM132B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM132B

No disorders were found for TMEM132B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM132B Gene

Publications for TMEM132B Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 67
  2. Lessons learned from whole exome sequencing in multiplex families affected by a complex genetic disorder, intracranial aneurysm. (PMID: 25803036) Farlow J.L. … Foroud T. (PLoS ONE 2015) 3
  3. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. (PMID: 24529757) Xie T. … Xu R. (Neurobiol. Aging 2014) 3
  4. Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2. (PMID: 24322204) Winham S.J. … Biernacka J.M. (Mol. Psychiatry 2013) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for TMEM132B Gene

Sources for TMEM132B Gene

Back to Top

Content