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Aliases for TMEM132B Gene

Aliases for TMEM132B Gene

  • Transmembrane Protein 132B 2 3
  • KIAA1786 4
  • KIAA1906 4

External Ids for TMEM132B Gene

Previous GeneCards Identifiers for TMEM132B Gene

  • GC12P124377
  • GC12P125811
  • GC12P122777
  • GC12P125671

Summaries for TMEM132B Gene

GeneCards Summary for TMEM132B Gene

TMEM132B (Transmembrane Protein 132B) is a Protein Coding gene. An important paralog of this gene is TMEM132A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM132B Gene

Genomics for TMEM132B Gene

Regulatory Elements for TMEM132B Gene

Genomic Location for TMEM132B Gene

Start:
125,186,836 bp from pter
End:
125,662,377 bp from pter
Size:
475,542 bases
Orientation:
Plus strand

Genomic View for TMEM132B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM132B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM132B Gene

Proteins for TMEM132B Gene

  • Protein details for TMEM132B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14DG7-T132B_HUMAN
    Recommended name:
    Transmembrane protein 132B
    Protein Accession:
    Q14DG7
    Secondary Accessions:
    • A2RRG8
    • Q8NA73
    • Q96JN9
    • Q96PY1

    Protein attributes for TMEM132B Gene

    Size:
    1078 amino acids
    Molecular mass:
    119477 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM132B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM132B Gene

Proteomics data for TMEM132B Gene at MOPED

Post-translational modifications for TMEM132B Gene

  • Glycosylation at Asn343, Asn366, and Asn381
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM132B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM132B Gene

Domains for TMEM132B Gene

Protein Domains for TMEM132B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM132B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14DG7

UniProtKB/Swiss-Prot:

T132B_HUMAN :
  • Q14DG7
Family:
  • Belongs to the TMEM132 family.
genes like me logo Genes that share domains with TMEM132B: view

No data available for Gene Families for TMEM132B Gene

Function for TMEM132B Gene

Gene Ontology (GO) - Molecular Function for TMEM132B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM132B: view

Phenotypes for TMEM132B Gene

GenomeRNAi human phenotypes for TMEM132B:
genes like me logo Genes that share phenotypes with TMEM132B: view

miRNA for TMEM132B Gene

miRTarBase miRNAs that target TMEM132B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM132B Gene

Localization for TMEM132B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM132B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM132B Gene COMPARTMENTS Subcellular localization image for TMEM132B gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMEM132B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM132B: view

Pathways for TMEM132B Gene

SuperPathways for TMEM132B Gene

No Data Available

Interacting Proteins for TMEM132B Gene

Gene Ontology (GO) - Biological Process for TMEM132B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM132B: view

No data available for Pathways by source for TMEM132B Gene

Transcripts for TMEM132B Gene

Unigene Clusters for TMEM132B Gene

Transmembrane protein 132B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM132B Gene

No ASD Table

Relevant External Links for TMEM132B Gene

GeneLoc Exon Structure for
TMEM132B
ECgene alternative splicing isoforms for
TMEM132B

Expression for TMEM132B Gene

mRNA expression in normal human tissues for TMEM132B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM132B Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (6.0), Brain - Anterior cingulate cortex (BA24) (5.5), Brain - Cortex (5.5), and Brain - Nucleus accumbens (basal ganglia) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM132B Gene

SOURCE GeneReport for Unigene cluster for TMEM132B Gene Hs.524838

genes like me logo Genes that share expressions with TMEM132B: view

No data available for mRNA Expression by UniProt/SwissProt for TMEM132B Gene

Orthologs for TMEM132B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM132B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM132B 35
  • 99.55 (n)
  • 99.66 (a)
TMEM132B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM132B 35
  • 86.71 (n)
  • 87.94 (a)
TMEM132B 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM132B 35
  • 87.08 (n)
  • 88.58 (a)
TMEM132B 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem132b 35
  • 82.99 (n)
  • 86.91 (a)
Tmem132b 16
Tmem132b 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM132B 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM132B 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem132b 35
  • 83.37 (n)
  • 87.57 (a)
chicken
(Gallus gallus)
Aves TMEM132B 35
  • 72.36 (n)
  • 73.15 (a)
TMEM132B 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM132B 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem132b 35
  • 66.41 (n)
  • 63.83 (a)
zebrafish
(Danio rerio)
Actinopterygii CT027623.1 36
  • 41 (a)
ManyToMany
CT583723.1 36
  • 34 (a)
ManyToMany
FP102168.1 36
  • 26 (a)
ManyToMany
si:dkey-112m2.1 36
  • 46 (a)
ManyToMany
si:dkey-1d7.3 36
  • 32 (a)
ManyToMany
si:dkey-215k6.1 36
  • 51 (a)
ManyToMany
si:dkeyp-14d3.1 36
  • 45 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14446 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.10 36
  • 19 (a)
OneToMany
Species with no ortholog for TMEM132B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM132B Gene

ENSEMBL:
Gene Tree for TMEM132B (if available)
TreeFam:
Gene Tree for TMEM132B (if available)

Paralogs for TMEM132B Gene

Paralogs for TMEM132B Gene

Selected SIMAP similar genes for TMEM132B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TMEM132B Gene

genes like me logo Genes that share paralogs with TMEM132B: view

Variants for TMEM132B Gene

Sequence variations from dbSNP and Humsavar for TMEM132B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs161713 -- 125,373,164(-) actgg(G/T)gatac intron-variant
rs161714 -- 125,406,525(-) CAAAG(A/G)GGAGC intron-variant
rs161715 -- 125,406,350(-) CTGCT(A/G)ATACA intron-variant
rs161716 -- 125,404,798(-) GATAC(A/G)CCCAG intron-variant
rs161881 -- 125,403,101(-) AGACA(C/T)TGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM132B Gene

Variant ID Type Subtype PubMed ID
nsv832540 CNV Gain 17160897
nsv918 CNV Insertion 18451855
esv2746571 CNV Deletion 23290073
dgv223e201 CNV Deletion 23290073
dgv224e201 CNV Deletion 23290073
esv7647 CNV Loss 19470904
esv2676988 CNV Deletion 23128226
esv24345 CNV Loss 19812545
nsv832541 CNV Gain 17160897
esv2746577 CNV Deletion 23290073
esv4399 CNV Deletion 18987735
esv2746578 CNV Deletion 23290073
esv2676387 CNV Deletion 23128226
nsv518416 CNV Loss 19592680
esv274917 CNV Loss 21479260
nsv899597 CNV Gain 21882294
esv2746579 CNV Deletion 23290073
esv2402185 CNV Deletion 18987734
esv2746580 CNV Deletion 23290073
esv2746581 CNV Deletion 23290073
esv991637 CNV Deletion 20482838
esv1336277 CNV Insertion 17803354
nsv919 CNV Insertion 18451855

Relevant External Links for TMEM132B Gene

HapMap Linkage Disequilibrium report
TMEM132B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM132B Gene

Disorders for TMEM132B Gene

Relevant External Links for TMEM132B

Genetic Association Database (GAD)
TMEM132B
Human Genome Epidemiology (HuGE) Navigator
TMEM132B
genes like me logo Genes that share disorders with TMEM132B: view

No data available for UniProtKB/Swiss-Prot for TMEM132B Gene

Publications for TMEM132B Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2. (PMID: 24322204) Winham S.J. … Biernacka J.M. (Mol. Psychiatry 2013) 3

Products for TMEM132B Gene

Sources for TMEM132B Gene

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