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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMEM132B Gene

protein-coding GIFtS: 43
GCID: GC12P125671

transmembrane protein 132B

Search for TMEM132B
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transmembrane Protein 132B¹ ²
KIAA1786¹ ³
KIAA1906¹ ³

External Ids:	HGNC: 29397¹	Entrez Gene: 114795²	Ensembl: ENSG00000139364⁷	UniProtKB: Q14DG7³

Export aliases for TMEM132B gene to outside databases

Previous GC identifers: GC12P124377 GC12P125811 GC12P122777

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009755.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TMEM132B gene promoter:
RP58 LHX3b/Lhx3b Brachyury GCNF CUTL1 GCNF-1 HFH-1 LHX3a/Lhx3a GCNF-2 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM132B promoter sequence

Search SABiosciences Chromatin IP Primers for TMEM132B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM132B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31

TMEM132B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM132B gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P125671: view genomic region (about GC identifiers)

Start:	125,671,382 bp from pter	End:	126,146,917 bp from pter
Size:	475,536 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: T132B_HUMAN, Q14DG7 (See protein sequence)

Recommended Name: Transmembrane protein 132B

Size: 1078 amino acids; 119477 Da

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Secondary accessions: A2RRG8 Q8NA73 Q96JN9 Q96PY1

Alternative splicing: 3 isoforms: Q14DG7-1 Q14DG7-2 Q14DG7-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM132B: NX_Q14DG7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14DG7

TMEM132B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_443139.2

ENSEMBL proteins:

ENSP00000299308 ENSP00000440436

Human Recombinant Protein Products for TMEM132B:

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0016021	integral to membrane	IEA	--

TMEM132B for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TMEM132B for domains About GeneDecksing

1 InterPro domain/family:

IPR026307 TMEM132

Graphical View of Domain Structure for InterPro Entry Q14DG7

ProtoNet protein and cluster: Q14DG7

UniProtKB/Swiss-Prot: T132B_HUMAN, Q14DG7

Similarity: Belongs to the TMEM132 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

TMEM132B for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for TMEM132B:

Decreased Wnt reporter activit

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM132B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMEM132B

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

TMEM132B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM132B
Search CenterWatch for drugs/clinical trials and news about TMEM132B / T132B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for TMEM132B gene:

NM_052907.2

Unigene Cluster for TMEM132B:

Transmembrane protein 132B

Hs.524838 [show with all ESTs]

Unigene Representative Sequence: NM_052907

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000418253 ENST00000535330 ENST00000299308(uc001uhe.1 uc001uhf.1)

ENST00000534945(uc021rgl.1) ENST00000535886

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Additional cDNA sequence:

AB067493.1 AK055283.1 AK090767.1 AK091512.1 AK093097.1 BC113366.1 BC113368.1 BC131621.1

3 DOTS entries:

DT.91718469 DT.100685688 DT.40276376

24/46 AceView cDNA sequences (see all 46):

BX119552 AW295831 AX746606 AK090767 AA740724 BI756057 AB067493 AA349544

T16299 AX747920 AI369234 AI369420 AK093097 AA984175 AX747032 AW298562

BI546107 BF963362 AK055283 AL698294 BF530074 BG913960 AK091512 AK094786

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM132B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

TMEM132B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TMEM132B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM132B

SOURCE GeneReport for Unigene cluster: Hs.524838

SABiosciences Custom PCR Arrays for TMEM132B

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TMEM132B gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TMEM132B¹	transmembrane protein 132B	72.36(n) 73.15(a)		416810 XM_415101.3 XP_415101.2
lizard (Anolis carolinensis)	Reptilia	TMEM132B⁶	--	68(a)	1 ↔ 1	LGb(984372-1162071)
zebrafish (Danio rerio)	Actinopterygii	LOC556622¹	similar to Transmembrane protein 132B	59.87(n) 54.29(a)		556622 XM_679464.4 XP_684556.4
fruit fly (Drosophila melanogaster)	Insecta	CG14446⁶	--	18(a)	1 → many	X(6119680-6127199)
worm (Caenorhabditis elegans)	Secernentea	Y71H2AM.10⁶	Protein Y71H2AM.10	15(a)	1 → many	III(2707729-2716269)

ENSEMBL Gene Tree for TMEM132B (if available)
TreeFam Gene Tree for TMEM132B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TMEM132B gene

TMEM132D² TMEM132A² TMEM132C² TMEM132E²

4 SIMAP similar genes for TMEM132B using alignment to 1 protein entry: T132B_HUMAN:

TMEM132D TMEM132C TMEM132E TMEM132A

TMEM132B for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for TMEM132B
PGOHUM00000239607 PGOHUM00000239955 PGOHUM00000239957

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148781561^1,2		--	125809196(+)	`ATTGTA/GAACTG`	1	--	us2k¹		0	--	--	--	--
rs80317235^1,2		--	125809238(+)	`TATGAC/TGTGAA`	1	--	us2k¹		1		EA	120
rs142382249^1,2		--	125809242(+)	`ACGTGA/GAACAG`	1	--	us2k¹		0	--	--	--	--
rs80328611^1,2		--	125809387(+)	`TAGCTA/GGACTC`	1	--	us2k¹		0	--	--	--	--
rs117488680^1,2	F	--	125809432(+)	`AGGTGA/GGCTGT`	1	--	us2k¹		1		EA	120
rs73233377^1,2	C	--	125809442(+)	`TGGACA/G/TTGGCA`	1	--	us2k¹		0	--	--	--	--
rs150091751^1,2		--	125809456(+)	`TCTTAC/TTTTGG`	1	--	us2k¹		0	--	--	--	--
rs77549682^1,2		--	125809563(+)	`AACGCA/CAAACA`	1	--	us2k¹		1		WA	118
rs147780242^1,2		--	125809569(+)	`AAACAA/GAGAGC`	1	--	us2k¹		0	--	--	--	--
rs191018116^1,2		--	125809576(+)	`GAGCTC/TTTCTG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TMEM132B (125671382 - 125921382 bp, first 250kb of TMEM132B)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TMEM132B
1 CNV: 61285
2 Indels: 71608 42299

1 SABiosciences Cancer Mutation PCR Assay for TMEM132B:

Cosmic Id	AA Change
108917	p.G822E

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM132B

DNA2.0 Custom Variant and Variant Library Synthesis for TMEM132B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMEM132B for disorders About MalaCards

TMEM132B for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: TMEM132B (1 document)

Export disorders for TMEM132B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMEM132B gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM132B)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)^{1, 2, 3} Nagase T....Ohara O. (2001)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)^{1, 2} Nagase T.... Ohara O. (2001)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
The finished DNA sequence of human chromosome 12. (PubMed id 16541075)² Scherer S.E.... Gibbs R.A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 114795	HGNC: 29397	AceView: KIAA1906	Ensembl:ENSG00000139364	euGenes: HUgn114795
ECgene: TMEM132B	H-InvDB: TMEM132B

(According to HUGE)
About This Section

HUGE: KIAA1786 KIAA1906

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TMEM132B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMEM132B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TMEM132B gene:
Search GeneIP for patents involving TMEM132B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM132B
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	GenScript Custom Purified and Recombinant Proteins Services for TMEM132B		GenScript cDNA clones with any tag delivered in your preferred vector for TMEM132B
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM132B

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TMEM132B

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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TMEM132B Gene

transmembrane protein 132B

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TMEM132B Gene

transmembrane protein 132B

Aliasesfor TMEM132B gene

Summariesfor TMEM132B gene

Genomic Viewsfor TMEM132B gene

Proteinsfor TMEM132B gene

Protein Domains /Familiesfor TMEM132B gene

Functionfor TMEM132B gene

Pathways & Interactionsfor TMEM132B gene

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Expression for TMEM132B gene

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External Searches for TMEM132B gene

Genome Databases showing TMEM132B gene

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for TMEM132B gene

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for TMEM132B gene

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for TMEM132B gene

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