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Aliases for TMEM132A Gene

Aliases for TMEM132A Gene

  • Transmembrane Protein 132A 2 3 5
  • Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) Binding Protein 1 2 3
  • HSPA5-Binding Protein 1 3 4
  • HSPA5BP1 3 4
  • Heat Shock 70kDa Protein 5 Binding Protein 1 3
  • Glucose-Regulated Protein, 78kDa 3
  • GRP78-Binding Protein 3
  • KIAA1583 4
  • GBP 3

External Ids for TMEM132A Gene

Previous HGNC Symbols for TMEM132A Gene

  • HSPA5BP1

Previous GeneCards Identifiers for TMEM132A Gene

  • GC11P060449
  • GC11P060691
  • GC11P057038

Summaries for TMEM132A Gene

Entrez Gene Summary for TMEM132A Gene

  • This gene encodes a protein that is highly similar to the rat Grp78-binding protein (GBP). Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMEM132A Gene

TMEM132A (Transmembrane Protein 132A) is a Protein Coding gene. An important paralog of this gene is TMEM132D.

UniProtKB/Swiss-Prot for TMEM132A Gene

  • May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM132A Gene

Genomics for TMEM132A Gene

Regulatory Elements for TMEM132A Gene

Promoters for TMEM132A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM132A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM132A Gene

Chromosome:
11
Start:
60,924,441 bp from pter
End:
60,937,159 bp from pter
Size:
12,719 bases
Orientation:
Plus strand

Genomic View for TMEM132A Gene

Genes around TMEM132A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM132A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM132A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM132A Gene

Proteins for TMEM132A Gene

  • Protein details for TMEM132A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q24JP5-T132A_HUMAN
    Recommended name:
    Transmembrane protein 132A
    Protein Accession:
    Q24JP5
    Secondary Accessions:
    • Q69YU7
    • Q86VZ8
    • Q86W97
    • Q9H8K3
    • Q9HCI9
    • Q9NWY0

    Protein attributes for TMEM132A Gene

    Size:
    1023 amino acids
    Molecular mass:
    110110 Da
    Quaternary structure:
    • Interacts with HSPA5/GRP78.
    SequenceCaution:
    • Sequence=BAB13409.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14613.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM132A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM132A Gene

Proteomics data for TMEM132A Gene at MOPED

Post-translational modifications for TMEM132A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM132A Gene

Antibody Products

No data available for DME Specific Peptides for TMEM132A Gene

Domains & Families for TMEM132A Gene

Protein Domains for TMEM132A Gene

Suggested Antigen Peptide Sequences for TMEM132A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q24JP5

UniProtKB/Swiss-Prot:

T132A_HUMAN :
  • Belongs to the TMEM132 family.
Family:
  • Belongs to the TMEM132 family.
genes like me logo Genes that share domains with TMEM132A: view

No data available for Gene Families for TMEM132A Gene

Function for TMEM132A Gene

Molecular function for TMEM132A Gene

UniProtKB/Swiss-Prot Function:
May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity).
genes like me logo Genes that share phenotypes with TMEM132A: view

Animal Models for TMEM132A Gene

MGI Knock Outs for TMEM132A:

Animal Model Products

CRISPR Products

miRNA for TMEM132A Gene

miRTarBase miRNAs that target TMEM132A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM132A Gene

Localization for TMEM132A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM132A Gene

Golgi apparatus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM132A Gene COMPARTMENTS Subcellular localization image for TMEM132A gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 3
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TMEM132A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM132A: view

Pathways & Interactions for TMEM132A Gene

SuperPathways for TMEM132A Gene

No Data Available

Interacting Proteins for TMEM132A Gene

Gene Ontology (GO) - Biological Process for TMEM132A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM132A Gene

Drugs & Compounds for TMEM132A Gene

(1) Drugs for TMEM132A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with TMEM132A: view

Transcripts for TMEM132A Gene

Unigene Clusters for TMEM132A Gene

Transmembrane protein 132A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM132A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3:
SP4: - - - - - - - -
SP5:
SP6: - -
SP7: - - - -
SP8: -
SP9: - - - - - - - -
SP10:
SP11:
SP12: - - -
SP13:

ExUns: 13b · 13c ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for TMEM132A Gene

GeneLoc Exon Structure for
TMEM132A
ECgene alternative splicing isoforms for
TMEM132A

Expression for TMEM132A Gene

mRNA expression in normal human tissues for TMEM132A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM132A Gene

This gene is overexpressed in NK cells (39.8), Fetal testis (8.2), Fetal ovary (7.7), and Fetal Liver (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM132A Gene



SOURCE GeneReport for Unigene cluster for TMEM132A Gene Hs.118552

genes like me logo Genes that share expression patterns with TMEM132A: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM132A Gene

Orthologs for TMEM132A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM132A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM132A 35
  • 87.94 (n)
  • 88.95 (a)
TMEM132A 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM132A 35
  • 86.78 (n)
  • 87.8 (a)
TMEM132A 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem132a 35
  • 83.68 (n)
  • 86.82 (a)
Tmem132a 16
Tmem132a 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM132A 35
  • 99.19 (n)
  • 98.93 (a)
TMEM132A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem132a 35
  • 83.09 (n)
  • 86.14 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM132A 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 67 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia TMEM132A 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem132a 35
  • 46.93 (n)
  • 37.75 (a)
zebrafish
(Danio rerio)
Actinopterygii TMEM132A 36
  • 23 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14446 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.10 36
  • 16 (a)
OneToMany
Species with no ortholog for TMEM132A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM132A Gene

ENSEMBL:
Gene Tree for TMEM132A (if available)
TreeFam:
Gene Tree for TMEM132A (if available)

Paralogs for TMEM132A Gene

Paralogs for TMEM132A Gene

(3) SIMAP similar genes for TMEM132A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM132A: view

Variants for TMEM132A Gene

Sequence variations from dbSNP and Humsavar for TMEM132A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs524523 - 60,935,931(-) CACGG(A/C/G/T)GGTCG reference, missense
VAR_032263 -
rs9513 -- 60,933,664(-) AGCAG(C/G)GGGGC reference, synonymous-codon
rs485310 -- 60,926,343(-) CGAGA(A/G)GTTAA intron-variant
rs7715 -- 60,934,515(+) GCGTC(A/G)GATGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TMEM132A Gene

Variant ID Type Subtype PubMed ID
nsv897599 CNV Loss 21882294
nsv897600 CNV Gain 21882294
nsv897601 CNV Loss 21882294

Variation tolerance for TMEM132A Gene

Residual Variation Intolerance Score: 66.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.11; 93.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM132A Gene

HapMap Linkage Disequilibrium report
TMEM132A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM132A Gene

Disorders for TMEM132A Gene

Relevant External Links for TMEM132A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM132A

No disorders were found for TMEM132A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM132A Gene

Publications for TMEM132A Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Cloning and characterization of a novel GRP78-binding protein in the rat brain. (PMID: 12514190) Oh-hashi K. … Tanaka M. (J. Biol. Chem. 2003) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3

Products for TMEM132A Gene

Sources for TMEM132A Gene

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