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Aliases for TMEM132A Gene

Aliases for TMEM132A Gene

  • Transmembrane Protein 132A 2 3
  • Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) Binding Protein 1 2 3
  • HSPA5-Binding Protein 1 3 4
  • HSPA5BP1 3 4
  • Heat Shock 70kDa Protein 5 Binding Protein 1 3
  • Glucose-Regulated Protein, 78kDa 3
  • GRP78-Binding Protein 3
  • KIAA1583 4
  • GBP 3

External Ids for TMEM132A Gene

Previous Symbols for TMEM132A Gene

  • HSPA5BP1

Summaries for TMEM132A Gene

Entrez Gene Summary for TMEM132A Gene

  • This gene encodes a protein that is highly similar to the rat Grp78-binding protein (GBP). Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMEM132A Gene

TMEM132A (Transmembrane Protein 132A) is a Protein Coding gene. An important paralog of this gene is TMEM132D.

UniProtKB/Swiss-Prot for TMEM132A Gene

  • May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM132A Gene

Genomics for TMEM132A Gene

Genomic Location for TMEM132A Gene

Start:
60,924,441 bp from pter
End:
60,937,159 bp from pter
Size:
12,719 bases
Orientation:
Plus strand

Genomic View for TMEM132A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM132A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM132A Gene

Regulatory Elements for TMEM132A Gene

Proteins for TMEM132A Gene

  • Protein details for TMEM132A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q24JP5-T132A_HUMAN
    Recommended name:
    Transmembrane protein 132A
    Protein Accession:
    Q24JP5
    Secondary Accessions:
    • Q69YU7
    • Q86VZ8
    • Q86W97
    • Q9H8K3
    • Q9HCI9
    • Q9NWY0

    Protein attributes for TMEM132A Gene

    Size:
    1023 amino acids
    Molecular mass:
    110110 Da
    Quaternary structure:
    • Interacts with HSPA5/GRP78.
    SequenceCaution:
    • Sequence=BAB13409.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14613.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM132A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM132A Gene

Proteomics data for TMEM132A Gene at MOPED

Post-translational modifications for TMEM132A Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn280, Ser800, and Thr805

Other Protein References for TMEM132A Gene

No data available for DME Specific Peptides for TMEM132A Gene

Domains for TMEM132A Gene

Protein Domains for TMEM132A Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

T132A_HUMAN
Family:
  • Belongs to the TMEM132 family.:
    • Q24JP5
genes like me logo Genes that share domains with TMEM132A: view

No data available for Gene Families for TMEM132A Gene

Function for TMEM132A Gene

Molecular function for TMEM132A Gene

UniProtKB/Swiss-Prot Function: May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity).

Gene Ontology (GO) - Molecular Function for TMEM132A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM132A: view

miRNA for TMEM132A Gene

miRTarBase miRNAs that target TMEM132A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM132A Gene

Localization for TMEM132A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM132A Gene

Golgi apparatus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM132A Gene COMPARTMENTS Subcellular localization image for TMEM132A gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 3
extracellular 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM132A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM132A: view

Pathways for TMEM132A Gene

SuperPathways for TMEM132A Gene

No Data Available

Interacting Proteins for TMEM132A Gene

Gene Ontology (GO) - Biological Process for TMEM132A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM132A: view

No data available for Pathways by source for TMEM132A Gene

Compounds for TMEM132A Gene

(1) HMDB Compounds for TMEM132A Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4
genes like me logo Genes that share compounds with TMEM132A: view

Transcripts for TMEM132A Gene

Unigene Clusters for TMEM132A Gene

Transmembrane protein 132A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM132A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3:
SP4: - - - - - - - -
SP5:
SP6: - -
SP7: - - - -
SP8: -
SP9: - - - - - - - -
SP10:
SP11:
SP12: - - -
SP13:

ExUns: 13b · 13c ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for TMEM132A Gene

GeneLoc Exon Structure for
TMEM132A
ECgene alternative splicing isoforms for
TMEM132A

Expression for TMEM132A Gene

mRNA expression in normal human tissues for TMEM132A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM132A Gene

SOURCE GeneReport for Unigene cluster for TMEM132A Gene Hs.118552

genes like me logo Genes that share expressions with TMEM132A: view

Orthologs for TMEM132A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM132A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM132A 36
  • 99.19 (n)
  • 98.93 (a)
TMEM132A 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM132A 36
  • 87.94 (n)
  • 88.95 (a)
TMEM132A 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM132A 36
  • 86.78 (n)
  • 87.8 (a)
TMEM132A 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem132a 36
  • 83.68 (n)
  • 86.82 (a)
Tmem132a 16
Tmem132a 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM132A 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem132a 36
  • 83.09 (n)
  • 86.14 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 67 (a)
OneToMany
-- 37
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia TMEM132A 37
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem132a 36
  • 46.93 (n)
  • 37.75 (a)
zebrafish
(Danio rerio)
Actinopterygii TMEM132A 37
  • 23 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14446 37
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.10 37
  • 16 (a)
OneToMany
Species with no ortholog for TMEM132A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM132A Gene

ENSEMBL:
Gene Tree for TMEM132A (if available)
TreeFam:
Gene Tree for TMEM132A (if available)

Paralogs for TMEM132A Gene

Paralogs for TMEM132A Gene

Selected SIMAP similar genes for TMEM132A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM132A: view

Variants for TMEM132A Gene

Sequence variations from dbSNP and Humsavar for TMEM132A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7715 -- 60,934,515(+) GCGTC(A/G)GATGA synonymous-codon, reference
rs9513 -- 60,933,664(-) AGCAG(C/G)GGGGC reference, synonymous-codon
rs485310 -- 60,926,343(-) CGAGA(A/G)GTTAA intron-variant
rs512233 -- 60,933,519(-) GCAGG(C/T)GGGCG intron-variant
rs524523 - 60,935,931(-) CACGG(A/C/G/T)GGTCG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for TMEM132A Gene

Variant ID Type Subtype PubMed ID
nsv897599 CNV Loss 21882294
nsv897600 CNV Gain 21882294
nsv897601 CNV Loss 21882294

Relevant External Links for TMEM132A Gene

HapMap Linkage Disequilibrium report
TMEM132A

Disorders for TMEM132A Gene

No disorders were found for TMEM132A Gene.

No data available for UniProtKB/Swiss-Prot for TMEM132A Gene

Publications for TMEM132A Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Cloning and characterization of a novel GRP78-binding protein in the rat brain. (PMID: 12514190) Oh-hashi K. … Tanaka M. (J. Biol. Chem. 2003) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. GRP78-binding protein regulates cAMP-induced glial fibrillary acidic protein expression in rat C6 glioblastoma cells. (PMID: 16806201) Oh-hashi K. … Kiuchi K. (FEBS Lett. 2006) 3
  5. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) KAPnig R. … Chanda S.K. (Cell 2008) 3

Products for TMEM132A Gene

Sources for TMEM132A Gene

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