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Aliases for TMEM132A Gene

Aliases for TMEM132A Gene

  • Transmembrane Protein 132A 2 3 5
  • Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) Binding Protein 1 2 3
  • HSPA5-Binding Protein 1 3 4
  • HSPA5BP1 3 4
  • Heat Shock 70kDa Protein 5 Binding Protein 1 3
  • Glucose-Regulated Protein, 78kDa 3
  • GRP78-Binding Protein 3
  • KIAA1583 4
  • GBP 3

External Ids for TMEM132A Gene

Previous HGNC Symbols for TMEM132A Gene

  • HSPA5BP1

Previous GeneCards Identifiers for TMEM132A Gene

  • GC11P060449
  • GC11P060691
  • GC11P057038

Summaries for TMEM132A Gene

Entrez Gene Summary for TMEM132A Gene

  • This gene encodes a protein that is highly similar to the rat Grp78-binding protein (GBP). Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMEM132A Gene

TMEM132A (Transmembrane Protein 132A) is a Protein Coding gene. An important paralog of this gene is TMEM132C.

UniProtKB/Swiss-Prot for TMEM132A Gene

  • May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM132A Gene

Genomics for TMEM132A Gene

Regulatory Elements for TMEM132A Gene

Enhancers for TMEM132A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G060970 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +48.4 48408 4.5 CTCF RB1 JUN ZNF2 RAD21 POLR2A EED SMC3 ZNF143 FOS CD5 CD6 SLC15A3 TMEM132A VPS37C CCDC86 FTH1 SDHAF2 RNU6-933P
GH11G061040 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +118.0 118021 3.0 HDGF TBP PKNOX1 WRNIP1 ZBTB40 RELB IKZF2 CREM GATAD2B TBX21 CD6 CD5 SLC15A3 TMEM132A SDHAF2 ENSG00000256733 LOC105369326
GH11G061007 1.4 Ensembl ENCODE dbSUPER 11.2 +83.7 83738 1.8 ZNF2 RAD21 EGR1 ZNF143 ZNF263 ZNF654 GATAD2B REST KAT8 CBX8 CD6 SLC15A3 TMEM132A LOC105369326 GC11M060996
GH11G060976 1 ENCODE dbSUPER 11.9 +54.2 54177 3.5 HDGF ZSCAN4 MAX ZFHX2 POLR2A NFE2 IKZF2 NFE2L2 NR2F1 MAFG SLC15A3 TMEM132A CD5 VPS37C FTH1 PTGDR2 CD6 RNU6-933P
GH11G061171 1.1 Ensembl ENCODE dbSUPER 10.8 +247.9 247885 1.5 PKNOX1 POLR2A CEBPB HMBOX1 TRIM24 IRF1 PRDM1 CD5 CD6 RNU6-933P SLC15A3 TMEM132A TKFC DDB1 GC11P061168 PGA3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM132A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM132A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040167 359 801 HDGF ARNT AGO1 ARID4B SIN3A DMAP1 ZNF121 ZNF143 MXD4 MIER2

Genomic Location for TMEM132A Gene

Chromosome:
11
Start:
60,924,441 bp from pter
End:
60,937,159 bp from pter
Size:
12,719 bases
Orientation:
Plus strand

Genomic View for TMEM132A Gene

Genes around TMEM132A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM132A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM132A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM132A Gene

Proteins for TMEM132A Gene

  • Protein details for TMEM132A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q24JP5-T132A_HUMAN
    Recommended name:
    Transmembrane protein 132A
    Protein Accession:
    Q24JP5
    Secondary Accessions:
    • Q69YU7
    • Q86VZ8
    • Q86W97
    • Q9H8K3
    • Q9HCI9
    • Q9NWY0

    Protein attributes for TMEM132A Gene

    Size:
    1023 amino acids
    Molecular mass:
    110110 Da
    Quaternary structure:
    • Interacts with HSPA5/GRP78.
    SequenceCaution:
    • Sequence=BAB13409.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14613.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM132A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM132A Gene

Post-translational modifications for TMEM132A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM132A Gene

Domains & Families for TMEM132A Gene

Protein Domains for TMEM132A Gene

Suggested Antigen Peptide Sequences for TMEM132A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q24JP5

UniProtKB/Swiss-Prot:

T132A_HUMAN :
  • Belongs to the TMEM132 family.
Family:
  • Belongs to the TMEM132 family.
genes like me logo Genes that share domains with TMEM132A: view

No data available for Gene Families for TMEM132A Gene

Function for TMEM132A Gene

Molecular function for TMEM132A Gene

UniProtKB/Swiss-Prot Function:
May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity).

Gene Ontology (GO) - Molecular Function for TMEM132A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM132A: view
genes like me logo Genes that share phenotypes with TMEM132A: view

Animal Models for TMEM132A Gene

MGI Knock Outs for TMEM132A:

Animal Model Products

CRISPR Products

miRNA for TMEM132A Gene

miRTarBase miRNAs that target TMEM132A

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM132A Gene

Localization for TMEM132A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM132A Gene

Golgi apparatus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM132A gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 3
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TMEM132A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IBA,IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA,IBA --
genes like me logo Genes that share ontologies with TMEM132A: view

Pathways & Interactions for TMEM132A Gene

SuperPathways for TMEM132A Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM132A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with TMEM132A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM132A Gene

Drugs & Compounds for TMEM132A Gene

(1) Drugs for TMEM132A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with TMEM132A: view

Transcripts for TMEM132A Gene

Unigene Clusters for TMEM132A Gene

Transmembrane protein 132A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM132A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3:
SP4: - - - - - - - -
SP5:
SP6: - -
SP7: - - - -
SP8: -
SP9: - - - - - - - -
SP10:
SP11:
SP12: - - -
SP13:

ExUns: 13b · 13c ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for TMEM132A Gene

GeneLoc Exon Structure for
TMEM132A
ECgene alternative splicing isoforms for
TMEM132A

Expression for TMEM132A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM132A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM132A Gene

This gene is overexpressed in NK cells (39.8), Fetal testis (8.2), Fetal ovary (7.7), and Fetal Liver (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM132A Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM132A Gene:

TMEM132A

SOURCE GeneReport for Unigene cluster for TMEM132A Gene:

Hs.118552

Evidence on tissue expression from TISSUES for TMEM132A Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with TMEM132A: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM132A Gene

Orthologs for TMEM132A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM132A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM132A 34 35
  • 99.19 (n)
cow
(Bos Taurus)
Mammalia TMEM132A 34 35
  • 87.94 (n)
dog
(Canis familiaris)
Mammalia TMEM132A 34 35
  • 86.78 (n)
mouse
(Mus musculus)
Mammalia Tmem132a 34 16 35
  • 83.68 (n)
rat
(Rattus norvegicus)
Mammalia Tmem132a 34
  • 83.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM132A 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 67 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia TMEM132A 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem132a 34
  • 46.93 (n)
zebrafish
(Danio rerio)
Actinopterygii TMEM132A 35
  • 23 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14446 35
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.10 35
  • 16 (a)
OneToMany
Species where no ortholog for TMEM132A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM132A Gene

ENSEMBL:
Gene Tree for TMEM132A (if available)
TreeFam:
Gene Tree for TMEM132A (if available)

Paralogs for TMEM132A Gene

Paralogs for TMEM132A Gene

(3) SIMAP similar genes for TMEM132A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM132A: view

Variants for TMEM132A Gene

Sequence variations from dbSNP and Humsavar for TMEM132A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000126500 -- 60,935,104(+) TACCC(A/G)GTTCC intron-variant
rs1000342054 -- 60,923,591(+) TCCAG(A/G)AGCAC intron-variant, upstream-variant-2KB
rs1000465634 -- 60,933,971(+) CGTAG(C/T)ACCCT intron-variant
rs1000589341 -- 60,927,990(+) TCTGC(C/T)CCCAC intron-variant
rs1000647072 -- 60,924,436(+) ATGTG(C/T)TGCGA upstream-variant-2KB

Variation tolerance for TMEM132A Gene

Residual Variation Intolerance Score: 66.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.11; 93.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM132A Gene

Human Gene Mutation Database (HGMD)
TMEM132A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM132A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM132A Gene

Disorders for TMEM132A Gene

Relevant External Links for TMEM132A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM132A

No disorders were found for TMEM132A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM132A Gene

Publications for TMEM132A Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Cloning and characterization of a novel GRP78-binding protein in the rat brain. (PMID: 12514190) Oh-hashi K. … Tanaka M. (J. Biol. Chem. 2003) 2 3 64
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for TMEM132A Gene

Sources for TMEM132A Gene

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