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Aliases for TMEM131L Gene

Aliases for TMEM131L Gene

  • Transmembrane 131 Like 2 3
  • KIAA0922 2 3 4 5
  • Transmembrane Protein 131-Like 3

External Ids for TMEM131L Gene

Previous HGNC Symbols for TMEM131L Gene

  • KIAA0922

Summaries for TMEM131L Gene

GeneCards Summary for TMEM131L Gene

TMEM131L (Transmembrane 131 Like) is a Protein Coding gene. An important paralog of this gene is TMEM131.

UniProtKB/Swiss-Prot for TMEM131L Gene

  • Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM131L Gene

Genomics for TMEM131L Gene

Regulatory Elements for TMEM131L Gene

Enhancers for TMEM131L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G153438 1.5 FANTOM5 Ensembl ENCODE dbSUPER 23.7 -27.1 -27050 2.4 CTCF HDGF TBL1XR1 MTA2 ZBED1 YBX1 EBF1 TBX21 ZBTB40 IKZF1 TMEM131L MND1 GC04P153424
GH04G153485 1.6 Ensembl ENCODE dbSUPER 18.1 +22.9 22922 7.9 HDGF PKNOX1 ARNT WRNIP1 SIN3A FEZF1 ZNF2 FOS ZNF263 JUNB TMEM131L MND1 PIR44013
GH04G153425 1.5 FANTOM5 Ensembl ENCODE dbSUPER 17.5 -38.7 -38686 4.4 CTCF CBX3 ZNF740 CAVIN1 HLF RAD21 ZNF592 CREB3 SMC3 IRF1 TMEM131L RNF175 GC04P153424
GH04G153432 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13 -32.6 -32649 2.4 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 YY1 CBX5 ZNF143 ZNF207 TMEM131L MND1 TLR2 GC04P153424
GH04G153512 1.3 Ensembl ENCODE dbSUPER 15.7 +47.8 47758 2.7 PKNOX1 JUN INSM2 CEBPG FEZF1 ZNF2 ZNF664 HIC1 ZNF316 ZNF366 TMEM131L MND1 RNF175 PIR44013 PIR33610
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM131L on UCSC Golden Path with GeneCards custom track

Promoters for TMEM131L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TMEM131L Gene

153,466,346 bp from pter
153,637,608 bp from pter
171,263 bases
Plus strand

Genomic View for TMEM131L Gene

Genes around TMEM131L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM131L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM131L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM131L Gene

Proteins for TMEM131L Gene

  • Protein details for TMEM131L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 131-like
    Protein Accession:
    Secondary Accessions:
    • B3KRV3
    • D3DP10
    • Q7LGA7
    • Q86Y92
    • Q8WU56
    • Q9H065
    • Q9Y2D7

    Protein attributes for TMEM131L Gene

    1609 amino acids
    Molecular mass:
    179339 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM131L Gene


neXtProt entry for TMEM131L Gene

Post-translational modifications for TMEM131L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM131L Gene

Domains & Families for TMEM131L Gene

Protein Domains for TMEM131L Gene


Suggested Antigen Peptide Sequences for TMEM131L Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM131 family.
  • Belongs to the TMEM131 family.
genes like me logo Genes that share domains with TMEM131L: view

No data available for Gene Families for TMEM131L Gene

Function for TMEM131L Gene

Molecular function for TMEM131L Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.
genes like me logo Genes that share phenotypes with TMEM131L: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM131L Gene

Localization for TMEM131L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM131L Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=During intrathymic development, resides in punctate cytoplasmic structures in DN1 and DN2 cells. In DN3 cells, found in large crescent-shaped membrane structures, which preferentially localize in cell-to-cell contact zones. {ECO:0000269 PubMed:23690469}.
Isoform 1: Endoplasmic reticulum. Note=Transmembrane localization is essential for Wnt signaling inhibition. {ECO:0000269 PubMed:23690469}.
Isoform 5: Cytoplasm. Note=Scattered throughout the cytoplasm in small-sized punctate structures. {ECO:0000269 PubMed:23690469}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM131L gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 3
extracellular 2
nucleus 2
lysosome 1

Gene Ontology (GO) - Cellular Components for TMEM131L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 23690469
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane IDA,IEA 23690469
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM131L: view

Pathways & Interactions for TMEM131L Gene

SuperPathways for TMEM131L Gene

No Data Available

Interacting Proteins for TMEM131L Gene

Gene Ontology (GO) - Biological Process for TMEM131L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016055 Wnt signaling pathway IEA --
GO:0033088 negative regulation of immature T cell proliferation in thymus IMP 23690469
GO:0090090 negative regulation of canonical Wnt signaling pathway IDA 23690469
genes like me logo Genes that share ontologies with TMEM131L: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM131L Gene

Drugs & Compounds for TMEM131L Gene

No Compound Related Data Available

Transcripts for TMEM131L Gene

Unigene Clusters for TMEM131L Gene

Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM131L Gene

No ASD Table

Relevant External Links for TMEM131L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM131L Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM131L Gene:


SOURCE GeneReport for Unigene cluster for TMEM131L Gene:


mRNA Expression by UniProt/SwissProt for TMEM131L Gene:

Tissue specificity: Expressed in thymocytes.

Evidence on tissue expression from TISSUES for TMEM131L Gene

  • Nervous system(4.4)
  • Muscle(4.2)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM131L Gene

Orthologs for TMEM131L Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM131L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KIAA0922 35 34
  • 99.52 (n)
(Canis familiaris)
Mammalia KIAA0922 35 34
  • 89.74 (n)
(Bos Taurus)
Mammalia KIAA0922 35 34
  • 84.78 (n)
(Rattus norvegicus)
Mammalia LOC679811 34
  • 82.1 (n)
(Mus musculus)
Mammalia D930015E06Rik 35 16 34
  • 81.86 (n)
(Ornithorhynchus anatinus)
Mammalia KIAA0922 35
  • 70 (a)
(Monodelphis domestica)
Mammalia KIAA0922 35
  • 70 (a)
(Gallus gallus)
Aves KIAA0922 35 34
  • 71.18 (n)
(Anolis carolinensis)
Reptilia KIAA0922 35
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0922 34
  • 59.67 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9794 34
(Danio rerio)
Actinopterygii si:ch211-208h7.4 34 35
  • 50.9 (n)
Dr.26860 34
fruit fly
(Drosophila melanogaster)
Insecta CG8370 35
  • 14 (a)
(Caenorhabditis elegans)
Secernentea C27F2.8 35
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
Species where no ortholog for TMEM131L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM131L Gene

Gene Tree for TMEM131L (if available)
Gene Tree for TMEM131L (if available)

Paralogs for TMEM131L Gene

Paralogs for TMEM131L Gene

genes like me logo Genes that share paralogs with TMEM131L: view

Variants for TMEM131L Gene

Sequence variations from dbSNP and Humsavar for TMEM131L Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000032399 -- 153,553,990(+) GGTGC(A/G)GTCAC intron-variant
rs1000038167 -- 153,561,391(+) AGTCA(A/G/T)GTTTT intron-variant
rs1000046089 -- 153,477,588(+) TTGAC(A/G)ATGAC intron-variant
rs1000071128 -- 153,517,269(+) CACTT(A/C)CTGTG intron-variant
rs1000071667 -- 153,489,704(+) AACTC(C/T)TGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM131L Gene

Variant ID Type Subtype PubMed ID
esv2661180 CNV deletion 23128226
esv2678129 CNV deletion 23128226
esv2728553 CNV deletion 23290073
esv3432324 CNV duplication 20981092
esv3602725 CNV loss 21293372
esv3602726 CNV loss 21293372
esv3602727 CNV loss 21293372
nsv1022081 CNV gain 25217958
nsv595749 CNV gain 21841781
nsv830118 CNV loss 17160897
nsv949833 CNV duplication 24416366

Variation tolerance for TMEM131L Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.61; 86.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM131L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM131L Gene

Disorders for TMEM131L Gene

Relevant External Links for TMEM131L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM131L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM131L Gene

Publications for TMEM131L Gene

  1. Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans. (PMID: 23690469) Maharzi N. … Canque B. (J. Immunol. 2013) 2 3 4 64
  2. Evolutionary conservation of Notch signaling inhibition by TMEM131L overexpression. (PMID: 28347816) Szuplewski S. … Canque B. (Biochem. Biophys. Res. Commun. 2017) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4 64

Products for TMEM131L Gene

Sources for TMEM131L Gene

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