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Aliases for TMEM131 Gene

Aliases for TMEM131 Gene

  • Transmembrane Protein 131 2 3 5
  • RW1 3 4
  • 2610524E03Rik 3
  • Protein RW1 4
  • KIAA0257 4
  • PRO1048 3
  • YR-23 3
  • CC28 3

External Ids for TMEM131 Gene

Previous GeneCards Identifiers for TMEM131 Gene

  • GC02M098372
  • GC02M092138

Summaries for TMEM131 Gene

GeneCards Summary for TMEM131 Gene

TMEM131 (Transmembrane Protein 131) is a Protein Coding gene. Diseases associated with TMEM131 include Subdural Empyema and Streptococcal Meningitis. An important paralog of this gene is KIAA0922.

UniProtKB/Swiss-Prot for TMEM131 Gene

  • May play a role in the immune response to viral infection.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM131 Gene

Genomics for TMEM131 Gene

Regulatory Elements for TMEM131 Gene

Enhancers for TMEM131 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F097867 1.6 FANTOM5 Ensembl ENCODE 16.5 +125.8 125798 5.2 HDGF PKNOX1 MLX ARID4B SIN3A ZNF48 YY1 CBX5 FOS SP5 TMEM131 RNU7-96P ZAP70 ANKRD36B LINC01125 GC02P097828 GC02M097914
GH02F097966 1.2 Ensembl ENCODE 16.1 +27.1 27132 4.4 ZFP64 ARID4B DMAP1 YY1 FOS MXD4 JUNB MIER2 TBX21 PPARG TMEM131 RNU7-96P VWA3B ANKRD36B LINC01125
GH02F097929 1.1 Ensembl ENCODE 16.1 +64.4 64431 4.6 TBP PKNOX1 TBL1XR1 EBF1 YBX1 ZNF316 CBX5 EED ETV6 CREM TMEM131 VWA3B ANKRD36B LINC01125 RNU7-96P
GH02F097948 1 Ensembl ENCODE 16.8 +45.1 45132 4.0 CTCF ZNF654 CEBPB TRIM22 PTRF ARID4B REST RFX5 JUND NFYB TMEM131 RNU7-96P ZAP70 VWA3B ANKRD36B ACTR1B ANKRD36 LINC01125
GH02F097934 1.1 Ensembl ENCODE 11.6 +60.2 60232 2.2 SIX4 HDAC1 TFAP4 PKNOX1 SAP130 SIN3A ZIC2 RARA GATA3 POLR2A TMEM131 ZAP70 ANKRD36B RNU7-96P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM131 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM131 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000594954 832 3401 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 CBX5

Genomic Location for TMEM131 Gene

Chromosome:
2
Start:
97,756,333 bp from pter
End:
97,995,932 bp from pter
Size:
239,600 bases
Orientation:
Minus strand

Genomic View for TMEM131 Gene

Genes around TMEM131 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM131 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM131 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM131 Gene

Proteins for TMEM131 Gene

  • Protein details for TMEM131 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92545-TM131_HUMAN
    Recommended name:
    Transmembrane protein 131
    Protein Accession:
    Q92545

    Protein attributes for TMEM131 Gene

    Size:
    1883 amino acids
    Molecular mass:
    205138 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM131 Gene

Post-translational modifications for TMEM131 Gene

  • Glycosylation at Asn 300
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM131 Gene

Domains & Families for TMEM131 Gene

Protein Domains for TMEM131 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM131 Gene

Graphical View of Domain Structure for InterPro Entry

Q92545

UniProtKB/Swiss-Prot:

TM131_HUMAN :
  • Belongs to the TMEM131 family.
Family:
  • Belongs to the TMEM131 family.
genes like me logo Genes that share domains with TMEM131: view

No data available for Gene Families for TMEM131 Gene

Function for TMEM131 Gene

Molecular function for TMEM131 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the immune response to viral infection.

Gene Ontology (GO) - Molecular Function for TMEM131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM131: view

Animal Model Products

miRNA for TMEM131 Gene

miRTarBase miRNAs that target TMEM131

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM131 Gene

Localization for TMEM131 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM131 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM131 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 3
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TMEM131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA,IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM131: view

Pathways & Interactions for TMEM131 Gene

SuperPathways for TMEM131 Gene

No Data Available

Interacting Proteins for TMEM131 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000186436%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000264018%0d%0a9606.ENSP00000321746%0d%0a
Selected Interacting proteins: ENSP00000186436 Q92545-TM131_HUMAN for TMEM131 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM131: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM131 Gene

Transcripts for TMEM131 Gene

Unigene Clusters for TMEM131 Gene

Transmembrane protein 131:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM131 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for TMEM131 Gene

GeneLoc Exon Structure for
TMEM131
ECgene alternative splicing isoforms for
TMEM131

Expression for TMEM131 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM131 Gene

Protein differential expression in normal tissues from HIPED for TMEM131 Gene

This gene is overexpressed in Serum (65.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM131 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM131 Gene:

TMEM131

SOURCE GeneReport for Unigene cluster for TMEM131 Gene:

Hs.469376
genes like me logo Genes that share expression patterns with TMEM131: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMEM131 Gene

Orthologs for TMEM131 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM131 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM131 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia TMEM131 34 35
  • 92.81 (n)
cow
(Bos Taurus)
Mammalia TMEM131 34 35
  • 89.4 (n)
rat
(Rattus norvegicus)
Mammalia Tmem131 34
  • 86.65 (n)
mouse
(Mus musculus)
Mammalia Tmem131 34 16 35
  • 86.58 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM131 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM131 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM131 34 35
  • 77.53 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM131 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem131 34
  • 71.16 (n)
Str.20200 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8560 34
zebrafish
(Danio rerio)
Actinopterygii tmem131 34 35
  • 63.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8370 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C27F2.8 35
  • 19 (a)
OneToMany
Species where no ortholog for TMEM131 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM131 Gene

ENSEMBL:
Gene Tree for TMEM131 (if available)
TreeFam:
Gene Tree for TMEM131 (if available)

Paralogs for TMEM131 Gene

Paralogs for TMEM131 Gene

genes like me logo Genes that share paralogs with TMEM131: view

Variants for TMEM131 Gene

Sequence variations from dbSNP and Humsavar for TMEM131 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10165072 -- 97,832,054(+) ATCTA(A/G)AAAAC intron-variant
rs10165306 -- 97,832,308(+) AAAAA(A/G)ATACT intron-variant
rs10166513 -- 97,852,952(+) agata(A/G)cagca intron-variant
rs10167772 -- 97,892,553(+) ataca(A/G)ggtgt intron-variant
rs10168543 -- 97,798,220(+) AGGTT(A/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM131 Gene

Variant ID Type Subtype PubMed ID
dgv222n21 CNV gain 19592680
dgv4027n100 CNV gain 25217958
dgv608e201 CNV deletion 23290073
esv2508372 CNV deletion 19546169
esv2672611 CNV deletion 23128226
esv2673220 CNV deletion 23128226
esv27014 CNV loss 19812545
esv2720425 CNV deletion 23290073
esv2720427 CNV deletion 23290073
esv3303867 CNV mobile element insertion 20981092
esv3323014 CNV insertion 20981092
esv3367587 CNV insertion 20981092
esv3421211 CNV insertion 20981092
esv3559825 CNV deletion 23714750
esv3575286 CNV gain 25503493
esv3583978 CNV loss 25503493
esv3591721 CNV loss 21293372
esv4457 CNV loss 18987735
nsv1013416 CNV gain 25217958
nsv1114118 CNV deletion 24896259
nsv1123361 CNV deletion 24896259
nsv1131494 CNV deletion 24896259
nsv1144906 CNV deletion 24896259
nsv1154097 CNV duplication 26484159
nsv2838 CNV insertion 18451855
nsv2839 CNV insertion 18451855
nsv518056 CNV gain 19592680
nsv819283 CNV loss 19587683
nsv953489 CNV duplication 24416366
nsv953490 CNV duplication 24416366
nsv953491 CNV duplication 24416366
nsv961841 CNV duplication 23825009

Variation tolerance for TMEM131 Gene

Residual Variation Intolerance Score: 13.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.38; 85.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM131 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM131

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM131 Gene

Disorders for TMEM131 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMEM131 Gene - From: DISEASES

Disorder Aliases PubMed IDs
subdural empyema
  • subdural abscess
streptococcal meningitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM131

Genetic Association Database (GAD)
TMEM131
Human Genome Epidemiology (HuGE) Navigator
TMEM131
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM131
genes like me logo Genes that share disorders with TMEM131: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM131 Gene

Publications for TMEM131 Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  4. Use of mRNA differential display to study the action of lymphocyte subsets in vivo and application to a murine model of herpes simplex virus infection. (PMID: 10996388) Tscharke D.C. … Simmons A. (Immunol. Lett. 2000) 2 3 64
  5. Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners. (PMID: 27100087) Alves da Silva A.F. … Medina-Acosta E. (PLoS ONE 2016) 3 64

Products for TMEM131 Gene

Sources for TMEM131 Gene

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