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Aliases for TMEM131 Gene

Aliases for TMEM131 Gene

  • Transmembrane Protein 131 2 3 5
  • RW1 3 4
  • 2610524E03Rik 3
  • Protein RW1 4
  • KIAA0257 4
  • PRO1048 3
  • YR-23 3
  • CC28 3

External Ids for TMEM131 Gene

Previous GeneCards Identifiers for TMEM131 Gene

  • GC02M098372
  • GC02M092138

Summaries for TMEM131 Gene

GeneCards Summary for TMEM131 Gene

TMEM131 (Transmembrane Protein 131) is a Protein Coding gene. Diseases associated with TMEM131 include subdural empyema and streptococcal meningitis. An important paralog of this gene is KIAA0922.

UniProtKB/Swiss-Prot for TMEM131 Gene

  • May play a role in the immune response to viral infection.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM131 Gene

Genomics for TMEM131 Gene

Regulatory Elements for TMEM131 Gene

Enhancers for TMEM131 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM131 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM131 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM131 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM131 Gene

Chromosome:
2
Start:
97,756,333 bp from pter
End:
97,995,932 bp from pter
Size:
239,600 bases
Orientation:
Minus strand

Genomic View for TMEM131 Gene

Genes around TMEM131 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM131 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM131 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM131 Gene

Proteins for TMEM131 Gene

  • Protein details for TMEM131 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92545-TM131_HUMAN
    Recommended name:
    Transmembrane protein 131
    Protein Accession:
    Q92545

    Protein attributes for TMEM131 Gene

    Size:
    1883 amino acids
    Molecular mass:
    205138 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM131 Gene

Proteomics data for TMEM131 Gene at MOPED

Post-translational modifications for TMEM131 Gene

  • Glycosylation at Asn 300
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM131 Gene

No data available for DME Specific Peptides for TMEM131 Gene

Domains & Families for TMEM131 Gene

Protein Domains for TMEM131 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM131 Gene

Graphical View of Domain Structure for InterPro Entry

Q92545

UniProtKB/Swiss-Prot:

TM131_HUMAN :
  • Belongs to the TMEM131 family.
Family:
  • Belongs to the TMEM131 family.
genes like me logo Genes that share domains with TMEM131: view

No data available for Gene Families for TMEM131 Gene

Function for TMEM131 Gene

Molecular function for TMEM131 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the immune response to viral infection.

Animal Model Products

CRISPR Products

miRNA for TMEM131 Gene

miRTarBase miRNAs that target TMEM131

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM131 Gene

Localization for TMEM131 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM131 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM131 Gene COMPARTMENTS Subcellular localization image for TMEM131 gene
Compartment Confidence
cytoskeleton 3
plasma membrane 3
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM131: view

Pathways & Interactions for TMEM131 Gene

SuperPathways for TMEM131 Gene

No Data Available

Interacting Proteins for TMEM131 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000186436%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000264018%0d%0a9606.ENSP00000321746%0d%0a
Selected Interacting proteins: Q92545-TM131_HUMAN ENSP00000186436 for TMEM131 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for TMEM131 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM131 Gene

Drugs & Compounds for TMEM131 Gene

No Compound Related Data Available

Transcripts for TMEM131 Gene

Unigene Clusters for TMEM131 Gene

Transmembrane protein 131:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM131 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for TMEM131 Gene

GeneLoc Exon Structure for
TMEM131
ECgene alternative splicing isoforms for
TMEM131

Expression for TMEM131 Gene

mRNA expression in normal human tissues for TMEM131 Gene

Protein differential expression in normal tissues from HIPED for TMEM131 Gene

This gene is overexpressed in Serum (65.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM131 Gene



SOURCE GeneReport for Unigene cluster for TMEM131 Gene Hs.469376

genes like me logo Genes that share expression patterns with TMEM131: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM131 Gene

Orthologs for TMEM131 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM131 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM131 35
  • 89.4 (n)
  • 92.66 (a)
TMEM131 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM131 35
  • 92.81 (n)
  • 95.36 (a)
TMEM131 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem131 35
  • 86.58 (n)
  • 89.5 (a)
Tmem131 16
Tmem131 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM131 35
  • 99.63 (n)
  • 99.58 (a)
TMEM131 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem131 35
  • 86.65 (n)
  • 89.04 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM131 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM131 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM131 35
  • 77.53 (n)
  • 79.8 (a)
TMEM131 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM131 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20200 35
tmem131 35
  • 71.16 (n)
  • 73.16 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8560 35
zebrafish
(Danio rerio)
Actinopterygii tmem131 35
  • 63.89 (n)
  • 63.02 (a)
tmem131 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8370 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C27F2.8 36
  • 19 (a)
OneToMany
Species with no ortholog for TMEM131:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM131 Gene

ENSEMBL:
Gene Tree for TMEM131 (if available)
TreeFam:
Gene Tree for TMEM131 (if available)

Paralogs for TMEM131 Gene

Paralogs for TMEM131 Gene

genes like me logo Genes that share paralogs with TMEM131: view

Variants for TMEM131 Gene

Sequence variations from dbSNP and Humsavar for TMEM131 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs717417 -- 97,800,387(-) ACTAC(A/C)AGCCA intron-variant
rs718159 -- 97,803,071(+) ATCCC(A/G)CGTAA intron-variant
rs1562293 -- 97,795,819(+) TATTA(C/T)ATATC intron-variant
rs1562294 -- 97,820,250(+) AATAT(G/T)TTTAC intron-variant
rs1578957 -- 97,921,970(+) AAACT(A/G)TATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM131 Gene

Variant ID Type Subtype PubMed ID
dgv651e201 CNV Deletion 23290073
esv4457 CNV Deletion 18987735
esv2720425 CNV Deletion 23290073
esv2672611 CNV Deletion 23128226
dgv222n21 CNV Gain 19592680
nsv819283 CNV Loss 19587683
nsv2838 CNV Insertion 18451855
esv272982 CNV Insertion 20981092
esv2720427 CNV Deletion 23290073
esv2673220 CNV Deletion 23128226
esv27014 CNV Loss 19812545
esv2508372 CNV Deletion 19546169
nsv2839 CNV Insertion 18451855
esv268146 CNV Insertion 20981092
nsv518056 CNV Gain 19592680

Variation tolerance for TMEM131 Gene

Residual Variation Intolerance Score: 13.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.38; 85.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM131 Gene

HapMap Linkage Disequilibrium report
TMEM131

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM131 Gene

Disorders for TMEM131 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMEM131 Gene - From: DISEASES

Disorder Aliases PubMed IDs
subdural empyema
  • subdural abscess
streptococcal meningitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM131

Genetic Association Database (GAD)
TMEM131
Human Genome Epidemiology (HuGE) Navigator
TMEM131
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM131
genes like me logo Genes that share disorders with TMEM131: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM131 Gene

Publications for TMEM131 Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4 67
  2. Use of mRNA differential display to study the action of lymphocyte subsets in vivo and application to a murine model of herpes simplex virus infection. (PMID: 10996388) Tscharke D.C. … Simmons A. (Immunol. Lett. 2000) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for TMEM131 Gene

Sources for TMEM131 Gene

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