Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM131 Gene

Aliases for TMEM131 Gene

  • Transmembrane Protein 131 2 3
  • KIAA0257 4 6
  • CC28 3 6
  • RW1 3 4
  • 2610524E03Rik 3
  • Protein RW1 4
  • PRO1048 3
  • YR-23 3

External Ids for TMEM131 Gene

Previous GeneCards Identifiers for TMEM131 Gene

  • GC02M098372
  • GC02M092138

Summaries for TMEM131 Gene

GeneCards Summary for TMEM131 Gene

TMEM131 (Transmembrane Protein 131) is a Protein Coding gene. Diseases associated with TMEM131 include campylobacteriosis. An important paralog of this gene is KIAA0922.

UniProtKB/Swiss-Prot for TMEM131 Gene

  • May play a role in the immune response to viral infection.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM131 Gene

Genomics for TMEM131 Gene

Regulatory Elements for TMEM131 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM131 Gene

97,756,333 bp from pter
97,995,926 bp from pter
239,594 bases
Minus strand

Genomic View for TMEM131 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM131 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM131 Gene

Proteins for TMEM131 Gene

  • Protein details for TMEM131 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 131
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TMEM131 Gene

    1883 amino acids
    Molecular mass:
    205138 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM131 Gene

Proteomics data for TMEM131 Gene at MOPED

Post-translational modifications for TMEM131 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM131 Gene

No data available for DME Specific Peptides for TMEM131 Gene

Domains for TMEM131 Gene

Protein Domains for TMEM131 Gene


Suggested Antigen Peptide Sequences for TMEM131 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q92545
  • Belongs to the TMEM131 family.
genes like me logo Genes that share domains with TMEM131: view

No data available for Gene Families for TMEM131 Gene

Function for TMEM131 Gene

Molecular function for TMEM131 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the immune response to viral infection.

Gene Ontology (GO) - Molecular Function for TMEM131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM131: view

Animal Model Products

CRISPR Products

miRNA for TMEM131 Gene

miRTarBase miRNAs that target TMEM131

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM131 Gene

Localization for TMEM131 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM131 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM131 Gene COMPARTMENTS Subcellular localization image for TMEM131 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM131: view

Pathways for TMEM131 Gene

SuperPathways for TMEM131 Gene

No Data Available

Interacting Proteins for TMEM131 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000186436 Q92545-TM131_HUMAN for TMEM131 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TMEM131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM131: view

No data available for Pathways by source for TMEM131 Gene

Transcripts for TMEM131 Gene

Unigene Clusters for TMEM131 Gene

Transmembrane protein 131:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM131

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM131 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - -
SP4: -

Relevant External Links for TMEM131 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM131 Gene

mRNA expression in normal human tissues for TMEM131 Gene

Protein differential expression in normal tissues for TMEM131 Gene

This gene is overexpressed in Serum (65.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM131 Gene

SOURCE GeneReport for Unigene cluster for TMEM131 Gene Hs.469376

genes like me logo Genes that share expressions with TMEM131: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for TMEM131 Gene

Orthologs for TMEM131 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM131 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM131 35
  • 89.4 (n)
  • 92.66 (a)
TMEM131 36
  • 92 (a)
(Canis familiaris)
Mammalia TMEM131 35
  • 92.81 (n)
  • 95.36 (a)
TMEM131 36
  • 95 (a)
(Mus musculus)
Mammalia Tmem131 35
  • 86.58 (n)
  • 89.5 (a)
Tmem131 16
Tmem131 36
  • 90 (a)
(Pan troglodytes)
Mammalia TMEM131 35
  • 99.63 (n)
  • 99.58 (a)
TMEM131 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tmem131 35
  • 86.65 (n)
  • 89.04 (a)
(Monodelphis domestica)
Mammalia TMEM131 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM131 36
  • 73 (a)
(Gallus gallus)
Aves TMEM131 35
  • 77.53 (n)
  • 79.8 (a)
TMEM131 36
  • 79 (a)
(Anolis carolinensis)
Reptilia TMEM131 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20200 35
tmem131 35
  • 71.16 (n)
  • 73.16 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8560 35
(Danio rerio)
Actinopterygii tmem131 35
  • 63.89 (n)
  • 63.02 (a)
tmem131 36
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8370 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea C27F2.8 36
  • 19 (a)
Species with no ortholog for TMEM131:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM131 Gene

Gene Tree for TMEM131 (if available)
Gene Tree for TMEM131 (if available)

Paralogs for TMEM131 Gene

Paralogs for TMEM131 Gene

genes like me logo Genes that share paralogs with TMEM131: view

Variants for TMEM131 Gene

Sequence variations from dbSNP and Humsavar for TMEM131 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs5865 -- 97,756,543(+) TTCAC(C/T)GTTCT utr-variant-3-prime
rs6875 -- 97,756,517(-) TCAGT(C/T)GAGAC utr-variant-3-prime
rs14423 -- 97,828,011(+) GAATT(A/G)TGTGC intron-variant
rs717417 -- 97,800,387(-) ACTAC(A/C)AGCCA intron-variant
rs718159 -- 97,803,071(+) ATCCC(A/G)CGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM131 Gene

Variant ID Type Subtype PubMed ID
dgv651e201 CNV Deletion 23290073
esv4457 CNV Deletion 18987735
esv2720425 CNV Deletion 23290073
esv2672611 CNV Deletion 23128226
dgv222n21 CNV Gain 19592680
nsv819283 CNV Loss 19587683
nsv2838 CNV Insertion 18451855
esv272982 CNV Insertion 20981092
esv2720427 CNV Deletion 23290073
esv2673220 CNV Deletion 23128226
esv27014 CNV Loss 19812545
esv2508372 CNV Deletion 19546169
nsv2839 CNV Insertion 18451855
esv268146 CNV Insertion 20981092
nsv518056 CNV Gain 19592680

Relevant External Links for TMEM131 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM131 Gene

Disorders for TMEM131 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TMEM131 Gene in MalaCards »

(1) Diseases for TMEM131 Gene including...

(1) University of Copenhagen DISEASES for TMEM131 Gene

Relevant External Links for TMEM131

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TMEM131: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for TMEM131 Gene

Publications for TMEM131 Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4
  2. Use of mRNA differential display to study the action of lymphocyte subsets in vivo and application to a murine model of herpes simplex virus infection. (PMID: 10996388) Tscharke D.C. … Simmons A. (Immunol. Lett. 2000) 2 3
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for TMEM131 Gene

Sources for TMEM131 Gene

Back to Top