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Aliases for TMEM129 Gene

Aliases for TMEM129 Gene

  • Transmembrane Protein 129, E3 Ubiquitin Protein Ligase 2 3
  • E3 Ubiquitin-Protein Ligase TM129 3
  • Transmembrane Protein 129 2
  • EC 6.3.2.- 4
  • D4S2561E 3

External Ids for TMEM129 Gene

Summaries for TMEM129 Gene

GeneCards Summary for TMEM129 Gene

TMEM129 (Transmembrane Protein 129, E3 Ubiquitin Protein Ligase) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM129 Gene

  • E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM129 Gene

Genomics for TMEM129 Gene

Genomic Location for TMEM129 Gene

Start:
1,715,952 bp from pter
End:
1,721,358 bp from pter
Size:
5,407 bases
Orientation:
Minus strand

Genomic View for TMEM129 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM129 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM129 Gene

Regulatory Elements for TMEM129 Gene

Proteins for TMEM129 Gene

  • Protein details for TMEM129 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0AVI4-TM129_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TM129
    Protein Accession:
    A0AVI4
    Secondary Accessions:
    • A6NH49
    • A6NI98
    • D3DVP8

    Protein attributes for TMEM129 Gene

    Size:
    362 amino acids
    Molecular mass:
    40464 Da
    Quaternary structure:
    • Integral component of ER-resident dislocation complexes

    Alternative splice isoforms for TMEM129 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM129 Gene

Proteomics data for TMEM129 Gene at MOPED

Post-translational modifications for TMEM129 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn229

Other Protein References for TMEM129 Gene

No data available for DME Specific Peptides for TMEM129 Gene

Domains for TMEM129 Gene

Protein Domains for TMEM129 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TM129_HUMAN
Domain:
  • The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity:
    • A0AVI4
Family:
  • Belongs to the TMEM129 family.:
    • A0AVI4
Similarity:
  • Contains 1 RING-type zinc finger.:
    • A0AVI4
genes like me logo Genes that share domains with TMEM129: view

No data available for Gene Families for TMEM129 Gene

Function for TMEM129 Gene

Molecular function for TMEM129 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation.

Enzyme Numbers (IUBMB) for TMEM129 Gene

Gene Ontology (GO) - Molecular Function for TMEM129 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TMEM129: view

Phenotypes for TMEM129 Gene

GenomeRNAi human phenotypes for TMEM129:
genes like me logo Genes that share phenotypes with TMEM129: view

miRNA for TMEM129 Gene

miRTarBase miRNAs that target TMEM129

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM129 Gene

Localization for TMEM129 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM129 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM129 Gene COMPARTMENTS Subcellular localization image for TMEM129 gene
Compartment Confidence
plasma membrane 3
extracellular 2
lysosome 1

Gene Ontology (GO) - Cellular Components for TMEM129 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM129: view

Pathways for TMEM129 Gene

SuperPathways for TMEM129 Gene

No Data Available

UniProtKB/Swiss-Prot A0AVI4-TM129_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Interacting Proteins for TMEM129 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000372394%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000372394 for TMEM129 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for TMEM129 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein IEA --
GO:0008150 biological_process ND --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with TMEM129: view

No data available for Pathways by source for TMEM129 Gene

Transcripts for TMEM129 Gene

Unigene Clusters for TMEM129 Gene

Transmembrane protein 129:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM129 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2:
SP3: - - - - -
SP4: -
SP5:

Relevant External Links for TMEM129 Gene

GeneLoc Exon Structure for
TMEM129
ECgene alternative splicing isoforms for
TMEM129

Expression for TMEM129 Gene

mRNA expression in normal human tissues for TMEM129 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM129 Gene

SOURCE GeneReport for Unigene cluster for TMEM129 Gene Hs.518562

genes like me logo Genes that share expressions with TMEM129: view

Orthologs for TMEM129 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM129 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM129 36
  • 99.88 (n)
  • 100 (a)
TMEM129 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM129 36
  • 89.32 (n)
  • 90.33 (a)
TMEM129 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM129 36
  • 88.12 (n)
  • 91.16 (a)
TMEM129 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem129 36
  • 84.35 (n)
  • 89.23 (a)
Tmem129 16
Tmem129 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM129 37
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM129 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem129 36
  • 84.9 (n)
  • 89.78 (a)
chicken
(Gallus gallus)
Aves TMEM129 36
  • 73.2 (n)
  • 75.41 (a)
TMEM129 37
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem129 36
  • 72.65 (n)
  • 74.86 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem129 36
  • 65.1 (n)
  • 64.82 (a)
tmem129 37
  • 65 (a)
OneToOne
wufc17d07 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011818 36
  • 37.43 (n)
  • 19.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14646 36
  • 49.2 (n)
  • 34.08 (a)
CG14646 37
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C34F6.7 36
  • 39.49 (n)
  • 27.69 (a)
C34F6.7 37
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6846 37
  • 42 (a)
OneToOne
Species with no ortholog for TMEM129:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM129 Gene

ENSEMBL:
Gene Tree for TMEM129 (if available)
TreeFam:
Gene Tree for TMEM129 (if available)

Paralogs for TMEM129 Gene

No data available for Paralogs for TMEM129 Gene

Variants for TMEM129 Gene

Sequence variations from dbSNP and Humsavar for TMEM129 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs712982 -- 1,717,906(-) GATTC(G/T)TGGGG intron-variant
rs712983 -- 1,718,090(-) TCTGG(C/T)GCCAC intron-variant
rs743569 -- 1,717,893(+) TGTCC(G/T)GAGTG intron-variant
rs798751 -- 1,717,845(+) ACGGG(A/G)CGGAC intron-variant
rs798752 - 1,718,585(-) AGCGG(A/C)TCCAC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for TMEM129 Gene

Variant ID Type Subtype PubMed ID
nsv878328 CNV Loss 21882294
nsv878347 CNV Loss 21882294
dgv5408n71 CNV Loss 21882294
nsv822437 CNV Loss 20364138
nsv470000 CNV Loss 18288195
dgv5414n71 CNV Loss 21882294
dgv1565e1 CNV Complex 17122850
nsv428434 CNV Gain 18775914
nsv508989 CNV Insertion 20534489
nsv878392 CNV Loss 21882294
nsv878393 CNV Loss 21882294
dgv5415n71 CNV Loss 21882294
dgv5416n71 CNV Loss 21882294
nsv292653 CNV Loss 16902084
esv2726832 CNV Deletion 23290073

Relevant External Links for TMEM129 Gene

HapMap Linkage Disequilibrium report
TMEM129

Disorders for TMEM129 Gene

Relevant External Links for TMEM129

Genetic Association Database (GAD)
TMEM129
Human Genome Epidemiology (HuGE) Navigator
TMEM129
genes like me logo Genes that share disorders with TMEM129: view

No data available for UniProtKB/Swiss-Prot for TMEM129 Gene

Publications for TMEM129 Gene

  1. A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation. (PMID: 24807418) van de Weijer M.L. … Lebbink R.J. (Nat. Commun. 2014) 2 3 4
  2. TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I. (PMID: 25030448) van den Boomen D.J. … Lehner P.J. (Proc. Natl. Acad. Sci. U.S.A. 2014) 2 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. (PMID: 20972438) Rothman N. … Chanock S.J. (Nat. Genet. 2010) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for TMEM129 Gene

Sources for TMEM129 Gene

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