TMEM129 Gene
protein-coding GIFtS: 42
GCID: GC04M001717
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Transmembrane Protein 129
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Aliases
for TMEM129 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 1291 2 | | D4S2561E2 |
Export aliases for TMEM129 gene to outside databasesPrevious GC identifers: GC04M001687 GC04M001660 |
Summaries
for TMEM129 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for TMEM129 Gene: 
TMEM129 (transmembrane protein 129) is a protein-coding gene. GO annotations related to this gene include molecular_function.
|
Genomic Views
for TMEM129 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NT_006051.18 NC_018915.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM129 gene promoter:
GR p53 GR-beta GR-alpha Nkx2-5 NF-E2 NF-E2 p45
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM129
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM129 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3TMEM129 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M001717: view genomic region
(about GC identifiers)
Start:
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1,717,679 bp from pter |
End:
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1,723,085 bp from pter |
Size:
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5,407 bases |
Orientation:
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minus strand |
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Proteins
for TMEM129 gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
|
UniProtKB/Swiss-Prot: TM129_HUMAN, A0AVI4 (See
protein sequence)Recommended Name: Transmembrane protein 129 precursor Size: 362 amino acids; 40464 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A6NH49 A6NI98 D3DVP8Alternative splicing: 2 isoforms: A0AVI4-1 A0AVI4-2 Explore the universe of human proteins at neXtProt for TMEM129: NX_A0AVI4
Explore proteomics data for TMEM129 at MOPED
Post-translational modifications:
View modification sites using PhosphoSitePlusView neXtProt modification sites for NX_A0AVI4
TMEM129 Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001120738.1 NP_612394.1
ENSEMBL proteins: ENSP00000305243 ENSP00000372394 ENSP00000417412 ENSP00000417259 ENSP00000441812
Human Recombinant Protein Products for TMEM129:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TMEM129 for ontologies About GeneDecksing
TMEM129 Antibody Products:
Assay Products for TMEM129: |
Protein
Domains /
Families
for TMEM129 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| 1 InterPro protein domain:Graphical View of Domain Structure for InterPro Entry A0AVI4 ProtoNet protein and cluster: A0AVI4 UniProtKB/Swiss-Prot: TM129_HUMAN, A0AVI4Similarity: Belongs to the TMEM129 family
TMEM129 for domains About GeneDecksing
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Function
for TMEM129 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
Vector BioLabs,
and Sirion Biotech,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
TMEM129 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for TMEM129:
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for TMEM129 | |  | Search LifeMap BioReagents cell lines for TMEM129 | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM129 |
Pathways & Interactions
for TMEM129 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM129
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TMEM129 (ENSP000003723944) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
TMEM129 for ontologies About GeneDecksing
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Drugs & Compounds
for TMEM129 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM129 (TM129)
Search CenterWatch for drugs/clinical trials and news about TMEM129 / TM129
|
Transcripts
for TMEM129 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Sirion Biotech,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM129 gene (2 alternative transcripts): NM_001127266.1 NM_138385.3 Unigene Cluster for TMEM129: Transmembrane protein 129 Hs.518562 [show with all ESTs]Unigene Representative Sequence: NM_0011272666 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000303277(uc003gdm.3) ENST00000382936(uc010iby.3 uc003gdn.3)
ENST00000460722 ENST00000476253 ENST00000480360 ENST00000536901
Primer
Products: |  | OriGene qSTAR qPCR primer pairs in human, mouse for TMEM129
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM129 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM129 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM129 |
Additional mRNA sequence: AK098466.1 AK303880.1 AK310320.1 BC009331.2 BC018921.2 BC126370.1 13 DOTS entries: DT.451775 DT.100755368 DT.100755370 DT.121216962 DT.99970945 DT.100755366 DT.121217001 DT.121216979 DT.92432167 DT.95082332 DT.95129749 DT.95129750 DT.97844837 24/206 AceView cDNA sequences (see all 206): BM973525 BC018921 AI474764 AI151168 AI369871 AL555494 AI573144 CA488731 BM977729 BI820666 BC009331 BQ675936 BM999885 AI632121 AI332525 BU738417 BU155586 AI262624 AL566420 BU616076 BM710305 BI821105 AI343463 BF525494
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM129 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|
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| SP1: | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | - | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM129
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Expression
for TMEM129 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM129 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCGGGAGCC
About this image
See TMEM129 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM129
SOURCE GeneReport for Unigene cluster: Hs.518562
SABiosciences Custom PCR Arrays for TMEM129
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for TMEM129
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM129 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM129 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM129 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM129 |
Orthologs
for TMEM129 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM129 gene from 5/13 species (see all 13) About this table
ENSEMBL Gene Tree for TMEM129 (if available)
TreeFam Gene Tree for TMEM129 (if available) |
Paralogs
for TMEM129 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM129 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM129 (1717679 - 1723085 bp)
Structural Variations
Database of Genomic Variants (DGV) 10/15 variations for TMEM129 (see all 15): About this table
| | SABiosciences Cancer Mutation PCR Assays |
| | SeqTarget long-range PCR primers for resequencing TMEM129 |
|
Disorders
/ Diseases
for TMEM129 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TMEM129 for disorders About MalaCards
TMEM129 for disorders About GeneDecksing
Genetic Association Database (GAD): TMEM129
Human Genome Epidemiology (HuGE) Navigator: TMEM129 (1 document)
Export disorders for TMEM129 gene to outside databases
|
Publications
for TMEM129 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM129 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM129) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A sequence variant at 4p16.3 confers susceptibility t o urinary bladder cancer. (PubMed id 20348956)1 Kiemeney L.A....Stefansson K. (2010)
- A multi-stage genome-wide association study of bladde r cancer identifies multiple susceptibility loci. (PubMed id 20972438)1 Rothman N....Chanock S.J. (2010)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TMEM129 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM129 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM129 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM129 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM129 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM129 gene:
Search GeneIP for patents involving TMEM129
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM129 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM129 | | | QIAGEN SeqTarget long-range PCR primers for resequencing TMEM129 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM129 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM129 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM129 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM129 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM129 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TMEM129 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM129 |
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