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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM128 Gene

protein-coding   GIFtS: 38
GCID: GC04M004237

Transmembrane Protein 128

  Search for TMEM128
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 1281 2

External Ids:    HGNC: 282011   Entrez Gene: 850132   Ensembl: ENSG000001324067   UniProtKB: Q5BJH23   

Export aliases for TMEM128 gene to outside databases

Previous GC identifers: GC04M004288 GC04M004172


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM128 Gene: 
TMEM128 (transmembrane protein 128) is a protein-coding gene. GO annotations related to this gene include molecular_function.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_006051.18  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM128 gene promoter:
         HOXA9   HOXA9B   YY1   Evi-1   POU2F1   POU2F1a   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM128 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM128

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM128


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

TMEM128 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM128 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M004237:  view genomic region     (about GC identifiers)

Start:
4,237,269 bp from pter      End:
4,249,950 bp from pter
Size:
12,682 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM128_HUMAN, Q5BJH2 (See protein sequence)
Recommended Name: Transmembrane protein 128  
Size: 165 amino acids; 18822 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B4DHS7 D3DVS3 Q5H9U6 Q96I94
Alternative splicing: 2 isoforms:  Q5BJH2-1   Q5BJH2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM128: NX_Q5BJH2

Explore proteomics data for TMEM128 at MOPED 

TMEM128 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TMEM128 Protein Expression

REFSEQ proteins: NP_116316.1  
ENSEMBL proteins: 
 ENSP00000254742   ENSP00000372201   ENSP00000442300   ENSP00000439174  

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--
GO:0016021integral to membrane IEA--

TMEM128 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q5BJH2


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
     
TMEM128 for ontologies           About GeneDecksing


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SwitchGear 3'UTR luciferase reporter plasmidTMEM128 3' UTR sequence
Inhib. RNA
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM128

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008150biological_process ND--

TMEM128 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM128 (TM128)

Search CenterWatch for drugs/clinical trials and news about TMEM128 / TM128

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM128 gene: 
NM_032927.2  

Unigene Cluster for TMEM128:

Transmembrane protein 128
Hs.12845  [show with all ESTs]
Unigene Representative Sequence: CR933611
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000254742(uc003ghq.1 uc003ghr.1 uc003ghs.3) ENST00000382753
ENST00000538516(uc011bvv.1 uc011bvw.1) ENST00000540397
miRNA
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SwitchGear 3'UTR luciferase reporter plasmidTMEM128 3' UTR sequence
Inhib. RNA
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Additional mRNA sequence: 

AK001453.1 AK054701.1 AK295248.1 AK296007.1 BC007729.2 BC091482.1 CR933611.1 

7 DOTS entries:

DT.216224  DT.100751381  DT.92429183  DT.95202682  DT.95325144  DT.121242973  DT.121242966 

24/145 AceView cDNA sequences (see all 145):

BQ774244 CR606526 AA731502 BX416075 CA943313 AI962753 AL519982 AW264527 
AA279404 AA555070 AI681856 AA328023 CA445436 AA279915 AA506271 BF792179 
D62868 BQ896897 BM453946 NM_032927 CA419469 CA414019 BX499927 BF817479 

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM128 (see all 6)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d
SP1:                    -                             -     -     -                           
SP2:                    -                                                                     
SP3:                                                  -     -     -                           
SP4:                    -                             -     -     -                           
SP5:                                                  -     -     -                           


ECgene alternative splicing isoforms for TMEM128

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM128 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGCCTTTAAC
TMEM128 Expression
About this image


See TMEM128 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM128

SOURCE GeneReport for Unigene cluster: Hs.12845
    SABiosciences Custom PCR Arrays for TMEM128
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM128
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM128

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TMEM128 gene from 5/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmem1281 , 5 transmembrane protein 1281, 5 85.19(n)1
88.15(a)1
  5 (20.33 cM)5
663091  NM_025480.31  NP_079756.21 
 382601855 
chicken
(Gallus gallus)
Aves TMEM1281 transmembrane protein 128 72.76(n)
67.31(a)
  422845  NM_001031163.1  NP_001026334.1 
lizard
(Anolis carolinensis)
Reptilia TMEM1286
transmembrane protein 128
59(a)
1 ↔ 1
GL343236.1(602673-619854)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.119562 Transcribed sequence with weak similarity to protein more 72.32(n)    CF346765.1 
zebrafish
(Danio rerio)
Actinopterygii tmem1281 transmembrane protein 128 57.14(n)
57.14(a)
  574426  NM_001029973.1  NP_001025144.1 


ENSEMBL Gene Tree for TMEM128 (if available)
TreeFam Gene Tree for TMEM128 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TMEM128 gene

TMEM128 for paralogs           About GeneDecksing


3 Pseudogenes.org Pseudogenes for TMEM128
PGOHUM00000234311 PGOHUM00000240765 PGOHUM00000245973


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/523 SNPs in TMEM128 are shown (see all 523)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1126650621,2
C,F--4236799(+) TACAGG/TCTGAC 1 -- int12Minor allele frequency- T:0.50WA NA 4
rs1830330911,2
--4236808(+) ACTACC/TCCTTC 1 -- int10--------
rs41336861,2
C,F--4236824(+) AATGCT/CTGGGA 1 -- int14Minor allele frequency- C:0.25NA WA 8
rs1116347781,2
C,F--4236909(+) GAGTGC/TCACGT 1 -- int12Minor allele frequency- T:0.50WA NA 4
rs1400653911,2
--4236912(+) TGTCAC/TGTCAG 1 -- int10--------
rs38569621,2
C,F,A,H--4236919(+) TCAGTC/AATCAA 1 -- int19Minor allele frequency- A:0.22NS EA NA WA 780
rs1437349181,2
--4237032(+) TAAGTC/GAGGTC 1 -- int10--------
rs1876266751,2
--4237053(+) GTCACA/CTTACA 1 -- int10--------
rs38569631,2
C--4237070(+) ACAATC/GAACAT 1 -- int16Minor allele frequency- G:0.20NA WA EA 364
rs743640071,2
C,F--4237207(+) TAATTC/TAAAGT 1 -- int11Minor allele frequency- T:0.03NA 120

HapMap Linkage Disequilibrium report for TMEM128 (4237269 - 4249950 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for TMEM128:    About this table     
Variant IDTypeSubtypePubMed ID
esv2661007CNV Deletion23128226
nsv822448CNV Gain20364138
dgv1566e1CNV Complex17122850
nsv469857CNV Complex16826518

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMEM128 for disorders           About MalaCards

TMEM128 for disorders           About GeneDecksing

Genetic Association Database (GAD): TMEM128

Export disorders for TMEM128 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TMEM128 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM128)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. Identifying protein partners of CLN8, an ER-resident p rotein involved in neuronal ceroid lipofuscinosis. (PubMed id 23142642)1 Passantino R....Guarneri P. (2013)
  4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
  5. Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data. (PubMed id 17052657)4 Fung H.C....Singleton A. (2006)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 85013 HGNC: 28201 AceView: MGC13159 Ensembl:ENSG00000132406 euGenes: HUgn85013
ECgene: TMEM128 H-InvDB: TMEM128

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TMEM128 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TMEM128 gene:
Search GeneIP for patents involving TMEM128

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Proteins for TMEM128
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM128
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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