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Aliases for TMEM128 Gene

Aliases for TMEM128 Gene

  • Transmembrane Protein 128 2 3 5

External Ids for TMEM128 Gene

Previous GeneCards Identifiers for TMEM128 Gene

  • GC04M004288
  • GC04M004172

Summaries for TMEM128 Gene

GeneCards Summary for TMEM128 Gene

TMEM128 (Transmembrane Protein 128) is a Protein Coding gene. Diseases associated with TMEM128 include Neuronal Ceroid Lipofuscinosis.

Additional gene information for TMEM128 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM128 Gene

Genomics for TMEM128 Gene

GeneHancer (GH) Regulatory Elements for TMEM128 Gene

Promoters and enhancers for TMEM128 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I004247 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 566.3 -0.1 -59 2.2 PKNOX1 SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 TMEM128 GC04P004281
GH04I004540 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 14.6 -293.6 -293621 2.7 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 STX18-AS1 STX18 TMEM128 FAM86EP NSG1 ZBTB49 RPS7P15
GH04I003368 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.1 +877.8 877795 3.1 RING1 MXI1 KLF1 ZBTB21 JUN MAX SIN3A BMI1 FEZF1 ZIC2 RGS12 GC04M003368 PIR55428 NOP14-AS1 TMEM128 FAM193A ZBTB49 PIR36896
GH04I004264 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 21.4 -20.5 -20457 7.5 CTCF ZNF146 JUN CEBPB MAX CEBPG RAD21 ZNF148 POLR2A CEBPA TMEM128 LYAR ZBTB49 GC04P004281
GH04I003953 Promoter/Enhancer 1.5 Ensembl ENCODE 10.1 +293.2 293222 4 HDGF PKNOX1 CLOCK ATF1 MLX ARID4B SIN3A GLIS2 ZNF207 FOS FAM86EP ENSG00000253917 LOC105374358 GC04P003954 ENSG00000271977 ZBTB49 ENPP7P9 STX18 TMEM128
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM128 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM128 gene promoter:

Genomic Locations for TMEM128 Gene

Genomic Locations for TMEM128 Gene
chr4:4,235,542-4,248,242
(GRCh38/hg38)
Size:
12,701 bases
Orientation:
Minus strand
chr4:4,237,269-4,249,950
(GRCh37/hg19)

Genomic View for TMEM128 Gene

Genes around TMEM128 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM128 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM128 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM128 Gene

Proteins for TMEM128 Gene

  • Protein details for TMEM128 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BJH2-TM128_HUMAN
    Recommended name:
    Transmembrane protein 128
    Protein Accession:
    Q5BJH2
    Secondary Accessions:
    • B4DHS7
    • D3DVS3
    • Q5H9U6
    • Q96I94

    Protein attributes for TMEM128 Gene

    Size:
    165 amino acids
    Molecular mass:
    18822 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM128 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM128 Gene

Post-translational modifications for TMEM128 Gene

No Post-translational modifications

Other Protein References for TMEM128 Gene

No data available for DME Specific Peptides for TMEM128 Gene

Domains & Families for TMEM128 Gene

Gene Families for TMEM128 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM128 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM128 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM128: view

No data available for UniProtKB/Swiss-Prot for TMEM128 Gene

Function for TMEM128 Gene

Phenotypes From GWAS Catalog for TMEM128 Gene

Gene Ontology (GO) - Molecular Function for TMEM128 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM128: view

Phenotypes for TMEM128 Gene

GenomeRNAi human phenotypes for TMEM128:
genes like me logo Genes that share phenotypes with TMEM128: view

Animal Model Products

CRISPR Products

miRNA for TMEM128 Gene

miRTarBase miRNAs that target TMEM128

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM128 Gene

Localization for TMEM128 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM128 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM128 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM128 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM128: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM128 Gene

Pathways & Interactions for TMEM128 Gene

SuperPathways for TMEM128 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM128 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM128: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM128 Gene

Drugs & Compounds for TMEM128 Gene

No Compound Related Data Available

Transcripts for TMEM128 Gene

Unigene Clusters for TMEM128 Gene

Transmembrane protein 128:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM128 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d
SP1: - - - -
SP2: -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: -

Relevant External Links for TMEM128 Gene

GeneLoc Exon Structure for
TMEM128
ECgene alternative splicing isoforms for
TMEM128

Expression for TMEM128 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM128 Gene

Protein differential expression in normal tissues from HIPED for TMEM128 Gene

This gene is overexpressed in Platelet (43.5) and CD4 Tcells (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM128 Gene



Protein tissue co-expression partners for TMEM128 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM128 Gene:

TMEM128

SOURCE GeneReport for Unigene cluster for TMEM128 Gene:

Hs.12845

Evidence on tissue expression from TISSUES for TMEM128 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with TMEM128: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM128 Gene

Orthologs for TMEM128 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM128 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM128 33 34
  • 99.25 (n)
cow
(Bos Taurus)
Mammalia TMEM128 33 34
  • 87.59 (n)
dog
(Canis familiaris)
Mammalia TMEM128 33 34
  • 86.13 (n)
mouse
(Mus musculus)
Mammalia Tmem128 33 16 34
  • 85.19 (n)
rat
(Rattus norvegicus)
Mammalia Tmem128 33
  • 83.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM128 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM128 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM128 33 34
  • 72.76 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM128 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493887 33
  • 66.42 (n)
Str.11956 33
zebrafish
(Danio rerio)
Actinopterygii tmem128 33
  • 57.04 (n)
TMEM128 34
  • 35 (a)
OneToOne
Species where no ortholog for TMEM128 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM128 Gene

ENSEMBL:
Gene Tree for TMEM128 (if available)
TreeFam:
Gene Tree for TMEM128 (if available)

Paralogs for TMEM128 Gene

genes like me logo Genes that share paralogs with TMEM128: view

No data available for Paralogs for TMEM128 Gene

Variants for TMEM128 Gene

Sequence variations from dbSNP and Humsavar for TMEM128 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs10004703 -- 4,248,408(-) C/A upstream_transcript_variant
rs1000592356 -- 4,246,836(-) C/T intron_variant
rs1001028301 -- 4,247,053(-) C/T intron_variant
rs1001234359 -- 4,242,828(-) T/G intron_variant
rs1001602358 -- 4,242,626(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM128 Gene

Variant ID Type Subtype PubMed ID
esv2661007 CNV deletion 23128226
esv2759219 CNV gain 17122850
esv34196 OTHER inversion 12058347
esv3599459 CNV loss 21293372
nsv1001885 CNV gain 25217958
nsv469857 CNV gain 16826518
nsv822448 CNV gain 20364138
nsv980180 CNV duplication 23825009

Variation tolerance for TMEM128 Gene

Residual Variation Intolerance Score: 63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.34; 70.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM128 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM128

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM128 Gene

Disorders for TMEM128 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM128 Gene - From: GeneCards

Disorder Aliases PubMed IDs
neuronal ceroid lipofuscinosis
  • batten disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM128

genes like me logo Genes that share disorders with TMEM128: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM128 Gene

Publications for TMEM128 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58
  5. An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka. (PMID: 24351856) Nanayakkara S … Koizumi A (Journal of occupational health 2014) 3 58

Products for TMEM128 Gene

Sources for TMEM128 Gene

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