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Aliases for TMEM128 Gene

Aliases for TMEM128 Gene

  • Transmembrane Protein 128 2 3 5

External Ids for TMEM128 Gene

Previous GeneCards Identifiers for TMEM128 Gene

  • GC04M004288
  • GC04M004172

Summaries for TMEM128 Gene

GeneCards Summary for TMEM128 Gene

TMEM128 (Transmembrane Protein 128) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM128 Gene

Genomics for TMEM128 Gene

Regulatory Elements for TMEM128 Gene

Promoters for TMEM128 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM128 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM128 Gene

Chromosome:
4
Start:
4,235,542 bp from pter
End:
4,248,242 bp from pter
Size:
12,701 bases
Orientation:
Minus strand

Genomic View for TMEM128 Gene

Genes around TMEM128 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM128 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM128 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM128 Gene

Proteins for TMEM128 Gene

  • Protein details for TMEM128 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BJH2-TM128_HUMAN
    Recommended name:
    Transmembrane protein 128
    Protein Accession:
    Q5BJH2
    Secondary Accessions:
    • B4DHS7
    • D3DVS3
    • Q5H9U6
    • Q96I94

    Protein attributes for TMEM128 Gene

    Size:
    165 amino acids
    Molecular mass:
    18822 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM128 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM128 Gene

Proteomics data for TMEM128 Gene at MOPED

Post-translational modifications for TMEM128 Gene

No Post-translational modifications

Other Protein References for TMEM128 Gene

No data available for DME Specific Peptides for TMEM128 Gene

Domains & Families for TMEM128 Gene

Protein Domains for TMEM128 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM128 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM128: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM128 Gene

Function for TMEM128 Gene

Phenotypes for TMEM128 Gene

GenomeRNAi human phenotypes for TMEM128:
genes like me logo Genes that share phenotypes with TMEM128: view

Animal Model Products

CRISPR Products

miRNA for TMEM128 Gene

miRTarBase miRNAs that target TMEM128

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM128 Gene

Localization for TMEM128 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM128 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM128 Gene COMPARTMENTS Subcellular localization image for TMEM128 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for TMEM128 Gene

Pathways & Interactions for TMEM128 Gene

SuperPathways for TMEM128 Gene

No Data Available

Interacting Proteins for TMEM128 Gene

Gene Ontology (GO) - Biological Process for TMEM128 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM128 Gene

Drugs & Compounds for TMEM128 Gene

No Compound Related Data Available

Transcripts for TMEM128 Gene

Unigene Clusters for TMEM128 Gene

Transmembrane protein 128:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM128 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d
SP1: - - - -
SP2: -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: -

Relevant External Links for TMEM128 Gene

GeneLoc Exon Structure for
TMEM128
ECgene alternative splicing isoforms for
TMEM128

Expression for TMEM128 Gene

mRNA expression in normal human tissues for TMEM128 Gene

Protein differential expression in normal tissues from HIPED for TMEM128 Gene

This gene is overexpressed in Platelet (43.5) and CD4 Tcells (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM128 Gene



SOURCE GeneReport for Unigene cluster for TMEM128 Gene Hs.12845

genes like me logo Genes that share expression patterns with TMEM128: view

Protein tissue co-expression partners for TMEM128 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM128 Gene

Orthologs for TMEM128 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM128 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM128 35
  • 99.25 (n)
  • 98.5 (a)
TMEM128 36
  • 80 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM128 36
  • 72 (a)
OneToOne
TMEM128 35
  • 87.59 (n)
  • 87.59 (a)
dog
(Canis familiaris)
Mammalia TMEM128 35
  • 86.13 (n)
  • 85.4 (a)
TMEM128 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem128 16
Tmem128 36
  • 73 (a)
OneToOne
Tmem128 35
  • 85.19 (n)
  • 88.15 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM128 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM128 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem128 35
  • 83.46 (n)
  • 85.93 (a)
chicken
(Gallus gallus)
Aves TMEM128 35
  • 72.76 (n)
  • 67.31 (a)
TMEM128 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM128 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493887 35
  • 66.42 (n)
  • 60.58 (a)
Str.11956 35
zebrafish
(Danio rerio)
Actinopterygii TMEM128 36
  • 35 (a)
OneToOne
tmem128 35
  • 57.04 (n)
  • 56.3 (a)
Species with no ortholog for TMEM128:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM128 Gene

ENSEMBL:
Gene Tree for TMEM128 (if available)
TreeFam:
Gene Tree for TMEM128 (if available)

Paralogs for TMEM128 Gene

Pseudogenes.org Pseudogenes for TMEM128 Gene

genes like me logo Genes that share paralogs with TMEM128: view

No data available for Paralogs for TMEM128 Gene

Variants for TMEM128 Gene

Sequence variations from dbSNP and Humsavar for TMEM128 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs2980104 -- 4,243,834(-) CACAC(A/G)TAAGA intron-variant
rs2980105 -- 4,243,362(-) gctca(C/T)gcctg intron-variant
rs2980108 -- 4,237,020(-) TGTCG(G/T)ATAAC intron-variant, utr-variant-3-prime
rs3952913 -- 4,244,202(+) CAGGT(A/G)CAGTG intron-variant
rs3846231 -- 4,245,065(-) CCCTC(A/G)TATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM128 Gene

Variant ID Type Subtype PubMed ID
dgv1566e1 CNV Complex 17122850
nsv469857 CNV Complex 16826518
nsv822448 CNV Gain 20364138
esv2661007 CNV Deletion 23128226

Variation tolerance for TMEM128 Gene

Residual Variation Intolerance Score: 63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.34; 70.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM128 Gene

HapMap Linkage Disequilibrium report
TMEM128

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM128 Gene

Disorders for TMEM128 Gene

Relevant External Links for TMEM128

Genetic Association Database (GAD)
TMEM128
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM128

No disorders were found for TMEM128 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM128 Gene

Publications for TMEM128 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. An Integrative Study of the Genetic, Social and Environmental Determinants of Chronic Kidney Disease Characterized by Tubulointerstitial Damages in the North Central Region of Sri Lanka. (PMID: 24351856) Nanayakkara S. … Koizumi A. (J Occup Health 2013) 3
  5. Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. (PMID: 23142642) Passantino R. … Guarneri P. (Biochim. Biophys. Acta 2013) 3

Products for TMEM128 Gene

Sources for TMEM128 Gene

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