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TMEM128 Gene

protein-coding   GIFtS: 39
GCID: GC04M004237

Transmembrane Protein 128

  Search for TMEM128
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 1281 2

External Ids:    HGNC: 282011   Entrez Gene: 850132   Ensembl: ENSG000001324067   UniProtKB: Q5BJH23   

Export aliases for TMEM128 gene to outside databases

Previous GC identifers: GC04M004288 GC04M004172


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM128 Gene:
TMEM128 (transmembrane protein 128) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM128 gene promoter:
         HOXA9   HOXA9B   YY1   Evi-1   POU2F1   POU2F1a   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM128 promoter sequence
   Search Chromatin IP Primers for TMEM128

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM128


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

TMEM128 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM128 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M004237:  view genomic region     (about GC identifiers)

Start:
4,237,269 bp from pter      End:
4,249,950 bp from pter
Size:
12,682 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM128_HUMAN, Q5BJH2 (See protein sequence)
Recommended Name: Transmembrane protein 128  
Size: 165 amino acids; 18822 Da
Secondary accessions: B4DHS7 D3DVS3 Q5H9U6 Q96I94
Alternative splicing: 2 isoforms:  Q5BJH2-1   Q5BJH2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM128: NX_Q5BJH2

Explore proteomics data for TMEM128 at MOPED


See TMEM128 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_116316.1  
ENSEMBL proteins: 
 ENSP00000254742   ENSP00000372201   ENSP00000442300   ENSP00000439174  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q5BJH2


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
     
Find genes that share ontologies with TMEM128           About GenesLikeMe


Animal Models:
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miRNA
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miRTarBase miRNAs that target TMEM128:
hsa-mir-124-3p (MIRT022301)

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Selected qRT-PCR Assays for microRNAs that regulate TMEM128 (see all 12):
hsa-miR-3163 hsa-miR-548d-3p hsa-miR-495 hsa-miR-7-2* hsa-miR-133b hsa-miR-548o hsa-miR-124 hsa-miR-1323
SwitchGear 3'UTR luciferase reporter plasmidTMEM128 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TM128_HUMAN, Q5BJH2: Membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane3

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with TMEM128           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM128
Interactions:

    Search GeneGlobe Interaction Network for TMEM128

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008150biological_process ND--

Find genes that share ontologies with TMEM128           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TMEM128 (TM128)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TMEM128 gene: 
NM_032927.2  

Unigene Cluster for TMEM128:

Transmembrane protein 128
Hs.12845  [show with all ESTs]
Unigene Representative Sequence: CR933611
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000254742(uc003ghq.1 uc003ghr.1 uc003ghs.3) ENST00000382753
ENST00000538516(uc011bvv.1 uc011bvw.1) ENST00000540397
miRNA
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Selected qRT-PCR Assays for microRNAs that regulate TMEM128 (see all 12):
hsa-miR-3163 hsa-miR-548d-3p hsa-miR-495 hsa-miR-7-2* hsa-miR-133b hsa-miR-548o hsa-miR-124 hsa-miR-1323
SwitchGear 3'UTR luciferase reporter plasmidTMEM128 3' UTR sequence
Inhib. RNA
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  QuantiFast Probe-based Assays in human, mouse, rat TMEM128

Additional mRNA sequence: 

AK001453.1 AK054701.1 AK295248.1 AK296007.1 BC007729.2 BC091482.1 CR933611.1 

7 DOTS entries:

DT.216224  DT.100751381  DT.92429183  DT.95202682  DT.95325144  DT.121242973  DT.121242966 

Selected AceView cDNA sequences (see all 145):

AA731502 AK054701 AA506271 BX499927 CR600962 CA445436 AA555070 BQ896897 
BM453946 CA943313 AW264527 AL519982 CA414019 D62868 CR606526 NM_032927 
AI962753 BI821616 BC007729 BX416075 AA279404 CR621378 BF792179 AI681856 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMEM128 (see all 6)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d
SP1:                    -                             -     -     -                           
SP2:                    -                                                                     
SP3:                                                  -     -     -                           
SP4:                    -                             -     -     -                           
SP5:                                                  -     -     -                           


ECgene alternative splicing isoforms for TMEM128

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMEM128 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGCCTTTAAC
TMEM128 Expression
About this image

TMEM128 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TMEM128 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.12845
    Custom PCR Arrays for TMEM128
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM128

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TMEM128 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmem1281 , 5 transmembrane protein 1281, 5 85.19(n)1
88.15(a)1
  5 (20.33 cM)5
663091  NM_025480.31  NP_079756.21 
 382601855 
chicken
(Gallus gallus)
Aves TMEM1281 transmembrane protein 128 72.76(n)
67.31(a)
  422845  NM_001031163.1  NP_001026334.1 
lizard
(Anolis carolinensis)
Reptilia TMEM1286
transmembrane protein 128
59(a)
1 ↔ 1
GL343236.1(602673-619854)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.119562 Transcribed sequence with weak similarity to protein more 72.32(n)    CF346765.1 
zebrafish
(Danio rerio)
Actinopterygii tmem1281 transmembrane protein 128 57.04(n)
56.3(a)
  574426  NM_001029973.1  NP_001025144.1 


ENSEMBL Gene Tree for TMEM128 (if available)
TreeFam Gene Tree for TMEM128 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TMEM128 gene

Find genes that share paralogs with TMEM128           About GenesLikeMe


3 Pseudogenes.org Pseudogenes for TMEM128
PGOHUM00000234311 PGOHUM00000240765 PGOHUM00000245973


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TMEM128 (see all 523)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1126650621,2
C,F--4236799(+) TACAGG/TCTGAC 1 -- int12Minor allele frequency- T:0.50WA NA 4
rs1830330911,2
--4236808(+) ACTACC/TCCTTC 1 -- int10--------
rs41336861,2
C,F--4236824(+) AATGCT/CTGGGA 1 -- int14Minor allele frequency- C:0.25NA WA 8
rs1116347781,2
C,F--4236909(+) GAGTGC/TCACGT 1 -- int12Minor allele frequency- T:0.50WA NA 4
rs1400653911,2
--4236912(+) TGTCAC/TGTCAG 1 -- int10--------
rs38569621,2
C,F,A,H--4236919(+) TCAGTC/AATCAA 1 -- int19Minor allele frequency- A:0.22NS EA NA WA 780
rs1437349181,2
--4237032(+) TAAGTC/GAGGTC 1 -- int10--------
rs1876266751,2
--4237053(+) GTCACA/CTTACA 1 -- int10--------
rs38569631,2
C--4237070(+) ACAATC/GAACAT 1 -- int16Minor allele frequency- G:0.20NA WA EA 364
rs743640071,2
C,F--4237207(+) TAATTC/TAAAGT 1 -- int11Minor allele frequency- T:0.03NA 120

HapMap Linkage Disequilibrium report for TMEM128 (4237269 - 4249950 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for TMEM128:    About this table    
Variant IDTypeSubtypePubMed ID
esv2661007CNV Deletion23128226
nsv822448CNV Gain20364138
dgv1566e1CNV Complex17122850
nsv469857CNV Complex16826518

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with TMEM128           About GenesLikeMe

Genetic Association Database (GAD): TMEM128

Export disorders for TMEM128 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TMEM128 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TMEM128)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. (PubMed id 23142642)1 Passantino R....Guarneri P. (Biochim. Biophys. Acta 2013)
  4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
  5. Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data. (PubMed id 17052657)4 Fung H.C....Singleton A. (Lancet Neurol 2006)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 85013 HGNC: 28201 AceView: MGC13159 Ensembl:ENSG00000132406 euGenes: HUgn85013
ECgene: TMEM128 H-InvDB: TMEM128

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TMEM128 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TMEM128 gene:
Search GeneIP for patents involving TMEM128

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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