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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM127 Gene

protein-coding   GIFtS: 49
GCID: GC02M096916

Transmembrane Protein 127

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 1271 2

External Ids:    HGNC: 260381   Entrez Gene: 556542   Ensembl: ENSG000001359567   OMIM: 6134035   UniProtKB: O752043   

Export aliases for TMEM127 gene to outside databases

Previous GC identifers: GC02M096280 GC02M090877


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMEM127 Gene:
This gene encodes a transmembrane protein with 3 predicted transmembrane domains. The protein is associated with a
subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with
lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and
several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein
have been identified. (provided by RefSeq, Aug 2010)

GeneCards Summary for TMEM127 Gene: 
TMEM127 (transmembrane protein 127) is a protein-coding gene. Diseases associated with TMEM127 include tmem127-related susceptibility to pheochromocytoma, and pheochromocytoma. GO annotations related to this gene include molecular_function.

UniProtKB/Swiss-Prot: TM127_HUMAN, O75204
Function: Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1.
May act as a tumor suppressor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM127 gene promoter:
         GR   E2F-4   E2F-3a   E2F-5   GR-beta   E2F-2   E4BP4   E2F   E2F-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM127 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM127

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM127


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

TMEM127 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM127 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M096916:  view genomic region     (about GC identifiers)

Start:
96,915,946 bp from pter      End:
96,931,751 bp from pter
Size:
15,806 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM127_HUMAN, O75204 (See protein sequence)
Recommended Name: Transmembrane protein 127  
Size: 238 amino acids; 25842 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Association of TMEM127 with the
cell membrane is enhanced by inhibition of endocytosis. In the cytoplasm, it colocalizes with markers of early
endosomal structures, Golgi apparatus and lysosomes
Miscellaneous: Consistent with the observation that mTORC1 signaling regulates cell growth and size in many
species, TMEM127 knockdown cells are larger and proliferate at higher rates compared to control cell lines. In
contrast, cell proliferation is reduced in cells overexpressing TMEM127 (PubMed:20154675)
Secondary accessions: D3DXH0

Explore the universe of human proteins at neXtProt for TMEM127: NX_O75204

Explore proteomics data for TMEM127 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75204

  • TMEM127 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM127 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001180233.1  NP_060319.1  

    ENSEMBL proteins: 
     ENSP00000258439   ENSP00000416660   ENSP00000411810  

    Human Recombinant Protein Products for TMEM127: 
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    Cloud-Clone Corp. Proteins for TMEM127 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0016021integral to membrane IEA--

    TMEM127 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: O75204

    UniProtKB/Swiss-Prot: TM127_HUMAN, O75204
    Similarity: Belongs to the TMEM127 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TM127_HUMAN, O75204
    Function: Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1.
    May act as a tumor suppressor

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    TMEM127 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TMEM127:
     Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM127 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM127

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM127 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM127 

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    SwitchGear 3'UTR luciferase reporter plasmidTMEM127 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM127

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TMEM127 (ENSP000002584394) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008285negative regulation of cell proliferation IMP--
    GO:0032007negative regulation of TOR signaling cascade IMP--

    TMEM127 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM127 (TM127)

    Search CenterWatch for drugs/clinical trials and news about TMEM127 / TM127

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM127 gene (3 alternative transcripts): 
    NM_001193304.2  NM_017849.3  NM_032218.1  

    Unigene Cluster for TMEM127:

    Transmembrane protein 127
    Hs.164303  [show with all ESTs]
    Unigene Representative Sequence: NM_017849
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258439(uc002svq.3 uc002svr.3) ENST00000432959 ENST00000435268

    miRNA
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    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM127 (see all 57):
    hsa-miR-3678-3p hsa-miR-4291 hsa-miR-3194-5p hsa-miR-330-5p hsa-miR-106a hsa-miR-29a hsa-miR-519a hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidTMEM127 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM127

    Additional mRNA sequence: 

    AK000514.1 AK025910.1 AK293276.1 AL117494.1 AL117581.1 BC028575.1 BC039892.1 

    12 DOTS entries:

    DT.75189536  DT.100755309  DT.95308720  DT.102840962  DT.95107645  DT.92433110  DT.100755310  DT.120996326 
    DT.95076587  DT.95308721  DT.120996288  DT.95240734 

    24/263 AceView cDNA sequences (see all 263):

    BQ478247 F02799 AA613086 BQ424031 CR599359 AI566879 CK822931 BC039892 
    AI566866 BQ899232 AW236246 C17160 BQ102342 BU753649 AI151054 BM678887 
    CO248571 AW139883 BM674890 BQ918420 BM469446 CK822930 AI659824 CK431185 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM127 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
    SP1:                    -     -                 -     -                                             
    SP2:              -     -     -     -           -     -                                             
    SP3:                    -                       -     -                                             
    SP4:                    -     -                 -                                                   
    SP5:                    -     -     -     -     -     -                                             


    ECgene alternative splicing isoforms for TMEM127

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM127 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTGGCCT
    TMEM127 Expression
    About this image


    See TMEM127 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM127

    SOURCE GeneReport for Unigene cluster: Hs.164303

    UniProtKB/Swiss-Prot: TM127_HUMAN, O75204
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for TMEM127
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM127

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM127 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1271 , 5 transmembrane protein 1271, 5 90.06(n)1
    98.74(a)1
      2 (61.87 cM)5
    694701  NM_175145.31  NP_780354.11 
     1272479085 
    chicken
    (Gallus gallus)
    Aves LOC1008572071 transmembrane protein 127-like 84.4(n)
    98.08(a)
      100857207  XM_003643430.1  XP_003643478.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1276
    Uncharacterized protein
    94(a)
    1 ↔ 1
    GL343858.1(165639-171184)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.11832 Transcribed sequence with moderate similarity to protein more 77.06(n)    142023213 
    zebrafish
    (Danio rerio)
    Actinopterygii tmem1271 transmembrane protein 127 74.44(n)
    85.17(a)
      553545  NM_001020524.1  NP_001018360.1 


    ENSEMBL Gene Tree for TMEM127 (if available)
    TreeFam Gene Tree for TMEM127 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/338 SNPs in TMEM127 are shown (see all 338)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219088231,2,4
    C,Fprobable-pathogenic196578673(-) AGACAG/ATGCTG 4 /M /V mis11Minor allele frequency- A:0.00NA 4552
    rs1219088201,2
    Cprobable-pathogenic196588866(-) TGTTGC/GGCTAT 4 R G mis10--------
    rs1219088191,2
    C,Fprobable-pathogenic196588875(-) TCTCCG/AACGTG 4 /N /D mis11Minor allele frequency- A:0.00NA 4272
    rs114218321,2
    C--90885147(+) AAAAAA/-GTAGG 2 -- int1 trp31Minor allele frequency- -:0.00CSA 2
    rs1443243911,2
    C--96573421(+) AAGTTC/TGTCAG 2 -- ds50010--------
    rs1487992391,2
    --96573442(+) TCTCCC/GCATAG 2 -- ds50010--------
    rs1161666511,2
    C,F--96573547(+) GCCCCA/GGATGC 2 -- ds50011Minor allele frequency- G:0.02NA 120
    rs1863965231,2
    --96573573(+) GTCCCA/TGGGTC 2 -- ds50010--------
    rs1904555201,2
    --96573632(+) TCTTCA/GCCTGT 2 -- ds50010--------
    rs787755371,2
    C,F--96573638(+) CCTGTG/ACAGTT 2 -- ds50012Minor allele frequency- A:0.03NA EA 240

    HapMap Linkage Disequilibrium report for TMEM127 (96915946 - 96931751 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TMEM127:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv650e201CNV Deletion23290073
    nsv874677CNV Loss21882294
    nsv874679CNV Gain21882294
    nsv834305CNV Gain17160897
    esv5003CNV Complex18987735


    Human Gene Mutation Database (HGMD): TMEM127
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM127
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM127

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613403   
    OMIM disorders: 171300  
    UniProtKB/Swiss-Prot: TM127_HUMAN, O75204
  • Pheochromocytoma (PCC) [MIM:171300]: A catecholamine-producing tumor of chromaffin tissue of the adrenal
    medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and
    norepinephrine, is hypertension, which may be persistent or intermittent. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry

  • 6 diseases for TMEM127:    About MalaCards
    tmem127-related susceptibility to pheochromocytoma    pheochromocytoma    hereditary paraganglioma-pheochromocytoma syndromes    von hippel-lindau disease
    paraganglioma    hypertension

    2 diseases from the University of Copenhagen DISEASES database for TMEM127:
    Paraganglioma     Von Hippel-Lindau disease

    TMEM127 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMEM127
    Human Genome Epidemiology (HuGE) Navigator: TMEM127 (2 documents)

    Export disorders for TMEM127 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM127 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with TMEM127)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Germline mutations in TMEM127 confer susceptibility t o pheochromocytoma. (PubMed id 20154675)1, 2, 4 Qin Y....Dahia P.L. (2010)
    2. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2, 3 Loftus B.J.... Adams M.D. (1999)
    3. Spectrum and prevalence of FP/TMEM127 gene mutations in pheochromocytomas and paragangliomas. (PubMed id 21156949)1, 4 Yao L....Dahia P.L. (2010)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. Identical germline mutations in the TMEM127 gene in tw o unrelated Japanese patients with bilateral pheochromocytoma. (PubMed id 22541004)1 Takeichi N....Takekoshi K. (2012)
    9. Minireview: the busy road to pheochromocytomas and pa ragangliomas has a new member, TMEM127. (PubMed id 21447639)1 Jiang S. and Dahia P.L. (2011)
    10. Germline mutations of the TMEM127 gene in patients wi th paraganglioma of head and neck and extraadrenal abdominal sites. (PubMed id 21613359)1 Neumann H.P....Eng C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55654 HGNC: 26038 AceView: FLJ20507 Ensembl:ENSG00000135956 euGenes: HUgn55654
    ECgene: TMEM127 H-InvDB: TMEM127

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM127 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM127 gene:
    Search GeneIP for patents involving TMEM127

    GeneCards and IP:
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