External Ids for TMEM127 Gene
Previous GeneCards Identifiers for TMEM127 Gene
This gene encodes a transmembrane protein with 3 predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2010]
GeneCards Summary for TMEM127 Gene
TMEM127 (Transmembrane Protein 127) is a Protein Coding gene. Diseases associated with TMEM127 include Pheochromocytoma and Hereditary Paraganglioma-Pheochromocytoma Syndromes. GO annotations related to this gene include Rab GTPase binding.
UniProtKB/Swiss-Prot for TMEM127 Gene
Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor.