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Aliases for TMEM127 Gene

Aliases for TMEM127 Gene

  • Transmembrane Protein 127 2 3 5

External Ids for TMEM127 Gene

Previous GeneCards Identifiers for TMEM127 Gene

  • GC02M096280
  • GC02M096916
  • GC02M090877

Summaries for TMEM127 Gene

Entrez Gene Summary for TMEM127 Gene

  • This gene encodes a transmembrane protein with 3 predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2010]

GeneCards Summary for TMEM127 Gene

TMEM127 (Transmembrane Protein 127) is a Protein Coding gene. Diseases associated with TMEM127 include Pheochromocytoma and Hereditary Paraganglioma-Pheochromocytoma Syndromes. GO annotations related to this gene include Rab GTPase binding.

UniProtKB/Swiss-Prot for TMEM127 Gene

  • Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM127 Gene

Genomics for TMEM127 Gene

Regulatory Elements for TMEM127 Gene

Enhancers for TMEM127 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F096244 1.5 FANTOM5 Ensembl ENCODE 13.4 +19.7 19713 3.4 HDGF NFRKB ZNF366 EGR2 ELF1 MEF2D ZNF589 SMARCA4 HMBOX1 ZBTB33 SNRNP200 GPAT2 TMEM127 ARID5A KCNIP3 KANSL3 DUSP2 GC02M096251 PIR52980
GH02F096142 1.5 FANTOM5 ENCODE 7.7 +119.8 119754 8.2 HDGF PKNOX1 WRNIP1 ZFP64 SIN3A DMAP1 SLC30A9 ZNF143 ZNF207 FOS GPAT2 DUSP2 ARID5A CIAO1 TMEM127 KANSL3 GPAT2P1 ZNF514 ASTL ENSG00000228873
GH02F096233 0.9 Ensembl ENCODE 12.5 +31.8 31750 1.5 HDGF CTCF MTA2 NRF1 TRIM22 TBX21 RAD21 IKZF1 NBN ZNF143 STARD7 STARD7-AS1 CIAO1 TMEM127 ADRA2B DUSP2 ASTL ITPRIPL1 NCAPH LOC105373495
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM127 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM127 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014687 113 2601 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207

Genomic Location for TMEM127 Gene

96,248,516 bp from pter
96,266,013 bp from pter
17,498 bases
Minus strand

Genomic View for TMEM127 Gene

Genes around TMEM127 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM127 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM127 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM127 Gene

Proteins for TMEM127 Gene

  • Protein details for TMEM127 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 127
    Protein Accession:
    Secondary Accessions:
    • D3DXH0

    Protein attributes for TMEM127 Gene

    238 amino acids
    Molecular mass:
    25842 Da
    Quaternary structure:
    No Data Available
    • Consistent with the observation that mTORC1 signaling regulates cell growth and size in many species, TMEM127 knockdown cells are larger and proliferate at higher rates compared to control cell lines. In contrast, cell proliferation is reduced in cells overexpressing TMEM127 (PubMed:20154675).

neXtProt entry for TMEM127 Gene

Post-translational modifications for TMEM127 Gene

  • Ubiquitination at Lys 25
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM127 Gene

No data available for DME Specific Peptides for TMEM127 Gene

Domains & Families for TMEM127 Gene

Protein Domains for TMEM127 Gene


Suggested Antigen Peptide Sequences for TMEM127 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM127 family.
  • Belongs to the TMEM127 family.
genes like me logo Genes that share domains with TMEM127: view

No data available for Gene Families for TMEM127 Gene

Function for TMEM127 Gene

Molecular function for TMEM127 Gene

UniProtKB/Swiss-Prot Function:
Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor.

Gene Ontology (GO) - Molecular Function for TMEM127 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0017137 Rab GTPase binding IDA 24334765
genes like me logo Genes that share ontologies with TMEM127: view
genes like me logo Genes that share phenotypes with TMEM127: view

Human Phenotype Ontology for TMEM127 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TMEM127 Gene

MGI Knock Outs for TMEM127:

Animal Model Products

miRNA for TMEM127 Gene

miRTarBase miRNAs that target TMEM127

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TMEM127 Gene

Localization for TMEM127 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM127 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Association of TMEM127 with the cell membrane is enhanced by inhibition of endocytosis. In the cytoplasm, it colocalizes with markers of early endosomal structures, Golgi apparatus and lysosomes. {ECO:0000269 PubMed:20154675, ECO:0000269 PubMed:21156949}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM127 gene
Compartment Confidence
plasma membrane 5
endosome 5
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TMEM127 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 20154675
GO:0005769 early endosome IDA 24334765
GO:0005886 plasma membrane IEA,IDA 20154675
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM127: view

Pathways & Interactions for TMEM127 Gene

SuperPathways for TMEM127 Gene

No Data Available

Interacting Proteins for TMEM127 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000258439 O75204-TM127_HUMAN for TMEM127 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM127 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007032 endosome organization IEA --
GO:0008285 negative regulation of cell proliferation IEA,IMP 20154675
GO:0032006 regulation of TOR signaling IEA --
GO:0032007 negative regulation of TOR signaling IEA,IMP 20154675
genes like me logo Genes that share ontologies with TMEM127: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM127 Gene

Transcripts for TMEM127 Gene

Unigene Clusters for TMEM127 Gene

Transmembrane protein 127:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM127 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - - -
SP6: -
SP7: - -

Relevant External Links for TMEM127 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM127 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM127 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM127 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM127 Gene:


SOURCE GeneReport for Unigene cluster for TMEM127 Gene:


mRNA Expression by UniProt/SwissProt for TMEM127 Gene:

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with TMEM127: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for TMEM127 Gene

Orthologs for TMEM127 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM127 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM127 34 35
  • 99.3 (n)
(Monodelphis domestica)
Mammalia TMEM127 35
  • 98 (a)
(Canis familiaris)
Mammalia TMEM127 34 35
  • 92.58 (n)
(Bos Taurus)
Mammalia TMEM127 34 35
  • 91.04 (n)
(Mus musculus)
Mammalia Tmem127 34 16 35
  • 90.06 (n)
(Rattus norvegicus)
Mammalia Tmem127 34
  • 89.64 (n)
(Gallus gallus)
Aves TMEM127 34
  • 83.13 (n)
(Anolis carolinensis)
Reptilia TMEM127 35
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem127 34
  • 75.93 (n)
Str.1183 34
(Danio rerio)
Actinopterygii tmem127 34 35
  • 76.19 (n)
Species where no ortholog for TMEM127 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM127 Gene

Gene Tree for TMEM127 (if available)
Gene Tree for TMEM127 (if available)

Paralogs for TMEM127 Gene

No data available for Paralogs for TMEM127 Gene

Variants for TMEM127 Gene

Sequence variations from dbSNP and Humsavar for TMEM127 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs121908818 Pheochromocytoma (PCC) [MIM:171300], Likely pathogenic 96,265,224(-) CGCCT(C/G)GTTGC intron-variant, upstream-variant-2KB, reference, missense
rs121908819 Pheochromocytoma (PCC) [MIM:171300], Likely pathogenic 96,265,174(-) TCTCC(A/G)ACGTG intron-variant, upstream-variant-2KB, reference, missense
rs121908820 Pheochromocytoma (PCC) [MIM:171300], other 96,265,165(-) TGTTG(C/G)GCTAT intron-variant, upstream-variant-2KB, reference, missense
rs121908823 Pheochromocytoma (PCC) [MIM:171300], other 96,254,974(-) AGACA(A/G)TGCTG reference, missense, utr-variant-5-prime
rs121908824 Pheochromocytoma (PCC) [MIM:171300], Likely pathogenic 96,254,962(-) TCCTG(C/G/T)GGGTC reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM127 Gene

Variant ID Type Subtype PubMed ID
dgv607e201 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv3591652 OTHER inversion 21293372
esv5003 OTHER complex 18987735
nsv1135873 CNV deletion 24896259
nsv834305 CNV gain 17160897

Variation tolerance for TMEM127 Gene

Residual Variation Intolerance Score: 54.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM127 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM127 Gene

Disorders for TMEM127 Gene

MalaCards: The human disease database

(10) MalaCards diseases for TMEM127 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards


  • Pheochromocytoma (PCC) [MIM:171300]: A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent. {ECO:0000269 PubMed:20154675, ECO:0000269 PubMed:21156949}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for TMEM127

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMEM127: view

No data available for Genatlas for TMEM127 Gene

Publications for TMEM127 Gene

  1. Spectrum and prevalence of FP/TMEM127 gene mutations in pheochromocytomas and paragangliomas. (PMID: 21156949) Yao L. … Dahia P.L. (JAMA 2010) 3 4 46 64
  2. Germline mutations in TMEM127 confer susceptibility to pheochromocytoma. (PMID: 20154675) Qin Y. … Dahia P.L. (Nat. Genet. 2010) 3 4 46 64
  3. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 2 3 4 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for TMEM127 Gene

Sources for TMEM127 Gene

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