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Aliases for TMEM123 Gene

Aliases for TMEM123 Gene

  • Transmembrane Protein 123 2 3 4
  • Keratinocytes-Associated Transmembrane Protein 3 3 4
  • Pro-Oncosis Receptor Inducing Membrane Injury 3 4
  • Porimin 3 6
  • KCT-3 3 4
  • KCT3 3 4
  • Pro Oncosis Receptor Inducing Membrane Injury Gene 2
  • Keratinocytes Associated Transmembrane Protein 3 3
  • Pro Oncosis Receptor Inducing Membrane Injury 3
  • Serine/Threonine-Rich Receptor 3
  • PORMIN 3

External Ids for TMEM123 Gene

Summaries for TMEM123 Gene

Entrez Gene Summary for TMEM123 Gene

  • This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMEM123 Gene

TMEM123 (Transmembrane Protein 123) is a Protein Coding gene. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot for TMEM123 Gene

  • Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.

Gene Wiki entry for TMEM123 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM123 Gene

Genomics for TMEM123 Gene

Genomic Location for TMEM123 Gene

Start:
102,396,325 bp from pter
End:
102,470,384 bp from pter
Size:
74,060 bases
Orientation:
Minus strand

Genomic View for TMEM123 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM123 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM123 Gene

Regulatory Elements for TMEM123 Gene

Proteins for TMEM123 Gene

  • Protein details for TMEM123 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N131-PORIM_HUMAN
    Recommended name:
    Porimin
    Protein Accession:
    Q8N131
    Secondary Accessions:
    • Q8IWS2
    • Q96QV2

    Protein attributes for TMEM123 Gene

    Size:
    208 amino acids
    Molecular mass:
    21531 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM123 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM123 Gene

Proteomics data for TMEM123 Gene at MOPED

Post-translational modifications for TMEM123 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn46, Asn50, Asn64, Asn68, Asn83, Asn96, Asn106, Asn124, and Asn138

Other Protein References for TMEM123 Gene

No data available for DME Specific Peptides for TMEM123 Gene

Domains for TMEM123 Gene

Protein Domains for TMEM123 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM123 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N131

UniProtKB/Swiss-Prot:

PORIM_HUMAN
Family:
  • Belongs to the CD164 family.:
    • Q8N131
genes like me logo Genes that share domains with TMEM123: view

No data available for Gene Families for TMEM123 Gene

Function for TMEM123 Gene

Molecular function for TMEM123 Gene

UniProtKB/Swiss-Prot Function: Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.

Gene Ontology (GO) - Molecular Function for TMEM123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity NAS 9600958
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM123: view

Phenotypes for TMEM123 Gene

MGI mutant phenotypes for TMEM123:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with TMEM123: view

Animal Models for TMEM123 Gene

MGI Knock Outs for TMEM123:

miRNA for TMEM123 Gene

miRTarBase miRNAs that target TMEM123

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TMEM123 Gene

Localization for TMEM123 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM123 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM123 Gene COMPARTMENTS Subcellular localization image for TMEM123 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
endosome 1
extracellular 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TMEM123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IDA 9600958
GO:0016021 integral component of membrane NAS 11481458
genes like me logo Genes that share ontologies with TMEM123: view

Pathways for TMEM123 Gene

SuperPathways for TMEM123 Gene

No Data Available

Interacting Proteins for TMEM123 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000381204%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000331327%0d%0a
Selected Interacting proteins: Q8N131-PORIM_HUMAN ENSP00000381204 for TMEM123 Gene via MINT STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for TMEM123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070267 oncosis IDA 11481458
genes like me logo Genes that share ontologies with TMEM123: view

No data available for Pathways by source for TMEM123 Gene

Transcripts for TMEM123 Gene

Unigene Clusters for TMEM123 Gene

Transmembrane protein 123:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM123 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - -
SP7:
SP8: -

Relevant External Links for TMEM123 Gene

GeneLoc Exon Structure for
TMEM123
ECgene alternative splicing isoforms for
TMEM123

Expression for TMEM123 Gene

mRNA expression in normal human tissues for TMEM123 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM123 Gene

SOURCE GeneReport for Unigene cluster for TMEM123 Gene Hs.503709

mRNA Expression by UniProt/SwissProt for TMEM123 Gene

Q8N131-PORIM_HUMAN
Tissue specificity: Ubiquitous. Not expressed in ovary. Expressed in keratinocytes.
genes like me logo Genes that share expressions with TMEM123: view

No data available for mRNA differential expression in normal tissues for TMEM123 Gene

Orthologs for TMEM123 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM123 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM123 35
  • 98.72 (n)
  • 98.56 (a)
TMEM123 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM123 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem123 35
  • 68.91 (n)
  • 56.99 (a)
Tmem123 16
Tmem123 36
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM123 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM123 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem123 35
  • 68.06 (n)
  • 58.12 (a)
chicken
(Gallus gallus)
Aves TMEM123 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM123 36
  • 27 (a)
OneToOne
Species with no ortholog for TMEM123:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM123 Gene

ENSEMBL:
Gene Tree for TMEM123 (if available)
TreeFam:
Gene Tree for TMEM123 (if available)

Paralogs for TMEM123 Gene

No data available for Paralogs for TMEM123 Gene

Variants for TMEM123 Gene

Sequence variations from dbSNP and Humsavar for TMEM123 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs484068 -- 102,397,796(+) TTAGT(A/T)GCCTG utr-variant-3-prime
rs485020 -- 102,397,897(+) ACAAG(C/G)GGTTC utr-variant-3-prime
rs524930 -- 102,401,402(+) GGGCC(A/C)AAAGG intron-variant
rs531350 -- 102,430,145(-) GTTGT(A/C)TTCTG intron-variant
rs545446 -- 102,399,862(-) ctccc(A/C)agtag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM123 Gene

Variant ID Type Subtype PubMed ID
esv2667796 CNV Deletion 23128226
esv2744989 CNV Deletion 23290073
nsv898334 CNV Loss 21882294
esv2744990 CNV Deletion 23290073
esv22282 CNV Loss 19812545
esv2677610 CNV Deletion 23128226

Relevant External Links for TMEM123 Gene

HapMap Linkage Disequilibrium report
TMEM123

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM123 Gene

Disorders for TMEM123 Gene

No disorders were found for TMEM123 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM123 Gene

Publications for TMEM123 Gene

  1. Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death. (PMID: 11481458) Ma F. … Schlossman S.F. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 23
  2. Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes. (PMID: 12752121) Bonkobara M. … Ariizumi K. (Br. J. Dermatol. 2003) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TMEM123 Gene

Sources for TMEM123 Gene

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