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Aliases for TMEM121 Gene

Aliases for TMEM121 Gene

  • Transmembrane Protein 121 2 3
  • HHOLE 4
  • Hole 3

External Ids for TMEM121 Gene

Previous GeneCards Identifiers for TMEM121 Gene

  • GC14P105064
  • GC14P105992
  • GC14P086193

Summaries for TMEM121 Gene

GeneCards Summary for TMEM121 Gene

TMEM121 (Transmembrane Protein 121) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM121 Gene

  • May play a role in MAPK signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM121 Gene

Genomics for TMEM121 Gene

Regulatory Elements for TMEM121 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM121 Gene

105,526,603 bp from pter
105,530,217 bp from pter
3,615 bases
Plus strand

Genomic View for TMEM121 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM121 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM121 Gene

Proteins for TMEM121 Gene

  • Protein details for TMEM121 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 121
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TMEM121 Gene

    319 amino acids
    Molecular mass:
    35814 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM121 Gene

Proteomics data for TMEM121 Gene at MOPED

Post-translational modifications for TMEM121 Gene

No Post-translational modifications

Other Protein References for TMEM121 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM121 Gene

Domains for TMEM121 Gene

Protein Domains for TMEM121 Gene


Suggested Antigen Peptide Sequences for TMEM121 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM121: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM121 Gene

Function for TMEM121 Gene

Molecular function for TMEM121 Gene

UniProtKB/Swiss-Prot Function: May play a role in MAPK signaling.

Gene Ontology (GO) - Molecular Function for TMEM121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM121: view

Phenotypes for TMEM121 Gene

GenomeRNAi human phenotypes for TMEM121:
genes like me logo Genes that share phenotypes with TMEM121: view

Animal Model Products

CRISPR Products

miRNA for TMEM121 Gene

miRTarBase miRNAs that target TMEM121

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM121 Gene

Localization for TMEM121 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM121 Gene

Membrane; Multi-pass membrane protein. Note=May localize to the plasma membrane. {ECO:0000269 PubMed:15950185}.

Subcellular locations from

Jensen Localization Image for TMEM121 Gene COMPARTMENTS Subcellular localization image for TMEM121 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM121: view

Pathways for TMEM121 Gene

SuperPathways for TMEM121 Gene

No Data Available

Interacting Proteins for TMEM121 Gene

Gene Ontology (GO) - Biological Process for TMEM121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM121: view

No data available for Pathways by source for TMEM121 Gene

Transcripts for TMEM121 Gene

mRNA/cDNA for TMEM121 Gene

Unigene Clusters for TMEM121 Gene

Transmembrane protein 121:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM121

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM121 Gene

No ASD Table

Relevant External Links for TMEM121 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM121 Gene

mRNA expression in normal human tissues for TMEM121 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM121 Gene

SOURCE GeneReport for Unigene cluster for TMEM121 Gene Hs.157527

mRNA Expression by UniProt/SwissProt for TMEM121 Gene

Tissue specificity: Highly expressed in heart and detected in pancreas, liver and skeletal muscle.
genes like me logo Genes that share expressions with TMEM121: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TMEM121 Gene

Orthologs for TMEM121 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM121 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM121 36
  • 98 (a)
(Canis familiaris)
Mammalia TMEM121 35
  • 95.25 (n)
  • 97.47 (a)
TMEM121 36
  • 97 (a)
(Mus musculus)
Mammalia Tmem121 35
  • 88.68 (n)
  • 97.48 (a)
Tmem121 16
Tmem121 36
  • 97 (a)
(Monodelphis domestica)
Mammalia TMEM121 36
  • 86 (a)
(Rattus norvegicus)
Mammalia Tmem121 35
  • 87.42 (n)
  • 97.48 (a)
(Gallus gallus)
Aves TMEM121 35
  • 76.39 (n)
  • 77.56 (a)
TMEM121 36
  • 78 (a)
(Anolis carolinensis)
Reptilia TMEM121 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem121 35
  • 64.32 (n)
  • 76.28 (a)
(Danio rerio)
Actinopterygii LOC799098 35
  • 72.84 (n)
  • 77.32 (a)
TMEM121 (1 of 3) 36
  • 76 (a)
TMEM121 (2 of 3) 36
  • 75 (a)
TMEM121 (3 of 3) 36
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for TMEM121:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM121 Gene

Gene Tree for TMEM121 (if available)
Gene Tree for TMEM121 (if available)

Paralogs for TMEM121 Gene Pseudogenes for TMEM121 Gene

genes like me logo Genes that share paralogs with TMEM121: view

No data available for Paralogs for TMEM121 Gene

Variants for TMEM121 Gene

Sequence variations from dbSNP and Humsavar for TMEM121 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs10569304 -- 105,529,713(+) CCGCC(-/GCC)GCTGC cds-indel
rs11624007 -- 105,525,846(+) TTTCC(A/C)CCAAA upstream-variant-2KB
rs12161868 -- 105,526,917(+) CCCCC(A/T)CCCGC intron-variant, upstream-variant-2KB
rs28662250 -- 105,530,004(+) CCCAG(C/G)GCGTG utr-variant-3-prime
rs28733392 -- 105,526,921(+) CTCCC(A/G)CCCCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM121 Gene

Variant ID Type Subtype PubMed ID
nsv902424 CNV Loss 21882294
nsv470679 CNV Loss 18288195
dgv2024n71 CNV Loss 21882294
dgv2025n71 CNV Loss 21882294
nsv517055 CNV Gain+Loss 19592680
dgv2033n71 CNV Loss 21882294
dgv2034n71 CNV Loss 21882294
dgv2035n71 CNV Loss 21882294
nsv902480 CNV Loss 21882294
nsv902481 CNV Loss 21882294
dgv2037n71 CNV Loss 21882294
nsv902490 CNV Loss 21882294
nsv1441 CNV Insertion 18451855
esv29981 CNV Gain 17803354
dgv2040n71 CNV Gain 21882294
dgv2041n71 CNV Gain 21882294
esv27023 CNV Gain+Loss 19812545
dgv2042n71 CNV Loss 21882294
dgv2043n71 CNV Gain+Loss 21882294
nsv902503 CNV Gain+Loss 21882294
esv2673275 CNV Deletion 23128226

Relevant External Links for TMEM121 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM121 Gene

Disorders for TMEM121 Gene

Relevant External Links for TMEM121

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TMEM121: view

No data available for UniProtKB/Swiss-Prot for TMEM121 Gene

Publications for TMEM121 Gene

  1. Hole is a novel gene product expressed in the developing heart and brain. (PMID: 12204283) Nesset A.L. … Bader D.M. (Mech. Dev. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Association between SNP rs10569304 on the second expressed region of hole gene and the congenital heart disease. (PMID: 20714865) Zhang Y. … Wang J. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2010) 3
  4. A novel six-transmembrane protein hhole functions as a suppressor in MAPK signaling pathways. (PMID: 15950185) Zhou J. … Liu M. (Biochem. Biophys. Res. Commun. 2005) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM121 Gene

Sources for TMEM121 Gene

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