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Aliases for TMEM120B Gene

Aliases for TMEM120B Gene

  • Transmembrane Protein 120B 2 3 5

External Ids for TMEM120B Gene

Previous GeneCards Identifiers for TMEM120B Gene

  • GC12P120635
  • GC12P122150
  • GC12P119162

Summaries for TMEM120B Gene

GeneCards Summary for TMEM120B Gene

TMEM120B (Transmembrane Protein 120B) is a Protein Coding gene. An important paralog of this gene is TMEM120A.

UniProtKB/Swiss-Prot for TMEM120B Gene

  • Necessary for efficient adipogenesis.

Additional gene information for TMEM120B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM120B Gene

Genomics for TMEM120B Gene

Regulatory Elements for TMEM120B Gene

Enhancers for TMEM120B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H121747 1.4 Ensembl ENCODE 15.1 +35.9 35898 2 PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF2 ZBTB7B SLC30A9 ZNF207 FOS ZCCHC8 KNTC1 RSRC2 SETD1B PSMD9 TMEM120B ANAPC5 ENSG00000272849 CCDC150P1 KDM2B
GH12H121708 1.6 FANTOM5 Ensembl ENCODE 11 +0.7 697 9 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 ZNF207 PSMD9 ZCCHC8 KNTC1 RSRC2 SETD1B KDM2B LOC101928346 ENSG00000256950 HPD TMEM120B
GH12H121765 1.1 Ensembl ENCODE 14.1 +54.2 54222 3 KLF17 FEZF1 TCF12 GLIS2 EGR1 ZNF366 ZSCAN5C RCOR1 FOS EGR2 TMEM120B RHOF SETD1B LINC01089 PSMD9 HPD ENSG00000256950 WDR66 ENSG00000272849
GH12H121742 0.9 ENCODE 15.8 +30.1 30133 0 HDAC1 TBP PKNOX1 ARNT FEZF1 ZBTB40 TCF12 GTF3C2 POLR3A FOS ZCCHC8 KNTC1 PSMD9 TMEM120B RSRC2 SETD1B ANAPC5 ENSG00000272849
GH12H121625 1.7 FANTOM5 ENCODE dbSUPER 7.2 -84.2 -84167 5 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZNF302 ZNF207 ZNF143 SP3 RSRC2 ZCCHC8 ENSG00000258435 IL31 ENSG00000256963 ENSG00000201945 RPL12P33 SETD1B LINC01089 ENSG00000272849
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM120B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM120B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058484 -52 1801 PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 YY1 TCF12 GLIS2 ELK1

Genomic Location for TMEM120B Gene

Chromosome:
12
Start:
121,712,752 bp from pter
End:
121,783,001 bp from pter
Size:
70,250 bases
Orientation:
Plus strand

Genomic View for TMEM120B Gene

Genes around TMEM120B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM120B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM120B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM120B Gene

Proteins for TMEM120B Gene

  • Protein details for TMEM120B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PK00-T120B_HUMAN
    Recommended name:
    Transmembrane protein 120B
    Protein Accession:
    A0PK00
    Secondary Accessions:
    • A0PK01
    • B3KX33

    Protein attributes for TMEM120B Gene

    Size:
    339 amino acids
    Molecular mass:
    40246 Da
    Quaternary structure:
    • Heterooligomer with TMEM120A.

neXtProt entry for TMEM120B Gene

Post-translational modifications for TMEM120B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM120B Gene

No data available for DME Specific Peptides for TMEM120B Gene

Domains & Families for TMEM120B Gene

Gene Families for TMEM120B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM120B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM120B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0PK00

UniProtKB/Swiss-Prot:

T120B_HUMAN :
  • Belongs to the TMEM120 family.
Family:
  • Belongs to the TMEM120 family.
genes like me logo Genes that share domains with TMEM120B: view

Function for TMEM120B Gene

Molecular function for TMEM120B Gene

UniProtKB/Swiss-Prot Function:
Necessary for efficient adipogenesis.

Phenotypes From GWAS Catalog for TMEM120B Gene

Gene Ontology (GO) - Molecular Function for TMEM120B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM120B: view
genes like me logo Genes that share phenotypes with TMEM120B: view

Animal Model Products

CRISPR Products

miRNA for TMEM120B Gene

miRTarBase miRNAs that target TMEM120B

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM120B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM120B Gene

Localization for TMEM120B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM120B Gene

Nucleus inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM120B gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM120B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005637 nuclear inner membrane ISS,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM120B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM120B Gene

Pathways & Interactions for TMEM120B Gene

SuperPathways for TMEM120B Gene

No Data Available

Interacting Proteins for TMEM120B Gene

Gene Ontology (GO) - Biological Process for TMEM120B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0045444 fat cell differentiation ISS,IEA --
GO:0051291 protein heterooligomerization ISS,IEA --
genes like me logo Genes that share ontologies with TMEM120B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM120B Gene

Drugs & Compounds for TMEM120B Gene

No Compound Related Data Available

Transcripts for TMEM120B Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM120B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM120B Gene

No ASD Table

Relevant External Links for TMEM120B Gene

GeneLoc Exon Structure for
TMEM120B
ECgene alternative splicing isoforms for
TMEM120B

Expression for TMEM120B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM120B Gene

mRNA differential expression in normal tissues according to GTEx for TMEM120B Gene

This gene is overexpressed in Brain - Cerebellum (x5.1) and Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for TMEM120B Gene

This gene is overexpressed in Rectum (56.3) and Pancreas (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM120B Gene



Protein tissue co-expression partners for TMEM120B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM120B Gene:

TMEM120B

Evidence on tissue expression from TISSUES for TMEM120B Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM120B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM120B Gene

Orthologs for TMEM120B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM120B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM120B 33 34
  • 95.94 (n)
cow
(Bos Taurus)
Mammalia TMEM120B 33 34
  • 90.36 (n)
rat
(Rattus norvegicus)
Mammalia Tmem120b 33
  • 89.77 (n)
dog
(Canis familiaris)
Mammalia TMEM120B 33 34
  • 89.58 (n)
mouse
(Mus musculus)
Mammalia Tmem120b 33 16 34
  • 88.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM120B 34
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM120B 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM120B 34
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM120B 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem120b 33
  • 72.77 (n)
Str.16706 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.22494 33
zebrafish
(Danio rerio)
Actinopterygii tmem120b 33 34
  • 72.57 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32795 34
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M01G5.3 33 34
  • 52.22 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G33230 33
  • 41.34 (n)
rice
(Oryza sativa)
Liliopsida Os02g0106800 33
  • 47.28 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10375 34
  • 55 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10116 33
Species where no ortholog for TMEM120B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM120B Gene

ENSEMBL:
Gene Tree for TMEM120B (if available)
TreeFam:
Gene Tree for TMEM120B (if available)

Paralogs for TMEM120B Gene

Paralogs for TMEM120B Gene

(1) SIMAP similar genes for TMEM120B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMEM120B: view

Variants for TMEM120B Gene

Sequence variations from dbSNP and Humsavar for TMEM120B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000104748 -- 121,729,691(+) CTACT(C/T)GGGAG intron-variant
rs1000135326 -- 121,754,530(+) GGCTT(C/T)GGGGA intron-variant
rs1000233999 -- 121,782,059(+) CAACA(C/T)GAGTA intron-variant, utr-variant-3-prime
rs1000239909 -- 121,745,331(+) TTTGT(C/T)TGTCT intron-variant
rs1000284728 -- 121,781,892(+) GATAC(C/T)TTAAT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM120B Gene

Variant ID Type Subtype PubMed ID
dgv2919n54 CNV loss 21841781
dgv2920n54 CNV gain+loss 21841781
dgv2921n54 CNV loss 21841781
dgv2922n54 CNV gain+loss 21841781
dgv2923n54 CNV loss 21841781
dgv2924n54 CNV loss 21841781
dgv2925n54 CNV loss 21841781
dgv882n106 CNV deletion 24896259
esv1527792 CNV insertion 17803354
esv1943412 CNV deletion 18987734
esv22633 CNV gain+loss 19812545
esv2625237 CNV deletion 19546169
esv2746492 CNV deletion 23290073
esv3630956 CNV loss 21293372
esv3630957 CNV loss 21293372
esv3892268 CNV loss 25118596
nsv1070555 CNV deletion 25765185
nsv1113529 CNV deletion 24896259
nsv1122774 CNV deletion 24896259
nsv1160065 CNV deletion 26073780
nsv560458 CNV loss 21841781
nsv560459 CNV loss 21841781
nsv560462 CNV gain+loss 21841781
nsv560463 CNV loss 21841781
nsv560464 CNV gain+loss 21841781
nsv560472 CNV gain+loss 21841781
nsv560489 CNV loss 21841781

Variation tolerance for TMEM120B Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.50; 92.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM120B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM120B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM120B Gene

Disorders for TMEM120B Gene

Relevant External Links for TMEM120B

Genetic Association Database (GAD)
TMEM120B
Human Genome Epidemiology (HuGE) Navigator
TMEM120B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM120B

No disorders were found for TMEM120B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM120B Gene

Publications for TMEM120B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60

Products for TMEM120B Gene

Sources for TMEM120B Gene

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