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Aliases for TMEM120B Gene

Aliases for TMEM120B Gene

  • Transmembrane Protein 120B 2 3

External Ids for TMEM120B Gene

Summaries for TMEM120B Gene

GeneCards Summary for TMEM120B Gene

TMEM120B (Transmembrane Protein 120B) is a Protein Coding gene. An important paralog of this gene is TMEM120A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM120B Gene

Genomics for TMEM120B Gene

Genomic Location for TMEM120B Gene

Start:
121,712,752 bp from pter
End:
121,783,001 bp from pter
Size:
70,250 bases
Orientation:
Plus strand

Genomic View for TMEM120B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM120B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM120B Gene

Regulatory Elements for TMEM120B Gene

Proteins for TMEM120B Gene

  • Protein details for TMEM120B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PK00-T120B_HUMAN
    Recommended name:
    Transmembrane protein 120B
    Protein Accession:
    A0PK00
    Secondary Accessions:
    • A0PK01
    • B3KX33

    Protein attributes for TMEM120B Gene

    Size:
    339 amino acids
    Molecular mass:
    40246 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM120B Gene

Proteomics data for TMEM120B Gene at MOPED

Post-translational modifications for TMEM120B Gene

No Post-translational modifications

Other Protein References for TMEM120B Gene

No data available for DME Specific Peptides for TMEM120B Gene

Domains for TMEM120B Gene

Protein Domains for TMEM120B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM120B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0PK00

UniProtKB/Swiss-Prot:

T120B_HUMAN
Family:
  • Belongs to the TMEM120 family.:
    • A0PK00
genes like me logo Genes that share domains with TMEM120B: view

No data available for Gene Families for TMEM120B Gene

Function for TMEM120B Gene

Gene Ontology (GO) - Molecular Function for TMEM120B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM120B: view

Phenotypes for TMEM120B Gene

genes like me logo Genes that share phenotypes with TMEM120B: view

miRNA for TMEM120B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM120B Gene

Localization for TMEM120B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM120B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM120B Gene COMPARTMENTS Subcellular localization image for TMEM120B gene
Compartment Confidence
plasma membrane 3
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM120B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM120B: view

Pathways for TMEM120B Gene

SuperPathways for TMEM120B Gene

No Data Available

Interacting Proteins for TMEM120B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000345152%0d%0a9606.ENSP00000300213%0d%0a
Selected Interacting proteins: ENSP00000345152 A0PK00-T120B_HUMAN for TMEM120B Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for TMEM120B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM120B: view

No data available for Pathways by source for TMEM120B Gene

Transcripts for TMEM120B Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM120B Gene

No ASD Table

Relevant External Links for TMEM120B Gene

GeneLoc Exon Structure for
TMEM120B
ECgene alternative splicing isoforms for
TMEM120B

Expression for TMEM120B Gene

mRNA expression in normal human tissues for TMEM120B Gene

mRNA differential expression in normal tissues according to GTEx for TMEM120B Gene

This gene is overexpressed in Brain - Cerebellum (5.1) and Brain - Cerebellar Hemisphere (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM120B Gene

genes like me logo Genes that share expressions with TMEM120B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM120B Gene

Orthologs for TMEM120B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM120B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM120B 35
  • 95.94 (n)
  • 94.66 (a)
TMEM120B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM120B 35
  • 90.36 (n)
  • 94.99 (a)
TMEM120B 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM120B 35
  • 89.58 (n)
  • 93.51 (a)
TMEM120B 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem120b 35
  • 88.99 (n)
  • 94.4 (a)
Tmem120b 16
Tmem120b 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM120B 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM120B 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem120b 35
  • 89.77 (n)
  • 94.69 (a)
chicken
(Gallus gallus)
Aves TMEM120B 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM120B 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22494 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16706 35
tmem120b 35
  • 72.77 (n)
  • 83.18 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem120b 35
  • 72.57 (n)
  • 79.43 (a)
tmem120b 36
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32795 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M01G5.3 35
  • 52.22 (n)
  • 44.55 (a)
M01G5.3 36
  • 38 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G33230 35
  • 41.34 (n)
  • 29.87 (a)
rice
(Oryza sativa)
Liliopsida Os02g0106800 35
  • 47.28 (n)
  • 35.15 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10116 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10375 36
  • 55 (a)
OneToMany
Species with no ortholog for TMEM120B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM120B Gene

ENSEMBL:
Gene Tree for TMEM120B (if available)
TreeFam:
Gene Tree for TMEM120B (if available)

Paralogs for TMEM120B Gene

Paralogs for TMEM120B Gene

Selected SIMAP similar genes for TMEM120B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for TMEM120B Gene

genes like me logo Genes that share paralogs with TMEM120B: view

Variants for TMEM120B Gene

Sequence variations from dbSNP and Humsavar for TMEM120B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs884884 -- 121,719,200(+) AGTTG(C/G)GGAGG intron-variant
rs884885 -- 121,719,292(+) GGGGG(A/G)CTAAT intron-variant
rs925530 -- 121,725,370(-) GAACA(C/T)GGGAG intron-variant
rs925531 -- 121,715,404(-) GCTAT(C/T)TAATT intron-variant
rs1107242 -- 121,745,010(-) tgctg(A/G)ggttC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM120B Gene

Variant ID Type Subtype PubMed ID
nsv899566 CNV Loss 21882294
esv2625237 CNV Deletion 19546169
esv1943412 CNV Deletion 18987734
esv2746492 CNV Deletion 23290073
esv22633 CNV Gain+Loss 19812545
esv1527792 CNV Insertion 17803354
nsv899567 CNV Gain 21882294

Relevant External Links for TMEM120B Gene

HapMap Linkage Disequilibrium report
TMEM120B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM120B Gene

Disorders for TMEM120B Gene

Relevant External Links for TMEM120B

Genetic Association Database (GAD)
TMEM120B
Human Genome Epidemiology (HuGE) Navigator
TMEM120B
genes like me logo Genes that share disorders with TMEM120B: view

No data available for UniProtKB/Swiss-Prot for TMEM120B Gene

Publications for TMEM120B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. (PMID: 24026423) Shameer K. … Kullo I.J. (Hum. Genet. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for TMEM120B Gene

Sources for TMEM120B Gene

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