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Aliases for TMEM120B Gene

Aliases for TMEM120B Gene

  • Transmembrane Protein 120B 2 3 5

External Ids for TMEM120B Gene

Previous GeneCards Identifiers for TMEM120B Gene

  • GC12P120635
  • GC12P122150
  • GC12P119162

Summaries for TMEM120B Gene

GeneCards Summary for TMEM120B Gene

TMEM120B (Transmembrane Protein 120B) is a Protein Coding gene. An important paralog of this gene is TMEM120A.

UniProtKB/Swiss-Prot for TMEM120B Gene

  • Necessary for efficient adipogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM120B Gene

Genomics for TMEM120B Gene

Regulatory Elements for TMEM120B Gene

Promoters for TMEM120B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM120B on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM120B Gene

Chromosome:
12
Start:
121,712,752 bp from pter
End:
121,783,001 bp from pter
Size:
70,250 bases
Orientation:
Plus strand

Genomic View for TMEM120B Gene

Genes around TMEM120B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM120B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM120B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM120B Gene

Proteins for TMEM120B Gene

  • Protein details for TMEM120B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PK00-T120B_HUMAN
    Recommended name:
    Transmembrane protein 120B
    Protein Accession:
    A0PK00
    Secondary Accessions:
    • A0PK01
    • B3KX33

    Protein attributes for TMEM120B Gene

    Size:
    339 amino acids
    Molecular mass:
    40246 Da
    Quaternary structure:
    • Heterooligomer with TMEM120A.

neXtProt entry for TMEM120B Gene

Proteomics data for TMEM120B Gene at MOPED

Post-translational modifications for TMEM120B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM120B Gene

No data available for DME Specific Peptides for TMEM120B Gene

Domains & Families for TMEM120B Gene

Protein Domains for TMEM120B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM120B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0PK00

UniProtKB/Swiss-Prot:

T120B_HUMAN :
  • Belongs to the TMEM120 family.
Family:
  • Belongs to the TMEM120 family.
genes like me logo Genes that share domains with TMEM120B: view

No data available for Gene Families for TMEM120B Gene

Function for TMEM120B Gene

Molecular function for TMEM120B Gene

UniProtKB/Swiss-Prot Function:
Necessary for efficient adipogenesis.
genes like me logo Genes that share phenotypes with TMEM120B: view

Animal Model Products

CRISPR Products

miRNA for TMEM120B Gene

miRTarBase miRNAs that target TMEM120B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM120B Gene

Localization for TMEM120B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM120B Gene

Nucleus inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM120B Gene COMPARTMENTS Subcellular localization image for TMEM120B gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM120B Gene

Pathways & Interactions for TMEM120B Gene

SuperPathways for TMEM120B Gene

No Data Available

Interacting Proteins for TMEM120B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000345152%0d%0a9606.ENSP00000300213%0d%0a
Selected Interacting proteins: ENSP00000345152 A0PK00-T120B_HUMAN for TMEM120B Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for TMEM120B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM120B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM120B Gene

Drugs & Compounds for TMEM120B Gene

No Compound Related Data Available

Transcripts for TMEM120B Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM120B Gene

No ASD Table

Relevant External Links for TMEM120B Gene

GeneLoc Exon Structure for
TMEM120B
ECgene alternative splicing isoforms for
TMEM120B

Expression for TMEM120B Gene

mRNA expression in normal human tissues for TMEM120B Gene

mRNA differential expression in normal tissues according to GTEx for TMEM120B Gene

This gene is overexpressed in Brain - Cerebellum (x5.1) and Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for TMEM120B Gene

This gene is overexpressed in Rectum (56.3) and Pancreas (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM120B Gene



genes like me logo Genes that share expression patterns with TMEM120B: view

Protein tissue co-expression partners for TMEM120B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM120B Gene

Orthologs for TMEM120B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM120B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM120B 36
  • 100 (a)
OneToOne
TMEM120B 35
  • 95.94 (n)
  • 94.66 (a)
cow
(Bos Taurus)
Mammalia TMEM120B 35
  • 90.36 (n)
  • 94.99 (a)
TMEM120B 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM120B 36
  • 91 (a)
OneToOne
TMEM120B 35
  • 89.58 (n)
  • 93.51 (a)
mouse
(Mus musculus)
Mammalia Tmem120b 36
  • 94 (a)
OneToOne
Tmem120b 16
Tmem120b 35
  • 88.99 (n)
  • 94.4 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM120B 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM120B 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem120b 35
  • 89.77 (n)
  • 94.69 (a)
chicken
(Gallus gallus)
Aves TMEM120B 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM120B 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22494 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16706 35
tmem120b 35
  • 72.77 (n)
  • 83.18 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem120b 36
  • 78 (a)
OneToOne
tmem120b 35
  • 72.57 (n)
  • 79.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32795 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M01G5.3 35
  • 52.22 (n)
  • 44.55 (a)
M01G5.3 36
  • 38 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G33230 35
  • 41.34 (n)
  • 29.87 (a)
rice
(Oryza sativa)
Liliopsida Os02g0106800 35
  • 47.28 (n)
  • 35.15 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10116 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10375 36
  • 55 (a)
OneToMany
Species with no ortholog for TMEM120B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM120B Gene

ENSEMBL:
Gene Tree for TMEM120B (if available)
TreeFam:
Gene Tree for TMEM120B (if available)

Paralogs for TMEM120B Gene

Paralogs for TMEM120B Gene

(1) SIMAP similar genes for TMEM120B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for TMEM120B Gene

genes like me logo Genes that share paralogs with TMEM120B: view

Variants for TMEM120B Gene

Sequence variations from dbSNP and Humsavar for TMEM120B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs884884 -- 121,719,200(+) AGTTG(C/G)GGAGG intron-variant
rs884885 -- 121,719,292(+) GGGGG(A/G)CTAAT intron-variant
rs1107242 -- 121,745,010(-) tgctg(A/G)ggttC intron-variant
rs1107243 -- 121,744,949(-) ACTCT(A/G)AGCCC intron-variant
rs1179893 -- 121,760,195(-) ctccc(A/G)agtag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM120B Gene

Variant ID Type Subtype PubMed ID
nsv899566 CNV Loss 21882294
esv2625237 CNV Deletion 19546169
esv1943412 CNV Deletion 18987734
esv2746492 CNV Deletion 23290073
esv22633 CNV Gain+Loss 19812545
esv1527792 CNV Insertion 17803354
nsv899567 CNV Gain 21882294

Variation tolerance for TMEM120B Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.50; 92.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM120B Gene

HapMap Linkage Disequilibrium report
TMEM120B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM120B Gene

Disorders for TMEM120B Gene

Relevant External Links for TMEM120B

Genetic Association Database (GAD)
TMEM120B
Human Genome Epidemiology (HuGE) Navigator
TMEM120B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM120B

No disorders were found for TMEM120B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM120B Gene

Publications for TMEM120B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. (PMID: 24026423) Shameer K. … Kullo I.J. (Hum. Genet. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3

Products for TMEM120B Gene

Sources for TMEM120B Gene

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