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Aliases for TMEM120A Gene

Aliases for TMEM120A Gene

  • Transmembrane Protein 120A 2 3 5
  • Transmembrane Protein Induced By Tumor Necrosis Factor Alpha 3 4
  • TMPIT 3 4
  • NET29 3

External Ids for TMEM120A Gene

Previous GeneCards Identifiers for TMEM120A Gene

  • GC07M075455
  • GC07M075618
  • GC07M070702

Summaries for TMEM120A Gene

GeneCards Summary for TMEM120A Gene

TMEM120A (Transmembrane Protein 120A) is a Protein Coding gene. An important paralog of this gene is TMEM120B.

UniProtKB/Swiss-Prot for TMEM120A Gene

  • Necessary for efficient adipogenesis (PubMed:26024229).

Additional gene information for TMEM120A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM120A Gene

Genomics for TMEM120A Gene

Regulatory Elements for TMEM120A Gene

Enhancers for TMEM120A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H075950 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.5 +43.6 43642 1 PKNOX1 SIN3A RAD21 RFX5 YY1 FOS RCOR1 HCFC1 USF2 CEBPB POR CCL26 SRRM3 MDH2 RHBDD2 GTF2IP1 TMEM120A SNORA14A GC07P075946
GH07H075989 1.6 Ensembl ENCODE dbSUPER 0.7 +4.4 4395 2 HNRNPUL1 PKNOX1 ATF1 ARNT SIN3A TCF12 ZNF766 GLIS2 CBX5 GATA2 STYXL1 STAG3L1 DTX2P1 PMS2P3 DTX2 GTF2IRD2B POMZP3 TMEM120A GC07P075946 SNORA14A
GH07H075993 1.3 ENCODE dbSUPER 0.7 +0.3 268 2 HDGF ATF1 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 ETS1 ZNF121 STYXL1 UPK3B TMEM120A SNORA14A GC07P075946
GH07H075997 1.2 Ensembl ENCODE dbSUPER 0.7 -2.8 -2774 0 HDAC1 SMARCE1 ATF1 ETV1 CEBPB CEBPG DPF2 ZBTB40 GABPA SMARCA4 TMEM120A ENSG00000280388
GH07H076008 1.2 Ensembl ENCODE dbSUPER 0.4 -16.0 -15977 4 CBFB EBF1 BATF RELA ZNF316 EED SCRT2 IKZF1 ETV6 MLLT1 STYXL1 MDH2 ENSG00000230882 SNORA14A POR RHBDD2 CCL24 SRRM3 UPK3B TMEM120A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM120A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM120A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000213847 274 1201 ATF1 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 ETS1 ZNF121 ELK1

Genomic Location for TMEM120A Gene

Chromosome:
7
Start:
75,986,837 bp from pter
End:
75,994,674 bp from pter
Size:
7,838 bases
Orientation:
Minus strand

Genomic View for TMEM120A Gene

Genes around TMEM120A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM120A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM120A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM120A Gene

Proteins for TMEM120A Gene

  • Protein details for TMEM120A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXJ8-T120A_HUMAN
    Recommended name:
    Transmembrane protein 120A
    Protein Accession:
    Q9BXJ8
    Secondary Accessions:
    • Q86TE9
    • Q8N6P1

    Protein attributes for TMEM120A Gene

    Size:
    343 amino acids
    Molecular mass:
    40610 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with TMEM120B.

    Alternative splice isoforms for TMEM120A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM120A Gene

Post-translational modifications for TMEM120A Gene

  • Glycosylation at posLast=117117
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM120A Gene

Domains & Families for TMEM120A Gene

Gene Families for TMEM120A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM120A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM120A Gene

Graphical View of Domain Structure for InterPro Entry

Q9BXJ8

UniProtKB/Swiss-Prot:

T120A_HUMAN :
  • Belongs to the TMEM120 family.
Family:
  • Belongs to the TMEM120 family.
genes like me logo Genes that share domains with TMEM120A: view

Function for TMEM120A Gene

Molecular function for TMEM120A Gene

UniProtKB/Swiss-Prot Function:
Necessary for efficient adipogenesis (PubMed:26024229).

Phenotypes From GWAS Catalog for TMEM120A Gene

Gene Ontology (GO) - Molecular Function for TMEM120A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM120A: view
genes like me logo Genes that share phenotypes with TMEM120A: view

Animal Model Products

CRISPR Products

miRNA for TMEM120A Gene

miRTarBase miRNAs that target TMEM120A

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM120A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM120A Gene

Localization for TMEM120A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM120A Gene

Nucleus inner membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM120A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005637 nuclear inner membrane IEA --
GO:0016020 membrane IEA,IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM120A: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TMEM120A Gene

Pathways & Interactions for TMEM120A Gene

SuperPathways for TMEM120A Gene

No Data Available

Interacting Proteins for TMEM120A Gene

Selected Interacting proteins: Q9BXJ8-T120A_HUMAN for TMEM120A Gene via IID

Gene Ontology (GO) - Biological Process for TMEM120A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0045444 fat cell differentiation IEA,IMP 26024229
GO:0051260 protein homooligomerization IDA,IEA 26024229
GO:0051291 protein heterooligomerization IEA,IDA 26024229
genes like me logo Genes that share ontologies with TMEM120A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM120A Gene

Drugs & Compounds for TMEM120A Gene

No Compound Related Data Available

Transcripts for TMEM120A Gene

Unigene Clusters for TMEM120A Gene

Transmembrane protein 120A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM120A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM120A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: -
SP2:
SP3: -
SP4: -
SP5: - -

Relevant External Links for TMEM120A Gene

GeneLoc Exon Structure for
TMEM120A
ECgene alternative splicing isoforms for
TMEM120A

Expression for TMEM120A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM120A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM120A Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for TMEM120A Gene

This gene is overexpressed in Spleen (15.8), Liver (8.3), and Testis (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM120A Gene



Protein tissue co-expression partners for TMEM120A Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM120A Gene:

TMEM120A

SOURCE GeneReport for Unigene cluster for TMEM120A Gene:

Hs.488835
genes like me logo Genes that share expression patterns with TMEM120A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM120A Gene

Orthologs for TMEM120A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM120A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM120A 33
  • 99.61 (n)
cow
(Bos Taurus)
Mammalia TMEM120A 33 34
  • 91.45 (n)
dog
(Canis familiaris)
Mammalia TMEM120A 33 34
  • 90.22 (n)
rat
(Rattus norvegicus)
Mammalia Tmem120a 33
  • 88.14 (n)
mouse
(Mus musculus)
Mammalia Tmem120a 33 16 34
  • 87.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 43 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TMEM120A 33 34
  • 79.43 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM120A 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem120a 33
  • 72.14 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem120a 33 34
  • 68.68 (n)
TMEM120A (2 of 2) 34
  • 63 (a)
OneToMany
Dr.14318 33
fruit fly
(Drosophila melanogaster)
Insecta CG32795 33 34
  • 59.79 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000285 33
  • 58.99 (n)
worm
(Caenorhabditis elegans)
Secernentea M01G5.3 34
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10375 34
  • 53 (a)
OneToMany
Species where no ortholog for TMEM120A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM120A Gene

ENSEMBL:
Gene Tree for TMEM120A (if available)
TreeFam:
Gene Tree for TMEM120A (if available)

Paralogs for TMEM120A Gene

Paralogs for TMEM120A Gene

(1) SIMAP similar genes for TMEM120A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM120A: view

Variants for TMEM120A Gene

Sequence variations from dbSNP and Humsavar for TMEM120A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs17685 Likely benign 75,986,787(-) AATCA(C/T)GTGGA intron-variant, utr-variant-3-prime
rs13921 Uncertain significance 75,986,721(+) GAGGC(C/T)TCTGG intron-variant, utr-variant-3-prime
rs148175064 Uncertain significance 75,986,386(+) ACATC(A/G)TGGCT downstream-variant-500B, reference, missense
rs184275273 Uncertain significance 75,986,660(+) CCACC(A/G)GCCCC intron-variant, utr-variant-3-prime
rs2286824 Uncertain significance 75,986,853(+) TTTCT(A/G)TATTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM120A Gene

Variant ID Type Subtype PubMed ID
dgv120n16 CNV deletion 17901297
esv27597 CNV loss 19812545
esv3613742 CNV loss 21293372
esv3613746 CNV loss 21293372
esv3613748 CNV loss 21293372
nsv1074519 CNV deletion 25765185
nsv1133662 CNV deletion 24896259
nsv428173 CNV gain 18775914
nsv528969 CNV gain 19592680
nsv607517 CNV loss 21841781
nsv951359 CNV deletion 24416366

Variation tolerance for TMEM120A Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM120A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM120A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM120A Gene

Disorders for TMEM120A Gene

Relevant External Links for TMEM120A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM120A

No disorders were found for TMEM120A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM120A Gene

Publications for TMEM120A Gene

  1. TMEM120A and B: Nuclear Envelope Transmembrane Proteins Important for Adipocyte Differentiation. (PMID: 26024229) Batrakou DG … Schirmer EC (PloS one 2015) 3 4 60
  2. An Interaction Landscape of Ubiquitin Signaling. (PMID: 28190767) Zhang X … Vermeulen M (Molecular cell 2017) 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for TMEM120A Gene

Sources for TMEM120A Gene

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