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Aliases for TMEM120A Gene

Aliases for TMEM120A Gene

  • Transmembrane Protein 120A 2 3 5
  • Transmembrane Protein Induced By Tumor Necrosis Factor Alpha 3 4
  • TMPIT 3 4
  • NET29 3

External Ids for TMEM120A Gene

Previous GeneCards Identifiers for TMEM120A Gene

  • GC07M075455
  • GC07M075618
  • GC07M070702

Summaries for TMEM120A Gene

GeneCards Summary for TMEM120A Gene

TMEM120A (Transmembrane Protein 120A) is a Protein Coding gene. An important paralog of this gene is TMEM120B.

UniProtKB/Swiss-Prot for TMEM120A Gene

  • Necessary for efficient adipogenesis (PubMed:26024229).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM120A Gene

Genomics for TMEM120A Gene

Regulatory Elements for TMEM120A Gene

Enhancers for TMEM120A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TMEM120A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM120A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM120A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM120A Gene

Chromosome:
7
Start:
75,986,837 bp from pter
End:
75,994,674 bp from pter
Size:
7,838 bases
Orientation:
Minus strand

Genomic View for TMEM120A Gene

Genes around TMEM120A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM120A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM120A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM120A Gene

Proteins for TMEM120A Gene

  • Protein details for TMEM120A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXJ8-T120A_HUMAN
    Recommended name:
    Transmembrane protein 120A
    Protein Accession:
    Q9BXJ8
    Secondary Accessions:
    • Q86TE9
    • Q8N6P1

    Protein attributes for TMEM120A Gene

    Size:
    343 amino acids
    Molecular mass:
    40610 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with TMEM120B.

    Alternative splice isoforms for TMEM120A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM120A Gene

Post-translational modifications for TMEM120A Gene

  • Glycosylation at Asn 117
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM120A Gene

Domains & Families for TMEM120A Gene

Protein Domains for TMEM120A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM120A Gene

Graphical View of Domain Structure for InterPro Entry

Q9BXJ8

UniProtKB/Swiss-Prot:

T120A_HUMAN :
  • Belongs to the TMEM120 family.
Family:
  • Belongs to the TMEM120 family.
genes like me logo Genes that share domains with TMEM120A: view

No data available for Gene Families for TMEM120A Gene

Function for TMEM120A Gene

Molecular function for TMEM120A Gene

UniProtKB/Swiss-Prot Function:
Necessary for efficient adipogenesis (PubMed:26024229).

Gene Ontology (GO) - Molecular Function for TMEM120A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM120A: view
genes like me logo Genes that share phenotypes with TMEM120A: view

Animal Model Products

CRISPR Products

miRNA for TMEM120A Gene

miRTarBase miRNAs that target TMEM120A

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM120A Gene

Localization for TMEM120A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM120A Gene

Nucleus inner membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM120A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005637 nuclear inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM120A: view

No data available for Subcellular locations from COMPARTMENTS for TMEM120A Gene

Pathways & Interactions for TMEM120A Gene

SuperPathways for TMEM120A Gene

No Data Available

Interacting Proteins for TMEM120A Gene

Gene Ontology (GO) - Biological Process for TMEM120A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0045444 fat cell differentiation IEA,IMP 26024229
GO:0051260 protein homooligomerization IEA,IDA 26024229
GO:0051291 protein heterooligomerization IEA,IDA 26024229
genes like me logo Genes that share ontologies with TMEM120A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM120A Gene

Drugs & Compounds for TMEM120A Gene

No Compound Related Data Available

Transcripts for TMEM120A Gene

Unigene Clusters for TMEM120A Gene

Transmembrane protein 120A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM120A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: -
SP2:
SP3: -
SP4: -
SP5: - -

Relevant External Links for TMEM120A Gene

GeneLoc Exon Structure for
TMEM120A
ECgene alternative splicing isoforms for
TMEM120A

Expression for TMEM120A Gene

mRNA expression in normal human tissues for TMEM120A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM120A Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for TMEM120A Gene

This gene is overexpressed in Spleen (15.8), Liver (8.3), and Testis (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM120A Gene



Protein tissue co-expression partners for TMEM120A Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM120A Gene:

TMEM120A

SOURCE GeneReport for Unigene cluster for TMEM120A Gene:

Hs.488835
genes like me logo Genes that share expression patterns with TMEM120A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM120A Gene

Orthologs for TMEM120A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM120A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM120A 34
  • 91.45 (n)
  • 95.04 (a)
TMEM120A 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM120A 34
  • 90.22 (n)
  • 95.58 (a)
TMEM120A 35
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem120a 34
  • 87.76 (n)
  • 94.75 (a)
Tmem120a 16
Tmem120a 35
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM120A 34
  • 99.61 (n)
  • 99.42 (a)
rat
(Rattus norvegicus)
Mammalia Tmem120a 34
  • 88.14 (n)
  • 93.88 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 43 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TMEM120A 34
  • 79.43 (n)
  • 79.23 (a)
TMEM120A 35
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM120A 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem120a 34
  • 72.14 (n)
  • 78.42 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14318 34
tmem120a 34
  • 68.68 (n)
  • 71.9 (a)
tmem120a 35
  • 70 (a)
OneToMany
TMEM120A (2 of 2) 35
  • 63 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000285 34
  • 58.99 (n)
  • 47.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32795 34
  • 59.79 (n)
  • 48.62 (a)
CG32795 35
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M01G5.3 35
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10375 35
  • 53 (a)
OneToMany
Species where no ortholog for TMEM120A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM120A Gene

ENSEMBL:
Gene Tree for TMEM120A (if available)
TreeFam:
Gene Tree for TMEM120A (if available)

Paralogs for TMEM120A Gene

Paralogs for TMEM120A Gene

(1) SIMAP similar genes for TMEM120A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM120A: view

Variants for TMEM120A Gene

Sequence variations from dbSNP and Humsavar for TMEM120A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs17852664 - 75,992,204(+) TCATC(C/T)GGTTC reference, missense
rs17855697 - 75,988,111(+) GAAGG(C/T)GGACA reference, missense
rs7788926 -- 75,990,332(+) GTGCC(A/G)GGAGC intron-variant
rs2286825 -- 75,987,631(+) CAGGA(C/T)GGCCA intron-variant
rs2286826 -- 75,992,343(+) AAACA(C/G)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM120A Gene

Variant ID Type Subtype PubMed ID
dgv120n16 CNV deletion 17901297
esv27597 CNV loss 19812545
esv3613742 CNV loss 21293372
esv3613746 CNV loss 21293372
esv3613748 CNV loss 21293372
nsv1074519 CNV deletion 25765185
nsv1133662 CNV deletion 24896259
nsv428173 CNV gain 18775914
nsv528969 CNV gain 19592680
nsv607517 CNV loss 21841781
nsv951359 CNV deletion 24416366

Variation tolerance for TMEM120A Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM120A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM120A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM120A Gene

Disorders for TMEM120A Gene

Relevant External Links for TMEM120A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM120A

No disorders were found for TMEM120A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM120A Gene

Publications for TMEM120A Gene

  1. TMEM120A and B: nuclear envelope transmembrane proteins important for adipocyte differentiation. (PMID: 26024229) Batrakou D.G. … Schirmer E.C. (PLoS ONE 2015) 3 4 65
  2. Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. (PMID: 25288136) . … Chasman D.I. (Mol. Psychiatry 2015) 3 65
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65

Products for TMEM120A Gene

Sources for TMEM120A Gene

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