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Aliases for TMEM120A Gene

Aliases for TMEM120A Gene

  • Transmembrane Protein 120A 2 3
  • Transmembrane Protein Induced By Tumor Necrosis Factor Alpha 3 4
  • TMPIT 3 4
  • NET29 3

External Ids for TMEM120A Gene

Previous GeneCards Identifiers for TMEM120A Gene

  • GC07M075455
  • GC07M075618
  • GC07M070702

Summaries for TMEM120A Gene

GeneCards Summary for TMEM120A Gene

TMEM120A (Transmembrane Protein 120A) is a Protein Coding gene. An important paralog of this gene is TMEM120B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM120A Gene

Genomics for TMEM120A Gene

Regulatory Elements for TMEM120A Gene

Genomic Location for TMEM120A Gene

Start:
75,986,837 bp from pter
End:
75,994,674 bp from pter
Size:
7,838 bases
Orientation:
Minus strand

Genomic View for TMEM120A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM120A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM120A Gene

Proteins for TMEM120A Gene

  • Protein details for TMEM120A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXJ8-T120A_HUMAN
    Recommended name:
    Transmembrane protein 120A
    Protein Accession:
    Q9BXJ8
    Secondary Accessions:
    • Q86TE9
    • Q8N6P1

    Protein attributes for TMEM120A Gene

    Size:
    343 amino acids
    Molecular mass:
    40610 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM120A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM120A Gene

Proteomics data for TMEM120A Gene at MOPED

Post-translational modifications for TMEM120A Gene

  • Glycosylation at Asn117
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM120A Gene

No data available for DME Specific Peptides for TMEM120A Gene

Domains for TMEM120A Gene

Protein Domains for TMEM120A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM120A Gene

Graphical View of Domain Structure for InterPro Entry

Q9BXJ8

UniProtKB/Swiss-Prot:

T120A_HUMAN :
  • Q9BXJ8
Family:
  • Belongs to the TMEM120 family.
genes like me logo Genes that share domains with TMEM120A: view

No data available for Gene Families for TMEM120A Gene

Function for TMEM120A Gene

Gene Ontology (GO) - Molecular Function for TMEM120A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM120A: view

Animal Model Products

CRISPR Products

miRNA for TMEM120A Gene

miRTarBase miRNAs that target TMEM120A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM120A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM120A Gene

Localization for TMEM120A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM120A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM120A Gene COMPARTMENTS Subcellular localization image for TMEM120A gene
Compartment Confidence
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM120A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM120A: view

Pathways for TMEM120A Gene

SuperPathways for TMEM120A Gene

No Data Available

Interacting Proteins for TMEM120A Gene

Selected Interacting proteins: Q9BXJ8-T120A_HUMAN for TMEM120A Gene via MINT I2D

Symbol External ID(s) Details
GOT1

Gene Ontology (GO) - Biological Process for TMEM120A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM120A: view

No data available for Pathways by source for TMEM120A Gene

Transcripts for TMEM120A Gene

Unigene Clusters for TMEM120A Gene

Transmembrane protein 120A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM120A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM120A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: -
SP2:
SP3: -
SP4: -
SP5: - -

Relevant External Links for TMEM120A Gene

GeneLoc Exon Structure for
TMEM120A
ECgene alternative splicing isoforms for
TMEM120A

Expression for TMEM120A Gene

mRNA expression in normal human tissues for TMEM120A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM120A Gene

This gene is overexpressed in Whole Blood (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TMEM120A Gene

SOURCE GeneReport for Unigene cluster for TMEM120A Gene Hs.488835

genes like me logo Genes that share expressions with TMEM120A: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM120A Gene

Orthologs for TMEM120A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM120A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM120A 35
  • 99.61 (n)
  • 99.42 (a)
cow
(Bos Taurus)
Mammalia TMEM120A 35
  • 91.45 (n)
  • 95.04 (a)
TMEM120A 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM120A 35
  • 90.22 (n)
  • 95.58 (a)
TMEM120A 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem120a 35
  • 87.76 (n)
  • 94.75 (a)
Tmem120a 16
Tmem120a 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tmem120a 35
  • 88.14 (n)
  • 93.88 (a)
chicken
(Gallus gallus)
Aves TMEM120A 35
  • 79.43 (n)
  • 79.23 (a)
TMEM120A 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM120A 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem120a 35
  • 72.14 (n)
  • 78.42 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14318 35
tmem120a 35
  • 68.68 (n)
  • 71.9 (a)
tmem120a 36
  • 70 (a)
OneToMany
TMEM120A (2 of 2) 36
  • 63 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000285 35
  • 58.99 (n)
  • 47.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32795 35
  • 59.79 (n)
  • 48.62 (a)
CG32795 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M01G5.3 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10375 36
  • 53 (a)
OneToMany
Species with no ortholog for TMEM120A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM120A Gene

ENSEMBL:
Gene Tree for TMEM120A (if available)
TreeFam:
Gene Tree for TMEM120A (if available)

Paralogs for TMEM120A Gene

Paralogs for TMEM120A Gene

Selected SIMAP similar genes for TMEM120A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM120A: view

Variants for TMEM120A Gene

Sequence variations from dbSNP and Humsavar for TMEM120A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2286825 -- 75,987,631(+) CAGGA(C/T)GGCCA intron-variant
rs2286826 -- 75,992,343(+) AAACA(C/G)GGCCC intron-variant
rs3214334 -- 75,989,504(+) GGGCA(-/C)CAAGA intron-variant
rs3735507 -- 75,994,765(-) GGGCT(A/G)GCAAC upstream-variant-2KB
rs4732519 -- 75,992,509(+) GTTCT(A/G)AAGTT reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for TMEM120A Gene

Variant ID Type Subtype PubMed ID
nsv528969 CNV Gain 19592680
essv14753 CNV CNV 17122850
dgv120n16 CNV Deletion 17901297
dgv2103e1 CNV Complex 17122850
nsv428173 CNV Gain 18775914
dgv2104e1 CNV Complex 17122850
esv27597 CNV Loss 19812545
nsv888386 CNV Gain 21882294

Relevant External Links for TMEM120A Gene

HapMap Linkage Disequilibrium report
TMEM120A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM120A Gene

Disorders for TMEM120A Gene

No disorders were found for TMEM120A Gene.

No data available for UniProtKB/Swiss-Prot for TMEM120A Gene

Publications for TMEM120A Gene

  1. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  4. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PMID: 21103663) Schaafhausen A. … MA1ller C.R. (Thromb. Haemost. 2011) 3
  5. Identification of the human testis protein phosphatase 1 interactome. (PMID: 21382349) Fardilha M. … da Cruz e Silva E.F. (Biochem. Pharmacol. 2011) 3

Products for TMEM120A Gene

Sources for TMEM120A Gene

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