TMEM120A Gene
protein-coding GIFtS: 44
GCID: GC07M075618
|
|
transmembrane protein 120A
| |
Aliases
for TMEM120A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 120A1 2 | | TMPIT1 2 3 | | NET291 2 | | Transmembrane Protein Induced By Tumor Necrosis Factor Alpha2 3 |
Export aliases for TMEM120A gene to outside databasesPrevious GC identifers: GC07M075455 GC07M070702 |
Summaries
for TMEM120A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM120A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM120A gene promoter:
Max1 Pax-5 Egr-1 FOXD3 LCR-F1 c-Ets-1 c-Myb ZIC2/Zic2 GCNF-2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM120A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM120A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q11.23 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11.23TMEM120A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M075618: view genomic region
(about GC identifiers)
Start:
|
75,616,155 bp from pter |
End:
|
75,623,992 bp from pter |
Size:
|
7,838 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 74,949,219-74,957,056 |
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Proteins
for TMEM120A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T120A_HUMAN, Q9BXJ8 (See
protein sequence)Recommended Name: Transmembrane protein 120A Size: 343 amino acids; 40610 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q86TE9 Q8N6P1Alternative splicing: 2 isoforms: Q9BXJ8-1 Q9BXJ8-2 Explore the universe of human proteins at neXtProt for TMEM120A: NX_Q9BXJ8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BXJ8
TMEM120A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_114131.1
Human Recombinant Protein Products for TMEM120A:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TMEM120A for ontologies About GeneDecksing
TMEM120A Antibody Products:
Assay Products for TMEM120A: |
Protein
Domains /
Families
for TMEM120A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM120A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BXJ8ProtoNet protein and cluster: Q9BXJ8 1 Blocks protein family: IPB012926 TMPIT-like
UniProtKB/Swiss-Prot: T120A_HUMAN, Q9BXJ8Similarity: Belongs to the TMEM120 family |
Function
for TMEM120A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
TMEM120A for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM120A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM120A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM120A (NM_031925) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM120A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM120A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM120A |
|
Pathways & Interactions
for TMEM120A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM120A
1 Interacting protein for TMEM120A (Q9BXJ82, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
TMEM120A for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM120A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM120A
Search CenterWatch for drugs/clinical trials and news about TMEM120A / T120A
|
Transcripts
for TMEM120A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM120A gene: NM_031925.2 Unigene Cluster for TMEM120A: Transmembrane protein 120A Hs.488835 [show with all ESTs]Unigene Representative Sequence: BM80511917 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000338761(uc003ued.3 uc003uec.2) ENST00000417509(uc003ueb.1)
ENST00000484946 ENST00000490656 ENST00000439537 ENST00000493251 ENST00000460127
ENST00000440632(uc022agl.1) ENST00000480899 ENST00000493111 ENST00000465989
ENST00000431867 ENST00000465494 ENST00000480538 ENST00000485200 ENST00000486865
ENST00000485581
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM120A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM120A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM120A (NM_031925) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM120A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM120A |
Additional cDNA sequence: AF327923.1 BC029487.1 BC040694.1 BC051850.1 16 DOTS entries: DT.100829178 DT.314204 DT.100797407 DT.121058932 DT.100797411 DT.121058854 DT.100036201 DT.75102554 DT.100797402 DT.100797405 DT.100797408 DT.100797410 DT.97794490 DT.100708585 DT.102838685 DT.121058913 24/367 AceView cDNA sequences (see all 367): CB853481 AI928433 AF327923 T35406 BG912682 CB528505 AF188201 BQ421226 CR611494 AI478719 CR590394 AF169648 CR615380 BM758538 BM797251 CR611131 AF169647 AA782050 AA961038 NM_016086 BQ016283 CR604706 CR606386 AI934101
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM120A About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | |
ECgene alternative splicing isoforms for TMEM120A
|
Expression
for TMEM120A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM120A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACCTCACTG
About this image
See TMEM120A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM120A
SOURCE GeneReport for Unigene cluster: Hs.488835
SABiosciences Custom PCR Arrays for TMEM120A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM120A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM120A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM120A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM120A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM120A |
Orthologs
for TMEM120A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TMEM120A gene from 6/11 species (see all 11) About this table
ENSEMBL Gene Tree for TMEM120A (if available)
TreeFam Gene Tree for TMEM120A (if available) |
Paralogs
for TMEM120A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM120A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM120A (75616155 - 75623992 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TMEM120A
3 CNVs: 3686 69966 22956 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TMEM120A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TMEM120A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM120A gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM120A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
|
External Searches for TMEM120A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM120A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM120A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM120A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM120A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM120A gene:
Search GeneIP for patents involving TMEM120A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM120A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM120A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM120A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM120A | | | OriGene Protein Over-expression Lysate for TMEM120A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM120A | | OriGene 3'-UTR Clone for TMEM120A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM120A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM120A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TMEM120A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM120A | | OriGene Custom Protein Services for TMEM120A | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM120A | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM120A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM120A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM120A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM120A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM120A |
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 | | | TMEM120A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM120A |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TMEM120A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM120A |
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