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Aliases for TMEM119 Gene

Aliases for TMEM119 Gene

  • Transmembrane Protein 119 2 3 5
  • Osteoblast Induction Factor 3 4
  • OBIF 3 4

External Ids for TMEM119 Gene

Previous GeneCards Identifiers for TMEM119 Gene

  • GC12M107487
  • GC12M108983
  • GC12M106047

Summaries for TMEM119 Gene

GeneCards Summary for TMEM119 Gene

TMEM119 (Transmembrane Protein 119) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM119 Gene

  • Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Upregulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM119 Gene

Genomics for TMEM119 Gene

Regulatory Elements for TMEM119 Gene

Enhancers for TMEM119 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G108619 1.4 Ensembl ENCODE dbSUPER 27 -23.4 -23350 4.6 PKNOX1 ARID4B DMAP1 CAVIN1 REST ZNF592 KAT8 MEF2D CREB3 ATF4 TMEM119 CORO1C LOC105369968 GC12M108565
GH12G108615 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.8 -19.1 -19086 3.4 HDGF WRNIP1 ARID4B ZNF2 ZNF48 CBX5 ZNF143 ZNF207 JUNB REST TMEM119 SELPLG CMKLR1 USP30 SSH1 LOC105369968 GC12M108565
GH12G108626 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -40.5 -40544 24.2 CREB3L1 MLX ZFP64 DMAP1 FEZF1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 PWP1 CORO1C SART3 PRDM4 UBE3B FICD KCTD10 SELPLG TMEM119 RPL17P38
GH12G108797 1.5 Ensembl ENCODE dbSUPER 10 -204.6 -204608 10.0 HDGF FOXA2 PKNOX1 ATF1 MLX ARNT ARID4B ZNF2 YY1 ZNF143 CORO1C SSH1 MIR619 SELPLG RNU7-169P TMEM119 ACACB ENSG00000257221 LOC101929204 ENSG00000274598
GH12G108596 1 ENCODE dbSUPER 13.1 +1.0 1027 3.0 BCOR KLF1 ESRRA ZNF146 ZSCAN4 KLF17 ZMYM3 NFXL1 CDC5L ZKSCAN1 TMEM119 ISCU
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM119 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM119 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000057068 620 201 MCM7 CDC5L ZKSCAN1

Genomic Location for TMEM119 Gene

Chromosome:
12
Start:
108,589,846 bp from pter
End:
108,598,320 bp from pter
Size:
8,475 bases
Orientation:
Minus strand

Genomic View for TMEM119 Gene

Genes around TMEM119 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM119 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM119 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM119 Gene

Proteins for TMEM119 Gene

  • Protein details for TMEM119 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4V9L6-TM119_HUMAN
    Recommended name:
    Transmembrane protein 119
    Protein Accession:
    Q4V9L6
    Secondary Accessions:
    • Q6UXE5
    • Q8N2F5

    Protein attributes for TMEM119 Gene

    Size:
    283 amino acids
    Molecular mass:
    29203 Da
    Quaternary structure:
    • Interacts with SMAD1, SMAD5 and RUNX2.

neXtProt entry for TMEM119 Gene

Post-translational modifications for TMEM119 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM119 Gene

No data available for DME Specific Peptides for TMEM119 Gene

Domains & Families for TMEM119 Gene

Protein Domains for TMEM119 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM119 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM119: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM119 Gene

Function for TMEM119 Gene

Molecular function for TMEM119 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Upregulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for TMEM119 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM119: view
genes like me logo Genes that share phenotypes with TMEM119: view

Animal Models for TMEM119 Gene

MGI Knock Outs for TMEM119:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM119

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM119 Gene

Localization for TMEM119 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM119 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Endoplasmic reticulum membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM119 gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 3
lysosome 1

Gene Ontology (GO) - Cellular Components for TMEM119 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IDA,IEA 20025746
genes like me logo Genes that share ontologies with TMEM119: view

Pathways & Interactions for TMEM119 Gene

SuperPathways for TMEM119 Gene

No Data Available

Interacting Proteins for TMEM119 Gene

Selected Interacting proteins: Q4V9L6-TM119_HUMAN for TMEM119 Gene via IID

Symbol External ID(s) Details
YWHAE
YWHAH

Gene Ontology (GO) - Biological Process for TMEM119 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IEA --
GO:0007283 spermatogenesis ISS --
GO:0008150 biological_process ND --
GO:0030154 cell differentiation IEA --
GO:0030501 positive regulation of bone mineralization IDA 20025746
genes like me logo Genes that share ontologies with TMEM119: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM119 Gene

Drugs & Compounds for TMEM119 Gene

No Compound Related Data Available

Transcripts for TMEM119 Gene

Unigene Clusters for TMEM119 Gene

Transmembrane protein 119:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM119 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for TMEM119 Gene

GeneLoc Exon Structure for
TMEM119
ECgene alternative splicing isoforms for
TMEM119

Expression for TMEM119 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM119 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM119 Gene

This gene is overexpressed in Bone marrow stromal cell (39.4) and Pancreas (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM119 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM119 Gene:

TMEM119

SOURCE GeneReport for Unigene cluster for TMEM119 Gene:

Hs.449718

mRNA Expression by UniProt/SwissProt for TMEM119 Gene:

Q4V9L6-TM119_HUMAN
Tissue specificity: Expressed in brain microglia (at protein level). Elevated expression levels seen in the brain of patients with Alzheimer disease. Expressed by osteoblast-like cells in bone tissues and follicular dendritic cells in lymphoid tissues.

Evidence on tissue expression from TISSUES for TMEM119 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with TMEM119: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM119 Gene

Orthologs for TMEM119 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM119 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM119 34 35
  • 99.18 (n)
dog
(Canis familiaris)
Mammalia TMEM119 34 35
  • 82.68 (n)
cow
(Bos Taurus)
Mammalia TMEM119 34 35
  • 79.83 (n)
rat
(Rattus norvegicus)
Mammalia Tmem119 34
  • 75.55 (n)
mouse
(Mus musculus)
Mammalia Tmem119 34 16 35
  • 75.42 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM119 35
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM119 34 35
  • 71.05 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM119 35
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem119b 35
  • 25 (a)
OneToOne
Species where no ortholog for TMEM119 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM119 Gene

ENSEMBL:
Gene Tree for TMEM119 (if available)
TreeFam:
Gene Tree for TMEM119 (if available)

Paralogs for TMEM119 Gene

No data available for Paralogs for TMEM119 Gene

Variants for TMEM119 Gene

Sequence variations from dbSNP and Humsavar for TMEM119 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000234390 -- 108,590,552(+) TTTAG(A/C)TGGGC utr-variant-3-prime
rs1000306980 -- 108,599,486(+) TCAGA(A/G)ACTTT upstream-variant-2KB
rs1000373047 -- 108,594,169(+) CGTGA(A/G/T)GATTC intron-variant
rs1000616343 -- 108,599,218(+) CCACC(A/G)CAATT upstream-variant-2KB
rs1001295586 -- 108,596,439(+) CACAC(-/A)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM119 Gene

Variant ID Type Subtype PubMed ID
nsv509475 CNV insertion 20534489
nsv524079 CNV loss 19592680
nsv883 CNV deletion 18451855

Variation tolerance for TMEM119 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.84; 58.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM119 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM119

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM119 Gene

Disorders for TMEM119 Gene

Relevant External Links for TMEM119

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM119

No disorders were found for TMEM119 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM119 Gene

Publications for TMEM119 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. TMEM119 marks a subset of microglia in the human brain. (PMID: 26250788) Satoh J.I. … Saito Y. (Neuropathology 2016) 3 4 64
  3. Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation. (PMID: 20025746) Kanamoto T. … Furukawa T. (BMC Dev. Biol. 2009) 3 4 64
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TMEM119 Gene

Sources for TMEM119 Gene

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