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Aliases for TMEM119 Gene

Aliases for TMEM119 Gene

  • Transmembrane Protein 119 2 3
  • Osteoblast Induction Factor 3 4
  • OBIF 3 4

External Ids for TMEM119 Gene

Previous GeneCards Identifiers for TMEM119 Gene

  • GC12M107487
  • GC12M108983
  • GC12M106047

Summaries for TMEM119 Gene

GeneCards Summary for TMEM119 Gene

TMEM119 (Transmembrane Protein 119) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM119 Gene

  • May promote the differentiation of myoblasts into osteoblasts.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM119 Gene

Genomics for TMEM119 Gene

Regulatory Elements for TMEM119 Gene

Genomic Location for TMEM119 Gene

108,589,846 bp from pter
108,598,320 bp from pter
8,475 bases
Minus strand

Genomic View for TMEM119 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM119 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM119 Gene

Proteins for TMEM119 Gene

  • Protein details for TMEM119 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 119
    Protein Accession:
    Secondary Accessions:
    • Q6UXE5
    • Q8N2F5

    Protein attributes for TMEM119 Gene

    283 amino acids
    Molecular mass:
    29203 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM119 Gene

Proteomics data for TMEM119 Gene at MOPED

Post-translational modifications for TMEM119 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM119 Gene

No data available for DME Specific Peptides for TMEM119 Gene

Domains for TMEM119 Gene

Protein Domains for TMEM119 Gene


Suggested Antigen Peptide Sequences for TMEM119 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM119: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM119 Gene

Function for TMEM119 Gene

Molecular function for TMEM119 Gene

UniProtKB/Swiss-Prot Function: May promote the differentiation of myoblasts into osteoblasts.

Gene Ontology (GO) - Molecular Function for TMEM119 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TMEM119: view

Phenotypes for TMEM119 Gene

MGI mutant phenotypes for TMEM119:
inferred from 1 alleles
GenomeRNAi human phenotypes for TMEM119:
genes like me logo Genes that share phenotypes with TMEM119: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM119 Gene

Localization for TMEM119 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM119 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM119 Gene COMPARTMENTS Subcellular localization image for TMEM119 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 2
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMEM119 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005783 endoplasmic reticulum IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM119: view

Pathways for TMEM119 Gene

SuperPathways for TMEM119 Gene

No Data Available

Interacting Proteins for TMEM119 Gene

Gene Ontology (GO) - Biological Process for TMEM119 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM119: view

No data available for Pathways by source for TMEM119 Gene

Transcripts for TMEM119 Gene

Unigene Clusters for TMEM119 Gene

Transmembrane protein 119:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM119

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM119 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for TMEM119 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM119 Gene

mRNA expression in normal human tissues for TMEM119 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM119 Gene

SOURCE GeneReport for Unigene cluster for TMEM119 Gene Hs.449718

genes like me logo Genes that share expressions with TMEM119: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM119 Gene

Orthologs for TMEM119 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM119 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM119 35
  • 99.18 (n)
  • 98.59 (a)
TMEM119 36
  • 99 (a)
(Bos Taurus)
Mammalia TMEM119 35
  • 79.83 (n)
  • 75.09 (a)
TMEM119 36
  • 72 (a)
(Canis familiaris)
Mammalia TMEM119 35
  • 82.68 (n)
  • 77.95 (a)
TMEM119 36
  • 63 (a)
(Mus musculus)
Mammalia Tmem119 35
  • 75.42 (n)
  • 71.04 (a)
Tmem119 16
Tmem119 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM119 36
  • 47 (a)
(Rattus norvegicus)
Mammalia Tmem119 35
  • 75.55 (n)
  • 69.11 (a)
(Gallus gallus)
Aves TMEM119 35
  • 71.05 (n)
  • 67.15 (a)
TMEM119 36
  • 53 (a)
(Anolis carolinensis)
Reptilia TMEM119 36
  • 49 (a)
(Danio rerio)
Actinopterygii tmem119b 36
  • 25 (a)
Species with no ortholog for TMEM119:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM119 Gene

Gene Tree for TMEM119 (if available)
Gene Tree for TMEM119 (if available)

Paralogs for TMEM119 Gene

No data available for Paralogs for TMEM119 Gene

Variants for TMEM119 Gene

Sequence variations from dbSNP and Humsavar for TMEM119 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs11718 -- 108,589,930(-) CCTCC(A/G)TCTGG utr-variant-3-prime
rs918302 -- 108,589,589(+) TCCCA(C/T)GGCCA downstream-variant-500B
rs1051924 -- 108,590,201(-) TCAGG(G/T)TGAAT utr-variant-3-prime
rs1051994 -- 108,589,960(-) AGGCT(C/T)TGGCA utr-variant-3-prime
rs2287557 -- 108,591,423(+) CAGGG(A/C)GGCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM119 Gene

Variant ID Type Subtype PubMed ID
nsv509475 CNV Insertion 20534489
nsv524079 CNV Loss 19592680
nsv883 CNV Loss 18451855

Relevant External Links for TMEM119 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM119 Gene

Disorders for TMEM119 Gene

(1) University of Copenhagen DISEASES for TMEM119 Gene

genes like me logo Genes that share disorders with TMEM119: view

No data available for UniProtKB/Swiss-Prot for TMEM119 Gene

Publications for TMEM119 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  4. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4

Products for TMEM119 Gene

Sources for TMEM119 Gene

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