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TMEM117 Gene

protein-coding   GIFtS: 45
GCID: GC12P044229

Transmembrane Protein 117

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 1171 2

External Ids:    HGNC: 253081   Entrez Gene: 842162   Ensembl: ENSG000001391737   UniProtKB: Q9H0C33   

Export aliases for TMEM117 gene to outside databases

Previous GC identifers: GC12P042517 GC12P041258


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM117 Gene:
TMEM117 (transmembrane protein 117) is a protein-coding gene. Diseases associated with TMEM117 include retinitis.

Gene Wiki entry for TMEM117 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM117 gene promoter:
         Sox5   AML1a   Olf-1   LCR-F1   C/EBPalpha   Meis-1b   Cart-1   Meis-1a   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM117 promoter sequence
   Search Chromatin IP Primers for TMEM117

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM117


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q12   HGNC cytogenetic band: 12q12

TMEM117 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM117 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P044229:  view genomic region     (about GC identifiers)

Start:
44,229,770 bp from pter      End:
44,783,545 bp from pter
Size:
553,776 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM117_HUMAN, Q9H0C3 (See protein sequence)
Recommended Name: Transmembrane protein 117  
Size: 514 amino acids; 60185 Da

Explore the universe of human proteins at neXtProt for TMEM117: NX_Q9H0C3

Explore proteomics data for TMEM117 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn353, Asn371
  • Modification sites at PhosphoSitePlus

  • See TMEM117 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001273140.1  NP_001273141.1  NP_001273142.1  NP_115632.1  

    ENSEMBL proteins: 
     ENSP00000448595   ENSP00000266534   ENSP00000446952   ENSP00000448657   ENSP00000445243  

    TMEM117 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9H0C3

    UniProtKB/Swiss-Prot: TM117_HUMAN, Q9H0C3
    Similarity: Belongs to the TMEM117 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    TMEM117 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TMEM117:
     High actin ratio cells  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM117
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    Selected qRT-PCR Assays for microRNAs that regulate TMEM117 (see all 9):
    hsa-miR-374b hsa-miR-513c hsa-miR-374a hsa-miR-570 hsa-miR-124 hsa-miR-593* hsa-miR-506 hsa-miR-514b-5p
    SwitchGear 3'UTR luciferase reporter plasmidTMEM117 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM117_HUMAN, Q9H0C3: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    plasma membrane3
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0016021integral component of membrane IEA--

    TMEM117 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM117
    Interactions:

        Search GeneGlobe Interaction Network for TMEM117

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    TMEM117 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM117 (TM117)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM117 gene (4 alternative transcripts): 
    NM_001286211.1  NM_001286212.1  NM_001286213.1  NM_032256.2  

    Unigene Cluster for TMEM117:

    Transmembrane protein 117
    Hs.444668  [show with all ESTs]
    Unigene Representative Sequence: BC060798
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546387 ENST00000551577(uc009zkc.3) ENST00000266534(uc001rod.3)
    ENST00000546868(uc001roe.3) ENST00000550495 ENST00000553253 ENST00000550623
    ENST00000546978 ENST00000536799
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TMEM117 (see all 9):
    hsa-miR-374b hsa-miR-513c hsa-miR-374a hsa-miR-570 hsa-miR-124 hsa-miR-593* hsa-miR-506 hsa-miR-514b-5p
    SwitchGear 3'UTR luciferase reporter plasmidTMEM117 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMEM117
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    GenScript: all cDNA clones in your preferred vector: TMEM117 (NM_032256)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM117
    Primer
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    OriGene qPCR primer pairs and template standards for TMEM117
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM117
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM117
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM117
      QuantiFast Probe-based Assays in human, mouse, rat TMEM117

    Additional mRNA sequence: 

    AK057287.1 AK097511.1 AL136855.1 BC016819.1 BC030284.1 BC042192.1 BC060798.1 

    7 DOTS entries:

    DT.441972  DT.100727854  DT.95264756  DT.100020167  DT.95298252  DT.95303175  DT.100690317 

    Selected AceView cDNA sequences (see all 56):

    AL136855 BF726164 BC042192 BC060798 AW263917 CR614846 BX398134 CD633750 
    NM_032256 N33224 AA662910 AK097511 N41940 AK057287 H99131 N24379 
    BC030284 AI245181 BM836802 N21193 BI548831 AI798952 BI549285 AI050061 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM117 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGAATTTG
    TMEM117 Expression
    About this image


    TMEM117 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Eye (Sensory Organs)
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
    TMEM117 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM117 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444668
        Custom PCR Arrays for TMEM117
    Primer
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    OriGene qPCR primer pairs and template standards for TMEM117
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM117

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM117 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1171 , 5 transmembrane protein 1171, 5 88.52(n)1
    95.91(a)1
      15 (48.65 cM)5
    3207091  NM_178789.41  NP_848904.11 
     946291855 
    chicken
    (Gallus gallus)
    Aves TMEM1171 transmembrane protein 117 79.83(n)
    85.66(a)
      417798  XM_416041.4  XP_416041.3 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1176
    transmembrane protein 117
    81(a)
    1 ↔ 1
    5(54223743-54589361)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.189402 Xenopus laevis transcribed sequence with weak similarity more 76.17(n)    CB197323.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.90572 Danio rerio mRNA similar to hypothetical protein DKFZp434K2435 more 74.12(n)    BC045388.1 


    ENSEMBL Gene Tree for TMEM117 (if available)
    TreeFam Gene Tree for TMEM117 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM117 (see all 10561)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1930555421,2
    --44227980(+) GTTTTA/CACTGA 1 -- us2k10--------
    rs1854172741,2
    --44228062(+) CACGTC/GTAACA 1 -- us2k10--------
    rs1402350291,2
    --44228163(+) ATGAGA/CCATTA 1 -- us2k10--------
    rs1874801201,2
    --44228236(+) GAAGAC/GTTCAT 1 -- us2k10--------
    rs1134144431,2
    C--44228327(+) AACAACT/-CTTTC 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1503182291,2
    --44228427(+) CAGTGG/TTGTGG 1 -- us2k10--------
    rs1155358641,2
    C,F--44228489(+) CATTTC/TGGTTC 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1170290801,2
    F--44228490(+) ATTTCG/AGTTCT 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1919292681,2
    --44228495(+) GGTTCC/TGATGA 1 -- us2k10--------
    rs1839719011,2
    C--44228578(+) TATGAA/GAGGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMEM117 (44229770 - 44479770 bp, first 250kb of TMEM117)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TMEM117 (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2599381CNV Deletion19546169
    esv2670553CNV Deletion23128226
    esv2676940CNV Deletion23128226
    esv2662955CNV Deletion23128226
    esv2672307CNV Deletion23128226
    esv2745829CNV Deletion23290073
    esv269807CNV Insertion20981092
    esv2581992CNV Insertion19546169
    esv273024CNV Insertion20981092
    esv269584CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM117
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for TMEM117:    
    About MalaCards
    retinitis


    TMEM117 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMEM117
    Human Genome Epidemiology (HuGE) Navigator: TMEM117 (4 documents)

    Export disorders for TMEM117 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM117 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with TMEM117)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    7. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (BMC Med. Genet. 2007)
    8. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
    9. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    10. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84216 HGNC: 25308 AceView: DKFZp434K2435 Ensembl:ENSG00000139173 euGenes: HUgn84216
    ECgene: TMEM117 H-InvDB: TMEM117

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM117 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM117 gene:
    Search GeneIP for patents involving TMEM117

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TMEM117  
     OriGene qPCR primer pairs and template standards for TMEM117   OriGene Protein Over-expression Lysate for TMEM117  
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     Block miRNA regulation of human, mouse, rat TMEM117 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TMEM117
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM117 Predesigned siRNA for gene silencing in human, mouse, rat TMEM117
     QuantiFast Probe-based Assays in human, mouse, rat TMEM117 QuantiTect SYBR Green Assays in human, mouse, rat TMEM117
     Custom PCR Arrays for TMEM117 Search Chromatin IP Primers for TMEM117
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     Regulatory tfbs in TMEM117 promoter
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     Novus Tissue Slides
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     Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM117
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM117
     SwitchGear 3'UTR luciferase reporter plasmids for TMEM117
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     Search ThermoFisher Antibodies for TMEM117
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM117
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM117
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM117
     LSBio Antibodies in human, mouse, rat for TMEM117
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