TMEM117 Gene
protein-coding GIFtS: 40
GCID: GC12P044229
|
|
transmembrane protein 117
| |
Aliases
for TMEM117 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 1171 2 | | DKFZp434K24351 |
Export aliases for TMEM117 gene to outside databasesPrevious GC identifers: GC12P042517 GC12P041258 |
Summaries
for TMEM117 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for TMEM117
|
Genomic Views
for TMEM117 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM117 gene promoter:
Sox5 AML1a Olf-1 LCR-F1 C/EBPalpha Meis-1b Cart-1 Meis-1a NF-kappaB1 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM117
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM117 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q12 Ensembl cytogenetic band: 12q12 HGNC cytogenetic band: 12q12TMEM117 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P044229: view genomic region
(about GC identifiers)
Start:
|
44,229,770 bp from pter |
End:
|
44,783,545 bp from pter |
Size:
|
553,776 bases |
Orientation:
|
plus strand |
|
Proteins
for TMEM117 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM117_HUMAN, Q9H0C3 (See
protein sequence)Recommended Name: Transmembrane protein 117 Size: 514 amino acids; 60185 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for TMEM117: NX_Q9H0C3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H0C3
TMEM117 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115632.1
ENSEMBL proteins: ENSP00000448595 ENSP00000266534 ENSP00000446952 ENSP00000448657 ENSP00000445243
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005783 | endoplasmic reticulum |
IDA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TMEM117 for ontologies About GeneDecksing
TMEM117 Antibody Products:
Assay Products for TMEM117: |
Protein
Domains /
Families
for TMEM117 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9H0C3 UniProtKB/Swiss-Prot: TM117_HUMAN, Q9H0C3Similarity: Belongs to the TMEM117 family |
Function
for TMEM117 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM117 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM117
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM117 (NM_032256) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM117 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM117 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM117 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
TMEM117 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TMEM117:
|
Pathways & Interactions
for TMEM117 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM117
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
TMEM117 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM117 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM117
Search CenterWatch for drugs/clinical trials and news about TMEM117 / TM117
|
Transcripts
for TMEM117 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM117 gene: NM_032256.1 Unigene Cluster for TMEM117: Transmembrane protein 117 Hs.444668 [show with all ESTs]Unigene Representative Sequence: BC0607989 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000546387 ENST00000551577(uc009zkc.3) ENST00000266534(uc001rod.3)
ENST00000546868(uc001roe.3) ENST00000550495 ENST00000553253 ENST00000550623
ENST00000546978 ENST00000536799
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM117 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM117
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM117 (NM_032256) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM117 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM117 |
Additional cDNA sequence: AK057287.1 AK097511.1 AL136855.1 BC016819.1 BC030284.1 BC042192.1 BC060798.1 7 DOTS entries: DT.441972 DT.100727854 DT.95264756 DT.100020167 DT.95298252 DT.95303175 DT.100690317 24/56 AceView cDNA sequences (see all 56): CD633750 BC042192 BC060798 BX398134 AA662910 BC030284 AL136855 N24379 AW263917 N33224 NM_032256 AI245181 H99131 AK057287 N41940 AK097511 BF726164 CR614846 CD633746 N21193 AW071936 BF726165 AI188272 AI201783
GeneLoc Exon Structure
|
Expression
for TMEM117 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM117 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGAATTTG
About this image
See TMEM117 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM117
SOURCE GeneReport for Unigene cluster: Hs.444668
SABiosciences Custom PCR Arrays for TMEM117
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM117
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM117 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM117 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM117 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM117 |
Orthologs
for TMEM117 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TMEM117 gene from 5/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tmem1171 , 5 |
transmembrane protein 1171, 5 |
88.52(n)1
95.91(a)1 |
|
15 (48.65 cM)5
3207091 NM_178789.41 NP_848904.11
946291855 |
chicken
(Gallus gallus) |
Aves |
TMEM1171 |
transmembrane protein 117 |
79.83(n)
85.66(a) |
|
417798 XM_416041.3 XP_416041.3 |
lizard
(Anolis carolinensis) |
Reptilia |
TMEM1176 |
-- |
73(a) |
1 ↔ 1 |
5(54225127-54242812) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.189402 |
Xenopus laevis transcribed sequence with weak similarity more |
76.17(n) |
|
CB197323.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.90572 |
Danio rerio mRNA similar to hypothetical protein DKFZp434K2435 more |
74.12(n) |
|
BC045388.1 |
ENSEMBL Gene Tree for TMEM117 (if available)
TreeFam Gene Tree for TMEM117 (if available) |
Paralogs
for TMEM117 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM117 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM117 (44229770 - 44479770 bp, first 250kb of TMEM117)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for TMEM117
7 CNVs: 66212 86348 101501 86349 101500 71499 66213
2 Indels: 76027 86350 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM117 |
|
Disorders
/ Diseases
for TMEM117 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TMEM117 for disorders About MalaCards
TMEM117 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: TMEM117 (4 documents)
Export disorders for TMEM117 gene to outside databases
|
Publications
for TMEM117 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM117 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TMEM117) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)
|
External Searches for TMEM117 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM117 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM117 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM117 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM117 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM117 gene:
Search GeneIP for patents involving TMEM117
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM117 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM117 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM117 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM117 | | | OriGene Protein Over-expression Lysate for TMEM117 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM117 | | OriGene 3'-UTR Clone for TMEM117 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM117 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM117 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM117 | | OriGene Custom Protein Services for TMEM117 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM117 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM117 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM117 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM117 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM117 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM117 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TMEM117 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TMEM117 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM117 |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM117 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM117 |
|
|
|
|
