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Aliases for TMEM116 Gene

Aliases for TMEM116 Gene

  • Transmembrane Protein 116 2 3 5

External Ids for TMEM116 Gene

Previous GeneCards Identifiers for TMEM116 Gene

  • GC12M110832
  • GC12M112369
  • GC12M109382

Summaries for TMEM116 Gene

GeneCards Summary for TMEM116 Gene

TMEM116 (Transmembrane Protein 116) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM116 Gene

Genomics for TMEM116 Gene

Regulatory Elements for TMEM116 Gene

Promoters for TMEM116 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM116 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM116 Gene

111,894,930 bp from pter
112,013,219 bp from pter
118,290 bases
Minus strand

Genomic View for TMEM116 Gene

Genes around TMEM116 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM116 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM116 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM116 Gene

Proteins for TMEM116 Gene

  • Protein details for TMEM116 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 116
    Protein Accession:
    Secondary Accessions:
    • G3V1W7
    • G5E985
    • Q6NSH5
    • Q8IZ66

    Protein attributes for TMEM116 Gene

    245 amino acids
    Molecular mass:
    27464 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM116 Gene


neXtProt entry for TMEM116 Gene

Proteomics data for TMEM116 Gene at MOPED

Post-translational modifications for TMEM116 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM116 Gene

Domains & Families for TMEM116 Gene

Protein Domains for TMEM116 Gene


Suggested Antigen Peptide Sequences for TMEM116 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM116: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM116 Gene

Function for TMEM116 Gene

genes like me logo Genes that share phenotypes with TMEM116: view

Animal Model Products

CRISPR Products

miRNA for TMEM116 Gene

miRTarBase miRNAs that target TMEM116

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM116 Gene

Localization for TMEM116 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM116 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM116 Gene COMPARTMENTS Subcellular localization image for TMEM116 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
nucleus 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM116 Gene

Pathways & Interactions for TMEM116 Gene

SuperPathways for TMEM116 Gene

No Data Available

Interacting Proteins for TMEM116 Gene

Gene Ontology (GO) - Biological Process for TMEM116 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM116 Gene

Drugs & Compounds for TMEM116 Gene

No Compound Related Data Available

Transcripts for TMEM116 Gene

Unigene Clusters for TMEM116 Gene

Transmembrane protein 116:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM116 Gene

No ASD Table

Relevant External Links for TMEM116 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM116 Gene

mRNA expression in normal human tissues for TMEM116 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM116 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.1).

SOURCE GeneReport for Unigene cluster for TMEM116 Gene Hs.506815

genes like me logo Genes that share expression patterns with TMEM116: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM116 Gene

Orthologs for TMEM116 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM116 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM116 35
  • 83.97 (n)
  • 75 (a)
TMEM116 36
  • 76 (a)
(Canis familiaris)
Mammalia TMEM116 35
  • 88.69 (n)
  • 85.76 (a)
TMEM116 36
  • 82 (a)
(Mus musculus)
Mammalia Tmem116 35
  • 78.34 (n)
  • 70.03 (a)
Tmem116 16
Tmem116 36
  • 65 (a)
(Pan troglodytes)
Mammalia TMEM116 35
  • 99.41 (n)
  • 98.81 (a)
TMEM116 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Tmem116 35
  • 77.24 (n)
  • 67.37 (a)
(Monodelphis domestica)
Mammalia TMEM116 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM116 36
  • 58 (a)
(Gallus gallus)
Aves TMEM116 35
  • 63.44 (n)
  • 58.12 (a)
TMEM116 36
  • 53 (a)
(Anolis carolinensis)
Reptilia TMEM116 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487315 35
  • 54.15 (n)
  • 43.69 (a)
(Danio rerio)
Actinopterygii si:ch211-157p22.10 35
  • 53.4 (n)
  • 44.75 (a)
TMEM116 36
  • 40 (a)
Species with no ortholog for TMEM116:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM116 Gene

Gene Tree for TMEM116 (if available)
Gene Tree for TMEM116 (if available)

Paralogs for TMEM116 Gene

No data available for Paralogs for TMEM116 Gene

Variants for TMEM116 Gene

Sequence variations from dbSNP and Humsavar for TMEM116 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs3752630 - 111,938,186(+) TTGAC(A/C)AACTC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs757160 -- 111,955,261(+) GTCCC(A/G)TAGCC intron-variant
rs1016078 -- 111,972,273(+) ggtgt(A/C)actta intron-variant
rs1016079 -- 111,972,382(+) cacaa(G/T)tatag intron-variant
rs1967628 -- 112,008,689(+) TTCTA(A/G)ggcca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM116 Gene

Variant ID Type Subtype PubMed ID
esv2746360 CNV Deletion 23290073
nsv887 CNV Loss 18451855

Variation tolerance for TMEM116 Gene

Residual Variation Intolerance Score: 65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.46; 64.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM116 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM116 Gene

Disorders for TMEM116 Gene

Relevant External Links for TMEM116

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM116 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM116 Gene

Publications for TMEM116 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TMEM116 Gene

Sources for TMEM116 Gene

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