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Aliases for TMEM116 Gene

Aliases for TMEM116 Gene

  • Transmembrane Protein 116 2 3

External Ids for TMEM116 Gene

Summaries for TMEM116 Gene

GeneCards Summary for TMEM116 Gene

TMEM116 (Transmembrane Protein 116) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM116 Gene

Genomics for TMEM116 Gene

Genomic Location for TMEM116 Gene

Start:
111,931,282 bp from pter
End:
112,013,219 bp from pter
Size:
81,938 bases
Orientation:
Minus strand

Genomic View for TMEM116 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM116 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM116 Gene

Regulatory Elements for TMEM116 Gene

Proteins for TMEM116 Gene

  • Protein details for TMEM116 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCL8-TM116_HUMAN
    Recommended name:
    Transmembrane protein 116
    Protein Accession:
    Q8NCL8
    Secondary Accessions:
    • G3V1W7
    • G5E985
    • Q6NSH5
    • Q8IZ66

    Protein attributes for TMEM116 Gene

    Size:
    245 amino acids
    Molecular mass:
    27464 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM116 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM116 Gene

Proteomics data for TMEM116 Gene at MOPED

Post-translational modifications for TMEM116 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM116 Gene

Domains for TMEM116 Gene

Protein Domains for TMEM116 Gene

ProtoNet:
genes like me logo Genes that share domains with TMEM116: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM116 Gene

Function for TMEM116 Gene

Gene Ontology (GO) - Molecular Function for TMEM116 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM116: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM116 Gene

Localization for TMEM116 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM116 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM116 Gene COMPARTMENTS Subcellular localization image for TMEM116 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM116 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM116: view

Pathways for TMEM116 Gene

SuperPathways for TMEM116 Gene

No Data Available

Interacting Proteins for TMEM116 Gene

Gene Ontology (GO) - Biological Process for TMEM116 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM116: view

No data available for Pathways by source for TMEM116 Gene

Transcripts for TMEM116 Gene

Unigene Clusters for TMEM116 Gene

Transmembrane protein 116:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM116 Gene

No ASD Table

Relevant External Links for TMEM116 Gene

GeneLoc Exon Structure for
TMEM116
ECgene alternative splicing isoforms for
TMEM116

Expression for TMEM116 Gene

mRNA expression in normal human tissues for TMEM116 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM116 Gene

This gene is overexpressed in Heart - Left Ventricle (4.1).

SOURCE GeneReport for Unigene cluster for TMEM116 Gene Hs.506815

genes like me logo Genes that share expressions with TMEM116: view

Orthologs for TMEM116 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM116 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM116 36
  • 99.41 (n)
  • 98.81 (a)
TMEM116 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM116 36
  • 83.97 (n)
  • 75 (a)
TMEM116 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM116 36
  • 88.69 (n)
  • 85.76 (a)
TMEM116 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem116 36
  • 78.34 (n)
  • 70.03 (a)
Tmem116 16
Tmem116 37
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM116 37
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM116 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem116 36
  • 77.24 (n)
  • 67.37 (a)
chicken
(Gallus gallus)
Aves TMEM116 36
  • 63.44 (n)
  • 58.12 (a)
TMEM116 37
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM116 37
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487315 36
  • 54.15 (n)
  • 43.69 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-157p22.10 36
  • 53.4 (n)
  • 44.75 (a)
TMEM116 37
  • 40 (a)
OneToOne
Species with no ortholog for TMEM116:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM116 Gene

ENSEMBL:
Gene Tree for TMEM116 (if available)
TreeFam:
Gene Tree for TMEM116 (if available)

Paralogs for TMEM116 Gene

No data available for Paralogs for TMEM116 Gene

Variants for TMEM116 Gene

Sequence variations from dbSNP and Humsavar for TMEM116 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs757160 -- 111,955,261(+) GTCCC(A/G)TAGCC intron-variant
rs1016078 -- 111,972,273(+) ggtgt(A/C)actta intron-variant
rs1016079 -- 111,972,382(+) cacaa(G/T)tatag intron-variant
rs1967628 -- 112,008,689(+) TTCTA(A/G)ggcca intron-variant
rs1967629 -- 112,008,906(+) GGAGG(C/T)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM116 Gene

Variant ID Type Subtype PubMed ID
esv2746360 CNV Deletion 23290073
nsv887 CNV Loss 18451855

Relevant External Links for TMEM116 Gene

HapMap Linkage Disequilibrium report
TMEM116

Disorders for TMEM116 Gene

No disorders were found for TMEM116 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM116 Gene

Publications for TMEM116 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4

Products for TMEM116 Gene

Sources for TMEM116 Gene

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