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Aliases for TMEM116 Gene

Aliases for TMEM116 Gene

  • Transmembrane Protein 116 2 3 5

External Ids for TMEM116 Gene

Previous GeneCards Identifiers for TMEM116 Gene

  • GC12M110832
  • GC12M112369
  • GC12M109382

Summaries for TMEM116 Gene

GeneCards Summary for TMEM116 Gene

TMEM116 (Transmembrane Protein 116) is a Protein Coding gene.

Additional gene information for TMEM116 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM116 Gene

Genomics for TMEM116 Gene

Regulatory Elements for TMEM116 Gene

Enhancers for TMEM116 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H112124 1.6 Ensembl ENCODE dbSUPER 37.5 -115.1 -115143 7 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 TMEM116 MAPKAPK5 BRAP ADAM1A NAA25 ERP29 TRAFD1 GC12P112151
GH12H112005 1.5 Ensembl ENCODE dbSUPER 27.6 +7.2 7209 0 HDGF PKNOX1 ZNF2 TCF12 ZNF207 FOS ATF7 SP3 MCM5 JUNB TMEM116 TRAFD1 GC12P112008 LOC724085
GH12H111991 1.5 Ensembl ENCODE dbSUPER 27.5 +19.5 19483 4 HDGF ATF1 ARNT TCF12 ZNF766 ATF7 RUNX3 NCOA1 JUNB ZNF592 TMEM116 ADAM1A ALDH2 GC12P111993 GC12M112001
GH12H112120 1.5 Ensembl ENCODE dbSUPER 26.9 -109.2 -109155 3 HDGF SIN3A FEZF1 ZNF2 GTF3C2 ZNF766 FOS SP5 ZNF491 ZNF518A TMEM116 MAPKAPK5 HSPA8P14 FAM109A ADAM1A TRAFD1 GC12P112109
GH12H112011 1.4 ENCODE dbSUPER 27.9 -0.3 -345 4 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 TMEM116 MAPKAPK5 HSPA8P14 HECTD4 ADAM1A NAA25 RPL6 TRAFD1 FAM109A ERP29
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM116 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM116 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000057487 -81 2201 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1

Genomic Location for TMEM116 Gene

Chromosome:
12
Start:
111,894,930 bp from pter
End:
112,013,219 bp from pter
Size:
118,290 bases
Orientation:
Minus strand

Genomic View for TMEM116 Gene

Genes around TMEM116 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM116 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM116 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM116 Gene

Proteins for TMEM116 Gene

  • Protein details for TMEM116 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCL8-TM116_HUMAN
    Recommended name:
    Transmembrane protein 116
    Protein Accession:
    Q8NCL8
    Secondary Accessions:
    • G3V1W7
    • G5E985
    • Q6NSH5
    • Q8IZ66

    Protein attributes for TMEM116 Gene

    Size:
    245 amino acids
    Molecular mass:
    27464 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM116 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM116 Gene

Post-translational modifications for TMEM116 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM116 Gene

Domains & Families for TMEM116 Gene

Gene Families for TMEM116 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TMEM116 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM116 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM116: view

No data available for UniProtKB/Swiss-Prot for TMEM116 Gene

Function for TMEM116 Gene

Phenotypes From GWAS Catalog for TMEM116 Gene

Gene Ontology (GO) - Molecular Function for TMEM116 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM116: view
genes like me logo Genes that share phenotypes with TMEM116: view

Animal Model Products

CRISPR Products

miRNA for TMEM116 Gene

miRTarBase miRNAs that target TMEM116

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM116 Gene

Localization for TMEM116 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM116 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM116 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
nucleus 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM116 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM116: view

Pathways & Interactions for TMEM116 Gene

SuperPathways for TMEM116 Gene

No Data Available

Interacting Proteins for TMEM116 Gene

Gene Ontology (GO) - Biological Process for TMEM116 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM116: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM116 Gene

Drugs & Compounds for TMEM116 Gene

No Compound Related Data Available

Transcripts for TMEM116 Gene

Unigene Clusters for TMEM116 Gene

Transmembrane protein 116:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM116 Gene

No ASD Table

Relevant External Links for TMEM116 Gene

GeneLoc Exon Structure for
TMEM116
ECgene alternative splicing isoforms for
TMEM116

Expression for TMEM116 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM116 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM116 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of TMEM116 Gene:

TMEM116

SOURCE GeneReport for Unigene cluster for TMEM116 Gene:

Hs.506815

Evidence on tissue expression from TISSUES for TMEM116 Gene

  • Nervous system(4.4)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with TMEM116: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM116 Gene

Orthologs for TMEM116 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM116 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM116 33 34
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia TMEM116 33 34
  • 88.69 (n)
cow
(Bos Taurus)
Mammalia TMEM116 33 34
  • 83.97 (n)
mouse
(Mus musculus)
Mammalia Tmem116 33 16 34
  • 78.34 (n)
rat
(Rattus norvegicus)
Mammalia Tmem116 33
  • 77.24 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM116 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM116 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM116 33 34
  • 63.44 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM116 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487315 33
  • 54.15 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-157p22.10 33
  • 53.4 (n)
TMEM116 34
  • 40 (a)
OneToOne
Species where no ortholog for TMEM116 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM116 Gene

ENSEMBL:
Gene Tree for TMEM116 (if available)
TreeFam:
Gene Tree for TMEM116 (if available)

Paralogs for TMEM116 Gene

No data available for Paralogs for TMEM116 Gene

Variants for TMEM116 Gene

Sequence variations from dbSNP and Humsavar for TMEM116 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000064098 -- 111,940,887(+) TTGAG(C/T)GAATG intron-variant
rs1000068238 -- 111,911,579(+) TACCC(C/T)GTTCT intron-variant
rs1000092907 -- 111,962,323(+) TAAAT(C/T)TCATA intron-variant
rs1000131772 -- 111,961,537(+) ATAAA(C/T)GTAAC intron-variant
rs1000134823 -- 112,009,857(+) AAAAA(A/C)CAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM116 Gene

Variant ID Type Subtype PubMed ID
esv2746360 CNV deletion 23290073
esv3630772 CNV loss 21293372
nsv1044606 CNV gain 25217958
nsv1045310 CNV gain 25217958
nsv887 CNV deletion 18451855

Variation tolerance for TMEM116 Gene

Residual Variation Intolerance Score: 65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.46; 64.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM116 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM116

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM116 Gene

Disorders for TMEM116 Gene

Relevant External Links for TMEM116

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM116

No disorders were found for TMEM116 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM116 Gene

Publications for TMEM116 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 60
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 60

Products for TMEM116 Gene

Sources for TMEM116 Gene

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