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Aliases for TMEM115 Gene

Aliases for TMEM115 Gene

  • Transmembrane Protein 115 2 3 5
  • Placental Protein 6 2 3 4
  • PL6 3 4
  • Testicular Tissue Protein Li 201 3
  • Protein PL6 4
  • PP6 3

External Ids for TMEM115 Gene

Previous GeneCards Identifiers for TMEM115 Gene

  • GC03M050368

Summaries for TMEM115 Gene

GeneCards Summary for TMEM115 Gene

TMEM115 (Transmembrane Protein 115) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for TMEM115 Gene

  • May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM115 Gene

Genomics for TMEM115 Gene

Regulatory Elements for TMEM115 Gene

Enhancers for TMEM115 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F050088 0.9 ENCODE 26.1 +270.0 270049 2.5 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 GTF3C2 RBM6 TMEM115 LAMB2 QRICH1 CCDC71 SEMA3F-AS1 RHOA-IT1 HEMK1 DAG1 IFRD2
GH03F049428 0.4 ENCODE 26 +930.1 930110 1.8 PKNOX1 CREB3L1 MLX ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 ZNF766 AMT TMEM115 QRICH1 LAMB2 CCDC71 IMPDH2 NICN1 WDR6 RHOA-IT1 SEMA3F-AS1
GH03F050598 1.6 VISTA FANTOM5 ENCODE 25.6 -246.9 -246877 15.0 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 TMEM115 HEMK1 C3orf18 SEMA3F-AS1 RAD54L2 DOCK3 MANF GMPPB AMIGO3 CISH
GH03F050663 1.2 Ensembl ENCODE 15.5 -303.9 -303891 0.6 NFIA TEAD1 SP5 TEAD2 MAX CEBPB CEBPG TEAD3 GTF3C2 CEBPA DOCK3 TMEM115 SEMA3F-AS1 RAD54L2 GMPPB AMIGO3 HEMK1 ENSG00000273356 CISH
GH03F049443 0.5 Ensembl ENCODE 15.4 +914.5 914476 3.9 HDGF TBL1XR1 THRB GTF3C2 ELK1 ETV6 FOS CREM NCOA1 JUNB AMT QRICH1 TMEM115 SEMA3F-AS1 RHOA-IT1 WDR6 CCDC71 TMEM89 GMPPB IMPDH2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM115 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM115 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001363892 310 1800 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for TMEM115 Gene

Chromosome:
3
Start:
50,354,749 bp from pter
End:
50,359,610 bp from pter
Size:
4,862 bases
Orientation:
Minus strand

Genomic View for TMEM115 Gene

Genes around TMEM115 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM115 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM115 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM115 Gene

Proteins for TMEM115 Gene

  • Protein details for TMEM115 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12893-TM115_HUMAN
    Recommended name:
    Transmembrane protein 115
    Protein Accession:
    Q12893
    Secondary Accessions:
    • A2IDB7
    • O14568
    • Q6IAY4
    • Q9UIX3

    Protein attributes for TMEM115 Gene

    Size:
    351 amino acids
    Molecular mass:
    38197 Da
    Quaternary structure:
    • Homooligomer (PubMed:24806965). Interacts with COPB1 (PubMed:24806965). May interact with LMAN1 (PubMed:24806965). Interacts with the COG complex; probably through COG3 (PubMed:24806965).
    SequenceCaution:
    • Sequence=AAB67308.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for TMEM115 Gene

Post-translational modifications for TMEM115 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM115 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM115 Gene

Domains & Families for TMEM115 Gene

Gene Families for TMEM115 Gene

Protein Domains for TMEM115 Gene

Suggested Antigen Peptide Sequences for TMEM115 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12893

UniProtKB/Swiss-Prot:

TM115_HUMAN :
  • Belongs to the TMEM115 family.
Family:
  • Belongs to the TMEM115 family.
genes like me logo Genes that share domains with TMEM115: view

Function for TMEM115 Gene

Molecular function for TMEM115 Gene

UniProtKB/Swiss-Prot Function:
May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.

Gene Ontology (GO) - Molecular Function for TMEM115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 24806965
GO:0042802 identical protein binding IDA 24806965
genes like me logo Genes that share ontologies with TMEM115: view

Phenotypes for TMEM115 Gene

GenomeRNAi human phenotypes for TMEM115:
genes like me logo Genes that share phenotypes with TMEM115: view

Animal Model Products

miRNA for TMEM115 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM115 Gene

Localization for TMEM115 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM115 Gene

Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM115 Gene COMPARTMENTS Subcellular localization image for TMEM115 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005634 nucleus IDA 17973242
GO:0005794 Golgi apparatus IEA,IDA 17973242
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM115: view

Pathways & Interactions for TMEM115 Gene

genes like me logo Genes that share pathways with TMEM115: view

Gene Ontology (GO) - Biological Process for TMEM115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IMP 24806965
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IMP 24806965
GO:0008285 negative regulation of cell proliferation NAS 17973242
genes like me logo Genes that share ontologies with TMEM115: view

No data available for SIGNOR curated interactions for TMEM115 Gene

Transcripts for TMEM115 Gene

mRNA/cDNA for TMEM115 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(194) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM115 Gene

Transmembrane protein 115:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM115 Gene

No ASD Table

Relevant External Links for TMEM115 Gene

GeneLoc Exon Structure for
TMEM115
ECgene alternative splicing isoforms for
TMEM115

Expression for TMEM115 Gene

mRNA expression in normal human tissues for TMEM115 Gene

Protein differential expression in normal tissues from HIPED for TMEM115 Gene

This gene is overexpressed in Placenta (29.3), Testis (27.7), and Blymphocyte (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM115 Gene



Protein tissue co-expression partners for TMEM115 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM115 Gene:

TMEM115

SOURCE GeneReport for Unigene cluster for TMEM115 Gene:

Hs.91566

mRNA Expression by UniProt/SwissProt for TMEM115 Gene:

Q12893-TM115_HUMAN
Tissue specificity: Expressed strongly in kidney and skeletal muscle, followed by liver, placenta, pancreas, and lung, with low amounts in heart and only traces in brain (PubMed:11085536). Widely expressed with ubiquitous expression in epithelial tissues (at protein level) (PubMed:17973242).
genes like me logo Genes that share expression patterns with TMEM115: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TMEM115 Gene

Orthologs for TMEM115 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM115 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM115 34 35
  • 99.34 (n)
mouse
(Mus musculus)
Mammalia Tmem115 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM115 34 35
  • 92.12 (n)
cow
(Bos Taurus)
Mammalia TMEM115 34 35
  • 91.74 (n)
rat
(Rattus norvegicus)
Mammalia Tmem115 34
  • 88.51 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM115 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM115 34 35
  • 77.83 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM115 35
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem115 34 35
  • 65.23 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9536 35
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F11A10.6 35
  • 24 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 19 (a)
OneToOne
-- 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G07950 34
  • 45.2 (n)
rice
(Oryza sativa)
Liliopsida Os07g0655400 34
  • 43.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8583 35
  • 43 (a)
OneToOne
Species where no ortholog for TMEM115 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM115 Gene

ENSEMBL:
Gene Tree for TMEM115 (if available)
TreeFam:
Gene Tree for TMEM115 (if available)

Paralogs for TMEM115 Gene

No data available for Paralogs for TMEM115 Gene

Variants for TMEM115 Gene

Sequence variations from dbSNP and Humsavar for TMEM115 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1051845 -- 50,354,820(-) ATTTT(C/T)TACAG intron-variant, utr-variant-3-prime
rs111275306 -- 50,360,678(+) GGGAT(A/G)CTGAG intron-variant, upstream-variant-2KB
rs111429932 -- 50,355,418(+) GTGGG(A/G)GCTTT intron-variant, reference, synonymous-codon
rs111501251 -- 50,357,352(+) AGGAG(C/T)CTTGG intron-variant
rs111610641 -- 50,361,209(+) AGCTG(C/T)GACTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM115 Gene

Variant ID Type Subtype PubMed ID
dgv8317n54 CNV loss 21841781
esv3584502 CNV gain 24956385
nsv460531 CNV loss 19166990
nsv470561 CNV loss 18288195
nsv523662 CNV loss 19592680
nsv590255 CNV loss 21841781
nsv834692 CNV loss 17160897
nsv834693 CNV loss 17160897
nsv954855 CNV deletion 24416366

Variation tolerance for TMEM115 Gene

Residual Variation Intolerance Score: 40.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM115 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM115

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM115 Gene

Disorders for TMEM115 Gene

Relevant External Links for TMEM115

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM115

No disorders were found for TMEM115 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM115 Gene

Publications for TMEM115 Gene

  1. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PMID: 11085536) Lerman M.I. … Minna J.D. (Cancer Res. 2000) 2 3 4 64
  2. TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport. (PMID: 24806965) Ong Y.S. … Hong W. (J. Cell Sci. 2014) 3 4 64
  3. Loss of PL6 protein expression in renal clear cell carcinomas and other VHL-deficient tumours. (PMID: 17973242) Ivanova A.V. … Lerman M.I. (J. Pathol. 2008) 3 4 64
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TMEM115 Gene

Sources for TMEM115 Gene

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