Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM115 Gene

Aliases for TMEM115 Gene

  • Transmembrane Protein 115 2 3
  • Placental Protein 6 2 3 4
  • PL6 3 4
  • Protein PL6 4
  • PP6 3

External Ids for TMEM115 Gene

Summaries for TMEM115 Gene

GeneCards Summary for TMEM115 Gene

TMEM115 (Transmembrane Protein 115) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM115 Gene

  • May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM115 Gene

Genomics for TMEM115 Gene

Genomic Location for TMEM115 Gene

Start:
50,354,749 bp from pter
End:
50,359,610 bp from pter
Size:
4,862 bases
Orientation:
Minus strand

Genomic View for TMEM115 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM115 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM115 Gene

Regulatory Elements for TMEM115 Gene

Proteins for TMEM115 Gene

  • Protein details for TMEM115 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12893-TM115_HUMAN
    Recommended name:
    Transmembrane protein 115
    Protein Accession:
    Q12893
    Secondary Accessions:
    • A2IDB7
    • O14568
    • Q6IAY4
    • Q9UIX3

    Protein attributes for TMEM115 Gene

    Size:
    351 amino acids
    Molecular mass:
    38197 Da
    Quaternary structure:
    • Homooligomer (PubMed:24806965). Interacts with COPB1 (PubMed:24806965). May interact with LMAN1 (PubMed:24806965). Interacts with the COG complex; probably through COG3 (PubMed:24806965).
    SequenceCaution:
    • Sequence=AAB67308.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for TMEM115 Gene

Proteomics data for TMEM115 Gene at MOPED

Post-translational modifications for TMEM115 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM115 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM115 Gene

Domains for TMEM115 Gene

Protein Domains for TMEM115 Gene

UniProtKB/Swiss-Prot:

TM115_HUMAN
Family:
  • Belongs to the TMEM115 family.:
    • Q12893
genes like me logo Genes that share domains with TMEM115: view

No data available for Gene Families for TMEM115 Gene

Function for TMEM115 Gene

Molecular function for TMEM115 Gene

UniProtKB/Swiss-Prot Function: May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.

Gene Ontology (GO) - Molecular Function for TMEM115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 24806965
GO:0042802 identical protein binding IDA 24806965
genes like me logo Genes that share ontologies with TMEM115: view

miRNA for TMEM115 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM115 Gene

Localization for TMEM115 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM115 Gene

Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM115 Gene COMPARTMENTS Subcellular localization image for TMEM115 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytoskeleton 3
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17973242
GO:0005794 Golgi apparatus IDA 17973242
GO:0016021 integral component of membrane IEA --
GO:0017119 colocalizes_with Golgi transport complex IDA 24806965
GO:0032580 Golgi cisterna membrane IDA 24806965
genes like me logo Genes that share ontologies with TMEM115: view

Pathways for TMEM115 Gene

SuperPathways for TMEM115 Gene

No Data Available

Interacting Proteins for TMEM115 Gene

Gene Ontology (GO) - Biological Process for TMEM115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IMP 24806965
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IMP 24806965
GO:0008285 negative regulation of cell proliferation NAS 17973242
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with TMEM115: view

No data available for Pathways by source for TMEM115 Gene

Transcripts for TMEM115 Gene

mRNA/cDNA for TMEM115 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(194) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM115 Gene

Transmembrane protein 115:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM115 Gene

No ASD Table

Relevant External Links for TMEM115 Gene

GeneLoc Exon Structure for
TMEM115
ECgene alternative splicing isoforms for
TMEM115

Expression for TMEM115 Gene

mRNA expression in normal human tissues for TMEM115 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM115 Gene

SOURCE GeneReport for Unigene cluster for TMEM115 Gene Hs.91566

mRNA Expression by UniProt/SwissProt for TMEM115 Gene

Q12893-TM115_HUMAN
Tissue specificity: Expressed strongly in kidney and skeletal muscle, followed by liver, placenta, pancreas, and lung, with low amounts in heart and only traces in brain (PubMed:11085536). Widely expressed with ubiquitous expression in epithelial tissues (at protein level) (PubMed:17973242).
genes like me logo Genes that share expressions with TMEM115: view

Orthologs for TMEM115 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM115 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM115 36
  • 99.34 (n)
  • 99.15 (a)
TMEM115 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM115 36
  • 91.74 (n)
  • 96.87 (a)
TMEM115 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM115 36
  • 92.12 (n)
  • 96.87 (a)
TMEM115 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem115 16
Tmem115 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM115 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem115 36
  • 88.51 (n)
  • 96.26 (a)
chicken
(Gallus gallus)
Aves TMEM115 36
  • 77.83 (n)
  • 78.26 (a)
TMEM115 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM115 37
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem115 36
  • 65.23 (n)
  • 68.1 (a)
tmem115 37
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9536 37
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F11A10.6 37
  • 24 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 19 (a)
OneToOne
-- 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G07950 36
  • 45.2 (n)
  • 36.4 (a)
rice
(Oryza sativa)
Liliopsida Os07g0655400 36
  • 43.65 (n)
  • 32.99 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8583 37
  • 43 (a)
OneToOne
Species with no ortholog for TMEM115:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM115 Gene

ENSEMBL:
Gene Tree for TMEM115 (if available)
TreeFam:
Gene Tree for TMEM115 (if available)

Paralogs for TMEM115 Gene

No data available for Paralogs for TMEM115 Gene

Variants for TMEM115 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM115 Gene

Variant ID Type Subtype PubMed ID
nsv523662 CNV Loss 19592680
nsv876769 CNV Loss 21882294
nsv470561 CNV Loss 18288195
nsv876770 CNV Loss 21882294
nsv834692 CNV Loss 17160897
nsv460531 CNV Loss 19166990
dgv5131n71 CNV Loss 21882294
dgv5132n71 CNV Loss 21882294
nsv834693 CNV Loss 17160897

Relevant External Links for TMEM115 Gene

HapMap Linkage Disequilibrium report
TMEM115

No data available for Sequence variations from dbSNP and Humsavar for TMEM115 Gene

Disorders for TMEM115 Gene

No disorders were found for TMEM115 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM115 Gene

Publications for TMEM115 Gene

  1. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PMID: 11085536) Lerman M.I. … Minna J.D. (Cancer Res. 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4
  4. Loss of PL6 protein expression in renal clear cell carcinomas and other VHL-deficient tumours. (PMID: 17973242) Ivanova A.V. … Lerman M.I. (J. Pathol. 2008) 3 4
  5. TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport. (PMID: 24806965) Ong Y.S. … Hong W. (J. Cell Sci. 2014) 3 4

Products for TMEM115 Gene

Sources for TMEM115 Gene

Back to Top

Content